cyclobenzaprine / Generic mfg. - LARVOL DELTA

EASE-TAR: Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release (clinicaltrials.gov) - P4 | N=40 | Recruiting | Sponsor: Northwestern University

New P4 trial • Gastroenterology • Pain

Evolving Concepts in the Diagnosis and Management of Fibromyalgia: A Moving Target. (PubMed, J Pain Res) - "Pharmacological therapies, including pregabalin, duloxetine, milnacipran, and cyclobenzaprine, are Food and Drug Administration-approved and provide clinically meaningful benefits to patients with FM. Although tramadol may be considered, the use of other opioids is generally not recommended because of their limited efficacy and potential risks...Therefore, this narrative review aims to provide a concise, updated, and clinically relevant overview of the current evidence regarding the pathogenesis, diagnosis, and multidisciplinary management of FM to improve diagnostic accuracy and support individualized patient management. Furthermore, future directions should prioritize improving diagnostic precision and developing mechanism-based interventions targeting the underlying pathophysiology of FM."

Journal • Review • CNS Disorders • Cognitive Disorders • Fatigue • Fibromyalgia • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Psychiatry • Rheumatology • Sleep Disorder

Multimodal Analgesia Effect on Post Surgical Patient (clinicaltrials.gov) - P4 | N=60 | Completed | Sponsor: University of California, Davis | Active, not recruiting ➔ Completed

Trial completion • Genetic Disorders • Obesity

Chronic Migraine Remission with Combination of Remote Electrical Neuromodulation (REN) and In-Clinic / Patient-Administered Sphenopalatine Ganglion (SPG) Block (PAINWeek 2026) - "Current acute treatments included rizatriptan, ubrogepant and acetaminophen with recent discontinued acute therapies including rimegepant and NSAIDS. Current preventative treatments include onabotulinumtoxinA, galcanezumab, amitriptyline, cyclobenzaprine, ondansetron and occipital nerve blocks with recent discontinued preventatives including topiramate... Patient was seen weekly for initial treatment sequence and noted near complete resolution of acute migraine symptoms after the first in-clinic SPG administration with smaller, although noticeable, levels of relief with self-administered SPG administration. Patient also noted significant, although not complete, reduction of acute pain and nausea within the first week of initiating REN. After one month of treatment, patient noted that migraine frequency reduced to one episode per week from the previous 4 to 6 episodes and was able to manage most acute episodes with acetaminophen, with rare need for other acute..."

Clinical • CNS Disorders • Depression • Migraine

When Rising Thyroglobulin Does Not Mean Cancer Recurrence: The Impact of Graves’ Disease on Thyroid Remnants (ETA 2026) - "At the age of 51, she developed GD and failed to achieve remission with methimazole (MM), leading to left hemithyroidectomy...Medication included levothyroxine 100µg od, methotrexate, folic acid, cyclobenzaprine and omeprazole... In this case, considering the low risk of PTC recurrence, autoimmune stimulated growth of residual thyroid tissue causing Tg increasing levels was the most likely diagnosis. However, it illustrates the diagnostic challenge of interpreting laboratory and sonography findings in patients with differentiated follicular cell-derived thyroid cancer and concomitant GD. Awareness of the described pitfalls is essential to prevent misinterpretation and avoid unnecessary interventions."

Endocrine Disorders • Fibromyalgia • Grave’s Disease • Immunology • Inflammatory Arthritis • Musculoskeletal Pain • Oncology • Rheumatoid Arthritis • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma • TG

Lack of Efficacy of Low-Dose Cyclobenzaprine on Electromyographic Activity Related to Sleep Bruxism: A Randomized Crossover Double-Blind Placebo-Controlled Clinical Trial. (PubMed, J Sleep Res) - "In conclusion, low-dose cyclobenzaprine was not effective in modifying SB-related muscle activity or masticatory muscle force, suggesting limited clinical utility for SB. Future studies using higher doses of cyclobenzaprine are warranted before ruling out its clinical utility, within a safety profile."

Clinical • Journal • Dental Disorders • Pain • Xerostomia

Sublingual Cyclobenzaprine Approval: Expanding Options for Fibromyalgia Management. (PubMed, Health Sci Rep) - "The approval of sCBP marks a significant advancement in the treatment of FM, addressing the limitations of current pharmacological options. As the prevalence of FM continues to rise, sCBP offers a promising therapeutic alternative, providing patients with a more effective and rapid treatment option for pain management."

Journal • Cardiovascular • CNS Disorders • Fatigue • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology • Sleep Disorder • Xerostomia

A Case of Spinal Epidural Abscess and Paraplegia After Group A Streptococcal Pharyngitis. (PubMed, Infect Dis Rep) - "Following treatment with amoxicillin, she returned with worsened back pain, radiculopathy, and leukocytosis, for which she was treated with cyclobenzaprine. To our knowledge, this is the first report of SEA preceded by GAS pharyngitis. This case exposes the critical association between a recent infection, progression of back pain, eventual neurologic symptoms, and inflammatory markers that should trigger concern for SEA and early evaluation with MRI."

Journal • Back Pain • CNS Disorders • Infectious Disease • Musculoskeletal Pain • Pain

Sublingual Cyclobenzaprine for Fibromyalgia: Pharmacokinetic Rationale, Clinical Evidence, and Place in Therapy. (PubMed, Curr Pain Headache Rep) - "Meta-analyses encompassing four clinical trials have reported modest efficacy comparable to established agents such as duloxetine and pregabalin. By shifting adverse effects from systemic manifestations to predominantly local oral effects, the sublingual formulation may offer improved tolerability compared with oral cyclobenzaprine. TNX-102 SL appears particularly well suited for patients with sleep-predominant FM symptoms who have not responded adequately to or cannot tolerate existing first-line treatments."

Journal • PK/PD data • Review • CNS Disorders • Cognitive Disorders • Fatigue • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology • Sleep Disorder

Stress reactivity, but not stressful life events, is associated with treatment selection and clinical outcomes in masticatory myofascial pain patients. A pilot study. (PubMed, Cranio) - "Patients received either conventional treatment (cyclobenzaprine plus physiotherapy; n = 15) or the same treatment plus botulinum toxin (BT) infiltration (n = 20)...SR, rather than SLE, may be a clinically relevant predictor of treatment selection and response in patients with masticatory myofascial pain. Assessing SR may support personalized treatment decisions."

Clinical data • Journal • Inflammatory Arthritis • Musculoskeletal Pain • Pain

Frozen in Laughter: A Curious Case of Paroxysmal Facial Pain (EAN 2026) - "Medications (clonazepam, haloperidol, cyclobenzaprine) were ineffective...Blink reflex was normal; during attacks, masseter reflex latency was delayed with reduced amplitude and an attenuated masseteric silent period... HMS should be considered in trigger-sensitive unilateral jaw-closing spasms with pain and hypertrophy even without facial hemiatrophy; attack-related impairment of inhibitory silent periods supports diagnosis and botulinum toxin is an effective first-line therapy."

Clinical • Dystonia • Immunology • Movement Disorders • Musculoskeletal Diseases • Neuralgia • Pain

Cyclobenzaprine for Postoperative Pain in Minimally Invasive Hysterectomy (clinicaltrials.gov) - P4 | N=36 | Not yet recruiting | Sponsor: Christiana Care Health Services

New P4 trial • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Solid Tumor • Uterine Leiomyoma • Women's Health

Review of Oral Muscle Relaxants Used for Chronic Temporomandibular Disorder Pain. (PubMed, Anesth Prog) - "This review summarizes the pharmacology, clinical evidence, and risk profiles of commonly prescribed SMRs-including cyclobenzaprine, baclofen, tizanidine, and others-within the context of chronic TMD management. Given concerns regarding sedation, dependence, hepatotoxicity, and interactions with polypharmacy, clinicians should employ these medications judiciously and primarily for acute exacerbations rather than long-term therapy. An evidence-based, multimodal approach remains essential for optimizing care in patients with chronic TMDs."

Journal • Review • Anesthesia • Musculoskeletal Diseases • Pain

A Case of Sustained Ventricular Tachycardia Soon after Initiation of Teriparatide (ENDO 2026) - "Clinical Case: A 73-year-old woman with a history of severe postmenopausal osteoporosis diagnosed eight years prior and treated with multiple doses of zoledronic acid, was referred to endocrinology for continued bone mineral density decline...Her medication regimen included trazodone, hydroxyzine, amitriptyline, and cyclobenzaprine, all of which have been associated with QT prolongation and ventricular arrythmias...After two amiodarone boluses and one defibrillation shock, she converted to sinus rhythm... It is unlikely that teriparatide increases risk of ventricular tachycardia. While atrial arrhythmias are associated with teriparatide use, ventricular arrhythmias due to treatment have not been reported. Thus, underlying predisposing cardiovascular conditions or cardiotoxic medications should be investigated in patients with major cardiac adverse events."

Clinical • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Endocrine Disorders • Heart Failure • Hypertension • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • Osteoporosis • Pulmonary Disease • Ventricular Tachycardia

Low Back Pain: A Review. (PubMed, JAMA) - "For patients with acute nonspecific low back pain, first-line therapies include heat application, spinal manipulation, massage, and acupuncture (typically provided by physical therapists, chiropractors, acupuncturists, and massage therapists) as well as nonsteroidal anti-inflammatory drugs (NSAIDs; such as ibuprofen) and skeletal muscle relaxants (such as cyclobenzaprine). For patients with acute nonspecific low back pain, first-line treatments include selected nonpharmacological therapies and medications (such as NSAIDs and skeletal muscle relaxants). For patients with chronic nonspecific low back pain, first-line treatment consists of exercise, psychological therapies (such as cognitive behavioral therapy), and combined multidisciplinary care."

Journal • Ankylosing Spondylitis • Back Pain • CNS Disorders • Diabetes • Genetic Disorders • Immunology • Infectious Disease • Lumbar Back Pain • Metabolic Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Obesity • Oncology • Orthopedics • Pain • Seronegative Spondyloarthropathies • Spondylarthritis

Co-occurring chronic overlapping pain conditions and pain management engagement in veterans diagnosed with fibromyalgia: A comparison of women and men. (PubMed, Pain Med) - "While women Veterans with fibromyalgia were more likely to receive nonpharmacological approaches, overall receipt for these approaches were low in both women and men. Future work in this area is needed to examine potential barriers to access and engagement."

Journal • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology

Unraveling the corrosion-mitigating action of cyclobenzaprine hydrochloride on carbon steel in acidic media: integrated experimental and multiscale molecular perspectives. (PubMed, Sci Rep) - "The electronic characteristics and active adsorption centers of CBA were elucidated through density functional theory calculations, Fukui function examination, and natural bond orbital investigation. Additionally, the significance of π-electron systems and heteroatoms in surface interactions was emphasized."

Journal

Leg Pain And Weakness - Community Member (ACSM 2026) - "He had minimal relief from trials of gabapentin, methylprednisolone dose pack, meloxicam, cyclobenzaprine, and oxycodone one time.PHYSICAL EXAMINATION:Left Lower Extremity: Atrophy of quadriceps and adductor compartment. 1. XR femur left: mild left hip osteoarthritis 2. MRI Lumbar Spine without contrast - L1/2, L2/3, L3/4, L4/5, L5/S1 bilateral facet arthropathy."

CNS Disorders • Diabetes • Diabetic Neuropathy • Endocrine Disorders • Immunology • Metabolic Disorders • Myositis • Osteoarthritis • Pain • Sleep Disorder • Type 2 Diabetes Mellitus

Quadruple Nerve Cryoneurolysis for Refractory Vulvodynia: A Case Study (ISPRM 2026) - "Case Description: A 32-year-old female with a history of vulvodynia following a hysterectomy in 2020 had been treated for several years with conservative management, including topical therapies (Ketoprofen 20%, cyclobenzaprine 2%, lidocaine 10%), oral medications (Gabapentin, Cymbalta, Ketamine), and various nerve blocks (Genitofemoral, Pudendal, Posterior Femoral Cutaneous). This case highlights the transformative potential of quadruple nerve cryoneurolysis for patients with chronic and refractory vulvodynia, particularly for those who have not responded to traditional post-surgical management. The successful application offers a novel treatment modality that could be considered by PM&R specialists in similar cases of intractable neuropathic pain. Furthermore, this represents an important step in exploring advanced treatments and expanding the role of interventional techniques in the field, particularly in managing chronic pelvic pain syndromes."

Case study • Clinical • Gynecology • Musculoskeletal Pain • Neuralgia • Women's Health

Efficacy and Safety of Pregabalin-Tizanidine vs Pregabalin in Patients with Fibromyalgia: Study Protocol for a Multicenter, Prospective, Randomized, Controlled, Open-Label, Blinded Endpoint Trial. (PubMed, J Pain Res) - P=N/A | "Cyclobenzaprine is a centrally acting muscle relaxant. All study procedures will be conducted in accordance with the Declaration of Helsinki (1964) and its subsequent amendments (7th revision, Fortaleza, Brazil, 2013). This trial will provide evidence for the efficacy and safety of pregabalin combined with tizanidine in the treatment of FM."

Journal • Fibromyalgia • Musculoskeletal Pain • Pain • Rheumatology

Anticholinergic Adverse Effects Associated With Skeletal Muscle Relaxants in the Intensive Care Unit. (PubMed, J Pharm Technol) - "Centrally acting skeletal muscle relaxants, including cyclobenzaprine and methocarbamol, are commonly used as adjuncts, yet data evaluating their anticholinergic adverse effects in critically ill populations are limited...These findings support the cautious use of centrally acting muscle relaxants as part of multimodal analgesia strategies. Pharmacists are uniquely positioned to evaluate and mitigate adverse drug effects in the critically ill."

Adverse events • Journal • Anesthesia • Critical care • Pain

Reset Osmostat: An Underrecognized Cause of Chronic Hyponatremia (NKF-SCM 2026) - "Pertinent medications included cyclobenzaprine, gabapentin, and prior olanzapine use. CONCLUSION This case emphasizes the importance of recognizing reset osmostat in chronic hyponatremia to avoid unnecessary interventions. Further research is needed to clarify its mechanisms and long-term implications."

Atrial Fibrillation • Cardiovascular • CNS Disorders • Endocrine Disorders • Heart Failure • Mood Disorders

Using Reverse Image Search and Artificial Intelligence Technology to Identify Prescription Pills (PAS 2026) - "All AI platforms should be designed to consistently provide an error message when presented with a request to identify a medication.Figure 1: Cyclobenzaprine 5mg TabletCyclobenzaprine was unidentified by ChatGPT, Copilot, and Google Lens... AI outputs were categorized as correct, incorrect, or no-answer. The no-answer category included outputs indicating that the pill could not be identified, a refusal to identify the pill, or an identification of something other than a medication. In total, 18.37% of responses across all AI platforms were correct identifications with 44.49% of trials resulting in no-answer."

Pediatrics

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants (clinicaltrials.gov) - P=N/A | N=1600 | Recruiting | Sponsor: Duke University | Trial completion date: Jul 2027 ➔ Jul 2028 | Trial primary completion date: Jul 2026 ➔ Jul 2027

Trial completion date • Trial primary completion date

Right Meralgia Paresthetica After a Laparoscopic ProGrip™ Bilateral Implant for Inguinal Hernia Repair: A Case Report. (PubMed, Cureus) - "Pain was controlled after discharge with oral pregabalin plus cyclobenzaprine. In a retrospective analysis, no classical risk factors of meralgia paresthetica (e.g., obesity, tight belts, or former local procedures) were identified for the patient under discussion. The authors could not find any similar case in medical literature."

Journal • Gastroenterology • Genetic Disorders • Neuralgia • Obesity • Pain