GSK-1482160 / GSK - LARVOL DELTA

P2X7R inhibitor blocks exosome secretion and delays proteopathic tau accumulation in P301S tau mice (Neuroscience 2018) - "Interestingly, hippocampal p-Tau ELISA data showed that tau phosphorylation level was significantly reduced in GSK1482160-treated group as compared to vehicle-treated group (p=0.0292).Conclusions GSK1482160 pre-treatment successfully suppresses exosome secretion by microglia in vitro. Its oral administration also significantly reduces Tau accumulation in the hippocampal region of P301S Tau mouse model. "

Preclinical • Alzheimer's Disease • CNS Disorders

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response. (PubMed) - Nucl Med Commun - "We conclude that [C]GSK1482160 has the potential for application in monitoring neuroinflammation."

Journal • Biosimilar • Immunology • Multiple Sclerosis