ELI-004 / Elicio Therap - LARVOL DELTA

Amphiphile (AMP)-Immunomodulator therapy controls growth and eradicates syngeneic solid tumors (SITC 2025) - P1, P1/2 | "Amphiphile (AMP)-CpG-7909 (ELI-004) is an ideal candidate in this context, as it has been designed to enhance tumor tissue retention by anchoring into cell membranes via its lipophilic AMP-tail.1 ELI-004 has been evaluated in multiple phase 1/2 trials (NCT04853017/NCT05726864) as part of an AMP-CpG-7909-adjuvanted peptide immunotherapy targeting mutant KRAS antigens (ELI-002). On day 42, ten days after the therapy phase concluded, tumor growth remained well controlled with 25% of mice achieving complete response and long-term non-progression, and no mice reaching euthanasia criteria. The 5 nmol AMP-CpG-7909 in situ treatment was well tolerated with no adverse safety observations.Conclusions Overall, these results demonstrate the potential for AMP-immunomodulators as promising off-the-shelf agents for in situ immunotherapy that is not patient-restricted or limited to specific tumor mutations and can induce potent cellular immune responses to control tumor growth."

Immunomodulating • IO biomarker • Oncology • Solid Tumor • KRAS

Title: Amphiphile (AMP)-Immunomodulator therapy controls growth and eradicates syngeneic solid tumors (GlobeNewswire) - "Elicio Therapeutics reports...new ELI-004 preclinical data at SITC....Therapeutic treatment of established solid tumors in mice with intratumoral ELI-004 induced complete eradication of tumors in >90% of cases; complete responders were protected from subsequent tumor recurrence 3-5 months following initial therapy suggesting robust development of immunological memory."

Preclinical • Solid Tumor

Elicio Therapeutics to Present…Preclinical Data at the SITC 2025 Annual Meeting (GlobeNewswire) - "...Preclinical data from ELI-004 for the treatment of advanced solid tumors...accepted [as] poster presentations at the Society for Immunotherapy of Cancer’s ('SITC') 40th Anniversary Annual Meeting."

Preclinical • Solid Tumor