Hepta (epoetin alfa biosimilar) / Roemmers - LARVOL DELTA

Ring-opening polymerization of new 3-O-branched 1, 6-anhydro glucopyranose di- and trisaccharide monomers. (PubMed) - Carbohydr Res - "Debenzylation of the resulting polymers gave 3-O-gluco- and mannopyranosidic (1 → 6)-α-D-glucopyranans in moderate yields. These results are the first reports of the polymerization of 3-O-branched 1, 6-anhydro glucopyranose disaccharide monomers to give 3-O-branched polysaccharides."

Journal • Biosimilar

Characterization of complex, heterogeneous lipid A samples using HPLC-MS/MS technique II. Structural elucidation of non-phosphorylated lipid A by negative-ion mode tandem mass spectrometry. (PubMed) - J Mass Spectrom - "Reversed-phase liquid chromatography in combination with negative-ion electrospray ionization quadrupole time-of-flight tandem mass spectrometry could provide sufficient information on the primary and secondary acyl residues of a non-phosphorylated lipid A. As a standard, the hexa-acylated ion at m/z 1636 with the Escherichia coli-type acyl distribution (from E. coli O111) was used. The method was tested and refined with the analysis of other non-phosphorylated hexa- and several hepta-, penta-, and tetra-acylated lipid A species detected in crude lipid A fractions from E. coli O111 and Proteus morganii O34 bacteria."

Journal • Biosimilar