clotiazepam / Generic mfg. - LARVOL DELTA

Autonomic Storm in a Patient With Amyotrophic Lateral Sclerosis in a Home-Care Setting. (PubMed, J Gen Fam Med) - "Clotiazepam did not adequately control the episodes; however, diazepam was associated with resolution of the episodes, followed by improved sleep and nutritional intake. This report highlights the importance of recognizing an autonomic storm in advanced ALS patients and the potential benefit of diazepam in home-care settings."

Journal • Amyotrophic Lateral Sclerosis • CNS Disorders

Efficacy of Clotiazepam for Respiratory Dyskinesia in a Patient With Parkinsonism: A Case Report. (PubMed, Cureus) - "These symptoms became prominent following the upward titration of a ropinirole patch to 24 mg/day. Although mirtazapine was subsequently added to address comorbid depressive symptoms, it failed to alleviate his respiratory distress...Our findings suggest that the anxiolytic and GABA-mediated muscle-relaxant properties of clotiazepam, combined with its favorable safety profile for the elderly due to its short half-life, may provide a useful and effective new therapeutic option for the management of refractory respiratory dyskinesia. Although the limitations of drawing conclusions from a single case must be acknowledged, these results warrant further large-scale prospective studies to validate the efficacy and safety of clotiazepam in this population."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease • Pulmonary Disease

Case Report: Hip Radiofrecuency Ablation in a 12 years Old Cancer Pain Girl (Rhabdomyosarcoma) (IASP 2024) - "Pharmacological treatment with paracetamol and pregabalin was started at home...For this purpose, 50 mg of ketamine and 2 mg of midazolam were administered...At the end of the procedure, Depomedrol 40 mg and Levobupivacaine 25 mg were injected upon leaving...3.5 mg ev every 4 hrs, Paracetamol 550 mg every 6 hrs ev (15 mg/kg/dose), Ketoprofen 35 mg every 12 hrs ev, Fentanyl 50 mcg/hr 1 transdermal patch every 3.5 days, Gabapentin 400 mg every 12 hrs PO , Clotiazepam 5 mg every 12 hours. Lansky scale 50%, that is, it requires considerable assistance for any active game; He is able to participate in restful games and after 24 hours he did not require analgesic rescue and in 72 hours he was able to taper off the use of continuous infusion of opioids, reducing the daily use of morphine to 20 kilo hour ranges, suspending the rescue bolus... There is a paucity of literature on joint denervation procedures in pediatric patients, however high quality prospective controlled trials..."

Case report • Clinical • Anesthesia • Immunology • Oncology • Pain • Pediatrics • Rhabdomyosarcoma • Sarcoma • Solid Tumor

Clinical practice for unspecified anxiety disorder in primary care. (PubMed, PCN Rep) - "While several benzodiazepine anxiolytics were familiar to primary care physicians, the frequencies of prescribing them, including alprazolam (4.6 ± 2.6), ethyl loflazepate (3.6 ± 2.4), and clotiazepam (3.5 ± 2.3), were low. Nonpharmacological interventions and switching to SSRI are modestly employed as primary treatment options and alternatives to benzodiazepine anxiolytics. To ensure the safe and effective treatment of unspecified anxiety disorder in primary care, more information should be provided from field experts."

Journal • CNS Disorders • Mood Disorders • Psychiatry

Jumping stump phenomenon: a case report. (PubMed, Prosthet Orthot Int) - "Treating this phenomenon remains challenging because pathophysiology is still not fully understood, and the available literature is limited. A multiprofessional and interdisciplinary treatment approach is recommended, and botulinum toxin treatment is promising."

Journal • Movement Disorders • Musculoskeletal Pain • Pain

Serotonin Syndrome Triggered by Increasing the Dose of Quetiapine. (PubMed, Clin Pract Cases Emerg Med) - "The use of atypical antipsychotics alone seldom increases the risk of SS. However, combining atypical antipsychotics with serotonergic agents increases the risk of SS because the activity of serotonin receptor subtype 1A is relatively enhanced. This report suggests that physicians should be aware that even a small increase in quetiapine could pose a risk of developing SS."

Journal • CNS Disorders • Depression • Movement Disorders • Psychiatry

Novel and Nonroutine Benzodiazepines and Suvorexant by LC-MS-MS. (PubMed, J Anal Toxicol) - "The target analytes included bromazepam, clobazam, clonazolam, clotiazepam, diclazepam, estazolam, etizolam, flualprazolam, flubromazepam, flubromazolam, loprazolam, lormetazepam, phenazepam, prazepam, suvorexant, tetrazepam and triazolam. The coefficient of variation of replicate analyses was within 14% and bias was within ±14%. The method provides a sensitive, efficient and robust procedure for the quantitation and/or qualitative identification of select novel and nonroutine benzodiazepines and suvorexant using LC-MS-MS and a sample volume of 200 µL."

Journal • CNS Disorders • Epilepsy

Benzodiazepine Concentrations in the Breast milk and Plasma of Nursing Mothers: Estimation of Relative Infant Dose. (PubMed, Breastfeed Med) - "The target benzodiazepines were alprazolam, brotizolam, clonazepam, clotiazepam, etizolam, ethyl loflazepate, flunitrazepam, and lorazepam. The RID results of this study suggest that drug exposure through breast milk is small; thus, maternal drug treatment and breastfeeding are compatible."

Journal • CNS Disorders • Insomnia • Obstetrics • Sleep Disorder

"Idem dito. Ik volg hem totaal NIET MEER. Totaal NIET MEER! Ik vraag me soms af wie die man pusht,vtm is toch een van Thillo zender. Middelbare #scholen, lees de tweets van @CarlvKeirsbilck ! - Afstandsonderwijs, waar en bij wie het kan, - Respecteer de ventilatienormen, enz." (,@gretav5)

Pressure ulcers induced by drug administration: A new concept and report of four cases in elderly patients. (PubMed) - J Dermatol - "...In these cases, the suspected DIPU were related to treatment with olanzapine, fluvoxamine, valproic acid, clotiazepam, triazolam and rilmazafone...Therefore, we propose that DIPU are potential ADR that have been overlooked in clinical practice. Thus, recognition of DIPU as an ADR may be important in preventing and appropriately managing pressure ulcers among elderly patients."

Journal • Alzheimer's Disease • Biosimilar