GFH276 / GenFleet Therap - LARVOL DELTA

GFH276: A molecular glue panRAS(on) inhibitor with broad spectrum anti-tumor activities (AACR 2025) - "Compared to SIIP-based KRAS G12C inhibitors Sotorasib, Adagrasib and Divarasib, GFH276 was not susceptible to upstream RTK-reactivation by EGF stimulation and remained effective against cell lines carrying second KRAS mutations or RTK alterations or with induced resistance to Sotorasib. GFH276 demonstrated strong therapeutic activities in tumors with activating RAS and RTK alterations. Encouraged by these promising results, we are advancing GFH276 into the Phase 1 clinical trial by conducting IND-enabling studies and the IND submission is planned in Q2 2025."

Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • BRAF • EGFR • FGFR2 • HRAS • KRAS • NRAS