budesonide (MAP0010) / AbbVie - LARVOL DELTA

Metagenomic analysis of the gut microbiota in major depressive disorder with different antidepressant efficacy: A prospective cohort study. (PubMed, J Affect Disord) - "The composition and functional pathways of gut microbiota exhibit significant differences between responders and non-responders to SSRIs or SNRIs among MDD patients, providing clues for the development of new treatment strategies."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Opposing Responses to Oxygen in the Rabbit Ductus Arteriosus and Fetal Pulmonary Arteries: Proteomic Analysis Reveals Significant Metabolic Differences (AHA 2024) - "This analysis reveals unique mitochondrial metabolic pathways that may contribute to the opposing tissue responses of these specialized blood vessels to O2. Exploration of these pathways may identify potential therapeutic targets and inform future investigations of differential O2 sensing in DA and rPA."

Omic analysis • Preclinical • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Bacillus velezensis Y6, a Potential and Efficient Biocontrol Agent in Control of Rice Sheath Blight Caused by Rhizoctonia solani. (PubMed, Microorganisms) - "Compared with the control, a large number of enriched genes were distributed in phenylpropanoid biosynthesis (map00940), glutathione metabolism (map00480), glycolysis/gluconeogenesis (map00010), and amino sugar and nucleotide sugar metabolism (map00520). In summary, this investigation provides a new perspective for studying the molecular mechanism of B. velezensis in controlling rice sheath blight."

Journal

Incidence of hypocortisolism with long-term use of budesonide irrigations for chronic rhinosinusitis (COSM 2023) - P=NA | N=290 | "Prolonged use (> 6 months) of budesonide irrigations is associated with a small risk of hypocortisolemia....Surveillance of cortisol levels should be considered in patients receiving budesonide irrigations on an extended basis."

Clinical data

Reduced Effect of Immune Checkpoint Therapy On Liver Metastases with Oral Budesonide Treatment: Implications for The Transplant Allograft? (ILTS 2023) - "Budesonide may be associated with reduced ICI effect in liver lesions, suggesting possible liver specific immune suppression that may impart a level of liver protection when used in combination immunosuppression in liver transplant recipients receiving ICI. Further investigation is warranted."

Insights from a Multi-Omics Integration (MOI) Study in Oil Palm (Elaeis guineensis Jacq.) Response to Abiotic Stresses: Part One-Salinity. (PubMed, Plants (Basel)) - "After performing SOA, 436 differentially expressed (DE) full-length transcripts, 74 DE proteins, and 19 DE metabolites underwent MOI analysis, revealing several pathways affected by this stress, with at least one DE molecule in all three omics platforms used. The Cysteine and methionine metabolism (map00270) and Glycolysis/Gluconeogenesis (map00010) pathways were the most affected ones, each one with 20 DE molecules."

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