DB-1421 / DualityBio - LARVOL DELTA

DB-1421, an optimized EGFR/MUC1 bispecific ADC, exhibits improved tumor selectivity, promising efficacy and safety in preclinical studies (AACR 2026) - "DB-1421 is an EGFR/MUC1 bispecific ADC with a common light chain bispecific antibody and a DNA topoisomerase I inhibitor. Through rational design and engineer of EGFR and MUC1 binding arm, DB-1421 showed improved tumor selectivity, efficacy and very good safety. The promising efficacy and safety profile warrants further clinical development of DB-1421."

ADC • Bispecific • Preclinical • Breast Cancer • Colorectal Cancer • Esophageal Squamous Cell Carcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • EGFR • MUC1