ropivacaine / Generic mfg. - LARVOL DELTA

Quadratus Lumborum vs Erector Spinae Supplementary Blocks With Lumbar Plexus Blocks for Hip PAO (clinicaltrials.gov) - P4 | N=0 | Withdrawn | Sponsor: Boston Children's Hospital | N=156 ➔ 0 | Trial completion date: Dec 2024 ➔ Dec 2025 | Active, not recruiting ➔ Withdrawn | Trial primary completion date: Dec 2024 ➔ Dec 2025

Enrollment change • Trial completion date • Trial primary completion date • Trial withdrawal • Anesthesia • Pain

Pericapsular nerve block and ablation as a novel pain modifying strategy in sickle cell patients wiht refractory hip pain due to avascular necrosis (ASH 2025) - "Beyond duloxetine, aserotonin and norepinephrine reuptake inhibitor (Brandow et al, Blood Adv, 2020), there is little progresson pain management for medication-resistant pain (Okpala et al, J R Soc Med, 2002)...Under ultrasound guidance, the iliopubiceminence was identified and a solution of 0.25% ropivacaine and 40mg of Kenalog was injected at thetarget area using a 25-gauge needle... A two-step approach to mitigating AVN-associated pain can provide sustained pain relief inpatients with sickle cell disease. Specifically, cryoablation offers nerve-sparing sustained pain relief forpatients who are not surgical candidates. Further work is needed to establish AVN-grade specifictreatment approaches for this patient population."

Clinical • Anesthesia • Genetic Disorders • Hematological Disorders • Immunology • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Pain • Sickle Cell Disease

Anterior Quadratus Lumborum Block: A Regional Anaesthetic Technique for the Management of Acute Back Pain in the Emergency Department. (PubMed, Cureus) - "Given ongoing severe pain (NRS = 8/10), ultrasound-guided bilateral AQLB was performed using 30 mL of 0.18% ropivacaine on each side with a 21G SonoPlex®II needle (Pajunk®, Geisingen, Germany), accompanied by intravenous dexamethasone (6 mg). This case suggests that AQLB is a feasible and effective opioid-sparing rescue technique for the management of acute back pain in the ED secondary to QL syndrome. It adds to emerging evidence supporting its role as a safe, effective, and resource-efficient intervention, meriting further prospective evaluation."

Journal • Anesthesia • Back Pain • Chronic Kidney Disease • Musculoskeletal Pain • Nephrology • Pain • Renal Calculi • Renal Disease

Effect of Ropivacain and Bupivacain on Calcium-Related and G-Protein Coupled Processes in PMNs: A Human In-Vitro Study. (PubMed, Health Sci Rep) - "Inhibition of the Gβγ subunit using gallein and PLC using U-73122 led to an earlier onset of NETosis and an increase in the maximum intracellular calcium. An additional effect of ropivacaine on the GPCR signaling pathway was not detectable."

Journal • Preclinical • Anesthesia

Impact of transversus abdominis plane block plus intravenous lidocaine on rapid recovery after bariatric surgery. (PubMed, Front Med (Lausanne)) - "The CG received ultrasound-guided TAPB with ropivacaine, while the SG received ultrasound-guided TAPB with ropivacaine plus intravenous lidocaine. The two groups were compared in terms of total doses of propofol, remifentanil, and sufentanil used; pain intensity; intraoperative conditions; levels of inflammatory factors; additional use of postoperative analgesics; incidence of adverse reactions; and postoperative recovery time...Furthermore, the SG exhibited a shorter time to first flatus, first defecation, and first ambulation, as well as a shorter length of hospital stay compared to the CG (all p < 0.05). TAPB combined with intravenous lidocaine may provide effective postoperative analgesia for patients after bariatric surgery and may accelerate their rapid recovery."

Journal • Oncology • Pain • IL6 • TNFA

Comparative Analysis of Postoperative Recovery and Analgesia in Gynecologic Laparoscopic Surgery with Total Intravenous Anesthesia Versus Combined Intravenous Inhalational Anesthesia Both with Ultrasound Guided Transversus Abdominis Plane Block: A Randomized Controlled Trial. (PubMed, J Invest Surg) - "Nausea/vomiting incidence was reduced with TIVA (p < 0.05). TIVA combined with ropivacaine TAP block accelerates early recovery, improves analgesia, attenuates surgical stress, and reduces nausea/vomiting."

Clinical • Journal • Anesthesia • Gynecology • Pain

Rapidly photocrosslinkable charged silk-based hydrogel for emergency hemostasis and multifunctional wound therapy. (PubMed, Bioact Mater) - "Controlled release assays demonstrate first-order kinetics for both the model protein (BSA) and ropivacaine, enabling sustained and timely delivery under neutral and mildly acidic wound environments. These findings position charged SAMA hydrogels as a clinically translatable solution for acute wound care, integrating rapid sealing, antimicrobial protection, immune regulation, and tissue repair into a low-cost platform suitable for wound and emergency applications."

Journal • Critical care • Infectious Disease • Inflammation • IL6 • SELP

The Effect of Pericapsular Nerve Group Block with Liposomal Bupivacaine on Postoperative Rebound Pain in Older Hip Fracture Patients: A Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - "Ninety patients scheduled for hip fracture surgery were randomized into three groups: LB (liposomal bupivacaine, 30 mL), R (0.375% ropivacaine, 30 mL), and C (saline, 30 mL)...There were no significant differences between the groups in adverse events. LB PENG blockade reduces rebound pain incidence post-nerve block in elderly hip fracture patients, decreases PCA demand, preserves quadriceps function, and enhances satisfaction."

Clinical • Journal • Musculoskeletal Diseases • Orthopedics • Pain

Thoracoscopy-Guided vs. Ultrasound-Guided Paravertebral Block in Thoracoscopic Surgery: A Non-Inferiority Randomized Trial. (PubMed, J Clin Med) - "Blocks were performed at the end of surgery at the T4 and T7 vertebra levels, using 10 mL of 0.5% ropivacaine per level...This approach may support streamlined perioperative workflows and optimize enhanced recovery protocols in thoracic surgery. (Trial registration number, KCT0006471)."

Head-to-Head • Journal • Anesthesia • Pain

Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness (clinicaltrials.gov) - P=N/A | N=25 | Not yet recruiting | Sponsor: Beijing Tiantan Hospital

New trial

Combined Betamethasone and Ropivacaine for Scalp Nerve Block for Patients Undergoing Elective Craniotomy: A Prospective, Randomized, Controlled Clinical Study. (PubMed, J Neurosurg Anesthesiol) - P=N/A | "Betamethasone plus 0.5% ropivacaine SNB significantly decreased postoperative pain intensity within and at 48 hours postoperatively, likely due to prolonged analgesia and reduced inflammatory responses."

Clinical • Journal • Anesthesia • Inflammation • Pain • IFNG • IL10 • IL6

Effect of External Oblique Intercostal Block on Postoperative Analgesia and Early Recovery in Patients Undergoing Open Liver Resection for Hepatocellular Carcinoma or Intrahepatic Bile Duct Stones: A Randomized Controlled Clinical Trial. (PubMed, Local Reg Anesth) - "EOI group received 30 mL of 0.25% ropivacaine bilaterally 30 min before induction of general anesthesia, whereas control group did not receive any block...The plasma levels of NE, Cor, HMGB1, TNF-α and IL-6 at 6 h postoperatively in EOI group were significantly lower than in control group. EOI block given to patients undergoing OLR could provide effective postoperative analgesia, enhance the quality of postoperative recovery, and attenuate postoperative stress and inflammation."

Clinical • Journal • Anesthesia • Hepatocellular Cancer • Oncology • Pain • Solid Tumor • HMGB1 • IL6 • TNFA

Pharmacovigilance assessment of ropivacaine safety using FAERS data (2004-2024). (PubMed, Medicine (Baltimore)) - "The detection of potential gender-specific reporting patterns and specific high-strength signals warrants further clinical investigation. These findings provide valuable hypothesis-generating evidence from real-world data to guide targeted monitoring and inform future research on ropivacaine's safety profile."

Adverse events • Journal • Retrospective data • Anesthesia

Effect of intratracheal dexmedetomidine combined with ropivacaine at various times prior to tracheal intubation in patients undergoing thyroidectomy: a randomized clinical trial. (PubMed, Eur J Med Res) - P=N/A | "Immediate endotracheal intubation following topical airway anesthesia, as a convenient approach, induces transient hemodynamic instability during the procedure but does not increase the incidence of sore throat and hoarseness 24 h postoperatively."

Clinical • Intubation • Journal • Anesthesia • Cough • Otorhinolaryngology • Pain • Respiratory Diseases

Liposomal Bupivacaine Versus Ropivacaine for Preperitoneal Infiltration Analgesia in Upper Abdominal Laparotomy (clinicaltrials.gov) - P=N/A | N=146 | Not yet recruiting | Sponsor: Qilu Hospital of Shandong University

New trial

Comparison of analgesia efficacy between single-orifice and multiorifice wire-reinforced catheters for labour analgesia with the dural puncture epidural technique: A double-blind randomised controlled trial. (PubMed, Eur J Anaesthesiol) - P=N/A | "DPE using a 25-G spinal needle and with a single-orifice catheter produced a significantly faster onset of analgesia than DPE with a multiorifice catheter during labour initiation."

Journal • Pain

Continuous Infusions vs Scheduled Bolus Infusions (clinicaltrials.gov) - P4 | N=240 | Recruiting | Sponsor: Stanford University | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date • Pain

Comparison of Two Approaches for Infraclavicular Brachial Plexus Block Using 0.5 % Ropivacaine Undergoing Forearm Surgery (clinicaltrials.gov) - P=N/A | N=40 | Completed | Sponsor: Sargodha Medical College

New trial

The Effect of Local Infiltration of Dexmedetomidine as an Adjuvant on Breakthrough Pain During Epidural Labor Analgesia: A Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - P=N/A | "Evaluation of the effectiveness of local dexmedetomidine and ropivacaine administration prior to epidural puncture in reducing breakthrough pain during labor analgesia. Administering local infiltration of 0.4 µg/kg or 0.6 µg/kg dexmedetomidine prior to epidural puncture in parturients undergoing elective labor analgesia has been shown to be effective in decreasing the incidence of breakthrough pain during labor analgesia. The trial has been registered in the Chinese Clinical Trials Registry (ChiCTR2400083244) https://www.chictr.org.cn/showproj.html?proj=227790."

Clinical • Journal • CNS Disorders • Depression • Pain • Postpartum Depression • Psychiatry

Evaluation of drug distribution, sensory and motor blockade regions in canine coccygeal epidural anesthesia. (PubMed, J Vet Med Sci) - "Six dogs received three different doses (0.1, 0.2, and 0.3 mL/kg) of a mixture containing equal volumes of ropivacaine and iohexol, administered via the first and second coccygeal intervertebral spaces...Despite the increased volume at 0.3 mL/kg, greater leakage through the neural foramina resulted in a net epidural dosage comparable to 0.2 mL/kg. These findings indicate that coccygeal anesthesia at 0.1 mL/kg provides SB from the tail to the perineal region while maintaining hindlimb motor function in dogs."

Journal • Anesthesia

Selective sympathetic action on heart rate variability after ultrasound-guided stellate ganglion block. (PubMed, Auton Neurosci) - "The current study demonstrates that usSGB renders HRV changes indicating selective sympathetic inhibition of the heart without affecting vagal tone."

Journal

The Influence of Dexmedetomidine Added to Ropivacaine on Its Pharmacokinetic and Pharmacodynamic Effects During Lumbar Plexus Block. (PubMed, Anesth Analg) - "Our research demonstrated that dexmedetomidine significantly influences the pharmacokinetics and pharmacodynamics of ropivacaine in LPB. When combining dexmedetomidine 0.5 µg·kg-1 with ropivacaine for LPB in a 66 kg adult, the maximum ropivacaine dose should not exceed 3.7 mg·kg-1."

Journal • PK/PD data • Anesthesia

Sacral Erector Spinae Plane Block: Computed Tomography Imaging in a Hip Fracture Patient. (PubMed, A A Pract) - "We report an 88-year-old patient undergoing hip fracture surgery in whom a sacral ESP block was performed at S1, injecting 20 mL 0.2% ropivacaine with 20 mL iomeprol (300 mg·mL⁻¹)...Analgesia was effective with only paracetamol for 48 hours. Further imaging and anatomical studies are warranted."

Journal • Anesthesia • Musculoskeletal Diseases • Orthopedics

IRICS: Intrapleural Ropivacaine Infusion in Cardiac Surgery (clinicaltrials.gov) - P4 | N=116 | Recruiting | Sponsor: Saint Petersburg State University, Russia | Not yet recruiting ➔ Recruiting

Enrollment open • Cardiovascular • Coronary Artery Disease

Pain Management of ACL Reconstruction (clinicaltrials.gov) - P=N/A | N=60 | Enrolling by invitation | Sponsor: University of California, Davis | Trial completion date: Jul 2025 ➔ Jul 2026 | Trial primary completion date: Jul 2025 ➔ Jul 2026

Trial completion date • Trial primary completion date • Pain