minocycline / Generic mfg. - LARVOL DELTA

Antibiotic resistance rates in Cutibacterium acnes isolated from patients with acne vulgaris: a systematic review and meta-analysis. (PubMed, Front Microbiol) - "A total of 8,846 studies were systematically retrieved and 23 studies were included, corresponding to 2,046 isolates of C. acnes, which have shown antibiotic resistance rates ranging from high to low: 48.17% (95% CI: 41.16-55.24%) for roxithromycin, 45.64% (95% CI: 20.49-73.22%) for clarithromycin, 43.33% (95% CI: 27.81-60.29%) for azithromycin, 29.20% (95% CI: 22.14-37.43%) for erythromycin, 22.38% (95% CI: 14.69-32.56%) for clindamycin, 5.93% (95% CI: 2.91-11.69%) for levofloxacin, 2.44% (95% CI: 0.99-5.89%) for doxycycline, 1.47% (95% CI: 0.00-85.72%) for trimethoprim-sulfamethoxazole (TMP-SMX), 1.31% (95% CI: 0.45-3.70%) for tetracycline, 0.28% (95% CI: 0.04-1.94%) for chloramphenicol, 0.22% (95% CI: 0.03-1.89%) for minocycline. In addition, the resistance rates to levofloxacin, erythromycin, and clindamycin markedly increased over time (p < 0.05). This emphasizes the significance of rational use of the antibiotics in acne treatment."

Journal • Retrospective data • Review • Acne Vulgaris • Dermatology

Molecular and epidemiological characterization of carbapenem-resistant hypervirulent Klebsiella pneumoniae in Huaian, China (2022-2024): a retrospective study. (PubMed, Front Cell Infect Microbiol) - "The CR-hvKP strains showed significantly higher resistance to the tested antibiotics, except for ceftazidime/avibactam and colistin. Resistance rates of CR-hvKP to the three tested antibiotics (minocycline, cotrimoxazole, and amikacin) were higher than those of CRnon-hvKP...Notably, the ST11 lineage carrying blaKPC-2 has emerged as a dominant high-risk clone in Huaian. Given the wide distribution of these novel CR-hvKP isolates, global monitoring and stricter control measures should be implemented to prevent their further spread in hospital settings."

Journal • Retrospective data • Diabetes • Infectious Disease • Metabolic Disorders • Pneumonia

Therapeutic efficacy of lascufloxacin in patients with Mycoplasma pneumoniae pneumonia. (PubMed, Microbiol Spectr) - "Therefore, differences in efficacy may exist among respiratory quinolones. In this study, we investigated the therapeutic efficacy of lascufloxacin in patients with macrolide-resistant M. pneumoniae pneumonia, confirming that it was equally effective as minocycline."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Minocycline treatment reduces the activation of mononuclear phagocytes and improves retinal function in a mouse model of Leber congenital amaurosis. (PubMed, Graefes Arch Clin Exp Ophthalmol) - "Our data indicates that MP migration into the subretina is associated with retinal degeneration in RPE65/rd12 mice. Inhibiting MP migration into the subretina was associated with improved retinal function. These findings may guide the development of therapies targeting MP activation for neuroprotection in LCA and potentially other retinoid cycle-related retinal degeneration blinding diseases."

Journal • Preclinical • Genetic Disorders • Inherited Retinal Dystrophy • Ocular Inflammation • Ophthalmology • Retinal Disorders • Retinitis Pigmentosa

A case report of peritoneal dialysis-associated peritonitis caused by Mycobacterium mageritense. (PubMed, IJID Reg) - "Based on susceptibility testing, treatment was initiated with trimethoprim/sulfamethoxazole (TMP/SMX) (80 mg/400 mg) 5 mg/kg every 24 hours in combination with minocycline 100 mg every 12 hours, which was subsequently changed to TMP/SMX plus faropenem 200 mg every 8 hours due to nausea caused by minocycline...We switched to TMP/SMX, imipenem/cilastatin 500 mg every 12 hours, and used linezolid 600 mg every 12 hours, which was later replaced with amikacin, guided by therapeutic drug monitoring...We treated the patient with TMP/SMX and sitafloxacin 100 mg every 24 hours, which was well-tolerated...Our findings underscore the importance of suspecting non-tuberculous mycobacteria in PD catheter-related infection and considering the early inclusion of acid-fast bacillus culture. Given the diagnostic challenges and the complexity of managing multi-drug antimicrobial therapy in patients with renal dysfunction, we recommend early catheter removal."

Journal • Chronic Kidney Disease • Diabetic Nephropathy • Infectious Disease • Nephrology • Nontuberculous Mycobacterial Disease • Renal Disease • Respiratory Diseases

A prospective, randomised comparative study to evaluate safety, tolerability, and efficacy of topical minocycline gel 4% plus oral isotretinoin against oral isotretinoin only in Indian patients with moderate-to-severe acne vulgaris. (PubMed, Postepy Dermatol Alergol) - "The concurrent use of tetracyclines and isotretinoin in acne treatment can cause pseudotumor cerebri (PTC). The combination of topical gel 4% and oral isotretinoin 20 mg capsule significantly reduced inflammatory lesions, improved IGA scores, and had a higher success rate at week 12 than isotretinoin alone, with similar tolerability. Therefore, this combination can be considered a preferable treatment option for moderate-to-severe acne."

Journal • Acne Vulgaris • CNS Disorders • Dermatology • Oncology

Iron Supplementation Switches Mode of Cell Death to Ferroptosis during Acetaminophen-induced Liver Injury in Mice Rendering it Resistant to N-acetylcysteine. (PubMed, Toxicology) - "Some animals also received a dose of Mito-TEMPO, the mitochondria-targeted SOD mimetic, or minocycline, an inhibitor of mitochondrial iron uptake. Consistent with these findings, delayed treatment with clinically relevant antidotes N-acetylcysteine and fomepizole did not reduce LPO or liver injury. Thus, liver injury after APAP+Fe2+ is no longer primarily driven by mitochondrial oxidant stress and peroxynitrite-mediated necrosis but by lipid peroxidation and a ferroptosis-like cell death."

Journal • Preclinical • Hepatology • Liver Failure • Metabolic Disorders

Microglia in the Rostral Ventromedial Medulla Mediate Synaptic Pruning via the C1q/C3-CR3 Signaling Pathway-A Mechanism for the Chronic Orofacial Pain. (PubMed, Mol Neurobiol) - "During the modeling process, administered daily stereotactic injections of ANX-005 and minocycline into the RVM, which resulted in a notable recovery in the rats' pain threshold and a significant increase in C1q/C3 and microglia in the RVM of CFA rats. This process results in a reduction in the proportion of excitatory synapses and a disruption in the physiological balance between RVM descending facilitation and descending inhibition. This leads to the predominance of descending facilitation in pain transmission in the RVM, which in turn facilitates the chronification of orofacial pain."

Journal • Pain • C1Q

Peripheral Immune-Inflammatory Pathways in Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: Exploring Their Potential as Treatment Targets. (PubMed, CNS Drugs) - "Antiinflammatory drugs have been repurposed as augmentation strategies for the treatment of MDD/BD and SCZ, including nonsteroidal antiinflammatory medications, such as cyclooxygenase-2 (COX-2) inhibitors; cytokine-targeting biologics, such as tumor necrosis factor-α monoclonal antibodies; and minocycline, an antibiotic that attenuates neuroinflammation. N-acetylcysteine, curcumin, and omega-3 polyunsaturated fatty acids demonstrate some efficacy as augmentation therapies in MDD, likely by diminishing IRS activation and O&NS...This review examines new potential therapeutic targets arising from recent discoveries in neuro-immune interactions and oxidative stress, including particular lymphocyte surface markers, the CIRS, and intracellular network molecules in both affective and psychotic disorders. The evidence underscores the clinical importance of immune-targeted augmentation treatments in psychiatric disorders and supports the ongoing development of these novel..."

Journal • Review • Bipolar Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Oncology • Psychiatry • Schizophrenia • Transplantation • TNFA

Nicotine exposure in adolescence triggers the activation and subsequent damage of microglia in the dentate gyrus and promotes depression later in life. (PubMed, Int Immunopharmacol) - "Pre-treatment with minocycline before the start of nicotine stimulation, which suppressed the initial activation of microglia, simultaneously prevented the depression-like behavior and the impairment of neurogenesis and microglia in the dentate gyrus. Restoration of microglia function by injection of an innate immune system stimulant, lipopolysaccharide (LPS, 100 μg/kg), reversed the depression-like behavior and decreased neurogenesis induced by nicotine exposure in adolescents. These results demonstrate a novel role of microglia in depression-like behavior induced by adolescent nicotine exposure and suggest that enhancing the function of microglia in the hippocampus may be a potential strategy for the treatment of depression induced by adolescent nicotine exposure."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry • Solid Tumor

Chemical constituents of Crepis napifera (Franch.) Babc. and their anti-inflammatory activities. (PubMed, Nat Prod Res) - "The results indicated that the compound had potential inhibitory activity. Among them, the IC50 value of compound 1 was 24.97 μM, which was comparable to the IC50 value of the positive control minocycline (31.54 μM)."

Journal

Progression independent of relapsing biology in multiple sclerosis: a real-word study. (PubMed, Front Neurol) - "PIRB was rare and rates remained consistent across disease-modifying therapies (3.75% dimethyl fumarate, 3.67% fingolimod, 3.72% ocrelizumab, 3.52% minocycline) despite varied rates of disability progression. PIRB may offer a practical alternative to the concept of PIRA."

Journal • CNS Disorders • Multiple Sclerosis

Dual therapy with minocycline and itraconazole in the treatment of superficial fungal infections (ANZCTR) - P=N/A | N=240 | Active, not recruiting | Sponsor: Duha khaleel Ismail / Al sader teaching hospital - Basrah

New trial • Dermatology • Infectious Disease

Memocycline: Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories (clinicaltrials.gov) - P=N/A | N=210 | Recruiting | Sponsor: Psychiatric University Hospital, Zurich | Trial completion date: Dec 2024 ➔ Jan 2026 | Trial primary completion date: Sep 2024 ➔ Nov 2025

Trial completion date • Trial primary completion date • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

Genomic insights of the co-existence of blaOXA-23, blaOXA-91, blaNDM-1 harboring carbapenem-resistant Acinetobacter baumannii isolates from the intensive care units environment in Shanghai. (PubMed, J Glob Antimicrob Resist) - "The resistance rate of CRAB was slightly lower in 2023 compared to 2019. However, the emergence of pan-drug-resistant CRAB, along with the coexistence of carbapenemase-producing strains (OXA-23, OXA-51-like, and NDM-1) in 2023, underscore the dynamic progression of antimicrobial resistance (AMR) in this pathogen. These findings suggest a potential epidemiological shift characterized by clonal diversification alongside persistent carbapenemase-driven resistance mechanisms."

Journal • Critical care • Novel Coronavirus Disease

Facial Skin With Conspicuous Enlarged Pores Closely Related to Severity of Facial Acneiform Rash and Therapeutic Effects of EGFR Inhibitors in RAS Wild-Type Metastatic Colorectal Cancer: Ancillary Analysis of FAEISS Study (NCCH1512). (PubMed, J Dermatol) - "Prophylactic treatment with oral minocycline or doxycycline, moisturizers, and sunscreens has been reported to be beneficial for acneiform rash (AfR) caused by epidermal growth factor receptor (EGFR) inhibitors. Moreover, the disease control rate (complete remission/partial remission/stable disease) of the primary disease was seen in 59.1%, 70.6%, and 87.0% of patients with an enlarged pore score of 1, 2, and 3, respectively, showing a statistically significant trend (p = 0.038). This study suggests that a facial skin type with a high number of enlarged pores may be a marker for predicting AfR risk due to anti-EGFR antibody therapy and better therapeutic effects for RAS wild-type metastatic colorectal cancer."

Journal • Colorectal Cancer • Dermatitis • Dermatology • Immunology • Oncology • Solid Tumor

Chlamydia psittaci infection-associated acute fibrinous and organizing pneumonitis: A case report. (PubMed, IDCases) - "After minocycline treatment, the patient's fever improved, but shortness of breath persisted...Shortness of breath improved after glucocorticoid therapy, with significant lesion absorption noted on follow-up chest CT. This case suggests a possible association between AFOP and C. psittaci infection, supporting the use of combined antibiotic and glucocorticoid therapy."

Journal • Cough • Infectious Disease • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases

Efficacy Analysis of Saccharomyces Boulardii Combined With Minocycline in Treatment-naïve Patients With Helicobacter Pylori Infection (clinicaltrials.gov) - P=N/A | N=208 | Not yet recruiting | Sponsor: Zhongda Hospital

New trial • Infectious Disease

Severe pneumonia, intracranial infection, and reversible splenial lesion syndrome caused by chlamydia psittacosis infection (PubMed, Zhonghua Jie He He Hu Xi Za Zhi) - "After treatment with minocycline, the patient was cured. His respiratory and neurological symptoms all disappeared."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Alzheimer's Disease: A Review of Molecular Mechanisms and Therapeutic Implications by Targeting Sirtuins, Caspases, and GSK-3. (PubMed, ACS Chem Neurosci) - "The promising inhibitors Q-VD-OPh and minocycline are found to be specific for caspase-7 and caspase-3, respectively...This review highlights the molecular mechanisms of sirtuin, caspase, and GSK-3 in the pathophysiology of AD. Further, promising modulators specific to these targets are described."

Journal • Review • Alzheimer's Disease • CNS Disorders • Inflammation • CASP3 • CASP7 • FAS • SIRT1

A Retrospective Study of Nonsurgical Management Options for Permanent Filler Complications of the Gluteal Region. (PubMed, Plast Reconstr Surg Glob Open) - "Contingency table analyses were conducted to determine which of the 5 types of treatments, minocycline, surgery, intralesional laser treatment (ILT), pressure garments, and omega-3 supplements, were related to pain relief and softening of the nodules...The latter outcome appears to be related to the ILT. Considering the information in the literature and our findings, a step-by-step treatment protocol was developed."

Journal • Retrospective data • Inflammation • Pain

Minocycline in chronic management of febrile infection-related epilepsy syndrome (FIRES): a case series and literature review of treatment strategies. (PubMed, Acta Epileptol) - P=N/A | "Additionally, a short literature review was conducted to explore various management strategies for chronic FIRES, including IL-1 receptor antagonist (anakinra) and IL-6 receptor antagonist (tocilizumab), centro-median thalamic nuclei deep brain stimulation, cannabidiol, responsive neurostimulation, intrathecal dexamethasone, ketogenic diet, and vagus nerve stimulation. In conclusion, considering the existing research on the etiological mechanisms of FIRES and based on our preliminary findings on the anti-inflammatory and antiepileptic properties of minocycline, early initiation of minocycline therapy in the chronic phase of FIRES should be explored further.Trial registrationClinicaltrials.gov (NCT05958069, retrospectively registered 22 July 2023)."

Journal • Review • CNS Disorders • Epilepsy • Infectious Disease • IL6

Vonoprazan-minocycline dual therapy for primary eradication of Helicobacter pylori infection:a prospective, multicenter, randomized controlled trial (ChiCTR) - P4 | N=580 | Not yet recruiting | Sponsor: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College, Huazhong University o

New P4 trial • Infectious Disease

A multicenter randomized controlled study of a first-line eradication of Helicobacter pylori with a combination of vonoprazan and minocycline (ChiCTR) - P=N/A | N=436 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Soochow University; The First Affiliated Hospital of Soochow University

New trial • Infectious Disease

Efficacy and incidence of adverse effects of quadruple therapy with low dose minocycline in eradicating Helicobacter pylori (ChiCTR) - P=N/A | N=240 | Completed | Sponsor: The Second Hospital of Tianjin Medical University; The Second Hospital of Tianjin Medical University

Adverse events • New trial • Infectious Disease