selenomethionine (SLM) / Holden Comprehensive Cancer Center, The University of Iowa - LARVOL DELTA

Seleno-L Methionine (SLM)-Axitinib-Pembrolizumab (clinicaltrials.gov) - P1/2 | N=55 | Active, not recruiting | Sponsor: Mohammed Milhem | Recruiting ➔ Active, not recruiting

Enrollment closed • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor

Structure, substrate recognition and therapeutic targeting of the human ADAMTS-5 spacer domain. (PubMed, Acta Crystallogr D Struct Biol) - "This structure reveals critical features of the spacer domain, including the hypervariable loops that function as exosites essential for the binding of aggrecan and versican. Our findings provide new structural insights into the molecular determinants of the substrate specificity of ADAMTS-5 and underscore the spacer domain as a promising target for the development of selective inhibitors."

Journal • Atherosclerosis • Cardiovascular • Immunology • Osteoarthritis • Pain • Rheumatology • ACAN • ADAMTS5 • VCAN

The role of GPD2 on ferroptosis in sepsis-induced acute lung injury. (PubMed, Biochem Biophys Res Commun) - "Selenomethionine (SeMet), a GPX4 activator, was administered 24 h prior to CLP surgery...Our results suggest that GPD2 may protect against pulmonary vascular permeability, neutrophil infiltration, oxidative stress, and inflammatory responses in septic mouse lung tissues by suppressing ferroptosis through the activation of the GPX4 pathway. These findings suggest that GPD2 could be a potential therapeutic target for sepsis-induced ALI."

Journal • Acute Lung Injury • Infectious Disease • Inflammation • Respiratory Diseases • Septic Shock • GPX4

Bioconversion-type selenium-enriched kombucha fermentation broth: preservation enhancement and organic selenium enrichment regulation in Lentinula edodes. (PubMed, Food Chem) - "Using three selenium sources (SeNPs, sodium selenate, selenite), SKFP achieved 55.76 % organic selenium conversion, predominantly as selenomethionine and methylselenocysteine...Principal component analysis optimized selenium concentrations for maximum efficacy. This technology represents a paradigm shift toward dual-functional preservation that mitigates postharvest loss and addresses micronutrient deficiency, offering a sustainable strategy for next-generation food preservation."

Journal

Foliar selenium application with compound auxiliaries enhances selenium accumulation, grain quality, and heavy metal detoxification in black wheat (Triticum aestivum L.). (PubMed, Front Plant Sci) - "Organic Se speciation analysis identified selenomethionine (SeMet) as the predominant form in grains, with T1 yielding the highest SeMet concentration, while the addition of auxiliaries (T2, T3, T4) significantly reduced SeMet content compared to T1...These results demonstrate a clear trade-off: foliar Se application alone (T1) optimizes nutritional quality via SeMet enrichment, whereas its combination with an adjuvant (T2) provides a balanced strategy, enhancing yield and Cd safety alongside robust Se biofortification. This integrated foliar application approach offers insights for balancing Se enrichment and heavy-metal mitigation in functional agriculture."

Journal

Role of a Tunable σ-Hole-Mediated Chalcogen Bond in the Substrate Specificity of Methionyl-tRNA Synthetase. (PubMed, J Phys Chem Lett) - "Using selenomethionine, we show that the strength of the Ch-bond can be tuned by changing the polarizability of the Ch-atom. ONIOM (QM/MM) calculations reveal that substituting sulfur with selenium leads to a shorter interaction distance and a more linear n → σ* approach, rationalizing the enhanced binding affinity observed with selenium. Our study shows that σ-hole-mediated S···O and Se···O Ch-bonds, which are analogous to hydrogen and halogen bonds, can facilitate substrate binding and molecular recognition."

Journal

Effects of pressing temperature on selenium speciation, volatile profiles, and sensory evaluation in selenium-enriched rapeseed oils. (PubMed, Food Res Int) - "Organic Se species, primarily selenomethionine, selenocystine, and Se-methylselenocysteine, were the dominant forms and exhibited higher thermal sensitivity, with reductions of 85.19 %, 66.20 %, and 74.96 % from CPO to MPO, respectively...Sensory evaluation revealed that low-temperature SROs were characterized by a predominant green aroma, associated with aldehydes, alcohols, and ketones, while high-temperature SROs displayed stronger roasted/nutty, burnt, pungent, and smoky notes, attributed to elevated levels of nitriles, sulfur compounds, and heterocyclics. These findings provide valuable insights for optimizing Se retention and flavor quality during SRO processing."

Journal

Different forms of selenium improve laying performance and ovarian antioxidant capacity: regulating gut microbiota and ovarian metabolism. (PubMed, Poult Sci) - "Compared with the sodium selenite (SeS), nano-selenium (SeN), selenomethionine (SeM), and selenium-enriched yeasts (SeY), as novel selenium sources, are increasingly popular in laying hen production...Meanwhile, the gut microbiota and differential metabolites of ovary were closely related to laying performance and antioxidant capacity of ovary. Therefore, 0.4 mg/kg SeN, SeM, and SeY showed an advantage on improving laying rate, ovary function, and gut microbiota in laying hens, and they could be potential additives using in laying hen production."

Journal • Metabolic Disorders • Oncology • Ovarian Cancer • GPX2 • SOD2

OsPT4 Facilitates Selenomethionine Transport and Biosynthesis to Enhance Seed Accumulation in Rice: Molecular Mechanisms and Biotechnological Potential. (PubMed, Plant Biotechnol J) - "Notably, OsPT4 significantly increased SeMet accumulation and promoted the formation of Se-rich micron-sized spherical particles in seeds under Se supplementation. These findings provide mechanistic insights into OsPT4-mediated SeMet trafficking and metabolism, advancing strategies for developing Se-biofortified rice cultivars with enhanced nutritional and therapeutic value."

Journal • Oncology

An Attack and Defense Strategy for Osteoarthritis Repair: Constructing a Trace Element Modulated Hydrogel to Mitigate Ferroptosis and Promote Cartilage Matrix Reconstruction. (PubMed, Research (Wash D C)) - "Based on this discovery, we innovatively pioneered the integration of Fe2+-capturing (attack) nanocatalysts and selenium-enriched (defense) polypeptides (selenomethionine [SeMet]) into a hydrogel platform...In vivo investigations showed its anti-inflammatory activity, ferroptosis-inhibiting capacity, and ability to reverse cartilage degeneration. This work establishes a therapeutic paradigm based on trace element synergy, providing a translatable disease-modifying candidate."

Journal • Hematological Disorders • Immunology • Osteoarthritis • Pain • Rheumatology • GPX4

Extractive Electrospray Ionization Mass Spectrometry for Rapid Analysis of Organic and Inorganic Selenium in Honey. (PubMed, Molecules) - "By leveraging the distinctive physicochemical properties of honey, we employed reactive extractive electrospray ionization mass spectrometry (EESI-MS) to rapidly analyze the presence of both organic selenium (selenomethionine) and inorganic selenium (sodium selenite) in diluted honey samples...This study presents a precise, rapid, and convenient method for selenium determination in diluted honey. Given the limited sample size in this preliminary study, future research with larger cohorts is required to validate our findings."

Journal

Time-dependent application strategies of selenium Nanofertilizer to enhance biofortification in rice and wheat. (PubMed, Food Chem X) - "Selenomethionine was the dominant Se species in both grains (>62 %), unaffected by fertilization timing. Delayed fertilization increased Se retention in the wheat inner fraction, enhancing Se recovery during flour processing. These findings offer practical guidance for optimizing Se biofortification strategies to improve grain Se content and nutritional quality."

Journal

Selenomethionine alleviates aortic dissection via PGC-1α/NRF2/TFAM-mediated mitochondrial biosynthesis against ferroptosis: an experimental study. (PubMed, Int J Surg) - "Set alleviated AD progression by suppressing ferroptosis-mediated phenotypic switching of VSMCs through targeted activation of the PGC-1α/NRF2/TFAM axis."

Journal • Cardiovascular • GPX4 • TFAM

Selenium status and supplementation in thyroid disorders: A narrative review of current evidence. (PubMed, J Trace Elem Med Biol) - "In GD and GO, Se supplementation, especially when combined with methimazole, has been shown to enhance hormone normalization and antioxidant capacity, although results vary across studies. In AIT and HT, consistent reductions in thyroid autoantibodies and inflammatory markers have been observed following Se supplementation, particularly with selenomethionine...In conclusion, Se supplementation offers potential therapeutic benefits, particularly in autoimmune thyroid diseases. However, further well-designed randomized-controlled trials are necessary to define the optimal form, dose, and duration of supplementation and to clarify its role across diverse thyroid conditions."

Journal • Review • Endocrine Disorders • Grave’s Disease • Immunology • Oncology • Solid Tumor • Thyroid Eye Disease • Thyroid Gland Carcinoma

Aflatoxin B1 triggers ferroptosis via inhibiting the NRF2 signaling pathway in duck granulosa cells. (PubMed, Poult Sci) - "Moreover, seleniummethionine (Se-Met), an NRF2 pathway activator, effectively alleviated AFB1-induced granulosa cell damage. This study elucidates the protective mechanism of the NRF2 signaling pathway against AFB1-induced ferroptosis and highlights the potential of Se-Met as a therapeutic strategy for alleviating AFB1-induced reproductive dysfunction in poultry."

Journal • Metabolic Disorders

Exploring the Potential Targets and Molecular Mechanisms of Selenomethionine to Attenuate Acute Kidney Injury Based on Network Pharmacology, Molecular Simulation Technology and Animal Experiments. (PubMed, Phytother Res) - "This study demonstrates that GPX3 and IL-6 may serve as potential targets for selenomethionine in alleviating renal IRI. Furthermore, selenomethionine may mitigate renal IRI by suppressing the MAPK signaling pathway."

Journal • Acute Kidney Injury • Cardiovascular • Inflammation • Nephrology • Renal Disease • Reperfusion Injury • GPX3 • IL6

Multiomics Analysis of the Drying Time Regulation on Selenomethionine Accumulation and Flavor Compound Changes in Selenium-Enriched Black Tea. (PubMed, J Agric Food Chem) - "SeMet peaked at 36 min (1.23 mg kg-1), which increased by 19.4, 17.1, 16.0, and 61.8% compared with 12, 24, 48, and 54 min (1.03, 1.05, 1.06, and 0.76 mg kg-1, respectively). Optimal drying (70 °C for 36 min; 3.0% moisture) minimized thermal degradation losses of flavor components like SeMet, providing a theoretical basis for maintaining the high-quality of tea."

Journal

The Role of Green Tea in Reducing Symptoms of Irritable Bowel Syndrome (IBS): A Systematic Review (ACG 2025) - "Several studies reported a statistically significant improvement in abdominal pain, bloating, and satisfaction with bowel habits. In a double-blind, placebo-controlled crossover RCT, a green tea-curcumin-selenomethionine combination significantly improved patient satisfaction with bowel habits (mean score reduced from 70.4 ± 33.1 to 61.8 ± 29.3; p = 0.037). Other studies indicated reduced inflammatory markers and improvement in IBS severity scores following polyphenol-rich green tea extract supplementation."

Review • Constipation • Gastroenterology • Gastrointestinal Disorder • Novel Coronavirus Disease

Effective agronomic biofortification of rice with selenium: Ensuring dietary intake through relative bioavailability and bioaccessible fractions. (PubMed, Food Res Int) - "Speciation analysis revealed a significant increase in organic Se (notably selenomethionine [SeMet]; P < 0.05), with no corresponding rise in inorganic Se in rice grains...Furthermore, ecological risk assessments (ecological risk factor < 40) confirmed no Se soil pollution with organic Se application. This work uniquely integrates total Se, bioaccessible Se, and Se-RBA into dietary Se risk evaluation, advancing agricultural and food chemistry by molecularly correlating Se absorption-utilization dynamics with population-specific intake and hazard assessment for consumption of Se-enriched crops, thereby enabling precision biofortification strategies in staple crops."

Journal

Unlocking the Therapeutic Potential: Selenium and Myo-Inositol Supplementation in Thyroid Disorders-Efficacy and Future Directions. (PubMed, Life (Basel)) - "The search used Boolean operators to combine the following keywords: ("selenium" OR "selenomethionine") AND ("myo-inositol" OR "inositol") AND (thyroid OR Hashimoto* OR Graves' OR hyperthyroid* OR hypothyroid* OR nodule* OR goiter OR orbitopathy)...However, further large-scale, well-designed clinical trials are needed to determine the appropriate dosages, treatment duration, and patient selection criteria. Personalized supplementation solutions may improve medication efficacy and help with more comprehensive thyroid disease care."

Journal • Review • Endocrine Disorders • Grave’s Disease • Immunology • Pediatrics

Differential Effects of Selenium Compounds on Mitochondrial Function in PRRSV-Infected Porcine Alveolar Macrophages. (PubMed, Viruses) - "This study examines the effects of organic (DL-Selenomethionine, L-Selenomethionine, yeast-selenium) and inorganic (sodium selenite) Se on PRRSV infection in vitro...Transcriptome analysis revealed infection-driven modulation, with upregulation of IL6, IL8, IL1B1, MX1, and TXNRD1, but Se had no significant effect. While Se did not exhibit antiviral activity in vitro, its enhancement of mitochondrial function offers additional insight supporting its potential immunomodulatory benefits observed in previous in vivo studies."

Journal • Preclinical • Infectious Disease • Respiratory Diseases • CXCL8 • IL6 • MX1

Na2SeO3 Exposure Inhibits Locomotion and Reproduction via Oxidative Stress Mechanism in Bioindicators C. elegans and Acrobeloides sp. (PubMed, Toxics) - "The results showed that total Se content in both nematodes increased significantly with higher Se exposure concentrations, and Se mainly exists in the speciation of selenomethionine (SeMet) and selenocysteine (SeCys2)...This study provides an important basis for the soil ecotoxicity assessment of Se and highlights the unique value of Acrobeloides sp. in ecotoxicological studies."

Journal

Protective effect of selenomethionine on spleen and sacculus rotundus injury induced by aflatoxin B1 in reserve male rabbits. (PubMed, Vet Res Commun) - "In addition, in this study, the effect of 0.4 mg/kg SeMet was the most effective. SeMet is a natural and safe drug that can prevent AFB1 poisoning in rabbit feed."

Journal • Preclinical • Inflammation

Identification of new selenium compounds produced by edible mushrooms. (PubMed, Food Chem) - "Selenomethionine was the most abundant species in P. ostreatus, accounting for over 45 % of absorbed selenium and much less abundant (15-18 %) in H. coralloides. The water-soluble selenometabolome, accounting for 40-60 % of selenium in the samples, was characterized by HILIC with ESI-MS, revealing the presence of ten additional metabolites. These included several selenoneine derivatives and vinyl-selenocysteine-containing dipeptides, suggesting previously unreported pathways for selenium metabolism in mushrooms."

Journal

Study on the Probiotic Properties of Xinjiang-Characteristic Selenium-Enriched Lactic Acid Bacteria and the Distribution of Selenium Element. (PubMed, Foods) - "Integrated metabolomic and proteomic studies have shown that selenium reduces the content of L-cysteine primarily by replacing sulfur and competing for key sites in cysteine-S-conjugate-β-lyase, S-adenosyl-L-cysteine hydrolase, and homocysteine synthase, ultimately leading to the synthesis of selenocysteine and selenomethionine. A correlation analysis between differential metabolites and proteins revealed selenium's significant impacts on the metabolic networks of LAB, antioxidant mechanisms, energy metabolism, and membrane stability. This research provides new insights for developing selenium-enriched probiotics for functional dairy products and health supplements."

Journal