tropisetron / Generic mfg. - LARVOL DELTA

Postoperative delirium in patients with free flap reconstruction after head and neck tumor surgery: influencing factors for severity and onset time, and a prediction model. (PubMed, BMC Oral Health) - "POD after head and neck tumor surgery shows marked heterogeneity in severity and onset. Neutrophils and platelets may respectively drive neuroinflammation occurrence and progression, synergizing with blood pressure to regulate POD subtyping. Identified factors enable early multidimensional warning. The prediction model performs well with optimal threshold 0.45-0.55."

Journal • CNS Disorders • Head and Neck Cancer • Oncology • Solid Tumor

A Bayesian network meta-analysis of randomized controlled trials comparing the efficacy and safety of cholinergic modulators in schizophrenia. (PubMed, J Psychopharmacol) - "Tropisetron and xanomeline demonstrated better efficacy in reducing schizophrenia symptoms, offering a promising alternative to traditional antipsychotics with comparable safety. Further RCTs and NMAs are needed to confirm these findings and guide clinical practice."

Journal • Retrospective data • Review • CNS Disorders • Psychiatry • Schizophrenia

Effect of esketamine on postoperative pain relief and depressive status in patients with traumatic fractures. (PubMed, Front Med (Lausanne)) - P=N/A | "All received a standard postoperative analgesic pump (sufentanil 2 μg/kg + tropisetron 10 mg in 100 ml saline, 1.5 ml/h basal rate, 2 ml PCA bolus, 20 min lockout)...The incidence of postoperative nausea/vomiting was significantly lower in groups L and H compared to group C (P < 0.05). Continuous postoperative infusion of esketamine (0.5-0.75 mg/kg over 24 h) in patients with traumatic lower limb fractures effectively alleviates postoperative depressive symptoms, provides opioid-sparing analgesia, reduces opioid-related adverse effects like nausea and vomiting, and is associated with increased BDNF and decreased IL-6 levels."

Journal • Anesthesia • CNS Disorders • Depression • Musculoskeletal Diseases • Orthopedics • Pain • Psychiatry • BDNF • IL6

Observation on the Efficacy of Oliceridine for Patient-Controlled Analgesia after Maxillofacial Surgery (ChiCTR) - P=N/A | N=210 | Not yet recruiting | Sponsor: Beijing Zhongguancun Hospital; Beijing Zhongguancun Hospital

New trial • Pain

The Effect of Oliceridine versus Hydromorphone on Gastrointestinal Tolerability in Patients Undergoing Major Abdominal Surgery with Multimodal Analgesia: A Prospective, Randomized Controlled Study (ChiCTR) - P4 | N=310 | Not yet recruiting | Sponsor: The Second Affiliated Hospital, Zhejiang University School of Medicine; Department of Anesthesiology, the Second Affiliated Hospital, Zhejiang Univers

New P4 trial • Pain

Effect of low-dose esketamine on postpartum depression in women undergoing general anesthesia for cesarean delivery: a dual-center, prospective, randomized controlled study (ChiCTR) - P=N/A | N=300 | Not yet recruiting | Sponsor: Shanghai First Maternity and Infant Hospital; Shanghai First Maternity and Infant Hospital

New trial • Anesthesia • CNS Disorders • Depression • Mood Disorders • Postpartum Depression • Psychiatry

The effect of low-dose esketamine on analgesic and recovery quality after cesarean section: a prospective, randomized, double-blind, controlled clinical trial (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: The Second Affiliated Hospital of Nanjing Medical University; The Second Affiliated Hospital of Nanjing Medical University

New trial • Pain

Clinical study on efficacy and safety of oxalidine fumarate injection for postoperative analgesia in elderly orthopedic patients (ChiCTR) - P=N/A | N=165 | Not yet recruiting | Sponsor: Mianyang 404 Hospital (The First People's Hospital Of Mianyang); Mianyang 404 Hospital (The First People's Hospital Of Mianyang)

New trial • Musculoskeletal Diseases • Orthopedics

Optimizing postoperative rehabilitation for female surgical patients: a new treatment strategy for postoperative sleep and pain management (ChiCTR) - P4 | N=140 | Not yet recruiting | Sponsor: Xishuangbanna Dai Autonomous Prefecture People's Hospital; Xishuangbanna Dai Autonomous Prefecture People's Hospital

New P4 trial • CNS Disorders • Pain • Sleep Disorder

Antifibrotic Effects of an α7 Nicotinic Acetylcholine Receptor Agonist in Keloid Fibroblasts and a Rat Scar Model. (PubMed, Int J Mol Sci) - "These results indicate that tropisetron exerts dual antifibrotic and anti-inflammatory effects through α7nAChR-mediated signaling and enhanced ECM remodeling. This study provides the first evidence supporting α7nAChR activation as a promising therapeutic strategy for managing keloids and other fibrotic skin disorders."

Journal • Preclinical • Dermatology • Fibrosis • Immunology • Inflammation • COL1A1 • COL3A1 • MMP1 • MMP3 • TGFB1 • TNFA

Palonosetron versus tropisetron with dexamethasone for prevention of postoperative nausea and vomiting in pediatric adenotonsillectomy: a single center, randomized controlled trial. (PubMed, Front Med (Lausanne)) - P4 | "After receiving their allocated drug, children received intravenous dexamethasone (0.15 mg/kg, maximum 5 mg) during induction. In pediatric adenotonsillectomy, palonosetron with dexamethasone gives better PONV prevention than tropisetron with dexamethasone, especially in the first 24 h, with comparable safety. https://www.chictr.org.cn/showproj.html?proj=127115, ChiCTR2100046848."

Journal • Anesthesia • Otorhinolaryngology • Pain • Pediatrics

Effects of Glycopyrronium Bromide as an Adjuvant Treatment in the Prevention of Nausea and Vomiting After Abdominal, Thyroid, and Breast Surgery: A Multicenter Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - P4 | "In 11 participating hospitals, patients who were scheduled to receive gynecological (n=123), gastrointestinal (n=201), thyroid (n=93), and breast surgery (n=51) under general anesthesia and received postoperative opioids were randomly allocated to receive 4 mg dexamethasone and 4 mg tropisetron (Group C) or 4 mg dexamethasone and 4 mg tropisetron combined with 0.2 mg glycopyrrolate bromide (Group G). The Hospital Ethics Committee of the Second Affiliated Hospital, Chongqing Medical University (Approval ID: 2022-14-1) approved this study. This trial was registered with Identifier NCT05331651 on ClinicalTrials.gov."

Clinical • Journal • Anesthesia

Morbidity and Mortality of Ondansetron in Patients with Non-congenital Long QT Syndrome: A Review Article. (PubMed, Cardiovasc Drugs Ther) - "Selective antagonists like ondansetron, granisetron, and tropisetron treat chemotherapy and post-surgical nausea, while non-selective antagonists include metoclopramide and prochlorperazine. This risk has led to FDA dosing recommendations and an emphasis on cardiac monitoring, particularly in patients with predisposing factors such as electrolyte imbalances, cardiac conditions, or concurrent QT-prolonging drugs. This review explores the underlying mechanisms of QT-interval prolongation associated with the selective 5-HT3 receptor antagonist ondansetron, evaluates its impact on morbidity and mortality in at-risk populations, and discusses risk mitigation strategies."

Journal • Review • Cardiovascular

Tropisetron modulates the firing activity of pyramidal and fast-spiking hippocampal CA1 neurons in a mouse model of Alzheimer's disease. (PubMed, Neurosci Lett) - "Tropisetron modulates the firing activity of pyramidal and fast-spiking hippocampal CA1 neurons in hAPP-J20 mice, suggesting its potential to restore network balance and mitigate AD-related dysfunctions. These findings support further investigation into tropisetron as a therapeutic agent for AD."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders

Different titration protocols in pain management after radical gastrectomy for gastric cancer patients. (PubMed, World J Gastrointest Oncol) - "Compared to the 24-hour titration regimen, the 12-hour titration regimen provided more effective control of early postoperative pain after radical gastrectomy, reduced total analgesic consumption, lowered the incidence of related adverse reactions, improved patient satisfaction, and shortened hospital stays."

Journal • CNS Disorders • Depression • Gastric Cancer • Oncology • Pain • Psychiatry • Solid Tumor

Effect of oliceridine for patient-controlled intravenous analgesia in patients after total knee arthroplasty (ChiCTR) - P=N/A | N=84 | Not yet recruiting | Sponsor: The Affiliated Hospital of Xuzhou Medical University; The Affiliated Hospital of Xuzhou Medical University

New trial • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatoid Arthritis • Rheumatology

Comparing the Effects of Fentanyl, Sufentanil, and Butorphanol Combined With Flurbiprofen Axetil on Postoperative Intravenous Patient-controlled Analgesia Post Cesarean Delivery. (PubMed, Pain Physician) - "The analgesic effect in patients who underwent cesarean delivery is similar when using different postoperative PCIA formulae. Although butorphanol displayed no analgesic advantage over fentanyl and sufentanil postoperatively, it caused fewer postoperative nausea and vomiting incidences than fentanyl and sufentanil."

Clinical • Journal • Retrospective data • Anesthesia • Pain

Efficacy and Safety of Pharmacologic Therapies for Nausea and Emesis in the Emergency Department: A Systematic Review and Bayesian Network Meta-analysis. (PubMed, Ann Emerg Med) - "Within a minimally contextualized framework, as single agents, intravenous tropisetron and intravenous prochlorperazine are definitely among the most effective, intravenous metoclopramide and intravenous droperidol are possibly among the most effective, and oral ondansetron is definitely among the least effective; considering certain adverse reactions, intravenous metoclopramide, intravenous droperidol, and intravenous promethazine are definitely among the most harmful."

Journal • Retrospective data

Tropisetron Suppresses Chronic Pancreatitis and Pancreatic Cancer by Blocking Interleukin 33 Expression. (PubMed, Cancers (Basel)) - "Tropisetron inhibited pancreatitis and its progression to pancreatic cancer in mice. Tropisetron is an IL-33 inhibitor and can provide a novel therapeutic strategy to prevent and treat chronic pancreatitis and its associated cancer."

Journal • Oncology • Pancreatic Cancer • Pancreatitis • Solid Tumor • IL33

Effects of Esketamine Combined with Sufentanil for Postoperative Analgesia on Postoperative Anxiety and Depression in Breast Cancer Patients with Preoperative Anxiety:a single-center, double blind, prospective, randomized controlled, clinical study (ChiCTR) - P=N/A | N=66 | Completed | Sponsor: Tangdu Hospital, Air Force Military Medical University; Tangdu Hospital, Air Force Military Medical University

New trial • Breast Cancer • CNS Disorders • Depression • Oncology • Psychiatry • Solid Tumor

Comparison of the effects of esketamine and dexmedetomidine on postpartum depression in women with prenatal depression following cesarean section : A prospective randomized controlled study (ChiCTR) - P=N/A | N=555 | Not yet recruiting | Sponsor: The First Maternity and Infant Hospital Affiliated to Tongji University; The First Maternity and Infant Hospital Affiliated to Tongji University

New trial • CNS Disorders • Depression • Mood Disorders • Postpartum Depression • Psychiatry

Clinical study of mannitol in preventing postoperative nausea and vomiting after posterior scleral reinforcement (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Eye Hospital of Wenzhou Medical University; Eye Hospital of Wenzhou Medical University

New trial

The effect of esketamine combined with continuous erector spinae plane block on postoperative depression in elderly frail patients undergoing thoracoscopic radical resection of lung cancer: A multicenter, randomized, double-blind, controlled study (ChiCTR) - P=N/A | N=318 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Bengbu Medical College; The First Affiliated Hospital of Bengbu Medical College

New trial • CNS Disorders • Depression • Geriatric Disorders • Lung Cancer • Oncology • Psychiatry • Solid Tumor

A prospective study of different postoperative analgesic regimens on the rehabilitation quality of elderly patients undergoing thoracolumbar spine surgery (ChiCTR) - P=N/A | N=120 | Completed | Sponsor: The First Affiliated Hospital of Guangxi Medical University; The First Affiliated Hospital of Guangxi Medical University

New trial • Orthopedics • Pain

The Effect of Oxycodone on Recovery of Gastrointestinal function in patients After Laparoscopic radical resection of Colorectal cancer (ChiCTR) - P=N/A | N=76 | Not yet recruiting | Sponsor: Affiliated Hospital of Xuzhou Medical University; Affiliated Hospital of Xuzhou Medical University

New trial • Colorectal Cancer • Oncology • Solid Tumor