BMS 687453 / BMS - LARVOL DELTA

Restoring cellular NAD(P)H levels by PPARα and LXRα stimulation to improve mitochondrial complex I deficiency. (PubMed, Life Sci) - "Collectively, PPARα and LXRα stimulation resulted in attenuated cellular NAD(P)H levels in CI-impaired HeLa cells and patient-derived fibroblasts and could eventually have a therapeutic potential in CI deficiency."

Journal • Metabolic Disorders • FASN • PPARA

Loquat leaf polysaccharides improve glomerular injury in rats with anti-Thy 1 nephritis via peroxisome proliferator-activated receptor alpha pathway. (PubMed, Am J Transl Res) - "A rat model of glomerulonephritis was used to study the effects of 8 weeks of enalapril or LLPS treatment. Furthermore, when an agonist of PPARα (BMS-687453) was used to stimulate PPARα activity, LLPS treatment suppressed the expression of fibrosis factor PAI-1 partially via PPARα inhibition. These findings demonstrate that LLPS improved glomerular injury in rats with anti-Thy 1 nephritis via the PPARα pathway."

Journal • Preclinical