Bikunin (ulinastatin) / Aerovance - LARVOL DELTA

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis. (PubMed, JOR Spine) - "This review illustrates the diverse structure and function of IVD PGs and their roles in cellular regulation and tissue function. Fragmentation of IVD PGs during normal tissue turnover generates some interesting bioactive PG fragments of potential application in tissue repair and regenerative processes that warrant further investigation."

Journal • Review • Fibrosis • Infectious Disease • Inflammation • ACAN

Effect of a chondroitin sulfate chain linked to the bikunin core peptide on gene expression in lipopolysaccharide-treated uterine cervical fibroblasts. (PubMed, Biochem Biophys Rep) - "Increased expression of genes, related to inflammation or collagen, by LPS was also suppressed by bikunin at the same time point. Ch4S-deficient bikunin did not show significant suppression compared to original bikunin, suggesting that the Ch4S structure of bikunin is important for the suppression of the inflammatory response induced by LPS."

Journal • Infectious Disease • Inflammation • Obstetrics • CXCL8

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities. (PubMed, Angew Chem Int Ed Engl) - "The three linkage region glycosyltransferases B4GalT7, B3GalT6 and B3GlcAT-1 were dimeric in solution and the crystal structure of B3GalT6 was solved showing a covalent dimer linked by a disulfide in the center of the large dimerization domain. This motif appears to be conserved in higher organisms and reinforces the concept of dimeric glycosyltransferases lining the Golgi."

Journal • Genetic Disorders

Elevation of urinary alpha-1-antitrypsin and transferrin excretion in children of patients with nephrolithiasis. (PubMed, Asian Biomed (Res Rev News)) - "Increased excretion of these proteins may impact stone formation in these high-risk childhood members by regulation of renal inflammation, oxidation, crystallization, and crystal growth. We propose that AAT and TF excretion rates are potentially used as indicators for urinary supersaturation in high-risk populations."

Journal • Inflammation • Nephrology • Renal Calculi • AHSG

Transcriptomic profiling of rumen epithelium, liver, and muscle reveals tissue-specific gene expression patterns in Hu sheep. (PubMed, BMC Genomics) - "This study reveals transcriptional specialization and inter-tissue coordination in Hu sheep metabolic organs, identifies tissue-specific gene modules associated with DMI and ADG, and highlights hub genes as potential targets for precision breeding and feeding strategies to improve feed efficiency and growth in Hu sheep."

Journal • AMBP • HDAC1 • SMARCD3

Proteomics-based monitoring of heatstroke recovery identifies molecular signatures of organ stress. (PubMed, Commun Med (Lond)) - "The findings suggest that these proteins may serve as blood biomarkers to assess heatstroke severity and monitor recovery. Their clinical application could improve early detection of organ damage and guide intervention strategies."

Journal • Inflammation • Metabolic Disorders • AMBP • CLU • PROS1

Serum Alpha-1-microglobulin (A1M) as an independent predictor of calcific aortic valve stenosis and its diagnostic value. (PubMed, Int J Cardiol) - "Serum A1M levels were significantly reduced in AVS patients and progressively decreased with disease severity. It served as an independent predictor and demonstrated strong diagnostic utility for both AVS presence and severity grading."

Journal • Cardiovascular • AMBP

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation. (PubMed, Metabolites) - " Integration with our prior CSF multi-omics data reinforced the relevance of identified molecules in IVDH-associated neurodegeneration, inflammation, and repair processes. This study offers insight into potential diagnostic biomarkers and therapeutic targets for canine IVDH through serum-based molecular profiling."

Journal • CNS Disorders • Immune Modulation • Immunology • Inflammation • Musculoskeletal Diseases • Neuralgia • Pain • AMBP • SERPINA5 • VTN

Molecular Profiling of Renal Function after Liver Transplantation (ERA 2025) - P=N/A | "This study revealed distinct metabolomic and proteomic signatures associated with renal function post-LT. Proteomic profiles indicated a delayed recovery compared to metabolomic profiles, suggesting a dynamic and muti-layered renal recovery process. These findings highlight the limitations of relying solely on serum creatinine measurements to assess kidney recovery or ongoing dysfunction in LT recipients."

Chronic Kidney Disease • Hepatology • Nephrology • Renal Disease • Transplantation • AMBP

Urine Exosomal Proteome analysis to identify significantly deregulated proteins post Renal Transplant : An Observational Study (ERA 2025) - "The analysis of the urine exosomal proteome following renal transplantation has unveiled a distinct profile of significantly deregulated proteins reflecting altered molecular pathways. Patient sample with biopsy proven graft rejection will be analyzed for the above exosomal protein panel."

Clinical • Observational data • Nephrology • Transplant Rejection • Transplantation • AMBP • APOA1 • AQP1 • B2M • EZR • HPX • MUC1 • VTN

AMBP protects against aortic valve calcification by inhibiting ERK1/2 and JNK pathways mediated by FHL3. (PubMed, Theranostics) - " AMBP protects valvular interstitial cells from osteoblastic differentiation and calcium deposit accumulation, thereby alleviating AV calcification. This study sheds additional light on the pathogenesis of CAVD and potential new therapeutic approaches."

Journal • Fibrosis • Immunology • Targeted Protein Degradation • AMBP • APOE • PDLIM4 • RUNX2 • UNC13D

Diagnostic and Therapeutic Approaches in Congenital Disorders of Glycosylation. (PubMed, Handb Exp Pharmacol) - "As CDG are rare diseases frequently lacking distinctive symptoms, biochemical and genetic testing bear important and complementary diagnostic roles.After an introduction on glycosylation and CDG, we review current biomarkers and analytical techniques in the field. Furthermore, we illustrate their interests in the follow-up of proven therapeutic approaches including D-mannose in MPI-CDG, D-galactose in PGM1-CDG, and manganese (MnSO4) in TMEM165-CDG."

Journal • Developmental Disorders • Hepatology • Mental Retardation • Metabolic Disorders • Rare Diseases

Development of a prognostic risk model for colorectal cancer and association of the prognostic model with cancer stem cell and immune cell infiltration. (PubMed, J Gastrointest Oncol) - "A high risk score was associated with poor prognosis, indicating that the adverse outcomes observed in patients with CRC may be influenced by cancer stem cell and immune cell infiltration. Our model provides a promising predictive method for the prognosis of CRC patients, but it still needs to be validated in a larger sample size."

Journal • Colorectal Cancer • Oncology • Solid Tumor • AMBP

Proteomic analysis emphasizes the adaptation of energy metabolism in horses during endurance races. (PubMed, BMC Vet Res) - "The endurance race caused several homeostatic imbalances characterized by various alterations in serum protein levels. The most pronounced changes emphasize the adaptation of energy metabolism to a more pronounced consumption of lipids."

Journal • AMBP • HP

Biomarkers. (PubMed, Alzheimers Dement) - "Am Jour Med Sci 2021;361:261-268 It appears that every patient below an MMSE of 12 becomes progressively dehydrated. Studies are underway to determine whether HPRWSP can serve as a biomarker of RSW in Alzheimer's disease and to determine the prevalence of RSW at different stages of dementia."

Biomarker • Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Dementia • Heart Failure • HP

Presence of heavy chain-hyaluronan/pentraxin 3 (HC-HA/PTX3) complex in human umbilical cord. (PubMed, Tissue Cell) - "HC-HA/PTX3 was purified from UC extract by successive runs of density gradient ultracentrifugation and verified the presence of HC1 but not HC2 or HC3 based on western blot analysis. These results suggest the presence of HC-HA/PTX3 complex in UC is similar to AM."

Journal • Oncology • PTX3 • TNFA

The function of the inter-alpha-trypsin inhibitors in the development of disease. (PubMed, Front Med (Lausanne)) - "The functions of BK and ITIH in various pathophysiological processes are discussed independently in this paper. In the meanwhile, this study offers suggestions for further research on the roles of BK and ITIH in the course of disease and summarizes the plausible mechanisms of the previous studies."

Journal • Review • Developmental Disorders

Urine biomarkers can predict prostate cancer and PI-RADS score prior to biopsy. (PubMed, Sci Rep) - "In combination with the PI-RADS score, the biomarkers improve the detection of prostate carcinoma-free men (AUC = 0.89) and of those with clinically significant PCa (AUC = 0.93). We have uncovered the potential of urinary biomarkers for a test that allows a more stringent prioritization of mpMRI use and improves the decision criteria for prostate biopsy, minimizing patient burden by decreasing the number of unnecessary prostate biopsies."

Biomarker • Biopsy • Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • AMBP • CD99 • HRNR • LYVE1 • SPARCL1

Haptoglobin related protein without signal peptide induces a new syndrome of renal salt wasting in Alzheimer’s disease (AAIC 2024) - "Am Jour Med Sci 2021;361:261-268 Conclusion : It appears that every patient below an MMSE of 12 becomes progressively dehydrated. Studies are underway to determine whether HPRWSP can serve as a biomarker of RSW in Alzheimer’s disease and to determine the prevalence of RSW at different stages of dementia."

Alzheimer's Disease • Cardiovascular • CNS Disorders • Dementia • Heart Failure • Nephrology • HP

iTRAQ-based mass spectrometry screen to identify serum biomarkers in systemic lupus erythematosus. (PubMed, Lupus Sci Med) - "Since serum AMBP is validated to be elevated in SLE and correlated with renal disease, the clinical utility of this novel biomarker warrants further analysis in longitudinal cohorts of patients with lupus and lupus nephritis."

Biomarker • Journal • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease • Systemic Lupus Erythematosus • AMBP • AZGP1 • RBP4

Biochemical diagnosis of congenital disorders of glycosylation. (PubMed, Adv Clin Chem) - "Here, after a brief introduction on glycosylation and CDG, we review historical and recent findings on CDG biomarkers and associated analytical techniques, with a particular emphasis on those with relevant use in the specialized clinical chemistry laboratory. We provide the reader with insights and methods which may help them properly assist the clinician in navigating the maze of glycosylation disorders."

Biomarker • Journal • Review • Hematological Disorders • Hepatology • Metabolic Disorders • Rare Diseases

Identification of Binding Partners of Inter-alpha Inhibitor Proteins in Human Umbilical Vein Endothelial Cells (PAS 2024) - "Biotin-conjugated IAIPs were observed to bind strongly to a distinct protein (molecular weight of 37kDa) within the membrane, cytoplasmic, and cytosolic fractions. LC-MS analysis identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and annexin A1 as the most strongly matched spectral patterns. These proteins were identified in all three fractions (Table 1)."

Cardiovascular • CNS Disorders • Infectious Disease • Inflammation • Septic Shock • Vascular Neurology • ANXA1 • GAPDH

Major endothelial damage markers identified from hemadsorption filters derived from treated patients with septic shock - endoplasmic reticulum stress and bikunin may play a role. (PubMed, Front Immunol) - "However, the strongest damage effect occurred, when, bikunin - cleaved off from alpha-1-microglobulin was present in high relative amounts (>65%) of protein contents in the most active fraction. Thus, a relevant combination of stressors appears to be removed by hemadsorption therapy which results in fulminant and rapid, though only transient, clinical restitution."

Biomarker • Journal • Inflammation • Septic Shock • PPBP • SAA1

UTILITY OF PROTEIN BIOMARKERS IN URINARY EXOSOMES AND WHOLE URINE FOR RISK STRATIFICATION OF DIABETIC KIDNEY DISEASE PROGRESSION (ISN-WCN 2024) - "UEs carry important biological information but are difficult and laborious to extract, making it impractical for clinical practice. Whole urine on the other hand is easy to profile but contains a lot of waste products not useful for understanding functions involved in the progression of kidney diseases. Using MS-based proteomics, we identified potential protein biomarkers, representative of both mediums, useful for risk stratification for DKD progression."

Biomarker • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Diabetic Retinopathy • Metabolic Disorders • Nephrology • Renal Disease • Retinal Disorders • Targeted Protein Degradation • Type 2 Diabetes Mellitus • AMBP • CFB • CST3 • ENO1 • PSMB9 • TSG101

Circulating leptin is associated with adverse vascular changes in young adult survivors of childhood cancer. (PubMed, Cardiol Young) - "This proteomics approach identified that leptin is higher in young asymptomatic adult survivors of childhood cancer than in healthy controls and is associated with adverse vascular changes. This could indicate a role for leptin in driving the cardiovascular disease burden in this population."

Journal • Cardiovascular • Oncology • Renal Disease • AMBP • KIM1 • LEP • MERTK • PTX3 • SELP