colistin sulphate / Generic mfg. - LARVOL DELTA

First Report and Comprehensive Risk Index of blaIMP-1-Harboring Brucella anthropi in Municipal Wastewater-Irrigated Soil. (PubMed, Microorganisms) - "SBA01 exhibited phenotypic resistance to carbapenems and colistin, the latter being independent of mcr genes...These findings position B. anthropi as a resilient environmental reservoir for clinically relevant carbapenemases. Expanding surveillance frameworks to include such adaptive hosts is necessary to better evaluate potential occupational exposures at the wastewater-soil interface."

Journal • Gene Therapies • Infectious Disease • Pneumonia

Fluoroquinolone-Resistant Avian Pathogenic Escherichia coli Isolated from Asymptomatic Broiler Chickens in a Slaughterhouse in Northern Thailand. (PubMed, Pathogens) - "Antimicrobial susceptibility to ciprofloxacin, cefotaxime, ceftazidime, imipenem, and colistin was examined. This study reveals a high prevalence of virulent APEC with fluoroquinolone resistance in slaughtered broiler chickens. Almost all virulent APEC strains belong to phylogroups F and C. The prediction of virulent APEC using hlyF, iroC, iroN, iutA, O78, and ompT may be useful."

Journal

Molecular Characterization of Colistin-Resistant Clinical Acinetobacter baumannii from Northern Greece: Phenotypic Colistin Susceptibility and lpx/pmrCAB Mutational Profiles. (PubMed, Antibiotics (Basel)) - " In this cohort from Northern Greece, chromosomal mutations in the pmrCAB operon, within a predominantly ST2/IC2 background, were strongly associated with colistin resistance. These findings underscore the urgent need for continued molecular surveillance and targeted infection-control measures to limit further spread of PDR A. baumannii."

Journal • Infectious Disease

Analysis of Antibiotic Consumption Trends and Pathogens' Epidemiological Profile Within a Multidisciplinary Clinical Hospital from Romania. (PubMed, Antibiotics (Basel)) - "For Reserve antibiotics, only slight annual fluctuations were observed, but there was an important reduction in colistin consumption. The most used were cephalosporins (cefazolin, cefuroxime and ceftriaxone), carbapenems (meropenem and ertapenem), vancomycin and linezolid... The analysis was carried out using tools recommended by the World Health Organisation (Access Watch Reserve antibiotics classification (AWaRe); Bacterial Priority Pathogen List (BBPL); Defined Daily Dose (DDD)), Average Annual Percent Change (AAPC) calculation and ESKAPE classification (bacteria group: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.). Relatively stable trends in bacterial isolates and resistant strains over five years (2020-2024) are consistent with effective antimicrobial stewardship practices."

Journal • Infectious Disease • Pneumonia

In Vitro Activity of Cefiderocol, Eravacycline, and Imipenem-Relebactam Against Multidrug-Resistant Acinetobacter baumannii Clinical Isolates. (PubMed, Antibiotics (Basel)) - " All isolates were resistant to imipenem and meropenem. Cefiderocol and eravacycline demonstrated promising in vitro activity against MDR A. baumannii, including colistin-resistant isolates, whereas imipenem-relebactam showed no activity. These findings support the potential role of cefiderocol and eravacycline as alternative treatment options for CRAB infections and highlight the multifactorial nature of cefiderocol resistance beyond OXA-type carbapenemase production."

Journal • Preclinical • Infectious Disease

Colistin Resistance: From Laboratory Research to Modern Clinical Management. (PubMed, Antibiotics (Basel)) - " The escalating prevalence of colistin resistance threatens the effectiveness of this critical last-line antibiotic. Optimized use, robust resistance surveillance, accurate detection methods, and the development of innovative therapeutic strategies are essential to preserve colistin's clinical utility and address the growing burden of MDR Gram-negative infections."

Journal • Review • Infectious Disease • Pneumonia

A natural probioenzyme strategy as an effective alternative to antibiotics against multidrug-resistant Klebsiella pneumoniae in broilers: Benefits for growth, immunity, and organ health. (PubMed, PLoS One) - "Antimicrobial susceptibility testing showed bacterial resistance to penicillin G (100%) but complete sensitivity to colistin sulphate (100%). These findings demonstrate that dietary probioenzyme is a viable alternative to antibiotics, effectively mitigating K. pneumoniae infection while improving growth, organ health, and immune competence without contributing to antimicrobial resistance. This strategy supports sustainable poultry production and aligns with global efforts to reduce antibiotic reliance."

Journal • Infectious Disease • Pneumonia • CAT

Epidemiological Insights into Carbapenem-Resistant Enterobacterales Throughout the COVID-19 Pandemic in Buenos Aires, Argentina. (PubMed, Antibiotics (Basel)) - "NS remained largely stable in HA, except for a significant increase in colistin NS, whereas HB showed a rise in NS to multiple antimicrobials over time...A temporal shift in carbapenemase prevalence was observed in each hospital, converging in similar frequencies of KPC and NDM by 2022 across both centres. This scenario was driven by the active dissemination of K. pneumoniae ST258."

Journal • Infectious Disease • Novel Coronavirus Disease • Pneumonia

Integrated Proteomics and Metabolomics Reveal Multifaceted Mechanisms of Colistin Resistance in Acinetobacter baumannii. (PubMed, Infect Drug Resist) - "Colistin resistance in A. baumannii appears to involve a multifaceted strategy integrating lipid A modification, cell membrane remodeling, and metabolic reprogramming. This study provides a high-resolution molecular blueprint of colistin resistant A. baumannii and generates testable hypotheses to inform future diagnostic and therapeutic strategies against resistant infections."

Journal • Infectious Disease

DECOLONIZATION OF MULTIDRUG-RESISTANT BACTERIA BY FECAL MICROBIOTA TRANSPLANTATION IN A PATIENT BEFORE ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (EBMT 2026) - "His course was complicated by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae bacteremia that was effectively treated with colistin...He was successfully treated with cefiderocol and high-dose extended infusion of meropenem in conjunction with debridement of right femoral osteomyelitis/abscess...Six weeks post-FMT, he underwent matched unrelated donor allogeneic HSCT using total marrow and lymphoid irradiation and cyclophosphamide conditioning and tacrolimus for graft-versus-host-disease (GvHD) prophylaxis... FMT for MDRO-decolonization pre-HSCT was successful, safe, and effective in this patient with one of the longest follow-up periods reported. Given limited therapeutic options to combat MDRO infections, safety and efficacy of gut microbial restoration with FMT in patients undergoing HSCT needs to be actively explored."

Clinical • Acute Graft versus Host Disease • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Febrile Neutropenia • Graft versus Host Disease • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Myositis • Pneumonia • Transplantation

The emergence of pan-drug-resistant Pseudomonas aeruginosa in Iran: A genomic and phenotypic analysis of clinical isolates, multifactorial resistance mechanisms, and its societal impact. (PubMed, New Microbes New Infect) - "Antimicrobial susceptibility testing revealed high resistance to fluoroquinolones (65.9%) and carbapenems (47.2%), while colistin remained most effective (95.6% susceptibility)...Efflux pump activity, detected in 28.9% of ciprofloxacin-resistant isolates, was prominent in all PDR strains...Multilocus sequence typing identified high-risk clones ST357, ST175, and ST664. This study underscores the critical convergence of multiple resistance mechanisms (enzymatic degradation, efflux overexpression, porin loss, and biofilm formation) driving the emergence of PDR P. aeruginosa in Iran, necessitating enhanced surveillance and innovative treatment strategies."

Journal • Infectious Disease

Efficacy and Safety of Different Colistin Administration Routes for Nosocomial Pneumonia Caused by Carbapenem-Resistant Organisms: A Single Centre, Open Label, Prospective Cohort Study. (PubMed, Drug Des Devel Ther) - "In critically ill patients with CRO-associated NP, inhaled colistin monotherapy provided comparable clinical efficacy to systemic administration. It achieved superior microbiological eradication and showed a favorable safety profile regarding nephrotoxicity, suggesting it represents a viable and potentially safer therapeutic strategy."

Journal • Acute Kidney Injury • Critical care • Infectious Disease • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

CLINICAL PROFILE AND OUTCOME OF TUNNELED CUFFED CATHETER AS VASCULAR ACCESS IN PATIENTS ON MAINTENANCE HEMODIALYSIS: A SINGLE TERTIARY CENTER STUDY IN INDIA (ISN-WCN 2026) - "Pseudomonas aeruginosa (n=4) and Klebsiella pneumoniae (n=2) were the most common bacterial isolates, with all strains sensitive to colistin...This prolonged catheter use comes at a cost, with a notable CRBSI rate of 18.4%, a finding comparable to other studies.The clinical impact of these infections was substantial, necessitating catheter removal in half of the affected patients and highlighting the morbidity associated with TCC dependency. Despite these risks, TCCs effectively fulfilled their bridging role, with nearly a quarter of patients successfully transitioning to a functional AVF, receiving a kidney transplant, or recovering renal function"

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Disorders • Hypotension • Infectious Disease • Myocardial Infarction • Nephrology • Pneumonia • Renal Disease • Thrombosis

COMBINED CYSTATIN C– AND CREATININE-BASED ESTIMATED GLOMERULAR FILTRATION RATE FOR COLISTIN DOSING TO PREVENT ACUTE KIDNEY INJURY: PRELIMINARY RESULTS OF THE COLD-PREVAKI RANDOMIZED CONTROLLED TRIAL (ISN-WCN 2026) - "Other clinical outcomes, including KRT use, hospital length of stay, and mortality, did not differ significantly.Download: Download high-res image (255KB)Download: Download full-size imageConclusion This trial, one of the first to test cystatin C–guided colistin dosing, demonstrated that although cystatin C-guided dosing could reduce colistin exposure without increasing serious adverse clinical outcomes, it did not lower AKI incidence compared to creatinine-based dosing. These findings suggest that cystatin C–guided dosing is feasible and safe, but its clinical benefit in preventing AKI remains unproven and warrants further study, particularly in patients with low muscle mass."

Clinical • Acute Kidney Injury • Chronic Kidney Disease • Infectious Disease • Nephrology • Renal Disease • Sarcopenia • CST3

Comparison between the antimicrobial activity of colistin and ceftazidime-avibactam against multidrug-resistant Pseudomonas aeruginosa isolated from patients with ventilator-associated pneumonia in intensive care units of Kasr Al-Ainy hospitals. (PubMed, BMC Infect Dis) - No abstract available

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Genomic convergence of multidrug resistance, virulence-associated loci, and phage defense systems in Klebsiella pneumoniae from pharmaceutical wastewater in Bangladesh. (PubMed, Sci Rep) - "JU-BAEC-01 belongs to a phylogenetically distinct lineage, serotype O3b: KL150 with resistance to nearly all clinically relevant antibiotic classes except carbapenems and colistin, mediated by an extensive acquired resistome, including tmexCD3-toprJ3 (tigecycline), armA, aac(6')-Ib-cr, qnrB4, oqxAB, blaDHA-1, blaSHV-182, and blaTEM-1B, mostly carried on conjugative IncC, IncFIB, IncHI1B, and IncR plasmids. pneumoniae JU-BAEC-01 is a "perfect storm" pathogen that combines multi-drug resistance (MDR), hypervirulence, and a multilayered, highly developed defense against bacteriophages. Together, these findings highlight the environmental emergence of a genetically distinct, multidrug-resistant K. pneumoniae with substantial virulence potential and complex phage-host interaction capacity, underscoring the need for genomic surveillance of pharmaceutical wastewater systems."

Journal • Infectious Disease • Pneumonia

Emerging co-occurrence of mcr-10 and broad-spectrum β-lactamase genes in Enterobacterales from surface waters in Brazil. (PubMed, Environ Monit Assess) - "These findings highlight the first report of the mcr-10 gene in Brazil and the early dissemination throughout the environmental sector. Therefore, the identification of Enterobacterales strains co-producing mcr-10 and broad-spectrum-β-lactamase genes draws attention to a new trend in antimicrobial resistance mediated by critical pathogens in the environment."

Journal • Infectious Disease • Pneumonia

Pus-Forming Infections in an Advanced Care Hospital in Morocco: Enterobacterales Dominance With High Burden of Extended-Spectrum β-Lactamase Producers and Carbapenem Resistance. (PubMed, Cureus) - "The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in S. aureus was 14.75%; resistance to penicillin G among staphylococci was very high, whereas all staphylococcal and enterococcal isolates remained susceptible to vancomycin and linezolid...In P. aeruginosa, resistance to ceftazidime and/or carbapenems was modest (7.69%), and all isolates were susceptible to amikacin and colistin, whereas 75.0% of Acinetobacter spp...Fine-needle aspirates outperformed superficial swabs for pathogen detection. These findings support the use of deep sampling whenever feasible, regular updating of local antibiograms, and rational use of antimicrobial agents, particularly regarding third-generation cephalosporins and carbapenems, to optimize empirical therapy for pus-forming infections in this setting."

Journal • Infectious Disease • Pneumonia

Bogland plant Tormentil inhibits multidrug-resistant pathogen growth and potentiates antibiotics by disrupting iron homeostasis. (PubMed, Microbiology (Reading)) - "We also demonstrated that Tormentil could potentiate the activity of the last-resort antibiotic, colistin. Overall, these findings valorize the centuries-old traditional use of Tormentil to treat infection and highlight how its bioactive constituents could be exploited to prolong the lifespan of our last line of antibiotic defence, colistin."

Journal • Infectious Disease

Comparative Colistin Sulfate versus Polymyxin B in Patients with Carbapenem-Resistant Organism Bloodstream Infections. (PubMed, J Glob Antimicrob Resist) - "CS and PMB were equally effective in treating patients with CRO-BSI, but the CS group experienced a lower rate of AKI."

Journal • Acute Kidney Injury • Infectious Disease • Nephrology • Renal Disease

Capsular polysaccharides of Acinetobacter baumannii modulate antimicrobial resistance and innate immune response. (PubMed, Sci Rep) - "CPS-deficient mutant (∆galU) displayed increased susceptibility to gentamicin, tetracycline, colistin, and sodium dodecyl sulfate (SDS). Moreover, purified CPS induced pro-inflammatory cytokine expression in sterile infection and promoted neutrophil chemotaxis. Altogether, this study demonstrates that CPS not only mask A. baumannii virulence surface structures, but also actively modulate host immune response and antimicrobial resistance."

Journal • Infectious Disease • Inflammation • CASP3

Letter: Emergence of a Colistin-Resistant Klebsiella pneumoniae ST694 on Fresh Parsley. (PubMed, Foodborne Pathog Dis) - No abstract available

Journal • Infectious Disease • Pneumonia

Colistin-stabilized antisolvent precipitation enables engineering of microcrystalline niclosamide for inhalable composite powders. (PubMed, Int J Pharm) - "Finally, a preliminary in vivo lung infection model was used to assess the feasibility of pulmonary administration and the antibacterial response of the co-processed formulation relative to a standard-of-care comparator. Together, these results establish a particle-engineering platform for producing high-drug-loading niclosamide-colistin inhalation powders, highlighting how one active ingredient can function as a processing aid for excipient-minimized co-delivery of antibiotic combinations."

Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Phenotypic and Genotypic Detection of Colistin Resistance (clinicaltrials.gov) - P=N/A | N=90 | Not yet recruiting | Sponsor: Assiut University

New trial • Infectious Disease

When in vitro meets in vivo: therapeutic role of ceftazidime/avibactam & aztreonam in metallo-β-lactamase-producing, colistin-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa: a five-case translational experience (ESCMID Global 2026) - No abstract available

Preclinical • Infectious Disease • Pneumonia