Undisclosed amine-based TEAD degrader / Amphista Therap - LARVOL DELTA

Title: Rational development of novel FBXO22-mediated TEAD Targeted Glues for Mesothelioma and NSCLC Treatment (GlobeNewswire) - "Amphista Therapeutics...announces three upcoming presentations at the American Association for Cancer Research (AACR) 2026 Annual meeting....We demonstrate that amine-based TEAD degrader amine scaffolds undergo extracellular conversion to reactive aldehyde species, which mediate covalent engagement of FBXO22 C326, triggering TEAD proteasomal degradation. The degraders identified were able to be rationally and systematically optimised for both degradation potency and kinetics, achieving enhanced degradation profiles...establishing design principles for this degrader class."

Preclinical • Mesothelioma • Non Small Cell Lung Cancer