Vitix / York Pharma - LARVOL DELTA

Promiscuous activity of β-carotene hydroxylase CrtZ on epoxycarotenoids leads to the formation of rare carotenoids with 6-hydroxy-3-keto-ε-ends. (PubMed, FEBS Lett) - "We suggest that the reaction mechanism is similar to that of a rhodoxanthin biosynthetic enzyme. Our results provide further understanding of the reaction mechanism of diiron-containing β-carotene hydroxylases, as well as insight into the biosynthesis of natural compounds with 6-hydroxy-3-keto-ε-end carotenoid derivatives."

Journal

Phytoconstituents from Adenanthera pavonina L. as antioxidants and inhibitors of inducible TNF-α production in BV2 cells. (PubMed, Nat Prod Res) - "Tamarixetin 3-O-(α-ʟ-rhamnopyranosyl)-(1→2)-β-ᴅ-galactopyranoside (11), a previously undescribed compound, was the most effective at suppressing TNF-α protein and m-RNA levels. Other flavonoid glycosides, quercetin 3-O-(α-ʟ-rhamnopyranosyl-(1→2)-β-ᴅ-xylopyranoside (4), isovitixin (5), and quercetin-3-O-[α-ʟ-rhamnopyranosyl-(1→2)]-[α-ʟ-rhamnopyranosyl-(1→6)]-β-ᴅ-galactopyranoside (9), also significantly lowered TNF-α production."

Journal • Immunology • Inflammation • Oncology • TNFA