granisetron intravenous / Generic mfg. - LARVOL DELTA

Granisetron as a Novel Treatment for Acute Food Protein-induced Enterocolitis Syndrome. (PubMed, JMA J) - "Our case series aimed to evaluate the effectiveness and safety of intravenous granisetron in acute FPIES episodes...Given the limited evidence on granisetron for FPIES, accumulating case reports is essential for guiding clinical trials and regulatory approval. Further comparative studies of granisetron and ondansetron are warranted."

Journal • Allergy • Food Hypersensitivity • Gastrointestinal Disorder • Immunology

Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections (clinicaltrials.gov) - P4 | N=330 | Completed | Sponsor: Ain Shams University | Not yet recruiting ➔ Completed

Trial completion • Anesthesia

Application of bilateral recto-intercostal fascial plane block as rescue analgesia after laparoscopic cholecystectomy: a case report (Euroanaesthesia 2025) - "described a new interfascial plane block technique called the "Recto-Intercostal Fascial Plane Block"(RIFPB).RIFPB is performed between the rectus abdominis muscle and the sixth and seventh costal cartilages just inferior lateral to the xiphoid.RIFPB targets the anterior and lateral cutaneous branches of the T6-T9 thoracoabdominal nerves.This case report, consisting of two cases, aims to share the analgesic effects of RIFPB when applied as rescue analgesia in patients whose pain could not be controlled with IV analgesics following laparoscopic cholecystectomy.Case Report: Informed consent was obtained, and standard ASA monitoring was performed for laparoscopic cholecystectomy surgery on a 51-year-old female patient with ASA II due to smoking and a 49-year-old female patient with ASA II due to hypertension.Anesthesia induction was performed with 1 mcg/kg fentanyl IV 1 mg/kg lidocaine IV and 2 mg/kg propofol IV.Maintenance anesthesia included sevoflurane..."

Case report • Clinical • Anesthesia • Cardiovascular • Hypertension • Pain

Retrospective observational study comparing the combination of granisetron and dexamethasone vs. ondansetron and dexamethasone as prophylaxis in patients at high risk for PONV undergoing orthopedic surgeries (Euroanaesthesia 2025) - "Dexamethasone 4 mg iv plus at the end of surgery approximately 30 minutes before extubation, they received either Ondansetron 4 mg iv or Granisetron 1 mg iv. A P-value less than 0.05 was considered statistically significant.Results and There was no statistically significant difference between the two groups for incidence of PONV or the need for rescue antiemetic.Conclusion(s): Combination therapy should consist of drugs from different classes, using minimum effective doses, and the choice of drugs will be determined by patient factors as well as institutional policy and drug availability. However, larger studies are needed on this subject."

Observational data • Retrospective data • Surgery • Anesthesia • Orthopedics

A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery (clinicaltrials.gov) - P4 | N=74 | Recruiting | Sponsor: University of Malaya | Not yet recruiting ➔ Recruiting

Enrollment open • Orthopedics

Comparison of the postoperative analgesic efficacy of the ultrasound-guided erector spinae plane block and intrathecal morphine in patients undergoing total abdominal hysterectomy under general anesthesia: a randomized controlled trial. (PubMed, J Anesth) - P4 | "3 mg intrathecal morphine was superior to erector spinae plane block for postoperative pain relief, 24 h after surgery, regarding attenuated stress response, lower pain scores at rest and on coughing and lower tramadol consumption. IRB: IRB 00006379//31-1-2022."

Journal • Anesthesia • CNS Disorders • Depression • Dermatology • Gynecology • Pain • Pruritus • Psychiatry

Intravenous Granisetron Vs Dexmedetomidine on Postspinal in the Cesarean Section. (clinicaltrials.gov) - P=N/A | N=99 | Enrolling by invitation | Sponsor: Minia University

New trial • Anesthesia

A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery (clinicaltrials.gov) - P4 | N=74 | Not yet recruiting | Sponsor: University of Malaya | Initiation date: Oct 2024 ➔ Jan 2025

Surgery • Trial initiation date • Orthopedics

A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery (clinicaltrials.gov) - P4 | N=74 | Not yet recruiting | Sponsor: University of Malaya

New P4 trial • Surgery • Orthopedics

Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections (clinicaltrials.gov) - P4 | N=330 | Not yet recruiting | Sponsor: Ain Shams University

New P4 trial • Anesthesia

Comparative Study Between Intravenous Granisetron and Ondansetron on Their Effect on Hemodynamics and Shivering After Spinal Anesthesia in Elective Cesarean Delivery (clinicaltrials.gov) - P=N/A | N=100 | Recruiting | Sponsor: Sohag University

New trial • Anesthesia

Effect of Selective 5-Hydroxytryptamine-3 Receptor and Neurokinin-1 Receptor Antagonists on Hemodynamic Changes and Arrhythmogenic Potential in Patients Receiving Chemotherapy: A Retrospective, Observational Study. (PubMed, J Clin Med) - "Patients were grouped by anti-emetic medication: intravenous granisetron (Group G), oral aprepitant plus IV granisetron (Group AG), IV palonosetron (Group P), and oral aprepitant plus IV palonosetron (Group AP). Hypotension was more frequent at 30 min post-medication in granisetron or aprepitant recipients. Considering no hypotension occurred when using palonosetron alone, this treatment was deemed safer."

Journal • Observational data • Retrospective data • Atrial Fibrillation • Cardiovascular • Hypotension

Doublet or triplet antiemetic prophylaxis for trastuzumab deruxtecan-induced nausea and vomiting: An open-label, randomized, multicenter, exploratory phase 2 study (SABCS 2023) - "Patients were randomly assigned to receive granisetron and dexamethasone (arm GD) or granisetron, dexamethasone, and aprepitant (fosaprepitant; arm GDA). Patients in both treatment arms were administered granisetron (1 mg i.v. 30 min before T-DXd on day 1)... Breast cancer patients receiving T-DXd require triple therapy, including mandatory NK1RA administration, for antiemetic prophylaxis. Further investigation is needed to explore the development of more appropriate combination therapies for T-DXd-induced nausea and vomiting."

Clinical • P2 data • Breast Cancer

Palonosetron vs Combination of Granisetron and Dexamethasone in Preventing PONV in Laparoscopic Cholecystectomy. (clinicaltrials.gov) - P4 | N=134 | Completed | Sponsor: Universiti Kebangsaan Malaysia Medical Centre

New P4 trial

Clonidine Versus Granisetron for Shivering Prevension (clinicaltrials.gov) - P2 | N=186 | Recruiting | Sponsor: Zagazig University

New P2 trial • Anesthesia

The effect of intravenous granisetron on prophylactic ephedrine for preventing hypotension after general anaesthesia induction in elderly patients: a randomized controlled trial. (PubMed, Sci Rep) - "The conclusion was further supported by probit regression analysis (0.09 mg kg [95% CI, 0.05-0.12 mg kg] in group granisetron and 0.14 mg kg [95% CI, 0.12-0.16 mg kg] in group control). Intravenous granisetron reduced the requirement of prophylactic ephedrine in preventing hypotension after general anaesthesia induction in elderly patients."

Journal • Anesthesia • Hypotension • Obstetrics

Comparison of Intravenous Granisetron and Ondansetron on Hemodynamics and Sensory Motor Block After Spinal Anaesthesia With Hyperbaric Bupivacaine in Patients Undergoing Elective Surgery: A Randomized Double-Blind Study. (PubMed, Cureus) - "Premedication with ondansetron 4mg and granisetron 1mg intravenously significantly reduces ephedrine use. Ondansetron provides better hemodynamic stability, earlier onset of the sensory and motor blocks as well as prolonged duration of sensory and motor blocks, and duration of analgesia compared to granisetron."

Journal • Surgery • Anesthesia • Cardiovascular • Hypotension

Comparison Between IT Fentanyl and IV Granisetron in Prevention of Vomiting in CS Under Spinal Anesthesia (clinicaltrials.gov) - P=N/A | N=90 | Recruiting | Sponsor: Mohamed Youssef Mohamed | Trial completion date: Jan 2023 ➔ Jan 2024 | Trial primary completion date: Dec 2022 ➔ Aug 2023

Trial completion date • Trial primary completion date • Anesthesia

To Compare the Effectiveness of Granisetron Versus Ondansetron to Control Nausea and Vomiting During Lower Segment Cesarean Section Under Subarachnoid Block. (PubMed, Anesth Essays Res) - "Ondansetron and granisetron intravenous (i.v.) are useful for avoiding bradycardia and hypotension...Eighty patients undergoing elective cesarean section under spinal anesthesia by intrathecal bupivacaine were randomly divided into two groups (40 pregnant females of the American Society of Anesthesiologists physical status Classes I and II in each Group). Group 1 received granisetron 40 mg.kg i.v. stat after clamping the cord and Group 2 given i.v. ondansetron 8 mg stat after clamping the cord...In the "early postoperative period," NV observed in 7.5% and 10.0% participants in Groups 1 and 2, respectively (P > 0.05), and in "late postoperative period," NV observed in 0.0% and 22.5% participants in Groups 1 and 2, respectively (P < 0.05). Granisetron reduces the severity of spinal-induced hypotension, need for rescue vasopressor, and incidence of nausea."

Journal • Anesthesia • Cardiovascular • Hypotension

Adjunctive granisetron therapy in patients with sepsis or septic shock (GRANTISS): A single-center, single-blinded, randomized, controlled clinical trial. (PubMed, Front Pharmacol) - " Adult patients with sepsis and procalcitonin ≥ 2 ng/ml were randomized in a 1:1 ratio to receive intravenous granisetron (3 mg every 8 h) or normal saline at the same volume and frequency for 4 days or until intensive care unit discharge... Granisetron did not improve 28-day mortality in patients with sepsis. However, a further clinical trial targeted to septic patients without abdominal/digestive tract infections perhaps is worthy of consideration."

Clinical • Journal • Critical care • Immunology • Infectious Disease • Inflammation • Septic Shock

Comparison Between IT Fentanyl and IV Granisetron in Prevention of Vomiting in CS Under Spinal Anesthesia (clinicaltrials.gov) - P=N/A | N=90 | Recruiting | Sponsor: Mohamed Youssef Mohamed

New trial • Anesthesia

A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy (clinicaltrials.gov) - P4 | N=25 | Recruiting | Sponsor: University of Vermont | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

ENDURRANCE-1: Exploring Durable Remission With Rituximab in Antineutrophil Cytoplasmic Antibody(ANCA)-Associated Vasculitis (clinicaltrials.gov) - P3 | N=100 | Recruiting | Sponsor: Leiden University Medical Center | N=47 ➔ 100

Enrollment change • Immunology • Vasculitis

Role of Granisetron in Preventing Hypotension After Spinal Anesthesia With Levobupivacaine in Rheumatic Patients Undergoing Elective Cesarean Section (clinicaltrials.gov) - P2/3 | N=102 | Recruiting | Sponsor: Assiut University

New P2/3 trial • Anesthesia • Hypotension

A retrospective study on chemotherapy-induced nausea and vomiting in highly/moderately emetogenic chemotherapy: incidence and prescribing practice. (PubMed, Support Care Cancer) - "This study provides evidence that there was suboptimal use of recommended agents for CINV, and there is a clear need for further improvements in CINV management."

CINV • Journal • Retrospective data • Chemotherapy-Induced Nausea and Vomiting • Oncology