QLS5132 / Qilu Pharma - LARVOL DELTA

A first-in-human phase 1 trial of a novel claudin 6 (CLDN6)-targeting antibody drug conjugate (ADC) QLS5132 in patients (pts) with platinum-resistant ovarian cancer (PROC) (AACR 2026) - P1 | "Ten (35.7%) pts received ≥5 lines of prior treatment, 25 (89.3%) pts received prior bevacizumab, and 22 (78.6%) pts received prior polyADP ribose polymerase inhibitors. QLS5132 was well-tolerated under potential recommended dose levels (<6.4 mg/kg) and presented remarkable antitumor activity in pts with advanced PROC. Patients enrollment for PROC, non-small cell lung cancer, gastric cancer, and other cancers are ongoing."

ADC • Clinical • First-in-human • P1 data • Platinum resistant • Fallopian Tube Cancer • Gastric Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Ovarian Cancer • Solid Tumor • CLDN6 • MUC16

QLS5132 Goes after CLDN6 in Ovarian Cancer. (PubMed, Cancer Discov) - "For patients with advanced platinum-resistant ovarian cancer, treatment options remain limited, but new agents are emerging. One is QLS5132, an antibody-drug conjugate targeting CLDN6; early data from a phase I trial indicates that it has a favorable safety profile and appears active in this disease."

Journal • Platinum resistant • Oncology • Ovarian Cancer • Solid Tumor • CLDN6

QLS5132, a highly selective anti-CLDN6 ADC with broader therapeutic window (AACR 2025) - "QLS5132 showed an expanded therapeutic window with superior efficacy and tolerability to TORL-1-23 in preclinical models. QLS5132 also demonstrated great potential to combine with PARPi in CLDN6 positive ovarian cancers. QLS5132 is expected to offer a novel and promising treatment option either as a single agent or combo with PARPi or other SoCs for patients with CLDN6 expressing tumors."

ADC • Endometrial Cancer • Genito-urinary Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Ovarian Cancer • Solid Tumor • Testicular Cancer • CLDN6

QLS5132 Combination Therapy in Advanced Solid Tumors (clinicaltrials.gov) - P1/2 | N=626 | Not yet recruiting | Sponsor: Qilu Pharmaceutical Co., Ltd.

New P1/2 trial • Endometrial Cancer • Gastric Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Ovarian Cancer • Solid Tumor

Phase 1 Clinical Study of QLS5132 Monotherapy in Advanced Solid Tumors (clinicaltrials.gov) - P1 | N=256 | Not yet recruiting | Sponsor: Qilu Pharmaceutical Co., Ltd.

Monotherapy • New P1 trial • Solid Tumor