RG7129 / Roche - LARVOL DELTA

Why did Roche kill off its Alzheimer's program for the BACE inhibitor RG7129? (FierceBiotech) - "Roche quietly axed its program for RG7129 recently without stirring much attention...a spokesperson for Roche told FierceBiotech in an email. 'Whilst we have decided to terminate the clinical development of this particular compound, we remain committed to the target...Safety fears prompted Merck to put its own BACE inhibitor through a preliminary safety review before hitting the green light on two late-stage studies which will enroll thousands of patients."

Discontinued • Alzheimer's Disease

Drug-induced Obstructive and Retrograde Nephropathy Associated with α2u-globulin in Male Rats. (PubMed, Toxicol Pathol) - "No treatment-related changes were observed in female rats or in castrated males. These results indicate that RG7129 induces α2u-globulin nephropathy, associated with retrograde and obstructive nephropathy secondary to precipitation in intact male rats only, constituting a species- and sex-specific syndrome that is not expected to occur in humans or other species."

Biomarker • Journal • Preclinical