ropivacaine / Generic mfg. - LARVOL DELTA

Green chiral HPLC method on a polysaccharide column under hydro-organic conditions for the determination of Levobupivacaine, Ropivacaine, and their enantiomeric impurities. (PubMed, BMC Chem) - "To our knowledge, the developed method is the first application of hydro-organic conditions on a polysaccharide column for these local anesthetics, offering a rapid, selective, and sustainable alternative to traditional modes used in chiral LC methods. Its simplicity and robustness make it well suited for routine quality control applications."

Journal • Anesthesia

Caudal-Threaded Versus Direct Lumbar/Thoracic Epidural Catheters in Small-Weight Infants-A Single-Center Retrospective Observational Study. (PubMed, Children (Basel)) - "Patients in the direct lumbar/thoracic epidural group were more likely than those in the caudal-threaded group to receive a ropivacaine/clonidine infusion (47% vs. 4%; p < 0.001) and a programmed intermittent bolus of epidural infusion (60% vs. 3%; p < 0.001). Direct lumbar/thoracic epidural catheters were associated with a higher incidence of postoperative catheter leakage and premature catheter removal; however, these complications cannot be attributed solely to the location of epidural catheter insertion. These findings may help clinicians select the most appropriate epidural technique for postoperative pain management in this population."

Journal • Observational data • Retrospective data • Anesthesia • Critical care • Pain • Pediatrics

The Role of Ultra-Low-Dose Naloxone as an Additive in Anesthesia and Nerve Block: A Systematic Review. (PubMed, Health Sci Rep) - "In anesthesia and analgesia, opioids alone or in combination with local anesthetics (bupivacaine, lidocaine, and ropivacaine) have been investigated to prolong peripheral nerve blocks...These findings should be interpreted as observations reported by individual studies rather than definitive treatment effects. Although no major safety concerns were identified, the available evidence is insufficient to establish the overall safety or efficacy of ultra-low-dose naloxone."

Journal • Review • Anesthesia • Pain

Peripheral Nerve Block with Ropivacaine Ameliorates Acute Compartment Syndrome by Promoting Macrophage M2 Polarization via JAK-STAT Signaling. (PubMed, Biomedicines) - "This study provides the first pre-clinical proof-of-concept that ropivacaine PNB can act as an adjunctive disease-modifying strategy for ACS (beyond analgesia), and identifies macrophage JAK2-STAT3 as the critical molecular cascade responsible for this immunomodulatory effect. This identifies a readily translatable adjunctive strategy for ACS and establishes JAK-STAT as a potential pharmacological target for compartment syndrome-associated inflammation."

Journal • Cardiovascular • Infectious Disease • Inflammation • Orthopedics • Pain • ARG1 • CD86 • CRP • IFNG • IL1B • IL6 • MRC1 • STAT3 • TNFA

Ultrasound-Guided Thoracic Paravertebral, Erector Spinae Plane and Quadratus Lumborum Blocks During Emergency Laparotomy in Dogs: A Multicenter Retrospective Study. (PubMed, Vet Sci) - "All regional blocks were performed using ropivacaine. Ultrasound-guided TPV, ESP, and QL blocks were associated with lower intraoperative rescue fentanyl requirements than systemic analgesia alone, while block-related technical complications were uncommon. These techniques may represent useful components of multimodal anesthesia for selected dogs undergoing emergency laparotomy, providing opioid-sparing effects without increasing the incidence of intraoperative hypotension compared with systemic opioid analgesia alone."

Journal • Retrospective data • Anesthesia • Cardiovascular • Hypotension • Pain

Efficacy of ultrasound-guided stellate ganglion block in the prevention of perioperative myocardial injury in high-risk patients undergoing noncardiac surgery (clinicaltrials.gov) - P=N/A | N=300 | Enrolling by invitation | Sponsor: Department of Anaesthesiology, People's Hospital of Chongqing Banan District | Not yet recruiting ➔ Enrolling by invitation

Enrollment open • Anesthesia • Cardiovascular

Effects of Dexmedetomidine or Sufentanil Plus Low-Dose Ropivacaine for Epidural Labor Analgesia on Maternal Intrapartum Temperature Changes and Delivery Outcomes. (PubMed, J Pain Res) - P=N/A | "Multicenter studies are warranted to confirm these findings. Registered at the Chinese Clinical Trial Registry (ChiCTR2500108053) on August 25th, 2025."

Journal • Pain

QLESP Block for Pain Control in Robotic Partial Nephrectomy (clinicaltrials.gov) - P=N/A | N=120 | Recruiting | Sponsor: Huazhong University of Science and Technology | Not yet recruiting ➔ Recruiting

Enrollment open • Genito-urinary Cancer • Kidney Cancer • Neuralgia • Oncology • Pain • Renal Cell Carcinoma • Solid Tumor

Effect of Bilateral Ultrasound-Guided Deep Parasternal Intercostal Plane Block Before Extubation on Early Recovery After Cardiac Surgery via Median Sternotomy: A Randomized Controlled Trial. (PubMed, Pain Ther) - P=N/A | "Bilateral ultrasound-guided DPIP block performed before extubation was associated with improved early recovery after median sternotomy cardiac surgery, reflected by higher QoR-15 score, lower postoperative sufentanil consumption, and less postoperative nausea and vomiting. These findings suggest that the timing of DPIP block administration may be important in optimizing recovery after cardiac surgery. Future multicenter studies or studies with extended follow-up may be conducted to validate the generalizability of these findings."

Journal • Cardiovascular • Pain

A Pilot Study Comparison of Programmed Intermittent Bolus Versus Continuous Infusion (clinicaltrials.gov) - P=N/A | N=10 | Not yet recruiting | Sponsor: Giorgio Veneziano

New trial • Anesthesia

Case Report: Brugada syndrome uncovered by delivery in a 32-year-old patient. (PubMed, Front Cardiovasc Med) - "She received epidural ropivacaine and sufentanil during labor. An implantable cardioverter-defibrillator was implanted. This case illustrates multifactorial unmasking of latent BrS-involving ropivacaine-mediated sodium channel blockade, postpartum autonomic instability, bradycardia, and electrolyte imbalance in a genotype-negative asymptomatic woman, highlighting the importance of recognizing concealed channelopathies in peripartum cardiac arrest."

Journal • Cardiovascular • Coronary Artery Disease • Genetic Disorders • Heart Failure

Crystal precipitates of local anaesthetic and adjuvant mixtures can be visualised and graded using ultrahigh-frequency ultrasound imaging. (PubMed, Reg Anesth Pain Med) - "All investigated mixtures demonstrated precipitation detectable by high-resolution ultrasound; the combination of ropivacaine, lidocaine and sodium bicarbonate showed the most pronounced effect. Ultrasound imaging proved to be a suitable method for detecting and grading crystalline structures in vitro and may represent a possible technology for future in vivo diagnostics."

Journal • Anesthesia

Comment on: "Effectiveness of Fascia Iliaca Compartment Blocks for Pain Relief After Hip Arthroplasty Using Ropivacaine and Dexamethasone". (PubMed, Asian J Anesthesiol) - No abstract available

Journal • Orthopedics • Pain

Effects of liposomal bupivacaine versus ropivacaine for fascia iliaca compartment block on postoperative pain and delirium in elderly patients undergoing hip arthroplasty. (PubMed, Am J Transl Res) - "FICB with liposomal bupivacaine may be associated with prolonged analgesia, a lower incidence of POD, faster recovery, and fewer complications in elderly patients undergoing THA."

Journal • CNS Disorders • Geriatric Disorders • Orthopedics • Pain

The Impact of Regional Motor-sparing Blocks on Early Rehabilitation Following Primary Hip or Knee Arthroplasty (clinicaltrials.gov) - P=N/A | N=220 | Not yet recruiting | Sponsor: Poznan University of Physical Education

New trial • Orthopedics

QoR40 Between Intercostal Block and Intercostal Block and Serratus Plane Catheter During VATS (clinicaltrials.gov) - P=N/A | N=200 | Completed | Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Recruiting ➔ Completed

Trial completion • Pain

Comparison of Ropivacaine vs Bupivacaine as Local Anaesthetic Agent in Open Inguinal Hernia Surgery- A Randomised Controlled Trial (ACS-CLINCON 2026) - "Abstract is embargoed at this time."

Clinical • Surgery • Gastroenterology

Analgesic Efficacy of Different Doses of Esketamine as an Adjuvant to Ropivacaine for Thoracoscopy-Guided Thoracic Paravertebral Block After Thoracoscopic Radical Resection for Lung Cancer: A Prospective Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - "Esketamine combined with ropivacaine for TG-TPVB prolonged postoperative analgesia, reduce pain scores, reduced analgesic consumption, and facilitated recovery. Esketamine at 0.2 mg/kg seems to show a good balance effect in many aspects."

Clinical • Journal • Anesthesia • Lung Cancer • Oncology • Pain • Solid Tumor

In Vitro Effects of Anaesthetic Compounds on a Panel of Solid Tumour Cell Lines-An Exploratory Study. (PubMed, J Cell Mol Med) - "Lidocaine and ropivacaine induced stress fibre formation and swelling, while tunnelling nanotubes were observed as signs of cellular stress...Anaesthetic agents exert pleiotropic, cell-line-dependent effects, primarily inhibiting tumour growth and motility in our cell models through structural destabilization and stress signalling. These findings underscore the need for advanced models to clarify clinical relevance and to confirm the best choice of anaesthesia technique tailored to the patient's specific cancer type."

Journal • Preclinical • Anesthesia • Oncology • Pain • Solid Tumor

Anterior Suprascapular Versus Interscalene Block for Postoperative Analgesia After Arthroscopic Shoulder Surgery in the Outpatient Setting (clinicaltrials.gov) - P=N/A | N=100 | Recruiting | Sponsor: ASST Sette Laghi

New trial • Orthopedics • Pain

Comparison of liposomal bupivacaine and modified cocktail analgesia for postoperative pain control after transforaminal lumbar interbody fusion: a prospective, double-blind, randomized controlled trial. (PubMed, J Neurosurg Spine) - P4 | "Both LB and the modified cocktail regimen administered via ESPB effectively reduced early incisional pain after TLIF. The modified cocktail provided satisfactory analgesia within 24 hours at substantially lower cost, whereas LB offered more prolonged analgesia up to 36 hours, with reduced opioid consumption and PCA demand. Chinese Clinical Trial Registry no.: ChiCTR2400089275 (https://www.chictr.org.cn/index.html)."

Journal • Pain

Analgesic Efficacy of Peritonsillar Ropivacaine Infiltration After Tonsillectomy in Children (clinicaltrials.gov) - P=N/A | N=60 | Completed | Sponsor: University Hospital, Mahdia

New trial • Anesthesia

Ropivacaine Spinal Anesthesia for IELD: Dose-Finding Pitfalls and Scoring Inconsistency [Letter]. (PubMed, Drug Des Devel Ther) - No abstract available

Journal • Anesthesia

Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone for Relieving Postoperative Pain After Thoracoscopic Surgery (clinicaltrials.gov) - P=N/A | N=346 | Recruiting | Sponsor: Beijing Tiantan Hospital | Initiation date: Jun 2026 ➔ Sep 2026

Trial initiation date • Pain

Study on the minimum effective dose of Oliceridine in PCIA combined with iliofascial block block for analgesia after knee arthroplasty (ChiCTR) - P=N/A | N=68 | Completed | Sponsor: The Second Hospital of Sanming city; The Second Hospital of Sanming

New trial • Musculoskeletal Diseases • Orthopedics