colistin sulphate / Generic mfg. - LARVOL DELTA

Protective Effects of Ethyl Pyruvate and Rutin Hydrate Against Colistin-Induced Nephrotoxicity in Rats. (PubMed, Pharmaceuticals (Basel)) - " These findings suggest that EP and RH may be promising adjuvant agents against colistin-induced nephrotoxicity. Combined EP and RH co-treatment showed numerically greater protection across most assessed parameters, although an overall advantage over single-agent co-treatment was not statistically established."

Journal • Preclinical • Infectious Disease • CASP3 • KIM1

Novel β-Lactam/β-Lactamase Inhibitors Versus Best Available Therapy on the Mortality-Related Carbapenem-Resistant Enterobacterales Infection: A Systematic Review and Meta-Analysis. (PubMed, Antibiotics (Basel)) - "Innovative BL/BLI combinations lower all-cause mortality compared to BAT. This effect is extremely reliant on the comparator regimen composition, the specific BL/BLI drug, and the underlying resistance mechanism. These data support a precision medicine approach guided by rapid molecular diagnostics. These findings underscore the urgent need for novel agents against MBL-producing strains, including the recently approved aztreonam-avibactam."

Journal • Retrospective data • Review • Infectious Disease • Pneumonia • Septic Shock

De-Escalation of Broad-Spectrum and Last-Resort Antibiotics in Critically Ill Adults with Gram-Negative Infections: A Scoping Review and Evidence-Informed Framework for Tertiary-Care ICUs. (PubMed, Antibiotics (Basel)) - "De-escalation appears safe but rests on low-certainty, heterogeneous evidence. We propose an evidence-informed framework, a structured 48-72 h time-out, an eligible-patient denominator and a minimum monitoring dataset for tertiary ICUs, and identify standardized definitions and resistance-focused trials as research priorities. These components represent an evidence-informed implementation proposal developed by the authors and require prospective local validation."

Journal • Review • Critical care • Infectious Disease

Practices and Perceptions of Infectious Diseases and Critical Care Clinicians Regarding Aerosolized Antimicrobial Therapy in the State of Qatar: A Multicenter Cross-Sectional Study. (PubMed, Antibiotics (Basel)) - "Gentamicin (88.6%) and colistin (72.7%) were the most frequently used aerosolized antimicrobial agents. Immunosuppression, renal function and infections due to multidrug-resistant organisms were reported by clinicians as factors that influenced their decision to use aerosolized antimicrobial therapy. A protocol for the administration of aerosolized antimicrobial therapy is recommended."

Journal • Observational data • Cognitive Disorders • Critical care • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Real-world effectiveness and treatment costs of ceftazidime-avibactam versus colistin-meropenem for ICU-acquired MDR gram-negative infections in liver transplant recipients. (PubMed, Eur J Clin Microbiol Infect Dis) - "When microbiologically appropriate, CAZ/AVI was associated with better clinical and microbiological outcomes and lower sepsis-related mortality than colistin-meropenem, without lower 30-day all-cause mortality. Given the observational design, incomplete treatment-appropriateness data, and limited economic scope, these associations require prospective validation before causal conclusions are drawn."

Journal • Real-world evidence • Infectious Disease • Septic Shock • Transplantation

Ceftazidime-Avibactam Versus Colistin-Based Regimens for Carbapenem-Resistant Enterobacterales Bloodstream Infections: A Six-Year Retrospective Cohort and 30-Day Mortality Analysis. (PubMed, Microorganisms) - "Vasopressor requirement, viral pneumonia and bacterial respiratory infection were independently associated with death, whereas definitive ceftazidime/avibactam with or without aztreonam (C/AVI ± AZT) was associated with lower mortality (adjusted OR 0.38; 95% CI 0.17-0.83). C/AVI ± AZT was associated with lower 30-day mortality than colistin, but the association was concentrated in the period when the agent was routinely available and did not survive adjustment for calendar time. These findings describe an association, not a causal survival advantage."

Journal • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Paired In Vitro Susceptibility of Cefiderocol and Colistin in Colistin-Resistant, Extensively Drug-Resistant Gram-Negative Bacilli: A Single-Centre, MIC-Based Analysis of 236 Clinical Isolates. (PubMed, Microorganisms) - "Secondary analyses were directionally consistent (incremental coverage 21.8-33.3 points). These in vitro findings support paired testing of both agents to identify isolates retaining cefiderocol activity when colistin does not; clinical benefit was not assessed."

Journal • Preclinical • Infectious Disease

Distribution of Non-Fermenting Gram-Negative Bacilli and Carbapenem Resistance Profiles in Intensive Care Units of a Foundation University Hospital: A 2023-2025 Retrospective Analysis. (PubMed, Medicina (Kaunas)) - "Identification and susceptibility testing used the BD Phoenix M50 system with year-specific EUCAST breakpoints (v13.0-v15.0); colistin MICs were determined by broth microdilution...Ceftazidime-avibactam resistance in P. aeruginosa was 24.3%. Of the S. maltophilia isolates, 85.8% were categorised as susceptible-increased exposure to trimethoprim-sulfamethoxazole...but rising for meropenem in P. aeruginosa. These data do not distinguish colonisation from infection and cannot be linked to clinical outcomes. They should therefore be used to inform local empirical-treatment policy alongside clinical assessment, rather than as evidence of treatment failure."

Journal • Retrospective data • Critical care • Infectious Disease

Membrane Disruption and Charge Neutralization Drive Synergy Between LL37-Derived Peptides and Polymyxins Against E. coli. (PubMed, Biomolecules) - "This study evaluated the synergistic effects of the human-derived AMP LL37 and its fragments FK16 and FK13, in combination with polymyxin B, colistin, and vancomycin, against three E. coli strains in vitro. The study demonstrates that LL37 and its fragments enhance the activity of conventional antibiotics against E. coli through membrane disruption and charge neutralization, as evidenced by the FICI values (0.3125-0.5), membrane disruption and charge neutralization. While divalent cations in physiological conditions influence AMP efficacy, these peptides show potential for clinical application against E.coli."

Journal

Widespread antibiotic-resistant Salmonella in reptiles and amphibians at a global exotic pet trade hub: An emerging zoonotic threat. (PubMed, One Health) - "Resistance was the highest to streptomycin (58.7%), followed by colistin (6.1%), and ampicillin (5.9%), raising critical public health concerns. This study provides evidence on MDR Salmonella in pet reptiles and amphibians, highlighting the underestimated zoonotic threats and public health risks posed by these animals in the global exotic pet trade. We advocate enhanced surveillance of resistant Salmonella in imported reptiles and amphibians and urge the enforcement of stricter regulations to mitigate pathogen transmission risks."

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Case Report: Successful salvage therapy with sulbactam-durlobactam combined with meropenem for carbapenem-resistant Acinetobacter baumannii bloodstream infection in a child after failure of allogeneic hematopoietic stem cell transplantation. (PubMed, Front Pediatr) - "The phase III ATTACK trial demonstrates that sulbactam-durlobactam (SUL-DUR), a novel β-lactam-β-lactamase inhibitor combination is non-inferior to colistin and is associated with fewer adverse events in adults. However, evidence for SUL-DUR use in post-transplant pediatric patients remains extremely limited. This article reports the first global case of a pediatric patient who experienced two successive HSCT failures and was successfully salvaged with SUL-DUR combined with meropenem for CRAB associated BSI after failing to respond to high-dose sulbactam (150 mg/kg/day) and tigecycline during persistent severe neutropenia, providing a novel strategy for managing resistant bacterial infections in high-risk transplant populations."

Journal • Bone Marrow Transplantation • Hematological Disorders • Infectious Disease • Neutropenia • Pediatrics • Transplantation

Microbial species isolation and antimicrobial resistance patterns of burn wounds infections in a tertiary care hospital. (PubMed, Int J Burns Trauma) - "The findings provide valuable insight into the prevalence of microorganisms in burn wounds and suggest that antibiotic resistance patterns can be useful in guiding the development of effective treatment strategies."

Journal • Infectious Disease

Microbial community structure and antibiotic resistance genes in Dinaric karst groundwater under contrasting hydrological conditions. (PubMed, J Hazard Mater) - "Clinically relevant ARGs, including vancomycin and colistin resistance genes, were detected at low relative abundances. These findings demonstrate associations between hydrological conditions, anthropogenic influence, and karst groundwater microbiomes and resistomes, highlighting the potential of molecular AMR surveillance in drinking water sources."

Journal

Intestinal Failure-Associated Liver Disease in a Child With Short Bowel Syndrome: Management Issues (ACG 2026) - "Stool cultures grew multidrug-resistant E. coli , treated with IV colistin and amikacin. Despite targeted antibiotics, diarrhea persisted, requiring amino acid-based formula, racecadotril, loperamide, and pantoprazole...Management included UDCA (bile salt inhibition, hepatoprotection), pantoprazole (short-term, for hypergastrinemia-driven losses), rifaximin (empirical SIBO treatment), and DHA (promotes adaptation, reduces cholestasis)...Figure: Table 1: Serial investigations of the patient. Note: PTBD: Percutaneous transhepatic biliary drainage, CRP: C-reactive protein, SGOT: Serum glutamate oxaloacetate transferase, SGPT: Serum glutamate pyruvate transferase, ALP: Alkaline phosphatase, GGT: Gamma glutamyl transferase."

Clinical • Cholestasis • Gastrointestinal Disorder • Hepatology • Hypoglycemia • Infectious Disease • Short Bowel Syndrome • CRP

Slaughtered pigs as reservoirs of One Health-relevant antimicrobial resistance genes in Klebsiella pneumoniae from Brazil. (PubMed, Front Microbiol) - "Antimicrobial susceptibility was determined by disk diffusion and broth microdilution for colistin...High frequencies of non-susceptibility were observed for tetracycline (86.8%), ciprofloxacin (77.4%), and amoxicillin-clavulanate (67.9%), while 34 isolates (64.2%) were classified as MDR...These findings demonstrate a high occurrence of MDR K. pneumoniae carrying clinically important resistance determinants in pigs at slaughter and reveal the circulation of distinct genomic lineages harboring acquired virulence-associated loci. The results suggest that swine production systems may contribute to the maintenance and potential dissemination of One Health-relevant K. pneumoniae and highlight the importance of integrated genomic surveillance to support antimicrobial stewardship and food safety."

Journal • Infectious Disease • Pneumonia

Community-acquired Acinetobacter baumannii bloodstream infection with central nervous system involvement: a case report. (PubMed, Front Med (Lausanne)) - "The patient was successfully treated with a combination of meropenem and both intravenous and intrathecal colistin methanesulfonate. While A. baumannii is primarily associated with hospital-acquired infections, this case highlights its potential to cause severe community-acquired bloodstream infections with CNS involvement."

Journal • Infectious Disease

Distribution of ceftazidime-avibactam and colistin MIC values in carbapenem-resistant Klebsiella pneumoniae and its association with carbapenemase genotypes in Can Tho, Vietnam. (PubMed, Acta Microbiol Immunol Hung) - "The CAZ-AVI MIC differed significantly among genotypes (p = 0.002): isolates carrying blaKPC or blaOXA-48-like retained the highest susceptibility, whereas all isolates carrying only a metallo-β-lactamase (blaNDM or blaVIM) were resistant; the colistin MIC did not differ among genotypes (p = 0.376). Carbapenemase genotyping should guide the use of CAZ-AVI in this setting, particularly for distinguishing serine carbapenemase producers from MBL producers, while the elevated colistin MIC90 supports continued surveillance of colistin susceptibility."

Journal • Infectious Disease • Pneumonia

Proteome-wide remodelling in Klebsiella pneumoniae during step-wise adaptive evolution against colistin. (PubMed, PLoS One) - "Since elevated arnA, arnB and phoU are known to reduce colistin binding to the bacterial surface, they may be facilitating the emergence of antibiotic resistance. Taken together, this research provides insight into SDE-induced colistin resistance in K. pneumoniae and may help to identify potential therapeutic and diagnostic interventions."

Journal • Infectious Disease • Pneumonia

Spread potential and architectural variant of a multiple-drug resistant Escherichia coli co-producing lipopolysaccharide-modifying determinants and extended-spectrum β-lactamases. (PubMed, Front Microbiol) - "Interestingly, polymyxin resistance conferred by arn was augmented by additional polysaccharides retrieved from Lycium barbarum (LBP) and antioxidant N-acetylcysteine (NAC), while no significant antimicrobial coordination was observed if combined with colistin. In addition, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and comparative transcriptomics demonstrated that the LPS production and morphology significantly varied in response to polymyxin stress, indicating that polymyxin can induce the transcription of arnBCADTEF, thereby promoting L-Ara4N modification and polymyxin resistance. Overall, our finding indicates that the co-occurrence of antibiotic resistance factors (such as MDR candidates and LPS architectural variation in this isolate) involves both chromosomal recombination and plasmid dissemination, thereby highlighting important implications for antimicrobial resistance surveillance, molecular epidemiological retrospection, and precision..."

Journal • Infectious Disease

The activity of a new bicyclic peptide, PLP-3, against colistin-resistant Pseudomonas aeruginosa biofilms. (PubMed, Biofilm) - "In contrast, colistin effectiveness was significantly compromised in resistant biofilms (89.8% surviving biovolume, p < 0.001 vs. PLP-3). Based on these in vitro results, PLP-3 may represent a promising candidate for further investigation as a potential treatment for recalcitrant colistin-resistant P. aeruginosa infections."

Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Trust, but Verify: Translating Dosing Evidence to Understudied Populations in Low- and Middle-Income Countries. (PubMed, Clin Pharmacol Ther) - "Using a metformin-dolutegravir drug interaction study and colistin pharmacokinetic study from South Africa, we illustrate how body composition and disease severity, respectively, can alter dosing assumptions. Drug development and post-registration programs should include explicit translation plans using target-population data to confirm, refine, or revise dosing recommendations in understudied target populations."

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Detection of cefotaxime- and enrofloxacin-resistant and mcr-1-positive Escherichia coli at farm level in younger and older calf groups across different production systems in Germany. (PubMed, BMC Microbiol) - "Differences in the qualitative farm-level detection and genetic diversity of CTX- and ENR-resistant and mcr-1-positive E. coli subpopulations were observed between production systems and between younger and older calf groups within farms. These findings suggest that production system and sampled calf group should be considered in the surveillance of antibiotic-resistant E. coli in calves."

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In-Hospital Mortality in Multiple Myeloma and Plasma Cell Disorders at a North Indian Tertiary Center (IMS 2026) - "MDR organisms were documented in 12/50 patients (24.0%); colistin was used pre-terminally in 6 patients (12.0%), 3 patients had pan-resistant MDR pathogens... In this small real-world Indian cohort, infections due to MDR pathogens dominated the terminal events in MM patients. High-risk FISH and heavier treatment burden appear to be associated with death due to sepsis. Mortality in AL amyloidosis is predominantly driven by cardiac events."

Clinical • Amyloidosis • Endocrine Disorders • Hematological Malignancies • Infectious Disease • Metabolic Disorders • Multiple Myeloma • Nephrology • Renal Disease • Respiratory Diseases • Septic Shock

Sorafenib analogues exhibit dual Colistin-potentiating and anti-MRSA activity. (PubMed, RSC Med Chem) - "NDM-773 acts as a standalone antibiotic against MRSA with an MIC of 0.781 μM (0.398 μg mL-1) and a frequency of mutation rate of <10-11 against MRSA BAA-1556. NDM-773 exhibits over three-fold reduction in HepG2 toxicity compared to sorafenib, and has therapeutic indices (TIs) up to 35.6 as a colistin adjuvant, and 68.4 as an MRSA antibiotic."

Journal • Infectious Disease • Pneumonia

Synergistic activity of colistin and stilbenoids against Pseudomonas aeruginosa clinical isolates. (PubMed, Microbiol Spectr) - "The combination improved colistin efficacy, increased membrane damage, and partially overcame lipopolysaccharide-mediated reduction of colistin activity. Importantly, these effects were achieved using low concentrations of pterostilbene under the experimental conditions tested."

Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases