CT 103 / Sienna - LARVOL DELTA

A case report on the choice of venous access after ectopic peripherally inserted central catheter in an upper limb of a patient with a second recurrence of right-side breast cancer. (PubMed, Medicine (Baltimore)) - "This case presents a rare and insightful clinical scenario. For patients with a history of infusion port placement, particularly via the left internal jugular vein, careful analysis of the innominate vena cava and examination of chest wall vein exposure are essential to determining the optimal vascular access strategy."

Journal • Breast Cancer • Oncology • Solid Tumor

BASELINE SBCMA PLASMA LEVEL HAS NO IMPACT ON THE EFFICACY OF EQUECABTAGENE AUTOLEUCEL,A BCMA-CAR T CELL THERAPY IN PATIENTS WITH RRMM: SUBANALYSIS OF FUMANBA-1 TRIAL (EBMT 2024) - P1/2 | "And all the subgroups showed a sharp sBCMA decrease with the response to CT103. These results demonstrate that eque-cel represents a promising treatment option for RRMM patients, including those with higher baseline serum sBCMA level and higher tumor burden. And the relatively long persistence of eque-cel is another demonstration that eque-cel is not inhibited or exhausted by sBCMA."

CAR T-Cell Therapy • Clinical • Multiple Myeloma

Synthesis of doxorubicin-loaded peptosomes hybridized with gold nanorod for targeted drug delivery and CT imaging of metastatic breast cancer. (PubMed, J Nanobiotechnology) - "In this regard, the synthesized theranostic peptosomes offer innovative hybrid multipurpose platform for fighting against breast cancer."

Journal • Breast Cancer • Oncology • Solid Tumor

Cancer Nanomedicines Based on Synthetic Polypeptides. (PubMed, Biomacromolecules) - "A few polypeptide-based nanoformulations (e.g., NK105, NC6004, NK911, CT2103) are under phases I-III clinical investigation for treating patients with advanced solid tumors. Moreover, virus-mimicking vehicles have been devised from polypeptides for efficient non-viral delivery of highly potent peptides, proteins, and nucleic acids, greatly advancing biotherapy for cancers. In this perspective, we highlight the state-of-the-art design and fabrication of cancer nanomedicines based on synthetic polypeptides, and at the end give our viewpoints on their future development for targeted cancer therapy and potential challenges for clinical translation."

Journal • Oncology • Psychiatry • Solid Tumor

Phenotypic differentiation between Klebsiella pneumoniae SHV-1 hyperproducers and ESBL-positive K. pneumoniae (ECCMID 2019) - "Background: K. pneumoniae has a chromosomally encoded SHV-1 gene resulting in intrinsic resistance to amoxicillin...Materials/ From results of clinical or surveillance cultures within the University Medical Center Groningen between 01/06/2014-15/09/2018, we selected K. pneumoniae isolates which met the following criteria as determined by Vitek antimicrobial susceptibility testing (AST): ceftazidime MIC>1mg/L, cefotaxime MIC<2mg/L, gentamicin sensitive, ciprofloxacin sensitive (according to prevailing EUCAST clinical breakpoints). We extracted MICs from Vitek AST and results of ESBL E-tests, Check-Points MDR CT103 Array (CP) and Next Generation Sequencing (NGS)... In K. pneumoniae the phenotypical pattern of an elevated ceftazidime MIC combined with a cefotaxime MIC <2mg/L in absence of co-resistance to ciprofloxacin, aminoglycosides and trimethoprim-sulfamethoxazole reliably excludes the presence of ESBL genes. This false-positive ESBL phenotype is frequently..."

Infectious Disease • Pneumonia • Respiratory Diseases

Prevalence and antibiotic susceptibility pattern of CTX-M type extended-spectrum β-lactamases among clinical isolates of gram-negative bacilli in Jimma, Ethiopia. (PubMed, BMC Infect Dis) - "This study demonstrates a remarkably high prevalence of bla genes among ESBL-producing isolates. The high level of resistance to β-lactam and non-β-lactam antibiotics as well as the trend to a MDR profile associated with the bla genes are alarming and emphasize the need for routine diagnostic antimicrobial susceptibility testing for appropriate choice of antimicrobial therapy."

Clinical • Journal • Biosimilar • Immunology

"#CT103 #mmsm #ASH19 #ASHsm ?antidrug abs no data so far" (@feldstej)

Elucidating vancomycin-resistant Enterococcus faecium outbreaks: the role of clonal spread and movement of mobile genetic elements. (PubMed, J Antimicrob Chemother) - "ST117 isolates were divided into CT24, CT103 and CT105. Combining these two methods allows investigation of both clonal spread as well as the spread of MGEs. This leads to new insights and thereby better understanding of the complex transmission routes in VREfm outbreaks."

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Detection of carbapenemases, AmpC and ESBL genes in Acinetobacter isolates from ICUs by DNA microarray. (PubMed, J Microbiol Methods) - "All of the strains of A. baumannii (47) were resistant to imipenem and meropenem. Sensitivity and specificity of microarray assay were 100% for bla-genes in comparison to PCR. This reveals that Check-MDR CT103 XL assay is an accurate method for the identification of ESBLs and carbapenemase genes in A. baumannii in comparison to the other methods."

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