clotrimazole topical / Generic mfg. - LARVOL DELTA

Development and Characterization of a Clotrimazole-loaded Bigel for Topical Drug Delivery. (PubMed, Antiinflamm Antiallergy Agents Med Chem) - "Among the prepared batches, B5 showed the largest zone of inhibition (36.33 ± 1.15 mm) against Candida albicans, demonstrating the potential of the developed bigel as an effective topical treatment for cutaneous fungal infections."

Journal • Infectious Disease

Economic Burden and Cost Differences Between Branded and Generic Topical Antifungals in India. (PubMed, Cureus) - " The market for topical antifungal agents demonstrates substantial price variation among available products. Regulatory authorities, pharmaceutical manufacturers, and clinicians must collaborate to achieve optimal reductions in drug costs. Strict implementation of cost regulation policies, along with increased awareness among clinicians regarding the rational selection of cost-effective therapies, is essential."

HEOR • Journal • Dermatology

Trephination and the Seldinger technique achieve comparable sinonasal distribution of clotrimazole cream in canine cadavers. (PubMed, Am J Vet Res) - "Both techniques achieved comparable sinonasal clotrimazole filling; however, procedural feasibility may be influenced by small‑breed cadavers and those with normal sinonasal anatomy. Further studies in live patients are required to determine procedural feasibility, complication rates, and effectiveness."

Journal • Pulmonary Disease • Respiratory Diseases

A case of palmarplantar erythrodysesthesia with twenty-nail dystrophy secondary to IgG myeloma managed with Itraconazole therapy (EADV-Sp 2026) - "In June 2017, he underwent further chemotherapy, a second autologous stem cell transplant, and maintenance Ixazomib until 2020. Subsequent regimens included Lenalidomide with Dexamethasone followed by Isatuximab–Pomalidomide–Dexamethasone from January 2023, before switching to Elranatamab in February 2025...Past medical history included coronary artery bypass grafting (2013), atrial fibrillation with complete heart block (August 2021, on apixaban), hypertension, chronic obstructive pulmonary disease, and possible primary hyperparathyroidism with mild hypercalcaemia and normal parathyroid hormone levels. He was initially treated with Clotrimazole cream and oral Itraconazole (100 mg once daily for eight weeks), alongside an ​antiseptic, moisturising soap substitute and a short course of topical antifungal with Hydrocortisone...He remained on Co-trimoxazole, Aciclovir, and monthly prophylactic intravenous Immunoglobulin replacement...Thus, recognising these side effects is..."

Clinical • Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • Dermatology • Endocrine Disorders • Hematological Disorders • Hematological Malignancies • Hypertension • Immunology • Infectious Disease • Multiple Myeloma • Pruritus • Pulmonary Disease • Respiratory Diseases

Dissolving Microneedles Loaded with Lipid Nanocarriers for Vaginal Delivery of Clotrimazole: In Vitro and Ex Vivo Evaluation. (PubMed, Mol Pharm) - "Notably, the LNC-loaded microneedles inhibited fungal growth at a 10-fold lower drug dose than a commercial clotrimazole cream. Finally, a device prototype was developed in the form of an intravaginal ring incorporating multiple microneedle arrays on its surface, delivering a total drug dose of 0.1 mg per ring with 600 μm microneedle height. Local vaginal drug delivery using such microneedle-based devices could enable more effective treatment strategies for VVC."

Journal • Preclinical • Candidiasis • Infectious Disease • Vaginitis

Candida Vulvovaginitis Treatment: A Comparative Clinical Trial of Clotrimazole and Prangos Ferulacea (Jashir) Vaginal Creams. (PubMed, Complement Ther Med) - "Prangos ferulacea vaginal cream demonstrated comparable efficacy to clotrimazole in relieving the symptoms and reducing the microbial burden of vulvovaginal candidiasis. Given its herbal origin and antifungal potential, Prangos ferulacea may serve as a natural and well-tolerated alternative or complementary therapy."

Clinical • Journal • Candidiasis • Vaginitis

Comparative Efficacy of Topical Oxiconazole Cream (1%) Versus Topical Clotrimazole Cream (1%) in the Treatment of Tinea CrurisAbstract (clinicaltrials.gov) - P1 | N=386 | Completed | Sponsor: Hayat Abad Medical Complex, Peshawar

New P1 trial • Dermatology

Preparation of novel in situ film-forming gel impregnated with clotrimazole-loaded liquid crystalline nanoparticles: In vitro, ex vivo, in vivo dermatopharmacokinetic and antifungal evaluation. (PubMed, J Pharm Sci) - "Ex vivo skin permeation and skin deposition study demonstrated that CLT-LCNP@FFG showed 3-fold higher skin permeation and 207 % higher CLT deposition in skin layers than a marketed product (CLT-MKT; Canesten, 1% w/w CLT)...The enhanced therapeutic efficacy of CLT-LCNP@FFG was confirmed by in vitro and in vivo antifungal activity experiments. These results showed that this hybrid system could potentially improve the efficacy of antifungal agents and patient compliance in the treatment of fungal infections."

Journal • PK/PD data • Preclinical • Infectious Disease

Clotrimazole Vaginal Cream for the Treatment of Recurrent Vulvovaginal Candidiasis (ChiCTR) - P=N/A | N=30 | Not yet recruiting | Sponsor: Peking University Shenzhen Hospital; Peking University Shenzhen Hospital

New trial • Candidiasis • Inflammation • Pain • Pruritus • Vaginitis

Development and evaluation of clotrimazole microemulsions for topical application: Effects of HLB value of surfactant mixture and cosurfactant type on formulation design. (PubMed, Int J Pharm ) - "The HET-CAM test showed the irritancy on skin of designed clotrimazole-loaded formulation was acceptable compared to the positive control of 0.8 % paraformaldehyde aqueous solution. The stability studies showed that the physicochemical characteristics and residual drug percentage (about 95.3 %) of F2 clotrimazole-loaded formulation were fairly stable after thermodynamic and storage tests, indicating designed microemulsions as a delivery carrier could be considered as a potential strategy for clotrimazole topical dosage form deployment."

Journal • Candidiasis • Dermatology • Vaginitis

Dual-Active Clotrimazole-Methyl Eugenol Topical Gel: In Vitro Antibiofilm Activity Against Candida spp. and Benchmarking versus Commercial Topical Antifungals. (PubMed, J Appl Microbiol) - "In vitro, the clotrimazole-methyl eugenol gel showed low MIC/MBIC50​ values (including against azole-tolerant C. glabrata), maintained cytocompatibility (>85% viability at MIC/MBIC50), and demonstrated robust pharmaceutical attributes, supporting further in vivo validation for biofilm-associated candidiasis."

Journal • Preclinical • Candidiasis

Guava Leaf Extract as a Sustainable Preservative Alternative in Semi-Solid Pharmaceuticals: Efficacy and Stability Assessment. (PubMed, Antibiotics (Basel)) - "Objectives: The aim of this research is to evaluate the efficacy of Psidium guajava (L.) leaf extract as a 10% (w/w) natural preservative in five different base formulations: creams (clotrimazole cream, permethrin cream, and gentamicin cream) and gels (indomethacin emulgel and ibuprofen gel). Certain semi-solid pharmaceuticals can benefit from the stability and antimicrobial protection provided by guava leaf extract, a natural preservative. The weak antifungal activity of the guava leaf extract emphasizes the necessity for specific improvements in the formulation."

Journal

Optimized TPL6 Peptide Gel Exhibits Broad-Spectrum Antimicrobial Activity and Effectively Treats Drug-Resistant Wound Infections in Diabetic Mice. (PubMed, Adv Healthc Mater) - "In ex vivo porcine skin and diabetic mouse wound models infected with MDR Staphylococcus aureus or Candida albicans, TPL6 gel shows superior therapeutic efficacy versus Bacineocin ointment and Canesten 1% cream. Thus, this study shows that structural modification and adjuvant-based formulation of TPL6 can overcome key translational barriers that have hindered clinical application of AMPs, supporting its potential as an antibiotic-free treatment for drug-resistant wound infections."

Journal • Preclinical • Diabetes • Infectious Disease

Comparison of the Effect of Hypericum perforatum Vaginal Gel and Clotrimazole Vaginal Cream on Vaginal Candida albicans Infection: A Double-Blind Randomized Clinical Trial. (PubMed, J Integr Complement Med) - "Further research is needed to explore its potential as an alternative or adjunctive therapy, particularly in specific symptom domains. Moreover, larger non-inferiority trials are required to assess comparative efficacy."

Clinical • Journal • Candidiasis • Gynecology • Infectious Disease • Inflammation • Vaginitis

Topical treatment of sinonasal aspergillosis with combined enilconazole infusion and frontal sinus deposition of clotrimazole cream in two cats. (PubMed, JFMS Open Rep) - "This treatment approach circumvents the need for systemic antifungal therapy, which is often prolonged, costly and potentially associated with toxicity. However, the success rate and tolerance of this method should be evaluated in a larger cohort of cats."

Journal • Anorexia • Inflammation • Pulmonary Disease • Respiratory Diseases

Voriconazole Loaded Spanlastics: Design, Formulation, Optimization, and Randomized Controlled Clinical Insights for Vulvovaginal Candidiasis Therapy. (PubMed, AAPS PharmSciTech) - "Notably, the clinical performance of optimized system gel was involved in a randomized controlled study for assessment of safety and efficacy in comparison to a market product (Canesten® 2% clotrimazole). (2% clotrimazole) exhibited comparable efficacy in terms of clinical satisfaction, side effects, and time to clinical cure from VVC. These findings highlight the potential of the optimized system as a promising approach for improved treatment outcomes in women with vaginal candidiasis with no adverse effects."

Journal • Candidiasis • Vaginitis

Knowledge and usage patterns of clotrimazole vaginal cream and tablet amongst females: a cross-sectional study. (PubMed, Front Pharmacol) - "Inappropriate usage patterns were also observed. These emergent findings have serious implications, particularly regarding the potential for resistance to the medicine."

Journal • Observational data • Candidiasis • Infectious Disease • Vaginitis

Outcomes in dogs with sinonasal aspergillosis treated via sinuscopic debridement and clotrimazole cream application. (PubMed, J Am Vet Med Assoc) - "This technique allowed direct visualization and video-assisted debridement of fungal plaques. Normograde sinoscopy could be considered as a technique to enhance topical treatments for extensive frontal sinus aspergillosis."

Journal • Orthopedics • Pulmonary Disease • Respiratory Diseases

A delayed-melting cryomicroneedle system for probiotic delivery against invasive Candida albicans infection. (PubMed, J Control Release) - "In murine models of invasive candidiasis, LA3-loaded cryoMNs demonstrated superior therapeutic efficacy compared with both topical LA3 gel and clotrimazole cream, with excellent biosafety (> 90 % cell viability, < 5 % hemolysis, and no detectable organtoxicity). By integrating strain-optimized probiotics with biomimetic delivery technology, this platform represents a minimally invasive strategy for treating deep-seated fungal infections."

Journal • Candidiasis • Hematological Disorders • Infectious Disease

A rare report of pediatric hailey-hailey disease (SID 2025) - "Initially treated with hydrocortisone ointment, clotrimazole cream, and hygiene counseling, her symptoms persisted...Treatment was updated to include Tacrolimus 0.1% ointment, Cetirizine, and a three-month course of doxycycline...Early recognition in patients with a positive family history may facilitate timely diagnosis and treatment. This highlights the importance of a proactive approach to evaluating hereditary conditions in pediatric patients."

Clinical • Dermatology • Genetic Disorders • Pain • Pediatrics • Pruritus

Vaginal Royal Jelly for Vulvovaginal Candidiasis Treatment: A Randomized Clinical Trial. (PubMed, Adv Biomed Res) - "Positive vaginal culture individuals were randomly allocated to receive either vaginal 1000 mg RJ soft gel capsules or (2%) Clotrimazole cream (45 participants per group)...Moreover, most patients in both groups became asymptomatic post-treatment. The present study points out the therapeutic effects of vaginal RJ, a novel natural drug for improving VVC."

Clinical • Journal • Candidiasis • Vaginitis

Computed Tomographic and Magnetic Resonance Imaging Diagnosis of Concurrent Sinonasal Aspergillosis and Meningoencephalocele in a Dog. (PubMed, Case Rep Vet Med) - "The dog had a history of seizures starting at 1 year of age that were controlled with phenobarbital...Rhinoscopy was performed to collect diagnostic samples, debride fungal plaques, and guide clotrimazole cream application...Postoperatively, the patient was treated with a short course of oral posaconazole...Despite the large cribriform plate defect resulting in exposure of the meninges and olfactory bulb, repeated debridement and topical antifungal treatment were well tolerated by this patient. There was no recurrence in signs for 3 years, after which the dog was lost to follow-up."

Journal • CNS Disorders • Epilepsy • Hematological Disorders • Inflammation • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Sinusitis

Efficacy and Safety of Clotrimazole+Lactulose Vaginal Suppositories Vs. Clotrimazole Monotherapy in Adult Women with Candidal Vaginitis/Vulvovaginitis (clinicaltrials.gov) - P2/3 | N=264 | Recruiting | Sponsor: AVVA Pharmaceuticals Ltd.

New P2/3 trial • Candidiasis • Gynecology • Vaginitis

Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial. (PubMed, Front Dent) - "In the first group, G. lucidum extract was administered in the form of 5% gel while 1% clotrimazole gel was prescribed for the second group...Thus, Ganoderma may be regarded as an alternative treatment, especially in patients' resistant to azoles. Nonetheless, further clinical studies are required to shed more light on this topic."

Clinical • Journal • Dental Disorders • Pain • Stomatitis

Comparing the effects of Mycozin and Clotrimazole 1% creams on vaginal candidiasis: a triple-blinded randomized controlled trial. (PubMed, Sci Rep) - "Considering the efficacy of Mycozin vaginal cream in eliminating most of the symptoms and signs associated with vaginal candidiasis and its positive effect in negating the results of culture, it can be used as a suitable alternative in the treatment of vaginal candidiasis in patients interested in herbal medicines and resistant to azole compounds.Trial registration: Iranian Registry of Clinical Trials (IRCT): IRCT20120718010324N77. Date of registration: 20/05/2023; URL: https://irct.behdasht.gov.ir/user/trial/68718/view ; Date of first registration: 31/05/2023."

Clinical • Journal • Candidiasis • Vaginitis