MI-219 / Sanofi, Ascenta - LARVOL DELTA

Molecular Detection of Theileria annulata among Dairy Cattle and Vector Ticks in the Herat Area, Afghanistan. (PubMed, Arch Razi Inst) - "Among the collected ticks, the numbers of male and female ticks were obtained at 219 and 130 ticks, respectively...The PCR results showed that seven pools belonging to salivary glands of H. anatolicum were infected with T. annulata. Based on the obtained results, it can be concluded that T. annulata had a high frequency in dairy cattle and H. anatoloicum was also identified, such as the vectors of T. annulata in the Herat area, Afghanistan."

Journal • PCR

[VIRTUAL] Medicsen Smartpatch: A New Approach to Diabetes Management (ENDO 2021) - "No significant differences were found between the circular dichroism spectra of samples (minimum peak at 219nm (sd+/-8.31) and that of the standard, which suggests that the molecular structure of insulin maintains stability...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021."

Diabetes • Metabolic Disorders • Pain • IL2 • TNFA

[VIRTUAL] PREVALENCE OF ANTI–SARS-CoV-2 ANTIBODIES IN SOUTH AFRICAN BLOOD DONORS (CROI 2021) - " Subject to meeting standard blood donor eligibility criteria, and a standing opt-out arrangement for research use of specimens primarily obtained for blood safety screening, unsolicited blood donations, obtained on particular 'collection days' at 219 donation sites in South Africa, during January 2021, were tested for SARS-CoV-2 antibodies using the Roche Cobas e411 platform... These are the first relatively widely representative SARSCoV-2 antibody prevalence estimates from South Africa. Population level representativeness of this methodology warrants further exploration – but it is worth noting that 1) as elsewhere, the obtained antibody prevalence estimates imply SARS-CoV-2 attack rates that are easily an order of magnitude higher than the apparently relatively uninformative official case counts; and 2) the marginal cost of performing this study, over the cost of routine blood bank operations, was almost entirely comprised of the cost of reagents. South..."

Late-breaking abstract • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Cyanides and Isocyanides of Zinc, Cadmium and Mercury: Matrix Infrared Spectra and Electronic Structure Calculations for the Linear MNC, NCMCN, CNMNC, NCMMCN, and CNMMNC Molecules. (PubMed, Chemphyschem) - "Final annealing to 35 K increases bands at 2187.3 and 2089.2 cm at the expense of weaker bands at 2194.6 and 2092.2 cm through addition of another cadmium atom...In the isocyanide case bond polarity results in very intense infrared absorptions. Group 12 metals produce shorter M-M bonds in the dimetal cyanides NCM-MCN and isocyanides CNM-MNC than in the M-M itself, and their computed M-M bond lengths compare favorably with those measured for dimetal complexes stabilized by large ring containing molecular ligands."

Journal

N-linked glycosylation plays an important role in budding of NA protein and virulence of influenza viruses. (PubMed, J Virol) - "Further studies showed that the NLG knock-out caused attenuation of virus in vitro and in vivo Notably the NLG at 219 position plays an important role in budding, replication, and virulence of H1N1 influenza virus...Loss of NLG attenuated viral budding and replication. Especially the 219 NLG site mutation significantly attenuated the replication and virulence of H1N1 influenza virus in vitro and in vivo, which suggested that NLG of NA protein is a novel virulence marker for influenza viruses."

Journal • Infectious Disease • Respiratory Diseases

Simultaneous determination of enalapril maleate and nitrendipine in tablets using spectrophotometric methods manipulating ratio spectra. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "The first method was first derivative ratio spectrophotometric method (DD) where the amplitudes maxima were measured at 219.2 nm and 233.4 nm for the determination of EN and NT, respectively. Statistical comparison of the results with the reported one showed no significant difference, regarding precision and accuracy. Routine analysis of the cited drugs in quality control laboratories could be performed using the developed methods."

Journal

Enzymolysis of walnut (Juglans regia L.) meal protein: Ultrasonication-assisted alkaline pretreatment impact on kinetics and thermodynamics. (PubMed, J Food Biochem) - "The reaction rate coefficient (k) for the proteolysis improved by 84.75%, 52.43%, 48.25%, and 37.79% at 219, 303, 313, and 323 K, correspondingly...PRACTICAL APPLICATIONS: Walnut meal protein has a well-balanced amino acid profile and its economic utilization could be increased practicably as a food ingredient via production of hydrolysates/peptides for the production of improved food ingredients instead of being cast off as animal feed. This study demonstrated a positive bearing of ultrasonication-assisted alkaline pretreatment on proteolytic reaction characteristics and its energy efficiency for walnut meal protein, which makes this technique applicable to the enhancement of plant proteins for inclusion in food products, especially tree nut and oil seed waste products from the oil industry."

Journal • Targeted Protein Degradation

Synthesis, crystal structure at 219 K and Hirshfeld surface analyses of 1,4,6-tri-methyl-quinoxaline-2,3(1H,4H)-dione monohydrate. (PubMed, Acta Crystallogr E Crystallogr Commun) - "The Hirshfeld surface analysis indicates that the most important contributions to the packing arrangement are due to H⋯H (51.3%) and O⋯H/H⋯O (28.6%) inter-actions. The mol-ecular structure calculated by density functional theory is compared with the experimentally determined mol-ecular structure, and the HOMO-LUMO energy gap has been calculated."

Journal

The role of ubiquitination in tumorigenesis and targeted drug discovery. (PubMed, Signal Transduct Target Ther) - "Among them, small molecule inhibitors targeting the proteasome, such as bortezomib, carfilzomib, oprozomib and ixazomib, have achieved tangible success. In addition, MLN7243 and MLN4924 (targeting the E1 enzyme), Leucettamol A and CC0651 (targeting the E2 enzyme), nutlin and MI-219 (targeting the E3 enzyme), and compounds G5 and F6 (targeting DUB activity) have also shown potential in preclinical cancer treatment. In this review, we summarize the latest progress in understanding the substrates for ubiquitination and their special functions in tumor metabolism regulation, TME modulation and CSC stemness maintenance. Moreover, potential therapeutic targets for cancer are reviewed, as are the therapeutic effects of targeted drugs."

Journal • Review • Oncology • Targeted Protein Degradation • MYC • PTEN • SOX2 • STING

Ternary solid dispersion to improve solubility and dissolution of meloxicam. (PubMed, J Basic Clin Physiol Pharmacol) - "The melting endotherm of SD3 was detected at 219.5 °C, in which case it originated from NA rather than from MLX, showing that MLX was molecularly dispersed and amorphous. The best result was given by SD3 with an MLX:HPMC:NA ratio of 1:2:1. Based on the characterization study, it is predicted that hydrophilic polymer and hydrogen bonding interactions play important roles in MLX solubility or dissolution rate improvement."

Journal

Evaluation of intensified dengue control measures with interrupted time series analysis in the Panadura Medical Officer of Health division in Sri Lanka: a case study and cost-effectiveness analysis. (PubMed, Lancet Planet Health) - "This study suggests that communities affected by dengue can benefit from investments in vector control if interventions are implemented rigorously and coordinated well across sectors. By doing so, it is possible to reduce the disease and economic burden of dengue in endemic settings."

Clinical • HEOR • Journal • Dengue Fever

[VIRTUAL] Case Series of ACTH-Secreting Pheochromocytoma: Diagnosis and Management (ENDO-I 2020) - "Pre-op 24-hour urine cortisol was checked as part of secondary HTN evaluation and found to be elevated at 219 (3.5-45mcg)...Due to persistent post-op hypotension and a low 10PM random cortisol level of 3.4mcg/dL, which was inappropriate given patient’s clinical status, hydrocortisone was started with subsequent hemodynamic improvement...Her labs showed elevated 24-hour urine epinephrine 115 (0-20mcg), norepinephrine 366 (0-135mcg), plasma M 288 (0-62pg/mL) and NM 475 (0-145pg/mL), and an AM cortisol was 47.9mcg/dL...AM cortisol level post 1mg dexamethasone was 62.6mcg/dL with an ACTH level of 222pg/mL...Failure to recognize ectopic ACTH pre-op can lead to post-op complications such as AI. Patient 2 demonstrates that treatment of the hypercortisolemia may be necessary in order to adequately control BP and glucose levels prior to surgery."

Clinical • Basal Cell Carcinoma • Cardiovascular • Hypotension • Movement Disorders • Neuroendocrine Tumor • Oncology • Solid Tumor

Active SMS-based surveillance of adverse events following immunisation with influenza and pertussis-containing vaccines in Australian pregnant women using AusVaxSafety. (PubMed, Vaccine) - "Self-reported AEFI rates did not differ by trimester (IIV), or by vaccine brand (IIV or dTpa). Concomitant influenza and pertussis vaccination was associated with more frequent, but low rates of minor, expected AEFI. These real world 'citizen science-based' data provide further reassuring evidence of the safety of maternal vaccination."

Adverse events • Clinical • Journal • Infectious Disease • Pain • Tetanus

Exceptional Structural Compliance of the B12F12(2-) Superweak Anion. (PubMed) - Inorg Chem - "...The superweak-anion nature of B12F12(2-) (Y(2-)) was demonstrated by the rapid reaction of microcrystalline Ag2(Y) with 1 atm of CO to form a nonclassical silver(I) carbonyl compound with an FTIR ν(CO) band at 2198 cm(-1) (and with the proposed formula [Ag(CO)n]2[Y])...The third, and most exceptional, manifestation is that the idealized structural reorganization accompanying the conceptual transformations Ag2(CH3CN)8(Y) → Ag2(CH3CN)5(Y) → Ag2(CH3CN)4(Y) involve close-packed layers of Y(2-) anions that sandwich the Ag(CH3CN)4(+) complexes splitting into staggered flat ribbons of interconnected (Y(2-))3 triangles that surround the Ag2(CH3CN)5(2+) complexes on four sides, conceptually re-forming close-packed layers of anions that sandwich the Ag(CH3CN)2(+) complexes. The interconnected (Y(2-))3 triangle lattice of anions in Ag2(CH3CN)5(Y) may be the first example of this structure type."

Journal • Biosimilar

Two dynamical regimes of the substrate radical rearrangement reaction in B12-dependent ethanolamine ammonia-lyase resolve contributions of native protein configurations and collective configurational fluctuations to catalysis. (PubMed) - "...The observed first-order rate constants display a piecewise-continuous Arrhenius dependence, with linear regions over 295 → 220 K (monoexponential) and 214 → 203 K (biexponential) that are delineated by a kinetic bifurcation and kinks at 219 and 217 K, respectively...Increases in activation enthalpy and entropy of both the microscopic enabling and reaction steps indicate that this non-native reaction coordinate is conducted by local, incremental fluctuations. Continuity in the Arrhenius relations indicates that the same sets of protein groups and interactions mediate the rearrangement over the 295 to 203 K range, but with a repertoire of configurations below 217 K that is restricted, relative the the native configurations accessible above 219 K. The experimental features of a culled reaction step, first-order kinetic measurements, and wide room-to-cryogenic temperature range, allow the direct demonstration and kinetic characterization of protein dynamical contributions to the

Journal • Biosimilar

Diagnostic Value Of Fecal B-cell Activating Factor in Patients with Abdominal Discomfort. (PubMed, Clin Exp Immunol) - "Fecal BAFF has shown a potential ability to be a sensitive screening parameter for IBD and gastrointestinal carcinoma, as well a useful tool to select patients with abdominal discomfort for further endoscopic examinations."

Biomarker • Clinical • Journal • Colonic Polyps • Colorectal Cancer • Crohn's disease • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Immunology • Inflammatory Bowel Disease • Oncology • Peptic Ulcer • Solid Tumor • Ulcerative Colitis

New genetic variant in the SERPINC1 gene: hereditary Antithrombin deficiency case report, familial thrombosis and considerations on genetic counseling. (PubMed, BMC Med Genet) - "The proband was provided with appropriate genetic counseling and referred to a hematologist. Based on all the evidence we classify the p.W221S variant as variant of unknown clinical significance. In this paper we discuss some aspects of genetic counseling, variant interpretation and thromboembolic prophilaxis."

Clinical • Journal

Case Series of ACTH-Secreting Pheochromocytoma: Diagnosis and Management (ENDO 2020) - "Pre-op 24-hour urine cortisol was checked as part of secondary HTN evaluation and found to be elevated at 219 (3.5-45mcg)...Due to persistent post-op hypotension and a low 10PM random cortisol level of 3.4mcg/dL, which was inappropriate given patient's clinical status, hydrocortisone was started with subsequent hemodynamic improvement...Her labs showed elevated 24-hour urine epinephrine 115 (0-20mcg), norepinephrine 366 (0-135mcg), plasma M 288 (0-62pg/mL) and NM 475 (0-145pg/mL), and an AM cortisol was 47.9mcg/dL...AM cortisol level post 1mg dexamethasone was 62.6mcg/dL with an ACTH level of 222pg/mL...Failure to recognize ectopic ACTH pre-op can lead to post-op complications such as AI. Patient 2 demonstrates that treatment of the hypercortisolemia may be necessary in order to adequately control BP and glucose levels prior to surgery."

Clinical

The role of ubiquitination in tumorigenesis and targeted drug discovery. (PubMed, Signal Transduct Target Ther) - "Among them, small molecule inhibitors targeting the proteasome, such as bortezomib, carfilzomib, oprozomib and ixazomib, have achieved tangible success. In addition, MLN7243 and MLN4924 (targeting the E1 enzyme), Leucettamol A and CC0651 (targeting the E2 enzyme), nutlin and MI-219 (targeting the E3 enzyme), and compounds G5 and F6 (targeting DUB activity) have also shown potential in preclinical cancer treatment. In this review, we summarize the latest progress in understanding the substrates for ubiquitination and their special functions in tumor metabolism regulation, TME modulation and CSC stemness maintenance. Moreover, potential therapeutic targets for cancer are reviewed, as are the therapeutic effects of targeted drugs."

Journal • Review • MYC • PTEN • SOX2

[VIRTUAL] ALTERED DNA METHYLATION OF CCR5 IN SIGMOID MUCOSAL TISSUES OF TRANSGENDER THAI WOMEN (CROI 2020) - "We observed the greatest differences in DNA methylation at 219,788 CpG sites showing absolute mean differences in methylation greater than 5% between TGW and MSM (-value >;0.05| and significant at FDR adjusted P < 0.05) in sigmoid biopsies...This occurred at several gene loci including CCR5 that are known to affect HIV susceptibility. Further investigations of biological HIV risk factors specific to TGW are needed to inform additional HIV prevention strategies"

Clinical

Long distance measurement by dynamic optical frequency comb. (PubMed, Opt Express) - "To verify the performance of presented method, a series of distance experiments have been devised in different scenarios. Compared with the reference values, the experimental results show the differences within 25 µm at 65 m range in the laboratory, and within 100 µm at 219 m range out of the lab."

Journal

The influence of protein restriction during mid- to late gestation on beef offspring growth, carcass characteristic and meat quality. (PubMed, Meat Sci) - "...After weaning at 219 ± 13 d of age, steers calves were stockered on natural pastures until 687 ± 13 d of age then placed into a feedlot for 83d before slaughter...Muscle fiber diameter was similar in LP and HP steers (P = .20), suggesting that increase of LM area in HP steers could be due to muscle hyperplasia. These data indicated that level of protein during mid to late gestation does not affect offspring growth but has impacts on carcass composition and meat quality of steer progeny."

Journal

Two-wavelength Tm:YLF/KGW external-cavity Raman laser at 2197 nm and 2263 nm. (PubMed, Opt Express) - "According to the achieved results and due to the KGW properties, it appears to be a suitable crystal for energy scaling and efficient Raman conversion in this spectral range. An estimation of the Raman gain coefficient for this wavelength is provided as well."

Journal

Trends in uterine cancer care at rural and public hospitals (SGO 2019) - "... Over the study period, 46,298 uterine cancer patients received care at 219 hospitals... Fewer women with uterine cancer are undergoing hysterectomies at rural hospitals, possibly reflecting a practice shift in referral patterns to centralize cancer care. While outcomes at public hospitals are similar to those at other centers, perioperative mortality is higher at rural hospitals."

Clinical

Trends in uterine cancer care at rural and public hospitals (SGO 2019) - "... Over the study period, 46,298 uterine cancer patients received care at 219 hospitals... Fewer women with uterine cancer are undergoing hysterectomies at rural hospitals, possibly reflecting a practice shift in referral patterns to centralize cancer care. While outcomes at public hospitals are similar to those at other centers, perioperative mortality is higher at rural hospitals."

Clinical