Suprastin (chloropyramine hydrochloride) / Egis - LARVOL DELTA

Asteatotic dermatitis induced by Pazopanib followed by Nivolumab in a patient with renal cancer (EADV 2024) - "We conducted treatment with Ceftriaxon, Methylprednisolone, Chloropyramine hydrochloride, Gentamycin cream, Flumetasone pivalate/Clioquinol ung., Potassium permanganate baths and emollients. The algorithm for management of patients with skin toxicity includes stop of the oncological therapy, treatment of the toxicity and then restart of the therapy. If the toxicity reappears the oncological therapy must be stopped, again treatment of the toxicity and the therapy must be switched to the next therapeutic line according to the guideline for the oncological disease. Our case is an example of a patient with Asteatotic dermatitis induced by Pazopanib followed by Nivolumab for treatment of renal cancer."

Clinical • IO biomarker • Dermatitis • Dermatology • Immunology • Infectious Disease • Kidney Cancer • Oncology • Pain • Pruritus • Renal Cell Carcinoma • Solid Tumor • FGFR1 • FLT1

Oral sedation in pediatric outpatient dentistry (PubMed, Stomatologiia (Mosk)) - "In order to maximize the effectiveness of using oral sedation as a method, it is necessary to take into account the duration and traumatism of the proposed procedure, the peculiarities of age psychology and the peculiarities of the psychological development of boys and girls."

Journal • Anesthesia • Mood Disorders • Pediatrics • Psychiatry

Suprastin (Chloropyramine) Causes Proarrhythmic Deterioration of Excitation Conduction, Depolarization and Potentiates Adrenergic Automaticity in the Pulmonary Veins Myocardium. (PubMed, Bull Exp Biol Med) - "In presence of epinephrine, chloropyramine induced spontaneous automaticity in the PV and could not be suppressed by atrial pacing. Chloropyramine change functional characteristics of PV and contribute to occurrence of atrial fibrillation. It should be noted that chloropyramine does not provoke atrial tachyarrhythmias, but create conditions for their occurrence during physical exercise and sympathetic stimulation."

Journal • Atrial Fibrillation • Cardiovascular

Personalized approach for patients with anaphylaxis to biologics used for chronic spontaneous urticaria (EADV-Sp 2024) - "On the night of omalizumab treatment the patient had anaphylaxis requiring therapy in the hospital with intravenous dexamethasone and chloropyramine. After 10 days, 8 mg methylprednisolone tablets was instituted but did not completely relieve symptoms... Combination of cyclosporine and low dose methylprednisolone provided better results compared with either methylprednisolone or cyclosporine monotherapy. In the absence of a sufficient clinical response to cyclosporine alone in a standard therapeutic dose, a steroid sparing approach using glucocorticosteroids beginning at a minimal dose which is then increased every week to a dose that will help control the manifestations of chronic spontaneous urticaria may be very effective as individualized treatment."

Clinical • Cardiovascular • Chronic Spontaneous Urticaria • Dermatology • Immunology • Pruritus • Urticaria

Acute generalized exanthematous pustulosis (AGEP) induced by terbinafine (EADV 2023) - "The most common culprits are antibiotics such as penicillins, cephalosporins, quinolones or tetracyclines, followed by calcium channel blockers, carbamazepine, non-steroidal anti- inflammatory drugs (NSAIDs) and antifungals, mostly terbinafine...Treatment with methylprednisolone 40mg, chloropyramine hydrochloride, infusions with serum glucose 500ml daily, and topical clobetasol dipropionate resulted in rapid complete remission... AGEP induced by terbinafine has only rarely been reported and the drug is not on the shortlist of medications responsible for this form of SCARs as it is mainly known to cause erythema multiforme, severe urticaria, erythroderma or worsening of pre-existing psoriasis. Terbinafine-induced AGEP may demonstrate slow recovery compared to other causative agents which is due to the presence of the drug in the skin for several weeks after exposure. Contrary to that experience, a rapid and complete recovery was observed in our patient after terbinafine..."

Dermatology • Dermatopathology • Immunology • Psoriasis • Urticaria

pyHeart4Fish: Chamber-specific heart phenotype quantification of zebrafish in high-content screens. (PubMed, Front Cell Dev Biol) - "We also found implications for arrhythmias, such as atrioventricular block caused by chloropyramine HCl, as well as (R)-duloxetine HCl-induced atrial flutter. Taken together, our study presents a novel open-access tool for heart analysis and new data on potentially cardiotoxic compounds."

Journal • Atrial Fibrillation • Cardiovascular • Heart Failure

Ways to solve the problem of cross-reactions during immunochromatographic examination of biological objects (PubMed, Sud Med Ekspert) - "The purpose of this review is to study the causes of cross-reactions of a number of drugs (mebeverine, phenibut, tropicamide, ramipril, metoprolol, phenylephrine, sertraline, chloropyramine and diphenhydramine) during the preliminary stage of laboratory diagnostics by immunochromatographic method and to propose a possible algorithm for solving this problem. Conducting a hair study in order to identify the fact of the use of psychoactive substances will increase the reliability of analytical diagnostics and reduce the likelihood of false positive results of the analysis. The use of a validated method of enzymatic hydrolysis of hair will eliminate unreliable results of the analysis due to the detection of the native molecule of the toxicant, increase the efficiency and accuracy of the diagnostic procedure."

Journal

Application of Moxidectin and Ultrasound-Aided Injection of Melarsomine During the American Heartworm Society Recommended Treatment Protocol in Dirofilaria immitis Infected Dogs. (PubMed, Vector Borne Zoonotic Dis) - "The American Heartworm Society (AHS) recommends the three-dose alternate melarsomine therapeutic regimen, together with a macrocyclic lactone (ML) to reduce new infections and eliminate susceptible larvae and doxycycline against Wolbachia bacteria...Microfilaremic dogs were pretreated with prednisolone and clopidogrel for 1 week before the first moxidectin application...On the first day, dexamethasone and chloropyramine were used to avoid potential adverse effects caused by the destroyed microfilariae...From the 60th day, dalteparin was applied for 10 days to decrease the chance of pulmonary thromboembolism...All dogs recovered clinically by the 120th day and no microfilaremia was seen that time. An antigen test performed in 37/44 animals on the 271st day was also negative in all cases."

Journal • Anorexia • Cardiovascular • Gastrointestinal Disorder • Infectious Disease • Pulmonary Disease • Pulmonary Embolism

Discovery of novel chloropyramine-cinnamic acid hybrids as potential FAK inhibitors for intervention of metastatic triple-negative breast cancer. (PubMed, Bioorg Med Chem) - "Further mechanism studies indicated the ability of 7d in disrupting Y925 autophosphorylation of FAK, reducing formation of focal adhesions (FAs) and stress fibers (SFs) as well as inducing apoptosis of TNBC cells. Together, 7d is a novel FAK inhibitor to inhibit the essential nonkinase scaffolding function of FAK via binding FAT domain and may be worth studying further for intervention of TNBC."

Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer

ADVERSE REACTIONS DURING INFUSION OF ALLOGENEIC HAEMATOPOIETIC STEM CELLS GRAFTS (EBMT 2022) - " The highest incidence of ARs was observed in patients that received cryopreserved PBSCs. ARs were mostly mild, classified as grade 1, and they resolved spontaneously or after symptomatic treatment. However, considering that severe, life–threating ARs were reported, we strongly recommend careful patient monitoring during the graft infusion to recognise potential ARs and prevent possible further complications."

Bone Marrow Transplantation • Cardiomyopathy • Cardiovascular • Cough • Critical care • Infectious Disease • Inflammation • Novel Coronavirus Disease • Pediatrics • Respiratory Diseases • Transplantation

Study of Antibody-Dependent Reactions of Mast Cells In Vitro and in a Model of Severe Influenza Infection in Mice. (PubMed, Front Immunol) - "When the protection was formed faster due to the earlier production of HI antibodies, the administration of histamine receptor blockers did not significantly affect the course of the infection. These data allow to propose that even if there are antibody-dependent MC reactions, they can be easily stopped by the administration of histamine receptor blockers."

Journal • Preclinical • Infectious Disease • Respiratory Diseases

Case of acute allergic reaction to sunflower seeds in the 4-years old boy (EAACI 2021) - "The childs condition returned to normal following iv chloropyramine hydrochloride (20 mg) and dexamethasone sodium phosphate (20 mg), Recommendations were made toexclude all kinds of nuts. If necessary Epipen junior. Refrain from eating nuts."

Clinical • Allergy • Food Hypersensitivity • Immunology

Takotsubo cardiomyopathy as complication of exceeded use of adrenalin in anaphylaxis treatment: a case report (EAACI 2021) - "In this case we cannot exclude that anaphylaxis per se as the cause of TC, but large amounts of adrenalin could also induce the same disease. It is advisable not to exceed amounts of adrenalin that are suggested in different anaphylaxis guidelines treatment."

Clinical • Late-breaking abstract • Allergy • Immunology

[(PPh)NiCl]-Catalyzed C-N Bond Formation Reaction via Borrowing Hydrogen Strategy: Access to Diverse Secondary Amines and Quinolines. (PubMed, J Org Chem) - "This method shows a superior activity (TON up to 10000) with a broad substrate scope at a low catalyst loading of 1 mol % and a short reaction time. Further, this strategy is also successful in accessing various quinoline derivatives following the acceptorless dehydrogenation pathway."

Journal

SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer. (PubMed, Sci Rep) - "The treatment of lung cancer cells with chloropyramine, a compound that increases SASH1 protein concentrations, reduced cellular proliferation and increased sensitivity to cisplatin in a SASH1-dependent manner. In summary, compounds that increase SASH1 protein levels could represent a novel approach to treat NSCLC and warrant further study."

Biomarker • Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer. (PubMed) - Oncotarget - "Overall, the data suggest that SASH1 is prognostic in breast cancer and could have subtype-dependent effects on breast cancer progression. Pharmacologic induction of SASH1 by chloropyramine treatment of breast cancer warrants further preclinical and clinical investigation."

Journal • Biosimilar • Breast Cancer • Oncology

The discovery of new and more potent chloropyramine (C4) analogues for the potential treatment of invasive breast cancer. (PubMed, Chem Biol Drug Des) - "Compound 5c was identified to display an average activity of IC50 = 23.5- 31.3 μM, which represents a significant improvement of C4 activity in the same assay model. Molecular modelling and pharmacokinetic studies provided more promising insights into the mechanistic features of this new series."

Journal • Biosimilar • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer

Effects of high levels of dietary zinc oxide on ex vivo epithelial histamine response and investigations on histamine receptor action in the proximal colon of weaned piglets. (PubMed) - J Anim Sci - "For the first time, however, H receptors were functionally identified in the pig colon that are localized either on neurons or on cells that activate secretion via neurons. Luminal histamine can elicit a secretory-type response via these receptors."

Journal • Biosimilar

Nickel(II) - NɅNɅO Pincer Type Complexes Catalyzed N-alkylation of Amines with Alcohols via Hydrogen Auto Transfer Reaction. (PubMed, J Org Chem) - "The present approach is environmentally benign which liberates water as the sole by-product. A short synthesis of drugs intermediate such as mepyramine and chloropyramine illustrates the utility of the present protocol."

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