reproxalap systemic (ADX-102 systemic) / Aldeyra - LARVOL DELTA

Transdifferentiation of mantle cell lymphoma into sarcoma with limited neuromuscular differentiation after conventional chemotherapy. (PubMed, Virchows Arch) - "An 81-year-old man with t(11;14)-positive MCL was treated with rituximab and bendamustine and achieved complete remission; however, just 2 months later, the patient developed multiple systemic tumors...Whole-exome sequencing detected 189 single nucleotide variants (SNVs) in the MCL and 205 SNVs in the sarcoma; 160 SNVs including NSD2, ATM, RB1, and TP53 mutations were shared between MCL and sarcoma cells. An additional PTPN11 mutation was specifically found in the sarcoma. These findings confirmed the shared clonal origin of MCL and sarcoma in this patient and indicated that MCL can transdifferentiate into sarcoma in rare cases."

Journal • Hematological Malignancies • Lymphoma • Mantle Cell Lymphoma • Oncology • Sarcoma • Solid Tumor • CCND1 • Myogenin • NCAM1 • PTPN11 • RB1 • SYP • TP53

A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing. (PubMed, 3 Biotech) - "Although NSPs are conserved among the βCoVs, mutations in NSP2 and NSP3 may play critical roles in transmitting the virus and cell tropism...This review provides a cumulative overview of the genomic structure, transmission, phylogeny of SARS-CoV-2 from Indian clusters, treatment options, updated discoveries, and future standpoints for COVID-19. The online version contains supplementary material available at 10.1007/s13205-021-02749-0."

Journal • Review • Acute Respiratory Distress Syndrome • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

[VIRTUAL] Pacemaker Macula Densa Cells Form a Nephron-Level Autonomous Somatosensory Neuronal Network (KIDNEY WEEK 2020) - "RNA seq analysis revealed enrichment of numerous genes involved in membrane depolarization and pacemaker activity, such as voltage-dependent sodium, potassium, and calcium channels (Scn4b, Scn2b, Kcnd3, Kcnc2, Cacna1d), in afterhyperpolarization (Kcnn2), in the initiation of pacemaker activity (Itpr1), and in synapse formation and transmission (Nsg2, Tmem158, Syt5-13, Sv2a). This study uncovered new neuron-like functional and molecular features of MD cells and established them as chief sensory neuroepithelial cells that form a nephron-level autonomous neuronal network to control key organ and somatosensory functions. Funding: NIDDK Support"

Diabetes

Aldeyra to screen clinical-stage compounds for activity in COVID-19 infection (Aldeyra Therapeutics Press Release) - "ldeyra Therapeutics, Inc....announced that it will begin screening its library of novel reactive aldehyde species (RASP) inhibitors, including ADX-629 and reproxalap, for potential anti-inflammatory and antiviral activity in the treatment of COVID-19 infection."

Clinical

Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin. (PubMed, Cell Physiol Biochem) - "The findings indicate that the Nsm2/ ceramide system plays an important role in systemic infection of mice with mycobacteria by regulating a signaling cascade via p38K, JNK, b1-integrin and Rac1."

Journal