acetylcysteine solution / Generic mfg. - LARVOL DELTA

Protective Effect of N-acetylcysteine on Oxaliplatin-Induced Neuropathy in Colorectal Cancer (clinicaltrials.gov) - P=N/A | N=46 | Completed | Sponsor: Tanta University

New trial • Colorectal Cancer • Oncology • Pain • Solid Tumor

N-ACETYLCYSTEINE AND ASCORBIC ACID ORAL ANTIOXIDANT THERAPY FOR TEPROTUMUMAB-RELATED AUDITORY DYSFUNCTION: CASE SERIES AND REVIEW OF LITERATURE (WRMC 2026) - "Antioxidant therapy with N-acetylcysteine and Vitamin C appears to be a promising, safe, and inexpensive potential treatment option for teprotumumab-related hearing dysfunction in our patient group. As seen with other causes of auditory dysfunction, NAC and ascorbic acid therapy can help prevent and reverse auditory damage caused by oxidative stress."

Clinical • Review • Ophthalmology • Otorhinolaryngology • Thyroid Eye Disease

NOT "JUST A VUS": EARLY ONSET TRMU DEFICIENCY IN TWO SIBLINGS WITH NOVEL HOMOZYGOUS SPLICE SITE VARIANT (WRMC 2026) - "Fetuses and infants diagnosed in a timely manner can be treated with N-acetylcysteine (NAC) and L-cysteine, which can possibly reduce life-threatening comorbidities... This case demonstrates the association between a novel homozygous splice site variant and severe cardiomyopathy in TRMU deficiency, highlights the health inequities of genetic testing and variant interpretation among underrepresented ancestries, and emphasizes the need for critical review of current variant classification criteria."

Cardiomyopathy • Cardiovascular • CNS Disorders • Epilepsy • Hepatology • Hypertrophic Cardiomyopathy • Hypoglycemia • Liver Failure • Metabolic Disorders • Respiratory Diseases

Effect of intratympanic N-acetylcystein (NAC) on vestibulotoxicity model formed with intratympanic gentamicin in Guinea pigs. (PubMed, Acta Otolaryngol) - "N-acetylcysteine (NAC) can protect against this damage. Tissue SOD and glutathione (GSH) were lower, while the malondialdehyde (MDA) and lipid hydroperoxide (LOOH) were the higher in group2. Gentamicin induced loss in c-VEMP responses and NAC played an effective role in reducing this loss which were confirmed by oxidative capacity at tissue and serum level."

Journal

Administration of N-acetylcysteine influence the expression of apoptotic genes in the granulosa cells of infertile women diagnosed with endometriosis. (PubMed, Sci Rep) - "Additionally, the expression of pro-apoptotic genes Bax and Caspase-3 in granulosa cells decreased compared to the placebo group, while the expression of the anti-apoptotic gene Bcl-2 increased. We conclude that administration of N-acetylcysteine (NAC) can reduce apoptosis in granulosa cells of women with infertility due to endometriosis."

IO biomarker • Journal • Endometriosis • Gynecology • Infertility • Sexual Disorders • Women's Health • BAX • BCL2 • CASP3

Systematic evaluation and comparison of the in vitro inhibitory activities of dietary supplements against calcium oxalate crystal formation, growth and aggregation: Implications for kidney stone prevention. (PubMed, Curr Res Food Sci) - "Caffeine (CAF), epigallocatechin-3-gallate (EGCG), N-acetylcysteine (NAC), resveratrol (RES) and trigonelline (TRIG) (at 1, 10 and 100 μM, which are within their physiologic levels in the urine) were subjected to CaOx crystallization, growth and aggregation assays...NAC was the only inhibitor against CaOx crystal aggregation (with the crystal aggregation-inhibitory activity of 22.97 ± 0.75 %). These data indicate the direct inhibitory effects of various dietary supplements against CaOx crystal formation, growth and aggregation, supporting their roles in KSD prevention."

Journal • Preclinical • Nephrology • Renal Calculi

Intrarenal Renin-Angiotensin System Inactivation Ameliorates Tubulopathy via Attenuation of Mitochondrial Oxidative Stress, Dysfunction and Senescence in Diabetes. (PubMed, Clin Sci (Lond)) - "Conditioned medium from senescent MDCK cells triggered epithelial-to-mesenchymal transition in HK-2 cells, which was reversed by losartan or N-acetylcysteine. These findings suggest that iRAS promotes tubulopathy in DKD through NOX4-induced mitochondrial oxidative stress and dysfunction in PTs and oxidative DNA damage-induced senescence in DTs, providing new therapeutic targets."

Journal • Diabetes • Diabetic Nephropathy • Fibrosis • Immunology • Inflammation • Metabolic Disorders • Nephrology • Renal Disease • Type 1 Diabetes Mellitus • AGT • CDKN2A • NOX4

ROS-Driven Rewiring of Hippo-Inflammation-Polycomb Axis by PFOA in 2D and 3D Lung Epithelial Models. (PubMed, Toxicology) - "Oxidative stress was identified as the central driver of epigenetic and Hippo pathway disruptions, as observed in cells pre-exposed to 1 mM N-acetylcysteine (NAC). Despite these molecular alterations, epithelial cell migration capacity remains unaffected under acute exposure. Our results provide key mechanistic insights into PFOA-mediated disruption of redox homeostasis, immune signaling, and epigenetic plasticity in A549 cells, as well as identifying biomarkers for future biomonitoring efforts and studying regulatory frameworks."

Journal • Inflammation • Pneumonia • CCL2 • CXCL8 • HMGB1 • IL6 • STAT3 • TLR4

Mechanistic Exploration of Methylglyoxal-Induced Hepatotoxicity Involving Oxidative Stress, Apoptosis, and Gluconeogenic Modulation. (PubMed, Chem Biol Interact) - "We examined the protective effects of N-acetylcysteine (NAC) against MG toxicity using MTT reagent, monitoring ROS generation, apoptosis (via flow cytometry), and mitochondrial membrane potential (with JC1 dye staining)...MG also increased the expression of proteins involved in apoptosis and gluconeogenesis. MG-induced caspase-dependent hepatotoxicity was mediated by the production of ROS and the activation of gluconeogenesis via SIRT1-Dependent PGC1α activation."

IO biomarker • Journal • BAX • BCL2 • CASP3 • SIRT1

Pyrazinamide-induced hepatotoxicity mediated by aldehyde oxidase and xanthine oxidase. (PubMed, Arch Toxicol) - "Both vitamin C (VC) and N-acetylcysteine (NAC) were found to reduce the generation of GSH conjugates derived from PZA and POA in incubation systems. Allopurinol administration attenuated the elevated serum ALT and AST in company with a reduction in the formation of GSH conjugates. This work provides solid evidence for the correlation between the metabolic activation of PZA and PZA-induced hepatotoxicity, enhancing the understanding of the underlying mechanisms of PZA toxicity in terms of molecular chemical structure."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

TRANSPLANTATION-ASSOCIATED THROMBOTIC MICROANGIOPATHY: INCIDENCE AND MANAGEMENT IN SETTINGS WITH LIMITED BIOMARKERS AND NO ACCESS TO TARGETED THERAPIES (EBMT 2026) - "Conditioning regimens were TBI or Busulfan iv-based. Graft versus host disease (GVHD) prophylaxis consisted on cyclosporine and short course of methotrexate +/- ATG...EASIX score was significantly higher in patients with TA-TMA compared to patients without TA-TMA, at day 30, day 100 and at last follow-up (p<10-3,<10-3 and 0.022, respectively).In multivariate analysis, acute GVHD and microbiologically documented fever were significantly associated with TA-TMA (p= 0.048 and 0.032, respectively).Cyclosporine was discontinued in all cases of TA-TMA and switched to mycophenolate mofetil...None patient received plasma exchange and one patient received iv N-acetylcysteine... In our experience, the TA-TMA was associated with a high NRM. Early monitoring using plasma sC5b-9 levels and access to targeted therapies are essential."

Biomarker • Acute Graft versus Host Disease • Acute Respiratory Distress Syndrome • Aplastic Anemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Immunology • Septic Shock • Transplantation • Transplantation Associated Thrombotic Microangiopathy

Effect of Intracoronary N-Acetylcysteine in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (clinicaltrials.gov) - P2 | N=70 | Completed | Sponsor: dr. Ahmad Yasa, Sp.JP, Subsp.K.I.(K), M.Kes, FIHA, FasCC, FA | Trial completion date: Aug 2025 ➔ Dec 2025 | Not yet recruiting ➔ Completed | N=32 ➔ 70

Enrollment change • Trial completion • Trial completion date • Cardiovascular • Myocardial Infarction

N-Acetylcysteine Reduces Alveolar Bone Loss and Mitigates Systemic Oxidative Damage in Rats With Apical Periodontitis. (PubMed, Int Endod J) - "The study findings suggest that NAC supplementation promoted greater preservation of bone quality, reduced periapical volume development, and modulation of endogenous antioxidant and oxidant aspects. This indicates that NAC can decrease local and systemic damage caused by AP, highlighting its potential as an adjunctive agent in processes involving systemic oxidative stress and the preservation of biological structures."

Journal • Preclinical • Dental Disorders • Osteoporosis • Periodontitis

Successful Heat Stroke-Induced Pediatric Acute Liver Failure Treatment With N-Acetylcysteine Case Report. (PubMed, Crit Care Explor) - "He was treated with N-acetylcysteine (NAC) with resolution of his PALF without complications. In this article, we review the patient's clinical course, the rationale for treatment with NAC, and the management of heat stroke-induced PALF."

Journal • Cardiovascular • CNS Disorders • Critical care • Hematological Disorders • Hepatic Encephalopathy • Hepatology • Liver Failure • Pediatrics

Anticollagenase Therapy for Canine Corneal Ulcers: A Narrative Review of Mechanisms, Efficacy, and Clinical Implementation. (PubMed, Vet Ophthalmol) - "Anticollagenase therapy may offer adjunctive benefit in the management of canine corneal ulcers, particularly in cases where proteolytic activity is suspected to contribute to disease progression. However, current evidence remains limited and heterogeneous, and further controlled clinical studies are required before definitive recommendations can be made regarding the selection or prioritization of specific agents."

Journal • Review • Keratitis • Ocular Inflammation • Ophthalmology

Development of a Drug-Induced Ototoxicity Model Using Inner Ear Organoids and Investigation of Protective Mechanisms (ARO 2026) - "To model ototoxic injury, organoids will be treated with aminoglycoside antibiotics and cisplatin, followed by evaluation of cell survival, ROS generation, and morphological changes using immunostaining and LDH assays. Protective strategies will be tested by applying small molecules, including the Wnt activator CHIR99021, the PTEN inhibitor VO-OHpic, and the ROS scavenger N-acetylcysteine... This study highlights the potential of human pluripotent stem cell–derived inner ear organoids as a physiologically relevant model for investigating drug-induced ototoxicity. Modulation of Wnt, PI3K/PTEN, and YAP signaling pathways is expected to provide novel insights into protective mechanisms for auditory hair cells. Such an approach may contribute to the establishment of a precise preclinical drug-screening platform and facilitate the development of innovative therapeutic strategies aimed at preventing or reducing hearing loss induced by ototoxic agents."

Otorhinolaryngology • ATOH1 • POU4F3 • SOX2

Furosemide Attenuates Noise-Induced Hearing Loss and Potentiates Preventive Effect of N-Acetylcysteine (ARO 2026) - "Furosemide effectively attenuates NIHL by transiently modulating cochlear physiology and enhancing drug permeability across the BLB. Its combination with NAC offers a promising strategy for preventing NIHL, highlighting a potential therapeutic approach for clinical application."

Otorhinolaryngology

N-acetylcysteine reduces serum creatinine, blood urea nitrogen, symmetric dimethylarginine and urine protein to creatinine ratio in cats with chronic kidney disease: a double-blind, placebo-controlled clinical trial. (PubMed, BMC Vet Res) - "The incorporation of NAC into treatment regimens demonstrates potential as a treatment strategy for cats with acute-on-chronic kidney disease."

Clinical • Journal • Nephrology • Renal Disease

Scoparone induces mitophagy and apoptosis via ROS accumulation in pancreatic cancer cells. (PubMed, Curr Res Toxicol) - "In addition, Scop increases the level of cellular reactive oxygen species (ROS) in PC cells, which may be a key factor, as the ROS inhibitor N-acetylcysteine significantly reversed the effects of mitophagy and apoptosis in PC cells. Our findings highlight Scop shows potential as a therapeutic lead candidate, offering novel insights into the antitumor potential of traditional Chinese medicine. This study elucidates the critical role of Scop in regulating mitophagy and apoptosis in PC cells, providing a foundation for future therapeutic development."

Journal • Oncology • Pancreatic Cancer • Solid Tumor

A case report and a literature review of drug-induced liver injury caused by Huzhang according to the updated RUCAM. (PubMed, Medicine (Baltimore)) - "The hepatotoxicity mechanism of emodin in Huzhang was explored, and it was suggested that traditional Chinese medicines containing emodin, such as Huzhang, should be cautious about hepatotoxicity risks, particularly in elderly patients, long-term users, and those with a history of surgery."

Journal • Review • Hepatology • Liver Failure

Dynamic response by commensal E. coli two-component system Cpx contributes to C. elegans development. (PubMed, BMC Biol) - "Our results illustrate that environmental factors can shape the regulation of the E. coli Cpx response to C. elegans, providing new evidence for why Cpx-mediated virulence phenotypes are inconsistent among gram-negative species in different ecological niches."

Journal • Developmental Disorders • Infectious Disease

Effect of N-acetylcysteine as Adjunct Therapy on the Clinical Outcome of Neonatal Sepsis (clinicaltrials.gov) - P3 | N=50 | Not yet recruiting | Sponsor: Ain Shams University

New P3 trial • Infectious Disease • Septic Shock

In vitro characterization of antimicrobial efficacy and cytotoxicity of polyvinylpyrrolidone-iodine, N-acetylcysteine, methylglyoxal, and N-chlorotaurine as alternative antimicrobials in treating bovine clinical endometritis. (PubMed, Front Vet Sci) - "In sum, the four tested substances can be considered potential alternatives to antibiotic treatments. Further research is, however, necessary to investigate their toxic effects in ex vivo or in vivo models and to identify effective dosages in animals."

Journal • Preclinical • Endometriosis • IL6

Effect of linezolid combined with N-acetylcysteine on lung function, blood gas and inflammation in patients with severe pneumonia. (PubMed, Pak J Pharm Sci) - "In treating severe pneumonia, linezolid combined with NAC can significantly improve the lung function of patients, improve the blood gas indicators and reduce the inflammatory response, thus alleviating the clinical symptoms."

Journal • Cough • Infectious Disease • Inflammation • Oncology • Pneumonia • Pulmonary Disease • Respiratory Diseases • CRP • IL6 • TNFA

N-Acetylcysteine is associated with changes in functional connectivity in patients with Parkinson's disease. (PubMed, Parkinsonism Relat Disord) - "The results suggest that NAC may positively affect brain functional connectivity in PD patients, with corresponding positive clinical effects. Larger scale studies are warranted."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease