clotrimazole topical / Generic mfg. - LARVOL DELTA

Optimized TPL6 Peptide Gel Exhibits Broad-Spectrum Antimicrobial Activity and Effectively Treats Drug-Resistant Wound Infections in Diabetic Mice. (PubMed, Adv Healthc Mater) - "In ex vivo porcine skin and diabetic mouse wound models infected with MDR Staphylococcus aureus or Candida albicans, TPL6 gel shows superior therapeutic efficacy versus Bacineocin ointment and Canesten 1% cream. Thus, this study shows that structural modification and adjuvant-based formulation of TPL6 can overcome key translational barriers that have hindered clinical application of AMPs, supporting its potential as an antibiotic-free treatment for drug-resistant wound infections."

Journal • Preclinical • Diabetes • Infectious Disease

Comparison of the Effect of Hypericum perforatum Vaginal Gel and Clotrimazole Vaginal Cream on Vaginal Candida albicans Infection: A Double-Blind Randomized Clinical Trial. (PubMed, J Integr Complement Med) - "Further research is needed to explore its potential as an alternative or adjunctive therapy, particularly in specific symptom domains. Moreover, larger non-inferiority trials are required to assess comparative efficacy."

Clinical • Journal • Candidiasis • Gynecology • Infectious Disease • Inflammation • Vaginitis

Topical treatment of sinonasal aspergillosis with combined enilconazole infusion and frontal sinus deposition of clotrimazole cream in two cats. (PubMed, JFMS Open Rep) - "This treatment approach circumvents the need for systemic antifungal therapy, which is often prolonged, costly and potentially associated with toxicity. However, the success rate and tolerance of this method should be evaluated in a larger cohort of cats."

Journal • Anorexia • Inflammation • Pulmonary Disease • Respiratory Diseases

Voriconazole Loaded Spanlastics: Design, Formulation, Optimization, and Randomized Controlled Clinical Insights for Vulvovaginal Candidiasis Therapy. (PubMed, AAPS PharmSciTech) - "Notably, the clinical performance of optimized system gel was involved in a randomized controlled study for assessment of safety and efficacy in comparison to a market product (Canesten® 2% clotrimazole). (2% clotrimazole) exhibited comparable efficacy in terms of clinical satisfaction, side effects, and time to clinical cure from VVC. These findings highlight the potential of the optimized system as a promising approach for improved treatment outcomes in women with vaginal candidiasis with no adverse effects."

Journal • Candidiasis • Vaginitis

Knowledge and usage patterns of clotrimazole vaginal cream and tablet amongst females: a cross-sectional study. (PubMed, Front Pharmacol) - "Inappropriate usage patterns were also observed. These emergent findings have serious implications, particularly regarding the potential for resistance to the medicine."

Journal • Observational data • Candidiasis • Infectious Disease • Vaginitis

Outcomes in dogs with sinonasal aspergillosis treated via sinuscopic debridement and clotrimazole cream application. (PubMed, J Am Vet Med Assoc) - "This technique allowed direct visualization and video-assisted debridement of fungal plaques. Normograde sinoscopy could be considered as a technique to enhance topical treatments for extensive frontal sinus aspergillosis."

Journal • Orthopedics • Pulmonary Disease • Respiratory Diseases

A delayed-melting cryomicroneedle system for probiotic delivery against invasive Candida albicans infection. (PubMed, J Control Release) - "In murine models of invasive candidiasis, LA3-loaded cryoMNs demonstrated superior therapeutic efficacy compared with both topical LA3 gel and clotrimazole cream, with excellent biosafety (> 90 % cell viability, < 5 % hemolysis, and no detectable organtoxicity). By integrating strain-optimized probiotics with biomimetic delivery technology, this platform represents a minimally invasive strategy for treating deep-seated fungal infections."

Journal • Candidiasis • Hematological Disorders • Infectious Disease

A rare report of pediatric hailey-hailey disease (SID 2025) - "Initially treated with hydrocortisone ointment, clotrimazole cream, and hygiene counseling, her symptoms persisted...Treatment was updated to include Tacrolimus 0.1% ointment, Cetirizine, and a three-month course of doxycycline...Early recognition in patients with a positive family history may facilitate timely diagnosis and treatment. This highlights the importance of a proactive approach to evaluating hereditary conditions in pediatric patients."

Clinical • Dermatology • Genetic Disorders • Pain • Pediatrics • Pruritus

Vaginal Royal Jelly for Vulvovaginal Candidiasis Treatment: A Randomized Clinical Trial. (PubMed, Adv Biomed Res) - "Positive vaginal culture individuals were randomly allocated to receive either vaginal 1000 mg RJ soft gel capsules or (2%) Clotrimazole cream (45 participants per group)...Moreover, most patients in both groups became asymptomatic post-treatment. The present study points out the therapeutic effects of vaginal RJ, a novel natural drug for improving VVC."

Clinical • Journal • Candidiasis • Vaginitis

Computed Tomographic and Magnetic Resonance Imaging Diagnosis of Concurrent Sinonasal Aspergillosis and Meningoencephalocele in a Dog. (PubMed, Case Rep Vet Med) - "The dog had a history of seizures starting at 1 year of age that were controlled with phenobarbital...Rhinoscopy was performed to collect diagnostic samples, debride fungal plaques, and guide clotrimazole cream application...Postoperatively, the patient was treated with a short course of oral posaconazole...Despite the large cribriform plate defect resulting in exposure of the meninges and olfactory bulb, repeated debridement and topical antifungal treatment were well tolerated by this patient. There was no recurrence in signs for 3 years, after which the dog was lost to follow-up."

Journal • CNS Disorders • Epilepsy • Hematological Disorders • Inflammation • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Sinusitis

Efficacy and Safety of Clotrimazole+Lactulose Vaginal Suppositories Vs. Clotrimazole Monotherapy in Adult Women with Candidal Vaginitis/Vulvovaginitis (clinicaltrials.gov) - P2/3 | N=264 | Recruiting | Sponsor: AVVA Pharmaceuticals Ltd.

New P2/3 trial • Candidiasis • Gynecology • Vaginitis

Antifungal Efficacy of Ganoderma lucidum and Clotrimazole for Treatment of Denture Stomatitis: A Randomized Clinical Trial. (PubMed, Front Dent) - "In the first group, G. lucidum extract was administered in the form of 5% gel while 1% clotrimazole gel was prescribed for the second group...Thus, Ganoderma may be regarded as an alternative treatment, especially in patients' resistant to azoles. Nonetheless, further clinical studies are required to shed more light on this topic."

Clinical • Journal • Dental Disorders • Pain • Stomatitis

Comparing the effects of Mycozin and Clotrimazole 1% creams on vaginal candidiasis: a triple-blinded randomized controlled trial. (PubMed, Sci Rep) - "Considering the efficacy of Mycozin vaginal cream in eliminating most of the symptoms and signs associated with vaginal candidiasis and its positive effect in negating the results of culture, it can be used as a suitable alternative in the treatment of vaginal candidiasis in patients interested in herbal medicines and resistant to azole compounds.Trial registration: Iranian Registry of Clinical Trials (IRCT): IRCT20120718010324N77. Date of registration: 20/05/2023; URL: https://irct.behdasht.gov.ir/user/trial/68718/view ; Date of first registration: 31/05/2023."

Clinical • Journal • Candidiasis • Vaginitis

Formulation of Emulgels Containing Clotrimazole for the Treatment of Vaginal Candidiasis. (PubMed, Gels) - "Moreover, in vitro release studies revealed sustained drug release profiles, which can be adjusted by varying the ratios of poloxamers and HPMC. These findings suggest that the developed emulgels offer a promising therapeutic option for vaginal candidiasis, addressing both the symptoms and the treatment of discomfort."

Journal • Candidiasis • Vaginitis

Treatment of mycotic rhinitis caused by aspergillus fumigatus in a quarter horse mare using topical clotrimazole and oral potassium iodide. (PubMed, Vet Res Commun) - "For the treatment, topical application of clotrimazole ointment was carried out in the rostral portion of the nasal cavity once a day and in the caudal portion of the nasal cavity, endoscopic guided every 48 h...The combination of clotrimazole and potassium iodide effectively treated fungal rhinitis in a shorter time than previously reported. This report provides useful guidance for other cases of fungal rhinitis, although further studies are needed."

Journal • Dermatology • Eosinophilia • Immunology • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases

Comparison of Recovery Rate of Otomycosis using One-Percent Gentian Violet and One-Percent Clotrimazole Topical Treatment. (PubMed, J Nepal Health Res Counc) - "Clotrimazole was more effective in treatment of otomycosis compared to Gentian Violet paint, though the result was not statistically significant."

Clinical • Journal • Infectious Disease • Otorhinolaryngology

Efficacy of Pyodine Soaked Gelfoam vs Single Topical Application of Clotrimazole in Treatment of Otomycosis: A Randomized Controlled Clinical Trial. (PubMed, Indian J Otolaryngol Head Neck Surg) - "In terms of treatment response 19(46.34%) patients in Group A and 21(51.21%) patients in Group B showed good treatment response at the end of 2nd post-treatment week with a p-value of 0.798. yodine-soaked gel foam placement in the external auditory canal is a safe and effective method for the treatment of otomycosis with the efficiency of this method comparable to a single topical clotrimazole ointment application."

Clinical • Journal • Diabetes • Metabolic Disorders • Otorhinolaryngology • Pruritus

Recurrent refractory candidal balanoposthitis on treatment with the antidiabetic agent: sodium-glucose cotransporter 2 inhibitor (SGLT2 inhibitor) (EADV 2024) - "He was treated with oral Itraconazole 200 mg once daily and topical 1% Clotrimazole cream...Teneligliptin/canagliflozin combination tablets were discontinued because the penile symptoms did not improve in spite of long-term antifungal therapies... SGLT2 inhibitors are prescribed more frequently in DM because of their effect on weight loss, a reduction in blood pressure, and favorable cardiovascular outcomes. However, they have a higher risk of genital mycotic infections compared with other hypoglycemic agents. Although topical therapy is usually sufficient in most cases of candidal balanoposthitis, it sometimes becomes incurable without the withdrawal of SGLT2 inhibitors like in our case."

Candidiasis • Cardiovascular • Dermatology • Human Immunodeficiency Virus • Infectious Disease • Metabolic Disorders • Mycosis Fungoides

Lichenoid drug eruption in children (EADV 2024) - "Before presenting to our facility, he sought medical treatment at a local facility where he initially received topical clotrimazole cream, with no relief. A week later lesions were progressing and subsequently, he received ceftriaxone, metronidazole, paracetamol and cetirizine, he reported improvement in pruritus but no regression in the lesions...The patient was started on topical clobetasol ointment 0.05% for the body and betamethasone ointment 0.1% for the face... In our setting, diagnosis of Lichenoid drug eruption can be challenging due to the limited number of dermatologists in the country, especially in rural areas, where patients are seen by clinical officers with little knowledge in dermatological conditions. Hence medical personnel at primary health care level need to be able to take a comprehensive clinical, medical, and drug history as well as physical examination to aid in distinguishing lichenoid drug eruption from other papulosquamous disorders, even when..."

Clinical • Dermatopathology • Infectious Disease • Lichen Planus • Pain • Pruritus • Respiratory Diseases

A Case Report With Dual Diagnosis of Candidiasis in a Patient With Uncontrolled Diabetes Mellitus. (PubMed, Cureus) - "The oral lesions were treated using the local application of clotrimazole gel and the discomfort subsided with Aceclofenac. The underlying condition was treated by a general physician who prescribed the tablet metformin 500mg. The patient was educated about the predisposing condition, and motivated to make some lifestyle changes and to maintain a proper diet."

Journal • Candidiasis • Diabetes • Infectious Disease • Metabolic Disorders

Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension. (PubMed, AAPS PharmSciTech) - "Using the Box-Behnken Design, a systematic evaluation was conducted toanalyze the impact of inlet temperature, % aspiration, and feed rate on the criticalquality attributes (CQAs) of the clotrimazole spray-dried nanosuspension (CLT-SDNS)...In vitrodissolution studies showed improved dissolution rates for the CLT-SD-NS (3.12-foldincrease in DI water and 5.88-fold increase at pH 7.2 dissolution media), attributed torapidly redispersing nanosized amorphous CLT particles. The well-designed studyutilizing the Design of Experiments (DoE) methodology."

Journal

Evaluation of the Therapeutic Effect of 15 ppm Silver Nanoparticle Spray Compared to Clotrimazole 1% on Candida Vaginitis: A Randomized Controlled Clinical Trial. (PubMed, J Family Reprod Health) - "Therefore, this study evaluated the therapeutic effect of silver nanoparticles (Nivasha spray15ppm) compared to clotrimazole 1% vaginal cream on candida vaginitis...Nivasha spray had more effectiveness compared to the clotrimazole 1%. Therefore, it can be used as an alternative drug in the treatment of Candida vaginitis."

Clinical • Journal • Gynecology • Vaginitis

Coated Microneedle System for Delivery of Clotrimazole in Deep-Skin Mycoses. (PubMed, Gels) - "From the analysis of the data, the MNs coated with CLO dissolved in hydrogel showed better antifungal activity. All received results seem to be helpful in developing further studies for MNs as carriers of antifungal substances."

Journal • Dermatology • Infectious Disease

Efficacy of Pyodine Soaked Gelfoam vs Single Topical Application of Clotrimazole in Otomycosis Treatment (clinicaltrials.gov) - P1 | N=90 | Completed | Sponsor: Rawalpindi Medical College

New P1 trial • Otorhinolaryngology

Efficacy of 1% Clotrimazole Powder Monotherapy for Treating Tinea Cruris: A Comparative Randomized Study. (PubMed, Mil Med) - "Monotherapy with 1% clotrimazole powder showed comparable efficacy to 1% clotrimazole cream. Furthermore, the powder treatment reduced sweat more effectively compared to the cream."

Journal • Monotherapy • Dermatology