IT901 / ImmuneTarget - LARVOL DELTA

c-Rel–Mediated Lipid Accumulation and Inflammatory Activation in Monocytes in Hypertriglyceridemia (AHA 2025) - "Compared to LDLRKO mice or healthy humans, A3LDLRKO mice and humans with HTG exhibited increased LD accumulation in Ly6ClowCD36+ (mouse) and CD16+ (human) int/ncMo. scRNA-seq of mouse monocytes revealed an HTG-responsive int/ncMo cluster enriched for genes involved in lipid metabolism and inflammatory pathways, including the transcription factor Rel. In vitro, compared to vehicle controls, VLDL treatment increased LD accumulation in primary and THP-1 monocytes and upregulated inflammatory markers including c-Rel examined by flow cytometry."

Atherosclerosis • Dyslipidemia • Hypertriglyceridemia • Inflammation • Severe Hypertriglyceridemia • APOB • APOC3 • CD36 • GLI2 • IL1B • IL1R1 • LDLR • LRP1 • PLIN2 • SCARB1 • TNFA

Pro-survival and anti-inflammatory roles of NF-κB c-Rel in the Parkinson's disease models. (PubMed, Redox Biol) - "c-Rel inhibitor IT901 aggravated the damage of MPTP on dopaminergic neurons and promoted the activation of microglia in the nigrostriatal pathway of mice. Moreover, the expression of c-Rel in blood samples of PD patients decreased dramatically. Our results indicate that the NF-κB/c-Rel subunit plays an important role in neuroprotection and neuroinflammation inhibition during PD progression."

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