granisetron intravenous / Generic mfg. - LARVOL DELTA

A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery (clinicaltrials.gov) - P4 | N=74 | Completed | Sponsor: University of Malaya | Recruiting ➔ Completed | Trial primary completion date: Jul 2026 ➔ Nov 2025

Trial completion • Trial primary completion date • Orthopedics

Effect of granisetron on the spinal anesthesia-induced hemodynamic changes: a meta-analysis of randomized controlled trials. (PubMed, J Anesth) - "Granisetron appears effective in reducing hypotension, vasopressor use, and shivering during spinal anesthesia, with early hemodynamic benefits in nonobstetric surgery. Given the heterogeneity and publication bias identified, findings warrant cautious interpretation requiring larger trials."

Journal • Retrospective data • Anesthesia • Cardiovascular • Hypotension

Granisetron Reduces Norepinephrine Requirement for Preventing Post‑Induction Hypotension in Elderly Patients Undergoing Laparoscopic Gastrointestinal Surgery. (PubMed, Drug Des Devel Ther) - "In this randomized double-blind trial, 64 patients (60-74 years) undergoing laparoscopic gastrointestinal resection received intravenous granisetron (3 mg) or saline placebo before induction...Granisetron pretreatment significantly reduces the ED50 of norepinephrine required to prevent post-induction hypotension in elderly patients by approximately 24% indicating a pharmacodynamic interaction consistent with enhanced vasopressor efficacy. These findings indicate that pre-induction antiemetic administration may represent a potentially favorable timing strategy."

Clinical • Journal • Hypotension

Study on the Efficacy and Safety of Tegilide Fumarate Intravenous Analgesia in Alleviating Postoperative Pain After Gynecological Surgery (ChiCTR) - P=N/A | N=120 | Sponsor: Women’s Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital; Women’s Hospital of Nanjing Medical University,

New trial • Gynecology • Pain

Intravenous granisetron for food protein-induced enterocolitis syndrome in Japanese children: A retrospective study. (PubMed, Pediatr Int) - "Intravenous GH was well-tolerated and may be effective in managing vomiting associated with FPIES during OFCs. These findings suggest that GH may be a practical therapeutic option, warranting further study."

Journal • Retrospective data • Allergy • Chemotherapy-Induced Nausea and Vomiting • Food Hypersensitivity • Gastrointestinal Disorder • Immunology • Pediatrics

Granisetron as a Novel Treatment for Acute Food Protein-induced Enterocolitis Syndrome. (PubMed, JMA J) - "Our case series aimed to evaluate the effectiveness and safety of intravenous granisetron in acute FPIES episodes...Given the limited evidence on granisetron for FPIES, accumulating case reports is essential for guiding clinical trials and regulatory approval. Further comparative studies of granisetron and ondansetron are warranted."

Journal • Allergy • Food Hypersensitivity • Gastrointestinal Disorder • Immunology

Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections (clinicaltrials.gov) - P4 | N=330 | Completed | Sponsor: Ain Shams University | Not yet recruiting ➔ Completed

Trial completion • Anesthesia

Application of bilateral recto-intercostal fascial plane block as rescue analgesia after laparoscopic cholecystectomy: a case report (Euroanaesthesia 2025) - "described a new interfascial plane block technique called the "Recto-Intercostal Fascial Plane Block"(RIFPB).RIFPB is performed between the rectus abdominis muscle and the sixth and seventh costal cartilages just inferior lateral to the xiphoid.RIFPB targets the anterior and lateral cutaneous branches of the T6-T9 thoracoabdominal nerves.This case report, consisting of two cases, aims to share the analgesic effects of RIFPB when applied as rescue analgesia in patients whose pain could not be controlled with IV analgesics following laparoscopic cholecystectomy.Case Report: Informed consent was obtained, and standard ASA monitoring was performed for laparoscopic cholecystectomy surgery on a 51-year-old female patient with ASA II due to smoking and a 49-year-old female patient with ASA II due to hypertension.Anesthesia induction was performed with 1 mcg/kg fentanyl IV 1 mg/kg lidocaine IV and 2 mg/kg propofol IV.Maintenance anesthesia included sevoflurane..."

Case report • Clinical • Anesthesia • Cardiovascular • Hypertension • Pain

Retrospective observational study comparing the combination of granisetron and dexamethasone vs. ondansetron and dexamethasone as prophylaxis in patients at high risk for PONV undergoing orthopedic surgeries (Euroanaesthesia 2025) - "Dexamethasone 4 mg iv plus at the end of surgery approximately 30 minutes before extubation, they received either Ondansetron 4 mg iv or Granisetron 1 mg iv. A P-value less than 0.05 was considered statistically significant.Results and There was no statistically significant difference between the two groups for incidence of PONV or the need for rescue antiemetic.Conclusion(s): Combination therapy should consist of drugs from different classes, using minimum effective doses, and the choice of drugs will be determined by patient factors as well as institutional policy and drug availability. However, larger studies are needed on this subject."

Observational data • Retrospective data • Surgery • Anesthesia • Orthopedics

A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery (clinicaltrials.gov) - P4 | N=74 | Recruiting | Sponsor: University of Malaya | Not yet recruiting ➔ Recruiting

Enrollment open • Orthopedics

Comparison of the postoperative analgesic efficacy of the ultrasound-guided erector spinae plane block and intrathecal morphine in patients undergoing total abdominal hysterectomy under general anesthesia: a randomized controlled trial. (PubMed, J Anesth) - P4 | "3 mg intrathecal morphine was superior to erector spinae plane block for postoperative pain relief, 24 h after surgery, regarding attenuated stress response, lower pain scores at rest and on coughing and lower tramadol consumption. IRB: IRB 00006379//31-1-2022."

Journal • Anesthesia • CNS Disorders • Depression • Dermatology • Gynecology • Pain • Pruritus • Psychiatry

Intravenous Granisetron Vs Dexmedetomidine on Postspinal in the Cesarean Section. (clinicaltrials.gov) - P=N/A | N=99 | Enrolling by invitation | Sponsor: Minia University

New trial • Anesthesia

A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery (clinicaltrials.gov) - P4 | N=74 | Not yet recruiting | Sponsor: University of Malaya | Initiation date: Oct 2024 ➔ Jan 2025

Surgery • Trial initiation date • Orthopedics

A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery (clinicaltrials.gov) - P4 | N=74 | Not yet recruiting | Sponsor: University of Malaya

New P4 trial • Surgery • Orthopedics

Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections (clinicaltrials.gov) - P4 | N=330 | Not yet recruiting | Sponsor: Ain Shams University

New P4 trial • Anesthesia

Comparative Study Between Intravenous Granisetron and Ondansetron on Their Effect on Hemodynamics and Shivering After Spinal Anesthesia in Elective Cesarean Delivery (clinicaltrials.gov) - P=N/A | N=100 | Recruiting | Sponsor: Sohag University

New trial • Anesthesia

Effect of Selective 5-Hydroxytryptamine-3 Receptor and Neurokinin-1 Receptor Antagonists on Hemodynamic Changes and Arrhythmogenic Potential in Patients Receiving Chemotherapy: A Retrospective, Observational Study. (PubMed, J Clin Med) - "Patients were grouped by anti-emetic medication: intravenous granisetron (Group G), oral aprepitant plus IV granisetron (Group AG), IV palonosetron (Group P), and oral aprepitant plus IV palonosetron (Group AP). Hypotension was more frequent at 30 min post-medication in granisetron or aprepitant recipients. Considering no hypotension occurred when using palonosetron alone, this treatment was deemed safer."

Journal • Observational data • Retrospective data • Atrial Fibrillation • Cardiovascular • Hypotension

Doublet or triplet antiemetic prophylaxis for trastuzumab deruxtecan-induced nausea and vomiting: An open-label, randomized, multicenter, exploratory phase 2 study (SABCS 2023) - "Patients were randomly assigned to receive granisetron and dexamethasone (arm GD) or granisetron, dexamethasone, and aprepitant (fosaprepitant; arm GDA). Patients in both treatment arms were administered granisetron (1 mg i.v. 30 min before T-DXd on day 1)... Breast cancer patients receiving T-DXd require triple therapy, including mandatory NK1RA administration, for antiemetic prophylaxis. Further investigation is needed to explore the development of more appropriate combination therapies for T-DXd-induced nausea and vomiting."

Clinical • P2 data • Breast Cancer

Palonosetron vs Combination of Granisetron and Dexamethasone in Preventing PONV in Laparoscopic Cholecystectomy. (clinicaltrials.gov) - P4 | N=134 | Completed | Sponsor: Universiti Kebangsaan Malaysia Medical Centre

New P4 trial

Clonidine Versus Granisetron for Shivering Prevension (clinicaltrials.gov) - P2 | N=186 | Recruiting | Sponsor: Zagazig University

New P2 trial • Anesthesia

The effect of intravenous granisetron on prophylactic ephedrine for preventing hypotension after general anaesthesia induction in elderly patients: a randomized controlled trial. (PubMed, Sci Rep) - "The conclusion was further supported by probit regression analysis (0.09 mg kg [95% CI, 0.05-0.12 mg kg] in group granisetron and 0.14 mg kg [95% CI, 0.12-0.16 mg kg] in group control). Intravenous granisetron reduced the requirement of prophylactic ephedrine in preventing hypotension after general anaesthesia induction in elderly patients."

Journal • Anesthesia • Hypotension • Obstetrics

Comparison of Intravenous Granisetron and Ondansetron on Hemodynamics and Sensory Motor Block After Spinal Anaesthesia With Hyperbaric Bupivacaine in Patients Undergoing Elective Surgery: A Randomized Double-Blind Study. (PubMed, Cureus) - "Premedication with ondansetron 4mg and granisetron 1mg intravenously significantly reduces ephedrine use. Ondansetron provides better hemodynamic stability, earlier onset of the sensory and motor blocks as well as prolonged duration of sensory and motor blocks, and duration of analgesia compared to granisetron."

Journal • Surgery • Anesthesia • Cardiovascular • Hypotension

Comparison Between IT Fentanyl and IV Granisetron in Prevention of Vomiting in CS Under Spinal Anesthesia (clinicaltrials.gov) - P=N/A | N=90 | Recruiting | Sponsor: Mohamed Youssef Mohamed | Trial completion date: Jan 2023 ➔ Jan 2024 | Trial primary completion date: Dec 2022 ➔ Aug 2023

Trial completion date • Trial primary completion date • Anesthesia

To Compare the Effectiveness of Granisetron Versus Ondansetron to Control Nausea and Vomiting During Lower Segment Cesarean Section Under Subarachnoid Block. (PubMed, Anesth Essays Res) - "Ondansetron and granisetron intravenous (i.v.) are useful for avoiding bradycardia and hypotension...Eighty patients undergoing elective cesarean section under spinal anesthesia by intrathecal bupivacaine were randomly divided into two groups (40 pregnant females of the American Society of Anesthesiologists physical status Classes I and II in each Group). Group 1 received granisetron 40 mg.kg i.v. stat after clamping the cord and Group 2 given i.v. ondansetron 8 mg stat after clamping the cord...In the "early postoperative period," NV observed in 7.5% and 10.0% participants in Groups 1 and 2, respectively (P > 0.05), and in "late postoperative period," NV observed in 0.0% and 22.5% participants in Groups 1 and 2, respectively (P < 0.05). Granisetron reduces the severity of spinal-induced hypotension, need for rescue vasopressor, and incidence of nausea."

Journal • Anesthesia • Cardiovascular • Hypotension

Adjunctive granisetron therapy in patients with sepsis or septic shock (GRANTISS): A single-center, single-blinded, randomized, controlled clinical trial. (PubMed, Front Pharmacol) - " Adult patients with sepsis and procalcitonin ≥ 2 ng/ml were randomized in a 1:1 ratio to receive intravenous granisetron (3 mg every 8 h) or normal saline at the same volume and frequency for 4 days or until intensive care unit discharge... Granisetron did not improve 28-day mortality in patients with sepsis. However, a further clinical trial targeted to septic patients without abdominal/digestive tract infections perhaps is worthy of consideration."

Clinical • Journal • Critical care • Immunology • Infectious Disease • Inflammation • Septic Shock