bilastine / Generic mfg. - LARVOL DELTA

Efficacy of Vitamin D3 Supplementation as an Adjunct to Bilastine 40 mg in Chronic Spontaneous Urticaria Patients With Vitamin D3 Deficiency: A Randomized, Double-Blind, Placebo-Controlled Study. (PubMed, Int J Dermatol) - No abstract available

Clinical • Journal • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria

Bioequivalence and Safety of Bilastine 20 mg Administered in Three Eight-Hourly Dose Versus a Single Daily Dose: A Randomized Two-Treatment, Two-Period, Cross-Over Comparative Study. (PubMed, Eur J Drug Metab Pharmacokinet) - "Our study concluded that the test product, bilastine + dextromethorphan hydrobromide + phenylephrine hydrochloride syrup (3.3 mg + 10 mg + 5 mg)/5 mL, and the reference product, bilastine solution 2.5 mg/mL, are bioequivalent with respect to the extent of absorption and were well tolerated."

Journal • Cough • Respiratory Diseases

Unspecified Degradation Impurities Identification and Characterization in Bilastine and Montelukast tablet formulations by using UPLC and LCMS/MS: Robustness by Design Expert and Green assessment. (PubMed, Ann Pharm Fr) - "The UPLC-based analytical method demonstrated in this study is an effective and efficient technique for the quantification of BLS, MTK, and their associated impurities in tablet formulations. This method has been validated in accordance with ICH Q2(R2) and USP guidelines."

Journal

Serum MRGPRX2 and substance P levels are biomarkers of disease activity rather than an antihistamine response in chronic spontaneous urticaria. (PubMed, Sci Rep) - "Severe CSU patients received 20 mg of bilastine, titrated up to 80 mg based on Urticaria Control Test (UCT) results at days 15, 30, and 60...Among the severe CSU patients, the baseline MRGPRX2 and SP levels did not significantly differ across the antihistamine response groups (P > 0.05); serum MRGRPX2 levels remained consistent over time after antihistamine treatment (P = 0.41), whereas serum SP concentrations significantly decreased (P < 0.001). Serum MRGPRX2 and SP levels are associated with disease severity in CSU patients but do not predict antihistamine response in severe cases."

Biomarker • Journal • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria

Balanced discussion about bilastine as a truly non-sedating antihistamine. (PubMed, Curr Med Res Opin) - No abstract available

Journal

The new bilastine eye drop formulation protects against conjunctival dehydration and promotes corneal wound healing in a comparative in vitro study. (PubMed, Sci Rep) - "In wound healing assays, preservative-free ketotifen 0.025%, bilastine 0.6%, and azelastine 0.05% promoted corneal wound repair at 72 h, outperforming preserved formulations. Overall, preservative-free bilastine 0.6% with HA enhances corneal hydration, retention, and re-epithelialization in vitro, suggesting potential benefits for the management of allergic conjunctivitis and offering promising advancements in treating this widespread condition."

Clinical • Journal • Preclinical • Conjunctivitis • Dermatology • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology • Urticaria

Effect of combining histaglobulin with antihistamines in patients with chronic spontaneous urticaria in a tertiary care hospital setting- a randomized trial. (PubMed, Arch Dermatol Res) - "The addition of Histaglobulin to bilastine provides a superior and well-tolerated treatment option for CSU, delivering faster symptom relief and better disease control. These findings support its use as an effective adjunctive therapy, warranting further investigation in larger sample size studies."

Clinical • Journal • Allergy • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria

GRAHAM-LITTLE-PICCARDI-LASSEUR SYNDROME IN A BULGARIAN PATIENT: CASE REPORT AND SHORT PATHOGENETIC UPDATE IN RELATION TO THE CONNECTION TO ANTIGEN/ MOLECULAR MIMICRY. (PubMed, Georgian Med News) - "Initial therapy included loratadine and topical clobetasol propionate. Due to the suspicion of possible drug-induced reaction, the antihypertensive therapy, which consisted of valsartan, bisoprolol, spironolactone, and chlorthalidone, was discontinued and replaced with moxonidine...Prescribed outpatient treatment included acitretin, bilastine, and topical prednisolone for the scalp. Improvement was observed in the lesions located on the trunk and upper and lower extremities following betamethasone/salicylic acid ointment was prescribed, and methylprednisolone aceponate cream...It is this fact that suggests that polymedication could also be considered as a trigger of lichen planus and its subforms such as GLPLS. The hypothesis surrounding alterations in tissue homeostasis as a potential trigger factor for autoimmunity is being discussed, with a specific focus on infectious and drug-induced forms of lichen planus, as well as Graham-Little-Lasseur syndrome."

Journal • Alopecia • Dermatology • Dermatopathology • Immunology • Infectious Disease • Lichen Planus • Urology

Evaluation of Bilastine's Efficacy and Safety in Treating Chronic Idiopathic Urticaria in Iraqi Patients. (PubMed, Med J Islam Repub Iran) - "However, after treatment, 51 patients (51%) became symptom-free and 49 patients (49%) had well-controlled urticaria. Switching over to bilastine 20mg/day resulted in significant improvement in patients with chronic idiopathic urticaria who had no/ or poor response to conventional antihistamines."

Journal • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria

Relationship between antihistamine residues in wastewater and airborne pollen concentrations: Insights into population-scale pollinosis response. (PubMed, Sci Total Environ) - "The first-generation antihistamine, diphenhydramine, demonstrated rather constant levels. In contrast, the three second-generation antihistamines - bilastine, cetirizine, and fexofenadine - showed pronounced day-to-day variation with strong correlations among each other...Our study demonstrates that WBE can effectively reveal substantial day-to-day variation in antihistamine use related to pollen exposure. Thus, WBE presents an objective and questionnaire-independent method for investigating pollinosis symptom treatment at a population-scale."

Journal • Allergic Rhinitis • Allergy • Immunology • Inflammation

Efficacy of Bilastine, Dextromethorphan, and Phenylephrine Syrup in Patients With Dry Cough: A Phase 3 Randomised Trial. (PubMed, Cureus) - "Methods In this open-label, randomized, active-controlled, multicentre, clinical trial, adult and adolescent subjects with acute dry cough received bilastine 6.6 mg/dextromethorphan 20 mg/phenylephrine 10 mg syrup (BDP) thrice daily or Alex® syrup (chlorpheniramine maleate 4 mg/dextromethorphan 20 mg/phenylephrine 10 mg) for seven days. No serious or severe adverse event was reported, and adverse events were comparable between the two groups. Conclusion Bilastine/dextromethorphan/phenylephrine combination syrup is efficacious, safe, non-sedating, and non-inferior to Alex® syrup in the treatment of acute dry cough due to a common cold or allergy."

Journal • P3 data • Allergy • Cough • Immunology • Respiratory Diseases

Comparing the effectiveness of four antihistamines with olopatadine in healthy Thoroughbred horses. (PubMed, J Vet Med Sci) - "The maximum wheal inhibition rate (mean ± SD) of olopatadine (85.3% ± 7.7%) was significantly higher than those of bilastine (51.1% ± 11.8%), rupatadine (55.3% ± 6.6%), and desloratadine (59.8% ± 6.4%), but not levocetirizine (85.4% ± 8.0%). Levocetirizine is expected to have a high antihistamine effect on horses."

Journal • Allergy • Dermatology • Immunology • Urticaria

In silico Evaluation of H1-Antihistamine as Potential Inhibitors of SARS-CoV-2 RNA-dependent RNA Polymerase: Repurposing Study of COVID-19 Therapy. (PubMed, Turk J Pharm Sci) - "These findings suggested that among all the analyzed drugs, bilastine, fexofenadine, montelukast, zafirlukast, mizolastine, and rupatadine might bind with the best binding energy (< -7.0 kcal/mol) and inhibit RdRp, potentially halting the replication of the virus. This study highlights the potential of H1-antihistamines in combating COVID-19 and underscores the value of computational approaches in rapid drug discovery and repurposing efforts. Finally, experimental studies are required to measure the potency of H1-antihistamines before their clinical use against COVID-19 as RdRp inhibitors."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Bilastine Reimagined: A Comprehensive Exploration of Pruritus Management With a Novel Antihistamine. (PubMed, Cureus) - "Current antihistamine treatments include first-generation antihistamines, which are associated with sedation, and second-generation antihistamines such as cetirizine and fexofenadine, which cause less sedation but have varying efficacy and safety profiles. This narrative review thoroughly synthesizes the evidence for the efficacy and safety of bilastine in treating CU and other pruritic conditions. By analyzing clinical trials, real-world evidence, and comparative studies, this review aims to provide a comprehensive understanding of the role of bilastine in managing pruritic conditions, emphasizing its pharmacokinetic properties, clinical efficacy, and safety profile compared to other antihistamines."

Journal • Review • Anesthesia • Chronic Spontaneous Urticaria • Dermatology • Immunology • Pruritus • Urticaria

Food and bile micelle binding of zwitterionic antihistamine drugs. (PubMed, ADMET DMPK) - "Bilastine (BIL), cetirizine (CET), fexofenadine (FEX), and olopatadine (OLO) were employed as model drugs. Bile micelle and food binding were suggested to cause a negative food effect on the oral absorption of these drugs. However, the AUC ratio was not quantitatively predicted by using FeSSIF + BFH."

Journal

RUPATADINE-INDUCED NOCTURNAL DYSKINESIA AND PAROXYSMAL SLEEP TERRORS IN A 72-YEAR-OLD MALE WITH ANAPHYLAXIS (ACAAI 2024) - "Case Description: A 72-year-old male, with a 10-year history of anaphylaxis and multiple ED admissions was treated with prednisone PRN, Epi-Pen, and Rupatadine (40mg/d), which resulted in anaphylaxis remission...Discontinuation of Rupatadine and initiation of Bilastine (20 mg daily) led to immediate and profound improvement in sleep quality, cessation of sleep terrors, and continued anaphylaxis remission. The only other case involving antihistamine induced night terrors is with cetirizine. Night terrors are a rare Rupatadine side effect with significant impact on quality of life."

Cardiovascular • Depression • Dyslipidemia • Fibromyalgia • Hypertension • Metabolic Disorders • Movement Disorders • Musculoskeletal Pain • Narcolepsy • Obstructive Sleep Apnea • Pain • Rheumatology

Dupilumab Induced Hair Repigmentation (EADV 2024) - "His past medical hyistory revealed hypertension, cholestasis and sleep disorders and medications Telmisartan for 3 years, Ursodeoxycholic acid for 1 year and Venlafaxine for 1.5 years. For dermatologic lesions topical calcineurin inhibitors, 10% topical urea, and bilastine was used for about 6 months... Very few cases regarding the effects of dupilumab on hair repigmentation has been reported. Melanocytes connects with numerous keratinocytes and transfer melanosomes Melanin is synthesized in the cytoplasm of melanocytes. Substances such as ET1, nerve growth factor (NGF) , α -MSH, ACTH, prostaglandin E2 (PGE2) and β endorphins from keratinocytes play a role in melanocyte dendritization."

IO biomarker • Atopic Dermatitis • Cardiovascular • Cholestasis • CNS Disorders • Dermatitis • Dermatology • Hepatology • Hypertension • Immunology • Inflammation • Sleep Disorder • CD40 • CD68 • IL13 • IL2 • IL4 • IL6

Comparison of the Efficacy and Safety of Bilastine 20 mg versus Fexofenadine 180 mg for Treatment of Perennial Allergic Rhinitis: Randomized Controlled Study. (PubMed, Indian J Otolaryngol Head Neck Surg) - "Bilastine was found to be more effective in overall as well as sneezing and rhinorrhoea noted two weeks after therapy. The online version contains supplementary material available at 10.1007/s12070-024-04770-0."

Journal • Allergic Rhinitis • Dermatology • Immunology • Inflammation • Urticaria

Efficacy and safety of switching to bilastine, an H1-antihistamine, in patients with refractory chronic spontaneous urticaria (H1-SWITCH): a multicenter, open-label, randomized, parallel-group comparative study. (PubMed, Front Immunol) - "Switching treatment to bilastine demonstrated non-inferiority to a double-dose of H1AH in terms of efficacy in patients with CSU refractory to standard dose H1AH with a favorable safety profile. https://jrct.niph.go.jp/latest-detail/jRCTs051180105, identifier jRCTs051180105."

Clinical • Journal • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria

Annular elastolytic giant cell granuloma: Lesions in non-sun exposed areas, treated with topical dapson, alongside topical steroids (EADV 2024) - "The patient ’ s medication history revealed metoprolol, doxazosin, lercanidipine and apixaban...The first biopsy showed urticarial reaction but the patient did not respond to bilastine 20mg/day...Afterwards, we changed the therapy to topical clobetasol propionate lotion %0.05, 2x1 on weekdays and topical dapson %7.5, 1x1, every day, and achieved nearly %90 remission in 4 months (second cycle of therapy)... To conclude, AECGC may be seen in non-sun-exposed areas, and if the suspicion of AEGCG is not indicated to the pathologist in advance, the diagnosis may be overlooked. And topical dapson therapy may be an option in the treatment of the disease, but further research is needed."

Atrial Fibrillation • Dermatology • Dermatopathology • Hematological Malignancies • Immunology • Monoclonal Gammopathy • Rare Diseases • Urticaria • Vasculitis

chronic spontaneous urticaria aggravated with mycoplasma pneumoniae (EADV 2024) - "Treatment plan included H1- antihistaminic up to 4 times (Bilastine) , short term prednisolone, leukotriene modifier and local therapy. Because od the poor response to treatment with Omalizumab a ciclosporin was given... In conclusion Mycoplasma pneumoniae infection may cause or trigger CSU and this case provides early awareness od MP infection among urticaria patients."

Cardiovascular • Chronic Spontaneous Urticaria • Dermatology • Gynecology • Hepatology • Immunology • Infectious Disease • Inflammation • Pain • Pneumonia • Urticaria

Finding the culprit: rosacea mimickers in the context of corticosteroid-induced rebound (EADV 2024) - "Materials & A 43 year old woman, with rosacea signs history, without a prior diagnostic, treated herself intermittently for 2 years with topical dipropionate clobetasol and dipropionate bethametasone. One week before her presentation, she was diagnosed in another service with periorificial dermatitis and topical metronidazole, erythromycin and corticoid discontinuation were prescribed. 2 days later, a papulo-pustular rash, with moderate itching, appeared and the treatment changed to topical fusidic acid, oral azithromycin and later oral ciprofloxacin, but without relief...During hospitalization it was started treatment with doxycycline 200 mg/day, a short course of methylprednisolone with dose-tapering, bilastine , NSAID on demand, topical 1% metronidazole gel, colorant solution and emollients with slow remission of the rash. At home the patient continued for 2 weeks the same treatment and after that switched to topical ivermectin, oral doxycycline 100 mg/day and..."

Dermatitis • Dermatology • Immunology • Inflammation • Pruritus • Rosacea

Between diagnostic obscurity and singularity: Familial annular erythema, a case report (EADV 2024) - "We elected to administer bilastine therapy considering the presumed diagnosis of familial annular erythema... Our case seems to best fit with the original description of familial annular erythema in terms of its clinical presentation and pathological features. There remains much to discover, even about epidemiological characteristics and diagnostic criteria. Additional research is also needed to establish a treatment consensus.**"

Case report • Clinical • Dermatitis • Dermatology • Immunology • Infectious Disease • Oncology • Pruritus • Urticaria

Favourable Response of Telangiectasia Macularis Eruptiva Perstans to 595 nm Pulsed Dye Laser (EADV 2024) - "His symptoms were mildly alleviated with bilastine, a non-sedating H1-antihistamine. Other treatment modalities including other antihistamines (cetirizine, loratadine, hydroxyzine) , montelukast and sodium cromoglycate - were all ineffective in relieving his itch... In conclusion, we present a case of TMEP with clinically favorable response to PDL, adding to the armamentarium of treatment options for this condition."

CNS Disorders • Dermatology • Ophthalmology • Pruritus • Rare Diseases

Allergic contact dermatitis to sodium metabisulfite in a rotigotine transdermal therapeutic system (EADV 2024) - "Considering the hypothesis of ACD, applications of TTS were stopped, and he was treated with betamethasone dipropionate cream 0.05% and bilastine 20mg bid, with complete clinical resolution. Sulfites, ubiquitous sulfur-based compounds widely used in cosmetics, pharmaceuticals, and foods, are a common cause of ACD. In medical applications, sulfites are prevalent in topical medications like antifungals, steroids, local anesthetics, and ophthalmic solutions to maintain stability and potency. While skin reactions to rotigotine TTS are generally transient and of mild to moderate severity, discontinuation is necessary in approximately 8% of patients."

Anesthesia • CNS Disorders • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Movement Disorders • Ophthalmology • Parkinson's Disease • Pruritus