dekaparin / Glycan Therapeutics - LARVOL DELTA

Characterization of Heparin Interactions With Recombinant Rodent Stabilin-2/Hyaluronic Acid Receptor for Endocytosis (HARE). (PubMed, Proteoglycan Res) - "The recombinant protein was analyzed for HA and heparin binding/endocytosis as well as synthetic heparin (Dekaparin) in a mouse knockout model...Metabolism of Dekaprin is delayed in a Stab2KO mouse model and affects liver sequestration of this drug. Rat Stab2/HARE has similar properties as the human Stab2/HARE with the exceptions that the rat recombinant protein has a different physical structure and has an increased HA and heparin internalization rate."

Journal • Preclinical • LYVE1