testosterone/progesterone (ARG103) / arGentis - LARVOL DELTA

The heat shock transcription factor regulates the expression of crustin in Portunus trituberculatus. (PubMed, Fish Shellfish Immunol) - "Furthermore, molecular docking simulations reveal that three amino acids (His66, Arg103, and Lys104) in the DBD of PtHSF binds to the promoter sequence of Ptcrustin1 via noncovalent interactions, such as hydrogen bonds and Van der Waals forces. This study enriches the understanding of the regulatory mechanisms underlying antimicrobial peptide expression in crustaceans and provides novel perspectives for disease control in P. trituberculatus aquaculture."

Journal • ADAM17

In Silico Identification of Novel Compounds as Anthelmintics Against Haemonchus contortus Through Inhibiting β-Tubulin Isotype 1 and Glutathione S-Transferase. (PubMed, Animals (Basel)) - "Similarly, in GST, Leu99, Asn100, Arg103, Lys107, Glu162, and Met163 were the most common interacting residues...The in silico studies identified potent compounds by targeting GST and β-tubulin isotype 1 against Haemonchus contortus. The reported findings provide a foundation for the development of novel anthelmintic therapies."

Journal

A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus. (PubMed, Proc Natl Acad Sci U S A) - "Positioning of the positively charged Arg103 side chain in the second coordination shell yields an overall charge-neutral Fe(III) binding state in structures determined by neutron diffraction and serial femtosecond crystallography...Dose series using serial synchrotron crystallography and an XFEL X-ray pump-probe approach capture the transition between Fe(III) and Fe(II) states, revealing how Arg203 operates as a switch to accommodate the different iron oxidation states. This switching ability of the Prochlorococcus FutA protein may reflect ecological adaptation by genome streamlining and loss of specialized FutA proteins."

Journal

Generating Monoclonal Antibodies against Buprofezin and Developing Immunoassays for Its Residue Detection in Tea Samples. (PubMed, J Agric Food Chem) - "The study identified π-π stacking interactions between hapten and TYR-61 at the mAb-19F2 site and alkyl/phosphate interactions with TRP-105 and ARG-103...The recovery rate of tea spiked recovered samples was 83.6%-92.2%, with an RSD of 5.3%-12.6%, and the results were consistent with the LC/MS method. This study is important for the real-time detection of buprofezin residues to ensure food safety and human health."

Journal

Lipid peroxidation-derived modification and its effect on the activity of glutathione peroxidase 1. (PubMed, Free Radic Biol Med) - "The GSH-binding sites modified were as follows: ONE, Arg57, 103, 184, and 185; HNE, Lys91; MG, Arg103...However, the activity of GPx1 was not restored to the initial level, indicating that ONE modified GPx1 irreversibly. This study suggests that oxidative damage to lipids, resulting in the formation of reactive aldehydes, can amplify cellular oxidative stress via direct inactivation of GPx1, which increases the production of intracellular peroxides."

Journal • CNS Disorders • Oncology • GPX1

Binding Mechanism of CD47 with SIRPα Variants and Its Antibody: Elucidated by Molecular Dynamics Simulations. (PubMed, Molecules) - "Significant effects were observed in the energy and structural analyses of the residues (Glu35, Tyr37, Leu101, Thr102, Arg103) in the C strand and FG region of CD47 when it binds to the SIRPα variants. For B6H12.2, the residues Tyr32, His92, Arg96, Tyr32, Thr52, Ser53, Ala101, and Gly102 in its initial half of the light and heavy chains exhibit obvious energetic and structural impacts upon binding with CD47. The elucidation of the binding mechanism of SIRPαv1, SIRPαv2, and B6H12.2 with CD47 could provide novel perspectives for the development of inhibitors targeting CD47-SIRPα."

Journal • Oncology • SIRPA

A Low-Activity Polymorphic Variant of Human NEIL2 DNA Glycosylase. (PubMed, Int J Mol Sci) - "Arg103 is located in a long disordered segment within the N-terminal domain of hNEIL2, while Pro304 occupies a position in the β-turn of the DNA-binding zinc finger motif. The P304T variant was also less proficient than the wild-type, or R103W hNEIL2, in the removal of damaged bases from single-stranded and bubble-containing DNA. Overall, hNEIL2 P304T could be worthy of a detailed epidemiological analysis as a possible cancer risk modifier."

Journal • Oncology

Neurologic Phenotypes Associated With Mutations in RTN4IP1 (OPA10) in Children and Young Adults. (PubMed, JAMA Neurol) - "In these patients, novel and very rare homozygous and compound heterozygous mutations were identified that led to the absence of the protein and complex I disassembly as well as mild mitochondrial network fragmentation. A broad clinical spectrum of neurologic features, ranging from isolated optic atrophy to severe early-onset encephalopathies, is associated with RTN4IP1 biallelic mutations and should prompt RTN4IP1 screening in both syndromic neurologic presentations and nonsyndromic recessive optic neuropathies."

Journal

Identification of Anti-filarial leads against Aspartate semialdehyde Dehydrogenase of Wolbachia endosymbiont of Brugia malayi: Combined Molecular Docking and Molecular Dynamics Approaches. (PubMed, J Biomol Struct Dyn) - "...The molecular docking and dynamics results revealed that the amino acid residues Arg103, Asn133, Cys134, Gln161, Ser164, Lys218, Arg239, His246, and Asn321 plays a crucial role in effective binding of Top leads into the active site of ASDase...Furthermore, density functional theory and binding free energy calculations were performed to rank the lead molecules. Thus, the identified lead molecules can be used for the development of anti-filarial agents to combat the pathogenecity of Brugia malayi."

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