QX007N / Qyuns Therap - LARVOL DELTA

Structural basis of QX007N neutralizing interleukin-33 for asthma and COPD treatment. (PubMed, Structure) - "Structural comparison of the QX007N-Fab/IL-33 complex with published antibody/IL-33 complexes and the IL-33/suppression of tumorigenicity 2 (ST2) complex reveals that QX007N-Fab recognizes epitope 2 on IL-33 and sterically inhibits ST2 binding, thereby preventing assembly of the IL-33/ST2/IL-1RAcP signaling complex and downstream signal transduction. These findings establish QX007N as a promising therapeutic candidate for asthma and COPD."

Journal • Allergy • Asthma • Chronic Obstructive Pulmonary Disease • Immunology • Oncology • Pulmonary Disease • Respiratory Diseases • IL1RAP • IL33 • ST2