S-8484 / Seismic Therap - LARVOL DELTA

Seismic Therapeutic Presents Preclinical Data on S-8484, Its Novel IgE Protease, for Treatment of Allergic Diseases (Businesswire) - "Highlights from the in vitro studies include demonstration of the following therapeutic properties: Potent, rapid and highly selective cleavage of soluble IgE; Concentration-dependent cleavage of IgE B cell receptor; Concentration-dependent reduction of expression of the high-affinity IgE Fc receptor, on bone marrow-derived mast cells from humanized mice. In vivo studies performed in mouse models demonstrate that an IgE protease achieved comparable efficacy to an approved anti-IgE therapy in animal models of anaphylaxis and allergy, including: Reduction in IgE-induced ear inflammation when dosed systemically, supporting good tissue penetration; Rapid resolution of systemic anaphylactic reaction in a therapeutic mouse model; Reduction of serum IgE and eosinophils in bronchoalveolar lavage (BAL) in rat allergen-induced asthma model."

Preclinical • Allergy • Immunology