LidoPain BP (lidocaine transdermal) / Immune Pharma - LARVOL DELTA

Management of Postdural Puncture Headache in a Patient on Anticoagulation (ASRA-PM 2017) - "...Two long cotton-tipped applicators with 5% lidocaine jelly were applied to each nostril and advanced posteriorly until resistance was met...The last Lovenox dose had been given 24 hours prior so an EBP was performed at L4-L5 with 20mL of autologous blood...While this patient reported only mild and temporary relief from the block, it was an appropriate and temporizing option for her at the time due to recent anticoagulation. Hence, topical sphenopalatine ganglion block may a less invasive option for cases in which EBP is contraindicated to relieve PDPH."

Clinical • Biosimilar • Demo Pain • Immunology • Pain

The Eyes Have It: Eyelid Swelling and Rash in a 79-year-old Woman With Macular Degeneration. (PubMed, Allergy Rhinol (Providence)) - "...Skin prick and intradermal testing were negative to aflibercept, ranibizumab, bevacizumab, and povidine...Due to her positive hypersensitivity testing to 2 ester anesthetics, the patient underwent skin prick and intradermal testing to the amide anesthetic, lidocaine...The culprit allergen, the local anesthetic, could have been overlooked without an assessment of all medications used during the procedure. This case highlights the importance of a thorough allergy evaluation of all medications used during procedures to determine the causative agent.Chief Complaint: Eyelid swelling and rash after ophthalmic procedures for macular degeneration."

Clinical • Journal • Age-related Macular Degeneration • Anesthesia • Biosimilar • Cardiovascular • Complement-mediated Rare Disorders • Dermatology • Gene Therapies • Immunology • Ophthalmology

Lid splinting eyelid retraction technique: a minimised sterile approach for intravitreal injections. (PubMed, Br J Ophthalmol) - "The technique of eyelid retraction for intravitreal injection has a low rate of endophthalmitis, similar to the reported rates using a metal lid speculum. This is beneficial for both the physician and the patient as it minimises patient discomfort as well as the duration of the procedure. To our knowledge, this is one of the largest studies performed to date evaluating intravitreal injection-related endophthalmitis."

Journal • Biosimilar • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology

Acute Lidocaine Toxicity; a Case Series. (PubMed, Emerg (Tehran)) - "...All subjects had used either 6.5% lidocaine spray or 2% topical formulations of lidocaine...Three patients experienced status epilepticus that led to cardiac arrest, and death (all cases with suicidal intention). Based on the results of this study, most cases of topical lidocaine toxicity were among < 40-year-old patients with a male to female ratio of 1.2, with suicidal attempt in 90%, need for intensive care in 36.6%, and mortality rate of 10%."

Clinical • Journal • Biosimilar • Cardiovascular • CNS Disorders • Epilepsy

Profile of the capsaicin 8% patch for the management of neuropathic pain associated with postherpetic neuralgia: safety, efficacy, and patient acceptability. (PubMed) - Patient Prefer Adherence - "The nature of administration and relatively high cost of capsaicin patches can significantly limit their use to a small number of patients with severe refractory symptoms. This review highlights recent evidence related to the use and effectiveness of the 8% capsaicin patch for Postherpetic Neuralgia and discusses its safety and side-effect profiles."

Journal • Review • Biosimilar • Cardiovascular • Demo Pain • Pain

SAFETY AND EFFICACY OF TAPENTADOL COMBINED WITH PREGABALIN AND LIDOCAINE 5% PATCH IN POSTHERPETIC NEURALGIA (EFIC 2017) - "Lidocaine, pregabalin and tapentadol in combination are effective with no clinically significant major adverse effects during long term use. Pregabalin and tapentadol association needs more increments in patients with deafferentation plus tactile allodynia signs and more possible side effects."

Clinical • HEOR • Pain

Effects of transdermal lidocaine or lidocaine with prilocaine or tetracaine on mechanical superficial sensation and nociceptive thermal thresholds in horses. (PubMed, Vet Anaesth Analg) - "Eutectic mixtures of lidocaine with either prilocaine or tetracaine led to a reduction in thermal nociception and mechanical sensation for up to 2 hours."

Journal • Biosimilar

Intracameral mydriatics and analgesics in cataract surgery (SOE 2017) - "Purpose: The objective of the study was to evaluate if intracameral injection of Mydrane (tropicamide 0,02%, phenylephrine 0,31% and lidocaine 1%) is as safe and effective as conventional topical mydriatics and analgesics for cataract surgery?... This study demonstrates that Mydrane can be safe and effective alternative to a standard topical mydriatics and analgesics and helps to maintain adequate mydriasis during cataract surgery without intra-operative pupil constriction even in patients with glaucoma and pseudoexfoliation syndrome."

Clinical • Biosimilar • Diabetes • Glaucoma • Ophthalmology • Pain

A case of erythromelalgia with a previously unclassified missense mutation of the SCN9A gene (BAD 2017) - "Neuromolecular Med 2013; 15: 265–78). We present this case as a novel missense mutation and for discussion of treatment options."

Biomarker • Clinical • HEOR • Biosimilar • Ophthalmology • Pain

Efficacy of Benzocaine 20% Topical Anesthetic Compared to Placebo Prior to Administration of Local Anesthesia in the Oral Cavity: A Randomized Controlled Trial. (PubMed) - "Regarding gender, male patients had higher values on the VAS compared with female patients, but these differences were not meaningful. The topical anesthetic and the placebo had similar effects on pain perception for injection of local anesthesia for the PSA and GPN."

Journal • Biosimilar • Pain

Tolerability of 2.5% Lidocaine/Prilocaine Hydrogel in Children Undergoing Cryotherapy for Molluscum Contagiosum. (PubMed) - Pediatr Dermatol - "These adverse reactions were considered unlikely to be related to the test product, because a patch test was negative in one of the individuals and the other event occurred in only one of the two treated areas. Nanorap is an efficacious and well-tolerated option for topical anesthesia in children undergoing cryotherapy for MC."

Journal • Biosimilar • Dermatitis • Eczema • Immunology

Economic Evaluation of Lidocaine/Tetracaine Patch Versus Lidocaine/Prilocaine Cream for Topical Anaesthesia Before Vascular Access In Egypt. (PubMed) - Value Health - No abstract available.

Journal • Biosimilar

APAVAC®, a very simple autologous vaccine (AV) process with clinical efficacy in advanced cancers (C ): results of a pilot study including 55 patients (CRI-CIMT-EATI-AACR 2018) - "...3 pts had HM including: 2 mantle cell lymphomas (MCL) with 3 PLT for 1 pt and 7 PLT for the other, all in PR after ibrutinib followed by CR under AV alone for 1 pt lasting 12 mo+...AIt could be used in combination with standard therapy and for residual disease control. Further clinical studies are planned in solid as well as HM. "

Clinical • Brain Cancer • Diffuse Large B Cell Lymphoma • Lung Cancer • Mantle Cell Lymphoma • Melanoma • Sarcoma

Topical ketamine-amitriptyline-lidocaine for chronic pruritus: A retrospective study assessing efficacy and tolerability. (PubMed) - No abstract available.

Journal • Biosimilar

SPONTANEUS PRENGNANCY AFTER VAGINISMUS TREATMENT (EBCOG 2017) - "...Pharmacological approach such as the use of local anaesthetics (lidocaine), muscle relaxants (nitroglycerin ointment and botulinum toxin) and anxiolytic medication has been touted for its efficacies...Dilatation alone appeared to result in favourable outcomes. Traditionally, progressive vaginal dilatation for desensitisation, sexual education, psycho-sexual therapy to reduce fear, negative conditioning and phobia, hypnotherapy, and biofeedback generally produced good outcome."

Clinical • Biosimilar • Endometriosis • Immunology • Pain • Vaginal Cancer

Simultaneous Determination of Dexpanthenol, Lidocaine Hydrochloride, Mepyramine Maleate and their Related Substances by a RP-HPLC Method in Topical Dosage Forms. (PubMed, J Chromatogr Sci) - "All drugs were subjected to stress conditions and degradation products were separated with acceptable peak tailing (T ≤ 2) and good resolution (Rs > 2). The validated method therefore can be adapted for quality control procedures of the drugs in pharmaceutical dosage forms and their stability studies."

Journal • Anesthesia • Biosimilar

Event-level impact of Promescent on quality of sexual experience in men with subjective premature ejaculation. (PubMed) - Int J Impot Res - "The product was reported as easy to use and did not interrupt the sexual experience. Findings suggest that the use of this topical spray significantly improves QSE and perception of partner experience, and that these improve with longer duration of use.International Journal of Impotence Research advance online publication, 25 August 2016; doi:10.1038/ijir.2016.31."

Journal • Biosimilar

Local anesthesia and pain perception during amniocentesis: A randomized double blind placebo-controlled trial (Prenat Diagn) - P=NA, N=76; PMID: 23939867; "Pain perception as characterized by the median 9.5 (2.1-21.0) visual analogue scale scores was significantly lower among women in the lidocaine group compared to among women in the placebo group 18.4 (12.9-31.3), P = 0.005]. Similarly the mean visual analogue scale scores was significantly lower in the lidocaine group (P = 0.02)."

Clinical data • Pain

An Investigation into Dental Local Anaesthesia Teaching in United Kingdom Dental Schools. - SAAD Dig - "2% Lidocaine with 1:80,000 Adrenaline remains the gold standard dental local anaesthetic with teaching about its safety and uses in all but a few situations. Most are taught the use of additional aids such as safety syringes and topical anaesthesia. There is variation with regards to the use of alternative anaesthetic agents."

Journal • Biosimilar

The effect of a lidocaine/prilocaine topical anesthetic on pain and discomfort associated with orthodontic elastomeric separator placement. (PubMed) - Prog Orthod - "The discomfort and pain resulting from the initial placement of orthodontic elastomeric separators can be significantly reduced with the lidocaine/prilocaine topical anesthetic."

Journal • Biosimilar • Pain

Fortacin™ Spray for the Treatment of Premature Ejaculation. (PubMed, Urologia) - "...Fortacin™ is a eutectic-like mixture of lidocaine 150 mg/mL and prilocaine 50 mg/mL that meets the requirements of an ideal treatment for PE because it is fast acting (within 5 minutes), has durable effects, can be easily used "on-demand", and shows minimal side-effects...This is translated into a delaying of the ejaculatory latency time without adversely affecting the sensation of ejaculation and orgasmic pleasure. The efficacy and safety of Fortacin™ have been proven by means of increased ejaculatory latency, control, and sexual satisfaction in large scale studies demonstrating the significant benefits for both patients and their partners."

Journal • Anesthesia • Biosimilar

Case series of ig e mediated anaphylactic shock due to polysorbate (EAACI 2018) - "...We report 3 cases of IgE-mediated anaphylactic shock.  CASE 1 An 18-year-old male, with no previous diseases, suffered an anaphylactic shock after the intramuscular administration of a commercial preparation containing dexamethasone 2mg/ml, lidocaine 30mg/ml, thiamine hydrochloride 25mg/ml and cyanocobalamin 125mcg/ml...Skin prick-prick to amiodarone and dronedarone tablets were negative...: Although IgE mediated reactions to excipients, are rare, they should be ruled out as causative agents when the allergological study to the active compound is negative given that they are contained in a wide range of drugs."

Clinical • Immunology

An Evidence-Based Approach to Minimizing Acute Procedural Pain in the Emergency Department and Beyond. (PubMed) - Pediatr Emerg Care - "In summary, there currently remains a knowledge-to-practice gap in the treatment of children's procedure-related pain. This article has identified multiple age-specific methods to improve the treatment of procedural pain. These simple interventions can improve the care provided to ill and injured children."

Journal • Biosimilar • Pain

The Use of Ropivacaine in Therapeutic Treatment of Oral Aphthosis. (PubMed, Biomed Res Int) - "These pharmaceutical products were used alone and in various possible combinations in the 8 groups. The results of this study are very interesting and show that in all the groups that used anaesthetics there was more satisfaction on the patients' part because their pain level became more manageable right after the first application of the drug and the patients could carry on with their normal lives."

Journal • Biosimilar • CNS Disorders • Pain

Effective needle-free buccal anesthesia by mucoadhesive films containing prilocaine and lidocaine hydrochlorides: "The end of jabs"? (PubMed, J Control Release) - "The total amount of drug retained in the epithelium showed to modulate the extent of both shallow and deep anesthesia. Thus, the combination of LCL and PCL in mucoadhesive films may offer dentists and their patients a safe improvement for pain management during dental procedures."

Journal • Biosimilar • CNS Disorders • Pain