Aimmugen (freeze-dried inactivated tissue culture hepatitis A vaccine) / Astellas, Meiji Seika, Mitsubishi Tanabe - LARVOL DELTA

Attenuation of hepatitis A antibody after immunization with hepatitis A vaccine (Aimmugen) in people living with HIV. (PubMed, Hepatol Res) - "Anti-HA-IgG titers of vaccinated MSM-LWHIV may be attenuated; thus, additional immunizations should be considered."

Journal • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation

Long-term durability of immune response to hepatitis A vaccination among people living with HIV (EACS 2023) - "Conclusions : Lower anti-HAV titer and heavy alcohol consumption are associated with earlier loss of immune response to HAV. Repeat assessment after achieving a primary response to HAV is warranted, especially in those with lower anti-HAV titers."

Human Immunodeficiency Virus • Infectious Disease • CD4

Long-term durability of immune response to hepatitis A vaccination among people living with HIV (EACS 2023) - "Conclusions : Lower anti-HAV titer and heavy alcohol consumption are associated with earlier loss of immune response to HAV. Repeat assessment after achieving a primary response to HAV is warranted, especially in those with lower anti-HAV titers."

Human Immunodeficiency Virus • Infectious Disease • CD4

Impact of frequency and duration of freeze-dried inactivated tissue culture hepatitis A vaccine (Aimmugen®) vaccination on antibody titers; a japanese cross-sectional study. (PubMed, Vaccine) - "Three doses of Aimmugen® are efficacious, but four or more doses induce more robust and sustained antibody production. Additionally, four or more doses may be effective when there is a need to ensure long-term immunity or risk of prolonged exposure."

Journal • Observational data • Hepatology • Infectious Disease • Inflammation

Delaying the third dose of Japanese aluminum-free hepatitis A vaccine Aimmugen elicits effective immune responses against hepatitis A in adults. (PubMed, Vaccine) - "Inactivated aluminum-adsorbed hepatitis A vaccines such as Havrix, Vaqta, and Avaxim are commonly used worldwide. Registered 03 April 2014. https://center6.umin.ac.jp/cgi-bin/ctr/ctr_view_reg.cgi?recptno=R000015906."

Journal • Hepatology • Infectious Disease • Inflammation

Predictors associated with a better response to the Japanese aluminum-free hepatitis A vaccine, Aimmugen , for people living with HIV. (PubMed, Hepatol Res) - "Three-dose of Aimmugen for MSM-LWHIV was effective while two-dose was less effective compared to non-HIV-infected people. People-LWHIV with shorter duration of ART and lesser CD4 cell count achieved lower titers of anti-HA-IgG and might require an additional vaccination."

Journal • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • CD4

Anaphylaxis to simultaneous administration of inactivated tissue culture hepatitis A vaccine and purified chick embryo cell rabies vaccine after multiple doses. (PubMed, BMJ Case Rep) - "Twenty cases of anaphylaxis due to PCECV (RabAvert) have been reported from 1997 to 2005 in USA, whereas 2 cases have been reported from 2006 to 2016. We report a case of anaphylaxis after multiple vaccinations in a 24-year-old man with ulcerative colitis, previous medical history of tonsillectomy for IgA nephropathy and no history of allergies."

Journal • Allergy • Gastroenterology • Gastrointestinal Disorder • Glomerulonephritis • Hepatology • IgA Nephropathy • Immunology • Infectious Disease • Inflammatory Bowel Disease • Renal Disease • Ulcerative Colitis

[VIRTUAL] Effectiveness of hepatitis A vaccination in human immunodeficiency virus-infected men who have sex with men during an outbreak of hepatitis A in Osaka, Japan (EASL-ILC-I 2020) - "This study indicated that three doses of Aimmugen achieved good immune response against HAV in HIV-infected MSM patients and that high initial CD4 lymphocyte count can be a predictive factor for HAV seroconversion."

Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease