FFP-102 / AbbVie - LARVOL DELTA

Complete genome sequences and genomic characterization of five plasmids harbored by environmentally persistent Cronobacter sakazakii strains ST83 H322 and ST64 GK1025B obtained from powdered infant formula manufacturing facilities. (PubMed, Gut Pathog) - "These data provide high resolution information on C. sakazakii genomes and emphasizes the need for furthering surveillance studies to link genotype to phenotype of strains from previous investigations. These results provide baseline data necessary for future in-depth investigations of C. sakazakii that colonize PIF manufacturing facility settings and genomic analyses of these two C. sakazakii strains and five associated plasmids will contribute to a better understanding of this pathogen's survival and persistence within various "built environments" like PIF manufacturing facilities."

Journal • CNS Disorders • Gastrointestinal Disorder • Infectious Disease

New global insights on the regulation of the biphasic life cycle and virulence via ClpP-dependent proteolysis in Legionella pneumophila. (PubMed, Mol Cell Proteomics) - "We further observed that ClpP-dependent proteolysis is required to monitor the abundance of fatty acid biosynthesis-related protein Lpg0102/Lpg0361/Lpg0362 and SpoT for the normal regulation of L. pneumophila differentiation...Furthermore, the ClpP-dependent proteolysis of T4BSS and effector proteins at a specific phase of the life cycle is essential for bacterial pathogenesis. Therefore, our findings provide novel insights on ClpP-dependent proteolysis, which spans a broad physiological spectrum involving key metabolic pathways that regulate the transition of the biphasic life cycle and bacterial virulence of L. pneumophila, facilitating adaptation to aquatic and intracellular niches."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases • Targeted Protein Degradation

JOSPT Infographic: Returning to Work After Injury. (PubMed, J Orthop Sports Phys Ther) - "This JOSPT Infographic on return to work after injury is based on clinical practice guidelines by Daley et al titled "Clinical Guidance to Optimize Work Participation After Injury or Illness: The Role of Physical Therapists" (J Orthop Sports Phys Ther 2021;51(8):CPG1-CPG102...J Orthop Sports Phys Ther 2021:51(10):529. doi:10.2519/jospt.2021.9002."

Journal

Clinical Guidance to Optimize Work Participation After Injury or Illness: The Role of Physical Therapists. (PubMed, J Orthop Sports Phys Ther) - "J Orthop Sports Phys Ther 2021;51(8):CPG1-CPG102. doi:10.2519/jospt.2021.0303."

Clinical • Journal • Orthopedics

Expression Characterization of Flavonoid Biosynthetic Pathway Genes and Transcription Factors in Peanut Under Water Deficit Conditions. (PubMed, Front Plant Sci) - "Six peanut varieties (BARD479, BARI2011, BARI2000, GOLDEN, PG1102, and PG1265) having variable responses against drought stress have been selected...Correlational analysis between the expression of TFs related to the biosynthesis of flavonoids and the accumulation of phenolics, flavonols, and anthocyanins indicated coregulation of flavonoid synthesis by TFs under water deficit conditions in peanut. This study would provide insight into the role of flavonoid biosynthetic pathway in drought response in peanut and would aid to develop drought-tolerant varieties of peanut."

Journal • Immunology

Safety and efficacy of PG102P for the control of pruritus in patients undergoing hemodialysis (SNUG trial): study protocol for a randomized controlled trial. (PubMed, Trials) - P=N/A | "The SNUG is a clinical study that aims to investigate the antipruritic effect of PG102P to ameliorate itching in patients undergoing hemodialysis."

Clinical • Journal • CNS Disorders • Depression • Dermatology • Immune Modulation • Inflammation • Nephrology • Pruritus • Renal Disease

A Water-Soluble Extract from Actinidia arguta (PG102) Can Inhibit Kidney Fibrosis (KIDNEY WEEK 2019) - "In vitro experiment, human kidney proximal tubular cells treated with TGF-β and PG102 showed significantly decreased protein expression of α-smooth muscle actin (47.8% of control), and phospho-p38 (51.5% of control). Conclusion PG102 attenuates kidney fibrosis in the unilateral ureteral obstruction mice model and TGF-β-treated human kidney proximal tubular cells, p38 MAPK pathway is inhibited after treatment of PG102."

PG102 Upregulates IL-37 through p38, ERK, and Smad3 Pathways in HaCaT Keratinocytes. (PubMed, Mediators Inflamm) - "PG102 also promoted colocalization of phospho-Smad3 and IL-37. Our results suggest that IL-37 inhibits the expression of AMPs and that PG102 upregulates IL-37 through p38, ERK, and Smad3 pathways in HaCaT cells."

Journal

A Water-Soluble Extract from Actinidia arguta (PG102) can Inhibit Kidney Fibrosis (KSN 2019) - "PG102 attenuates kidney fibrosis in the unilateral ureteral obstruction mice model and TGF-β-treated human kidney proximal tubular cells, p38 MAPK pathway is inhibited after treatment of PG102."