folate-conjugated rapamycin (EC0371) / Novartis - LARVOL DELTA

Rapamycin-sensitive mTORC1 signaling in the medial prefrontal cortex contributes to the antidepressant-like behavioral effects of shikimic acid in mice. (PubMed, Life Sci) - "These findings suggest that SA exerts antidepressant-like effects via rapamycin-sensitive mTORC1-dependent mechanisms within the mPFC. Our results support SA as a candidate compound targeting mPFC mTORC1-related signaling for novel rapid-acting antidepressants."

Journal • Preclinical • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease. (PubMed, Am J Physiol Renal Physiol) - "However, FC-rapa lacks the extra-renal effects of unconjugated rapamycin, in particular immunosuppressive effects. We conclude that folate-conjugation is a promising avenue for increasing the tissue specificity of small-molecule compounds to facilitate very long-term treatment in ADPKD."

Journal • Preclinical