Novolin 70/30 (isophane insulin 70%/recombinant human insulin 30%) / Novo Nordisk - LARVOL DELTA

As Ozempic, Wegovy Take Priority, Novo Nordisk Winds Down insulin Portfolio In India (Medical Dialogues) - "Danish pharmaceutical giant Novo Nordisk has announced plans to phase out Human Mixtard, India's top-selling insulin brand. The decision is part of the company's global strategy to prioritize newer, patented therapies such as Ozempic and Wegovy. The discontinuation will also affect products in the Rs 5,000 crore insulin market like Actrapid, Insulatard, Insulin Detemir, Levimir, and Xultophy, primarily available in pre-filled disposable pens and cartridges (prefill and FlexPen)."

Commercial • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus

Persistent hypoglycemia - insulin overdose (EUSEM 2024) - "77 years old male with Background of ESRF on Haemodialysis(HD), Type 2 DM on Insulin, HTN and Parkinson's disease Patient was noticed unconscious, on floor with insulin syringe next to himNoticed Empty bottle of mixtard 30/70...His blood glucose and GCS continued to be low.He was intubated and sent to ICU , required continous infusion of dexttrose and mutiple rounds of haemodialysis.His low neurological status persisted because of neuroglycopenia, underwent MRI brain ,EEG Gradually neurological status improved on day 7.He subsequently recovered well and was sent to general ward with psychiatrist review and councelling.Leanining points in dealing with Subcutaneous insulin overdose.1. Multiple sites of large dose of Subcutaous insulin in obese patient results in sustained release for long.2.Renal failure futher slows done the clearance 3.Multiple coomorbidities took longer time to recover 4.Patience in cases with overdose is the best stratergy to follow."

CNS Disorders • Hypoglycemia • Movement Disorders • Obesity • Parkinson's Disease • Psychiatry • Renal Disease

"The destination is important, and so is the journey. Insulin is important, and so is Insulin Technique @insulin @OpenInsulin @T1DN @Toujeo @tresiba @tresiba3ml @LHumalog @lantus @kkudash @Mixtard3070 @InsulinNation @mappewpwellps @DiabetesHealth_ @BDandCo @HboyTohBad" (@SanjayKalraDr1)

Diabetes • Metabolic Disorders

"The same Novolin 70/30 vial - retailing at $24.99 / vial at walmart can cost local pharmacies around $140; pricing and cost in pharma follows no formula.. numbers such as U&C , AWP : MAC price are just one way to siphon Medicare dollars into retails chain, PBM and brokers." (@YoungsvilleP)

Medicare • Pricing • Reimbursement

"I feel you! My mama is a type 1 diabetic and 1 vial or humalog or novolog is $$$! We have switched to Novolin 70/30 for $25 at Walmart and no RX needed. Times are hard.Hope big pharma will listen to us!" (@MochiThePoodle)