PRLX 93936 / Prolexys - LARVOL DELTA

TRIM21-NUP98 Interface Accommodates Structurally Diverse Molecular Glue Degraders. (PubMed, ACS Chem Biol) - "Here, we analyzed public compound toxicity data across a large collection of cell lines and identified two additional molecular glue degraders, PRLX 93936 and BMS-214662, which engage the TRIM21-NUP98 interface to induce selective degradation of nuclear pore proteins. Additionally, we confirmed that HGC652, another TRIM21-dependent molecular glue degrader, also binds at this interface. Together with our previously characterized degrader (S)-ACE-OH, these findings demonstrate that the TRIM21-NUP98 interface can accommodate structurally diverse molecular glue degraders."

Journal • Targeted Protein Degradation • NUP98 • TRIM21

Cisplatin synergizes with PRLX93936 to induce ferroptosis in non-small cell lung cancer cells. (PubMed, Biochem Biophys Res Commun) - "In the current study, we showed that cisplatin and PRLX93936, an analog of erastin that has been tested in clinical trials, demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells. Nrf2 silencing increased this sensitivity while inhibition of Keap1 attenuated it. Overall, our data reveal a new effective treatment for NSCLC by synergizing cisplatin and PRLX93936 to induce ferroptosis."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • GPX4