PH44 / Trino Therapeutics - LARVOL DELTA

Serum EphA4 is Associated with both Parenchymal Hematoma and Increased Blood-Brain Barrier Permeability after Ischemic Stroke. (PubMed, Neurocrit Care) - "Elevated EphA4 levels in serum are associated with higher risk of PH after ischemic stroke, especially among patients showing greater permeability of the BBB as reflected in higher ipsilateral FED on computed tomography perfusion."

Journal • Cardiovascular • Hematological Disorders • Hepatocellular Cancer • Ischemic stroke • Oncology • Solid Tumor • EPHA4

Severe Hyperkalaemia: A Retrospective Study of Clinical Characteristics, Aetiology, and Management. (ERA 2025) - "Additional diagnostic tests that aid the diagnosis and management of hyperkalaemia were performed in less than 50% of cases including measure of pH (44%), Glucose (44.5%) and creatinine kinase (CK) (23%)... Severe HK is a clinical condition that is commonly seen in hospitalised patients, in particular with sepsis and active malignancy. Timely recognition and management is crucial to prevent adverse outcomes and further research is warranted to refine correction protocols and improve outcomes."

Retrospective data • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Diabetic Nephropathy • Heart Failure • Infectious Disease • Metabolic Disorders • Nephrology • Oncology • Renal Disease • Septic Shock

Isolation and characterization of a relatively broad-spectrum phage against Escherichia coli. (PubMed, Arch Microbiol) - "After adding PH444, the bacterial load in milk could be reduced from 3 × 103 PFU/ mL to zero within 1 h. In consideration of the biological properties of phage PH444, it was, therefore, demonstrated that PH444 has the potential to be used in phage biocontrol."

Journal

Long-term deposition of fly ash regulates bacterial communities in different disturbance zones: Evidence from diversity, network complexity and predictive metabolic function. (PubMed, Sci Total Environ) - "Among all factors, AK (33.9 %) and pH (44.3 %) were the key environmental limiting factors for the bacterial community in the DW and the LF, respectively. (4) FA perturbation reduced the complexity, connectivity and modularity of the interaction network between bacteria and disturbed them by increasing the metabolic pathways that degrade pollutants. In conclusion, our results revealed the changes in the bacterial community and the main environmental driving factors under different pathways of FA disturbance; this information provides a theoretical basis for ecological environment management."

Journal

Preparation and characterization of sequilhos-type biscuits added with almond flour of Acrocomia intumescens. (PubMed, Front Nutr) - "The analysis of the flour allowed to find 4.29% of moisture, 1.13% of acidity, 5.33 of pH, 44.46% of carbohydrates, 28.74% of lipids, 20.06% of proteins and 2.45% of ash...In microbiological analyzes it was highlighted that the sequilhos presented adequate sanitary conditions. The results indicate almond flour as an ingredient to be incorporated in the preparation of sequilhos, which in turn, presented satisfactory physico-chemical properties and microbiological results."

Journal

The role of exercise right heart catheterization to guide pulmonary hypertension therapy in older adults. (PubMed, Pulm Circ) - "Exercise changed the proportional breakdown of hemodynamic diagnoses from 36% No PH, 44% PAH, and 20% PH-LHD at rest to 15% No PH, 36% PAH, and 49% PH-LHD...Patients receiving PAH therapy demonstrated significant improvement in self-reported quality of life. Exercise RHC appeared to influence selection of PAH drug therapy."

Journal • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Heart Failure • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Hemodynamics and Survival in Systemic Sclerosis-Associated Pulmonary Hypertension (ATS 2022) - " Of 509 SSc-PH patients included in our study, 312 had WSPH Group 1 PH, 151 had Group 3 PH, 44 had Group 2 PH, and 2 had Group 4 PH... Transplant-free continues to be worse for WSPH Group 3 SSc-PH patients compared to those with WSPH Groups 1 and 2 SSc-PH. Among hemodynamic parameters, PVR and SVI were independently associated with survival in SSc-PH patients for Group 1 PH and Group 3 PH, both at baseline and at first follow-up RHC."

Fibrosis • Hypertension • Immunology • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Scleroderma • Systemic Sclerosis • Transplantation

Uric acid in children and adolescents with primary hypertension (PubMed, Pol Merkur Lekarski) - "Children with PH have increased serum uric acid concentration compared to healthy children. The risk factors for hyperuricemia in pediatric patients with PH are male sex and high body weight."

Clinical • Journal • Hypertension • Pediatrics

Pathological and immunohistochemical studies following the experimental infection of ayu (Plecoglossus altivelis) by Edwardsiella ictaluri. (PubMed, Microsc Res Tech) - "The fish were observed for clinical signs, with daily collection of dead fish, and isolation of bacteria from the posterior kidney was performed and confirmed to be E. ictaluri by slide agglutination using anti-PH0744 serum...Post-mortem lesions were recorded as exophthalmia, bloody ascitis, hemorrhagic kidney and distended gallbladder, meningio-encephalitis, hemorrhagic vent, and petechial hemorrhages on viscera. Histopathological examination revealed diffuse severe congestion in blood vessels and several degenerative and necrotic changes inconcurrent with positive antigenic staining by immunohistochemistry."

Journal • CNS Disorders • Hematological Disorders • Ophthalmology

Facile fabrication of pH-sensitive nanoparticles based on nanocellulose for fast and efficient As(V) removal. (PubMed, Carbohydr Polym) - "Additionally, the biosorbent exhibited rapid adsorption during the initial 10 min and the As(V) adsorption capacity of the nanoparticles reached approximately 255.19 mg g at pH 3, which was five times greater than that achieved with the As(V) solution at its initial pH (44.33 mg g)...Meanwhile, the adsorbent displayed excellent performance even after eight regeneration cycles. This novel material demonstrates enormous potential for the removal of arsenic contaminants and for the development of pH-sensitive materials."

Journal

DIFFERENT PATTERNS OF BCR-ABL EXPRESSION IN PHILADELPHIA CHROMOSOME-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA AND THE IMPACT OF ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION (EBMT 2020) - "On the other hand, better survival rates were observed in patients with multi-Ph compared with those with uni-Ph (overall survival (OS) at 4 years: uni-Ph, 44% vs. multi-Ph, 79%, P=0.01; progression-free survival (PFS) at 4 years: uni-Ph, 33% vs. multi-Ph, 74%, P=0.01)... We confirmed multi-Ph in more than one third of Ph+ALL. Although no specific molecular characteristics were identified, multi-Ph was associated with better treatment outcome in both patients who underwent allo-HCT and those who did not underwent allo-HCT. Allo-HCT could improve the outcome of Ph+ALL, but could not overcome the difference in treatment outcome due to the difference in BCR-ABL expression."

GEP