Derazol DDR (dexrabeprazole) / Neutec - LARVOL DELTA

Reply to the letter to the editor "Clarifications on the safety of dexrabeprazole vs. omeprazole in the treatment of gastroesophageal reflux disease". (PubMed, Gac Med Mex) - No abstract available

Journal • Gastroenterology • Gastroesophageal Reflux Disease

Clarifications on the safety of dexrabeprazole vs. omeprazole in the treatment of gastroesophageal reflux disease. (PubMed, Gac Med Mex) - No abstract available

Journal • Gastroenterology • Gastroesophageal Reflux Disease

Efficacy and safety comparative study of dexrabeprazole vs. esomeprazole for the treatment of gastroesophageal reflux disease. (PubMed, Gac Med Mex) - "In the treatment of non-erosive GERD, the use of dexrabeprazole at 10 mg/day is as effective as esomeprazole 20 mg/day, with the advantage that the dose is lower with an appropriate safety profile."

Journal • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Pain

THE EFFECT OF DEXRABEPRAZOLE ON INTRAGASTRIC AND INTRAESOPHAGEAL ACIDITY AND SYMPTOMS OF GASTROESOPHAGEAL REFLUX DISEASE (UEGW 2022) - "Enantiomers are widely prescribed alternatives to the racemic mixtures however generally used for doubled doses from standart doses of original molecules such as esomeprazol 40 mg or dexlansoprazole 60 mg.  10 mg dexrabeprazole had similar effectiveness compared to20 mg rabeprazole. The agent was more effective than rabeprazole in reducing the 24-hour intraesophageal pH<4. Besides, it was observed that its effect on regurgitation started earlier than rabeprazole which is known with its quick effect."

Gastroenterology • Gastroesophageal Reflux Disease • Infectious Disease

Determination of Proton Pump Inhibitors by Spectrophotometric, Chromatographic and by Hyphenated Techniques: A Review. (PubMed, Crit Rev Anal Chem) - "The review includes literature survey of PPI drugs namely omeprazole (OPZ), lansoprazole (LPZ), pantoprazole (PPZ) rabeprazole (RPZ), dexlansoprazole (DLPZ), esomeprazole (EPZ), dexrabeprazole (DRPZ), ilaprazole (IPZ), and tenatoprazole (TPZ). The examined literature survey addressed chromatographic (HPLC and UPLC) and UV visible spectrophotometric methods with LC-MS/MS methods used in pure forms, pharmaceutical formulations, and human plasma and other biological fluids for their estimation. In case of validation parameters mostly Linearity, Recovery study, LOD and LOQ was considered and mentioned."

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Chiral separation of lansoprazole and rabeprazole by capillary electrophoresis using dual cyclodextrin systems. (PubMed, Electrophoresis) - "The optimized methods (25 mM phosphate buffer, pH = 7.0, 10 mM sulfobutyl-ether-β-CD/20 mM γ-CD, +20 kV voltage; 17°C temperature; 50 mbar/3 s injection, detection at 210 nm for lansoprazole; 25 mM phosphate buffer, pH = 7.0, 15 mM sulfobutyl-ether-β-CD/30 mM γ-CD, +20 kV voltage; 18°C temperature; 50 mbar/3 s injection, detection at 210 nm for rabeprazole) provided baseline separation for lansoprazole (Rs = 2.91) and rabeprazole (Rs = 2.53) enantiomers with favourable migration order (in both cases the S-enantiomers migrates first). The optimized methods were validated according to current guidelines and proved to be reliable, linear, precise and accurate for the determination of 0.15% distomer as chiral impurity in dexlansoprazole and dexrabeprazole samples ."

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PPI Long Term Use: Risk of Neurological Adverse Events? (PubMed, Front Neurol) - "The authors performed a literature review of available studies on the research topic describing the adverse effect of proton pum inhibitors (PPIs) (omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole, pantoprazole, dexrabeprazole, ilaprazole). At this time when depression and dementia are rising in the population, this is a very worrying fact that needs to be highlighted, and which needs to be carefully studied and evaluated, ideally trying to prevent it. The findings of most research studies described in this review indicate that there is a direct association between the onset of dementia and depression on one side and the long-term use of PPIs on the other."

Adverse events • Journal • Review