minocycline / Generic mfg. - LARVOL DELTA

Combination Therapy by Minocycline and Rolipram Delivered by PgP Nanocarrier Improves Motor Function and Mitigates Secondary Injury in a Rat CCI TBI Model (Neuroscience 2026) - "Histologically, we observed reduced lesion volume, neuroinflammation, astrogliosis, and apoptosis and improved neuronal survival in Rm-PgP + Mino group compared to Mino alone and untreated TBI group. These data demonstrate that combination therapy by local Rm-PgP and systemic minocycline synergistically mitigates secondary injury cascades and accelerates functional recovery, offering a highly promising combinatorial platform for clinical TBI management."

Combination therapy • Preclinical • CNS Disorders • Vascular Neurology

MINOCYCLIN TREATMENT PREVENTS INFLAMMATORY DEVELOPMENT OF MICROGLIA IN THE 6-OHDA MOUSE MODEL OF PARKINSON’S DISEASE (Neuroscience 2026) - "Minocycline (MINO) is an antibiotic drug, but studies show an off-label anti-inflammatory activity, which might reduce inflammation in the respiratory nuclei...Parkinson’s Disease. Respiratory deficits."

Preclinical • CNS Disorders • Movement Disorders • Parkinson's Disease • TNFA

BMAA induces zinc-dependent neuronal death through MMP9 activation in cortical neurons (Neuroscience 2026) - "To determine the functional role of zinc and MMP9, neurons were co-treated with the membrane-permeable zinc chelator TPEN or the MMP9 inhibitor minocycline...Together, these results demonstrate that BMAA induces zinc-dependent neuronal death in cortical neurons, at least in part through MMP9 activation. Our findings identify zinc dysregulation and MMP9 activation as potential downstream mediators of BMAA neurotoxicity and provide mechanistic support for a link between environmental neurotoxin exposure and ALS-related neurodegeneration."

Alzheimer's Disease • CNS Disorders • Dementia • Movement Disorders • Parkinson's Disease • MMP9

MINOCYCLINE AND DOXYCYCLINE MODULATE ACID SENSING ION CHANNEL CURRENTS (Neuroscience 2026) - "These findings show that Ts modulate ASIC activity and may contribute to the neuroprotective actions of Min and Dox. Moreover, they highlight Ts as starting points for the development of new molecules with improved affinity, specificity, and selectivity toward ASIC subunits, potentially expanding the therapeutic options for neuroprotection."

CNS Disorders

Sex-specific spinal neurotrophin receptors mediate chronic stress-induced tactile allodynia in rats. (PubMed, J Pain) - "Minocycline diminished allodynia and increased BDNF levels in both sexes, with a greater effect in stressed males...Likewise, ovariectomy abolished the effect of THX-B in females, while estradiol replacement restored it through estrogen receptor-α activation. These findings suggest that chronic stress induces tactile allodynia through distinct molecular pathways: BDNF-TrkB signaling in males and BDNF-p75NTR signaling in females, with KCC2 dysfunction contributing to allodynia in both sexes."

Journal • Preclinical • Pain • AR • ER • NGFR

Effects of Sub-Inhibitory Rifampicin, Minocycline, and Dalbavancin on Early Biofilm Formation and Transcriptional Responses in Staphylococcus aureus SA113. (PubMed, Microorganisms) - "Sub-inhibitory antibiotic exposure differentially modulated early biofilm formation in SA113 in a drug-specific manner. Overall, the distinct dalbavancin-associated response may be relevant for the development of preventive local drug-delivery systems."

Journal • Infectious Disease

Beyond Recanalization: Neurovascular Unit Protection and Precision Adjunctive Therapy for Ischemic Stroke in the Reperfusion Era. (PubMed, Biomolecules) - "ESCAPE-NEXT and RODIN were neutral; TASTE-2 suggested a borderline overall effect and imaging-defined heterogeneity for edaravone dexborneol; BAST supported potential benefit from butylphthalide; and the positive EMPHASIS trial contrasted with neutral EVT-specific MIST-A findings for minocycline. Next-generation trials should combine target engagement, imaging enrichment, prespecified biomarker interactions, and adaptive designs. Current evidence supports redesigning cerebroprotection, not adopting any candidate as a universal adjunct to reperfusion."

Journal • Review • Cardiovascular • Hematological Disorders • Inflammation • Ischemic stroke

Genomic characterization of a mobile-element-associated resistance island in trimethoprim-sulfamethoxazole-resistant Stenotrophomonas maltophilia isolates sharing the same PFGE genotype. (PubMed, Front Cell Infect Microbiol) - "Susceptibility to trimethoprim-sulfamethoxazole (TMP-SMX), levofloxacin and minocycline was determined by disk diffusion. The discordance between dfrA27-target PCR positivity, phenotype and WGS highlights the need to interpret molecular screening together with phenotypic susceptibility and orthogonal confirmation. The WGS component provides a local genomic-context characterization rather than evidence of cross-genotype dissemination."

Journal

Continuous local minocycline delivery from PLA nanosphere-coated dental implants with long-term antibacterial activity and biocompatibility. (PubMed, RSC Adv) - "Collectively, the results demonstrate that MC-coated dental implants provided prolonged local antibiotic delivery and long-term antibacterial activity while maintaining biocompatibility and osseointegration. The PLA nanosphere coating approach may facilitate the development of drug-eluting dental implants for localized delivery of therapeutic agents to support peri-implant tissue health and reduce the risk of implant-associated infections."

Journal • Hematological Disorders • Immunology • Infectious Disease • Inflammation

Challenges in establishing epidemiological cut-off values for the Burkholderia cepacia complex. (PubMed, J Clin Microbiol) - "Here, we present an analysis of BCC ECVs for ceftazidime (CAZ), levofloxacin (LVX), meropenem (MEM), minocycline (MIN), and trimethoprim-sulfamethoxazole (TMP-SMX). Additionally, we encountered significant challenges in our analyses, including data limitations for these organisms and high ECVs that are not clinically useful. These challenges limit the practical use of these ECVs in helping guide treatment and support the removal of ECVs from the CLSI M100 standards document."

Journal • Infectious Disease

Neural Mechanisms of Heart-Lung Crosstalk in Chronic Heart Failure. (PubMed, Circ Res) - "Anti-inflammatory interventions, including oral minocycline, systemic macrophage depletion, and local epidural delivery of thermo-responsive hydrogel-forming dexamethasone prodrug (ProGel-Dex), significantly reduced DRG neuroinflammation, restored voltage-gated potassium channel levels, and attenuated exaggerated cardiac sympathetic afferent reflex and pulmonary spinal afferent reflex responses. These findings identify a neural inflammatory cascade involving cytokine uptake, glial activation, and macrophage activation as a contributor to cardiopulmonary afferent sensitization after MI. Targeting DRG inflammation, particularly with sustained dexamethasone delivery using ProGel-Dex, offers a prospect of precision medicine to dampen pathological sympathetic activation and improve cardiac outcomes in chronic heart failure."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Inflammation • Myocardial Infarction • Oncology • TNFA

Pro-inflammatory microglia drive escalated alcohol consumption during early abstinence. (PubMed, bioRxiv) - "LC-MS/MS proteomics of primary microglia from the aIC of rats following CIE with and without minocycline treatment indicate minocycline promotes metabolic and ribosomal re-wiring of microglia during early abstinence. These data suggest a role for microglia in driving both IRF7 levels and escalation in ethanol self-administration in early abstinence."

Journal • Addiction (Opioid and Alcohol) • IRF7

Biological Performance of a Nitrofurantoin-Based Triple Antibiotic Paste for Regenerative Endodontics. (PubMed, Int Endod J) - "The nitrofurantoin-based EXP paste demonstrated comparatively improved cytocompatibility toward DPSCs relative to the conventional Hoshino formulations and greater preservation of cell viability than the tested Ca(OH)2 paste under the present experimental conditions. Together with its previously demonstrated antimicrobial activity, these findings support EXP as a promising candidate for further investigation in REPs."

Journal • CCL4 • CXCL8 • IL15 • IL17A • IL1B • IL2 • IL5 • IL6

Type II Minocycline-Induced Hyperpigmentation During Long-Term Management of an Epidermal Growth Factor Receptor (EGFR) Inhibitor-Associated Acneiform Eruption. (PubMed, Cureus) - "We report the case of a 40-year-old man with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) who developed an EGFR inhibitor-associated papulopustular eruption shortly after initiating erlotinib and bevacizumab. Persistent disease despite doxycycline therapy and concern for doxycycline-associated photosensitivity prompted a transition to long-term minocycline...This case highlights the importance of longitudinal dermatologic follow-up in patients receiving prolonged tetracycline therapy for EGFR inhibitor-associated cutaneous toxicities. Periodic reassessment of treatment necessity, dose optimization, and early recognition of delayed medication-related adverse effects may minimize cumulative toxicity while preserving effective oncologic therapy."

Journal • Dermatology • Genito-urinary Cancer • Nephrology • Oncology • Renal Cell Carcinoma • Solid Tumor

Enhanced Versus Standard Dermatologic Management With Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC: The COCOON Global Randomized Controlled Trial. (PubMed, J Thorac Oncol) - P2 | "An uncomplicated, widely available, prophylactic regimen (COCOON DM) reduced the incidence of DAEIs with amivantamab-lazertinib and the impact of symptoms on QoL."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR

Dermatologic prophylaxis and impact on patient-reported outcomes in first-line EGFR-mutant advanced NSCLC treated with amivantamab plus lazertinib: Results from the phase 2 COCOON trial. (ASCO 2025) - P2 | "COCOON DM included oral doxycycline/minocycline (100 mg BID Wks 1–12), clindamycin 1% lotion on scalp (QD Wks 13–52), chlorhexidine 4% to wash hands and feet QD, and non-comedogenic ceramide-based moisturizer to body and face QD. Among pts with EGFR-mutant advanced NSCLC, COCOON DM reduced the severity of dermatologic AEs and reduced the impact of those AEs on QoL compared to SoC DM."

Clinical • Metastases • P2 data • Patient reported outcomes • Dermatopathology • Infectious Disease • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EGFR

Comparison of Efficacy of Minocyclin and Celecoxib as Adjunctive Treatment in Treatment Resistant Cases of Major Depressive Disorder (clinicaltrials.gov) - P=N/A | N=78 | Completed | Sponsor: Lahore General Hospital

New trial • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Effectiveness of Pristinamycin and Minocycline against Fluoroquinolone-resistant Mycoplasma genitalium Infection: A Study of Consecutive Patients Attending a Sexual Health Clinic (EADV 2026) - No abstract available

Clinical • Infectious Disease

Efficacy of Minocycline in Refractory Hidradenitis Suppurativa: A Case Report (EADV 2026) - No abstract available

Case report • Clinical • Dermatology • Hidradenitis Suppurativa • Immunology

Methenamine, minocycline, metronidazole and pristinamycin (M3P) for multi-drug-resistant Mycoplasma genitalium urethritis: A case series. (PubMed, Int J STD AIDS) - "Prior treatments included multiple courses of doxycycline, minocycline, azithromycin, fluoroquinolones, pristinamycin and other salvage regimens. Treatment with M3P for 14 days was associated with complete resolution of symptoms and negative post-treatment M. genitalium nucleic acid amplification tests in all four cases. No adverse effects were reported.ConclusionsM3P is a useful salvage therapy for MDR M. genitalium infections that do not respond to other regimens."

Journal • Infectious Disease

Analysis of Antimicrobial Resistance and Infection Characteristics of Myroides odoratimimus Harboring the bla MOC-1 Metallo-β-Lactamase Gene. (PubMed, Infect Drug Resist) - "Antimicrobial susceptibility testing showed that the isolate exhibited broad-spectrum resistance and was only susceptible to minocycline, doxycycline, levofloxacin, and cefepime. The patient presented with severe septic shock, showed no response to empirical therapy, developed multiple organ injury, and exhibited abnormally elevated biomarkers of inflammation, metabolism, and cardiovascular function. The findings of this study suggest that the blaMOC-1 gene is carried by this strain and is associated with its broad-spectrum antimicrobial resistance characteristics."

Journal • Cardiovascular • Critical care • Infectious Disease • Inflammation • Septic Shock

Epidemiology, resistance profiles, and molecular characteristics of pediatric salmonella isolates: prevalence of a clonal blaNDM-5 -bearing S. typhimurium ST34 cluster in Nanning. (PubMed, Front Cell Infect Microbiol) - "High resistance rates were observed for ampicillin (70.1%), chloramphenicol (49.1%), sulfamethoxazole (41.0%), and minocycline (39.4%), with S. Typhimurium exhibiting significantly higher resistance to multiple antibiotics (including ceftriaxone and carbapenems) than non-Typhimurium strains (p < 0.05). Importantly, the detection of this genetically related, blaNDM-5 -positive S. Typhimurium ST34 lineage among pediatric patients underscores the risk of potential clonal dissemination within the clinical setting. These findings underscore the urgent need for continuous genomic surveillance of carbapenem-resistant Salmonella in pediatric settings."

Journal • Retrospective data • Infectious Disease • Pediatrics

Minocycline ameliorates CNS autoimmunity through restraint of CD4+CD11bc+ cells. (PubMed, Front Immunol) - "Minocycline is a tetracycline antibiotic with profound anti-inflammatory activity directed primarily against microglial cells and macrophages. Taken together, these data indicate that beneficial effects of minocycline in EAE is primarily based on its ability to limit the generation of ROS and NO in CNS CD4+CD11bc+ cells and that its overall effect on EAE is Nrf2-independent. Our results substantiate the idea that minocycline is a valid candidate for further multiple sclerosis-related research and point to CD4+CD11bc+ cells as an important disease causative myeloid cell population in the CNS autoimmunity."

Journal • CNS Disorders • Immunology • Inflammation • Multiple Sclerosis • CD4 • CD8

Whole-genome characterization of clinical Stenotrophomonas maltophilia in Lebanon: sequence types, resistome, and T6SS diversity. (PubMed, Microbiol Spectr) - "Phenotypically, 28.1% and 3.5% of isolates were resistant to levofloxacin and trimethoprim-sulfamethoxazole, respectively; 71.9% were non-susceptible to colistin; and one (1.8%) was non-susceptible to minocycline. These results highlight the importance of combining genomic data with phenotypic analysis to better understand pathogen evolution and transmission. By providing the first comprehensive molecular overview of clinical S. maltophilia isolates from Lebanon, this study supports the implementation of genomic surveillance frameworks and informed infection control strategies to limit the spread of this multidrug-resistant pathogen."

Journal • Critical care • Infectious Disease

Difference in structural and function alteration of pleural lymphatic and blood vessels by pleurodesis agents in mouse (ERS 2026) - "OK-432 offers a superior profile for pleural effusion absorption relative to minocycline and talc. A comprehensive understanding of these pharmacological properties may be crucial for optimizing the management and treatment of pleural effusions."

Preclinical • Respiratory Diseases • CD31 • CDH5 • LYVE1 • PECAM1