cimetidine / Generic mfg. - LARVOL DELTA

Pseudomonas plecoglossicida disrupts intestinal homeostasis through manipulation of palmitoleic acid microbial metabolism. (PubMed, NPJ Biofilms Microbiomes) - "Although no key bacteria linked to tryptophan-derived metabolite metabolism were detected, we identified three microbiota members and several metabolites, including cimetidine, palmitoleic acid (PA), 16-hydroxypalmitate, imidazoleacetic acid, quinolinic acid, and glycerol, associated with homeostasis disruption...Exogenous PA supplementation mitigated infection-induced appetite loss, restored microbial balance, and improved epithelial integrity. These findings reveal that non-intestinal pathogens can disturb gut homeostasis and promote SAA via reduced PA levels, suggesting dietary PA supplementation as a potential therapeutic strategy to enhance appetite and recovery in infected fish."

Journal • Anorexia • Infectious Disease

Drug-Induced Thrombocytopenia from Proton Pump Inhibitors and H₂ Blockers: A Systematic Review and Comparative Analysis of Published Case Reports (THSNA 2026) - "Representative PPI reports (pantoprazole, lansoprazole, omeprazole/esomeprazole) and classical H₂RA reports (cimetidine, ranitidine, famotidine) were abstracted for onset (days), recovery (days), bleeding and ICU status. Case-level evidence indicates both PPIs and H₂RAs can cause abrupt, reversible thrombocytopenia with onset within days and recovery within 1–2 weeks; PPI reports show a trend toward earlier onset and higher bleeding documentation. Findings are limited by reporting bias and small numbers; prospective pharmacovigilance and mechanistic testing are needed to confirm class-specific risks. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author."

Case report • Clinical • Review • Hematological Disorders • Thrombocytopenia

Potentially inappropriate medication use in older adult patients living with cancer using the Beers, STOPP, GO-PIM and Chinese criteria: A retrospective cross-sectional study. (PubMed, Medicine (Baltimore)) - "The drugs with the highest incidence were metoclopramide, medroxyprogesterone, and cimetidine. The consistency between the 2023 STOPP criteria and the 2024 Chinese criteria was moderate (κ = 0.448), but with the GO-PIM scale was poor (κ = 0.345). The results of multiple logistic regression analysis showed that polypharmacy was the main influencing factor for the occurrence of PIMs in all criteria (P<.001)."

Journal • Observational data • Retrospective data • Oncology

IL3RA identified as novel biomarker and therapeutic target for ER+ breast cancer through plasma proteome-wide mendelian randomization and TCGA database analysis. (PubMed, Clin Proteomics) - "Our study identified IL3RA as novel biomarker and therapeutic target for ER+ breast cancer. Further validation and mechanistic studies are warranted to advance precision oncology strategies for ER+ breast cancer management."

Biomarker • Journal • Breast Cancer • Estrogen Receptor Positive Breast Cancer • Hormone Receptor Breast Cancer • Oncology • Solid Tumor • CD123 • CD8 • ER • IL3RA

Toxicity profile of supratherapeutic loperamide: a systematic review and dose-response analysis. (PubMed, Clin Toxicol (Phila)) - "Purposeful co-ingestion of substances in order to increase loperamide exposure was reported in 5% cases (n = 6, all cimetidine). Patients presenting with supratherapeutic loperamide exposure appear to be at high risk for life-threatening dysrhythmias, and close cardiac monitoring should be broadly considered in this population. Management options include appropriate antiarrhythmic and cardiocirculatory support measures."

Journal • Review • Addiction (Opioid and Alcohol) • Cardiovascular • Ventricular Tachycardia

Unilateral Fractionated Thoracic Irradiation Induces Abscopal Injury in Contralateral Lung through NF-κB Pathway. (PubMed, Radiat Res) - "Therapeutic inhibition of NF-κB, as well as administration of cimetidine, markedly mitigated radiation-induced pneumonitis and fibrosis in the contralateral lung. These results demonstrate that abscopal lung injury following unilateral irradiation may be driven by increased macrophages, offering novel mechanistic insight and a potential treatment for lung injury associated with thoracic radiotherapy."

Journal • Fibrosis • Immunology • Inflammation • Pneumonia • Respiratory Diseases

Association Between Long-term Use of H2 Receptor Antagonists and Prostate Cancer Risk: A Case-Control Study in Taiwan. (PubMed, J Cancer) - " These findings suggest that long-term use of cimetidine and ranitidine may increase prostate cancer risk in older men, while famotidine was not associated with prostate cancer risk. Risk varies by age and drug type, highlighting the need for drug-specific evaluation in cancer pharmacoepidemiology."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

The Potential Impact of Histamine-2 Receptor Antagonists on Gynecologic Cancer Risk: A Population-Based Study of 23 Million Individuals. (PubMed, Cancer Epidemiol Biomarkers Prev) - "Findings support repurposing H2RAs as accessible chemopreventive candidates for further translational application in women."

Journal • Cervical Cancer • Endometrial Cancer • Gynecologic Cancers • Oncology • Ovarian Cancer • Solid Tumor

Colchicine prophylaxis in pediatric PFAPA: a systematic review. (PubMed, Eur J Pediatr) - "Colchicine reduced attack frequency, lengthened attack-free intervals, and lowered steroid use, with benefits often within 1 month. A short randomized comparison showed similar 3-month efficacy to cimetidine. Adverse events were mostly mild gastrointestinal; discontinuations were uncommon. MEFV variants as predictors of response remain uncertain. Current evidence supports colchicine as an efficacy and generally well-tolerated preventive option."

Journal • Review • Dental Disorders • Gastrointestinal Disorder • Genetic Disorders • Inflammation • Pediatrics • Stomatitis

Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice. (PubMed, CNS Neurosci Ther) - "These findings highlight the HAergic system as a critical regulator of alcohol-related behaviors. The LHb HA signaling and norepinephrine neurotransmission might underlie pitolisant's potential novel therapeutic strategy for AUD."

Journal • Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Mood Disorders • Psychiatry

New pharmacotherapies for the erythropoietic protoporphyrias: an analysis of trial protocols from a patient perspective. (PubMed, Orphanet J Rare Dis) - No abstract available

Journal • Genetic Disorders • Metabolic Disorders • Rare Diseases

Use of cimetidine to enhance systemic acyclovir concentrations in patients with ineffective suppressive therapy for recurring herpes simplex virus infections: A novel purpose for an old drug. (PubMed, Br J Clin Pharmacol) - "We report a series of patients nonresponsive to suppressive valacyclovir therapy, explained by subtherapeutic acyclovir plasma levels. After a dose increase, or in some patients only after concomitant prescription of cimetidine, adequate levels were reached associated with significant clinical improvement."

Journal • Herpes Simplex • Infectious Disease

Mitogenomic analysis and phylogenetic implications for the Deltocephalinae (Hemiptera: Cicadellidae). (PubMed, Invertebr Syst) - "Included members of the following tribes were consistently monophyletic: Athysanini, Chiasmini, Deltocephalini, Drabescini, Macrostelini, Paralimnini, Penthimiini, Scaphoideini and Stenometopiini. Consistent with other recent analyses, Fieberiellini, Goniagnathini and Penthimiini are early diverging lineages within Deltocephalinae. Overall, our results indicate that complete mitogenome sequences provide robust data for phylogenetic reconstruction."

Journal

Asparaginase-Associated Toxicities and Hypersensitivity Reactions in Pediatric and Adolescent Down Syndrome Patients with Acute Lymphoblastic Leukemia or Lymphoma (ASH 2023) - "Pegaspargase (PEG) is integral in protocols for the treatment of pediatric ALL and lymphoblastic lymphoma (LBL), and full exposure to all doses of PEG can be limited by toxicities, including hypersensitivity reactions (HSR) due to the production of anti-asparaginase antibodies rendering PEG therapy ineffective...An H1 blocker (diphenhydramine) and H2 blocker (ranitidine, famotidine or cimetidine) were administered prior to PEG administration in consolidation and subsequent cycles...Most toxicity occurred during the consolidation phase and no grade 4 or 5 toxicities were observed. Given the PEG-associated toxicity observed in DS ALL/LBL, we are conducting pharmacokinetic analysis to propose a lower dose of PEG which may minimize toxicity while maintaining therapeutic efficacy."

Clinical • Acute Lymphocytic Leukemia • Developmental Disorders • Genetic Disorders • Hematological Malignancies • Hepatology • Immunology • Leukemia • Lymphoma • Obesity • Oncology • Pediatrics

Glomerulus-Tubule Integrated Kidney-on-a-Chip Platform for Preclinical Evaluation of Chemotherapy-Induced Nephrotoxicity and Therapeutic Interventions (KIDNEY WEEK 2025) - "Nephrotoxicity was modeled by applying chemotherapeutic agents known to preferentially affect specific nephron segments: Cisplatin and Oxaliplatin predominantly affecting the tubule, and Sunitinib primarily targeting the glomerulus, each for 48 hours. Cimetidine, a tubule-protective agent, and Sildenafil, a glomerulus-targeted therapeutic, were administered to evaluate potential protective effects...Conclusion This study developed an integrated glomerulus-tubule kidney-on-a-chip and established chemotherapy-induced nephrotoxicity models. Therapeutic effects were experimentally validated using the chip, which shows promise as a preclinical tool for toxicity and drug efficacy evaluation."

Preclinical • Nephrology • AQP1

EGLN1-Positive Familial Erythrocytosis: A Rare Variant with an Unusually Aggressive Clinical Course (ASH 2024) - "These symptoms do not respond to cimetidine or hydroxyzine but are partially controlled to HCT targets well below 45%, with the best symptom relief at 38-40%.Furthermore, he has subsequently developed idiopathic inflammatory polyarthritis and interstitial pulmonary disease with exhaustive work up by rheumatology and pulmonology, respectively, returning negative for specific cause.ConclusionsThis case is the first clinical characterization of EGLN1 c.494del p(Pro165Glnfs*9) positive familial erythrocytosis. His refractory symptoms despite optimal hematologic control suggest that HCT level may be an inadequate indicator of disease control in familial erythrocytosis. As recognition, awareness, and testing of congenital JAK2 negative erythrocytosis increases, further research is needed to characterize the genotype and phenotype correlation for variants of this rare condition."

Clinical • Cardiovascular • Dermatology • Dyslipidemia • Fatigue • Fibrosis • Hematological Disorders • Immunology • Inflammatory Arthritis • Interstitial Lung Disease • Metabolic Disorders • Polycythemia Vera • Pruritus • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Rheumatology • Thrombosis • Venous Ulcer • CALR • EGLN1 • JAK2

Treatment of Dapsone-Induced Methemoglobinemia in a Transplant Recipient With Isosulfan Blue Allergy (ACG 2025) - "1 month post-LT, pneumocystis jirovecii pneumonia (PJP) prophylaxis was switched from sulfamethoxazole/trimethoprim (SMZ/TMP) to dapsone due to renal impairment...Dapsone was switched to atovaquone, which was not tolerated due to nausea; and was restarted 21 days later. Other medications included tacrolimus, cellcept and valcyte...Cimetidine use was weighed with balancing the risks for kidney injury due to acute interstitial nephritis with recent KT with improvement in MethHb.Figure: Figure 1. Methemoglobin Level after Cimetidine Initiation*Day of Cimetidine 400mg TID for 5 days initiation"

Clinical • Allergy • Anemia • Fatigue • Fibrosis • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Leukopenia • Metabolic Dysfunction-Associated Steatohepatitis • Nephrology • Pneumonia • Pulmonary Disease • Renal Disease • Respiratory Diseases • Transplantation • G6PD • HP

Erythema Annulare Centrifugum: A Dermatologic Suspicion for Malignancy (ACG 2025) - "Although the pathogenesis of EAC is not currently fully understood, it is commonly characterized as a hypersensitivity reaction that occurs in congruence with a multitude of different entities: infectious diseases (viruses, bacteria and parasites) and drugs (chloroquine, cimetidine, aceclofenac). It is of utmost importance for the PCP to recognize this malignant association, relay the importance of proper cancer screening, and refer the patient for a prompt dermatology follow-up. With an early detection of PEACE, the underlying cancer can be detected at an earlier stage of the disease ultimately resulting in a better long-term prognosis for the patient.Figure: Paraneoplastic Erythema Annulare Centrifugum Eruption shown on the torso from the initial presentationFigure: Resolution of previously seen Paraneoplastic Erythema Annulare Centrifugum Eruption after resection of his colorectal adenocarcinoma (as evidenced by abdominal surgical scar)"

Colorectal Adenocarcinoma • Colorectal Cancer • Dermatology • Immunology • Infectious Disease • Oncology • Solid Tumor

Structural basis of drug recognition by human MATE1 transporter. (PubMed, Nat Commun) - "To understand the molecular basis of drug recognition by hMATE1, we determined cryo-electron microscopy structures of the transporter in complex with the substrates 1-methyl-4-phenylpyridinium (MPP) and metformin and with the inhibitor cimetidine. Molecular dynamics simulations provide insights into the different binding modes and dynamic behaviour of the ligands within the pocket. Collectively, these findings define the structural basis of hMATE1 substrate specificity and shed light on its role in drug transport and drug-drug interactions."

Journal

Risk of Drug Induced Liver Injury with Use of Avacopan in ANCA Vasculitis - Results from Real-World Data (ACR Convergence 2025) - "Additionally, avacopan group had significantly higher use CYP3A4 inhibitors including itraconazole, ketoconazole, fluconazole, posaconazole, voriconazole, nirmatrelvir, ritonavir, amiodarone, diltiazem, cimetidine, and cyclosporine (all p < 0.05) (Table 2). In this matched cohort analysis, the incidence of DILI was low and comparable between patients treated with avacopan and those who were not. While no significant difference was observed, the limited number of events precludes definitive conclusions regarding comparative risk."

Clinical • Real-world • Real-world evidence • ANCA Vasculitis • Cardiovascular • Diabetes • Hepatology • Hypertension • Immunology • Infectious Disease • Inflammation • Liver Failure • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Vasculitis

A rare case of hyperuricemia and acute kidney injury in a kidney transplant patient. (PubMed, Pediatr Nephrol) - "Subsequently, her uric acid remained low, suggesting the cessation of cimetidine maintained her baseline uric acid level. This case highlights the significance of monitoring uric acid levels post-transplant and the importance of attention to potential drug interactions."

Journal • Acute Kidney Injury • Dermatology • Dyslipidemia • Genetic Disorders • Metabolic Disorders • Nephrology • Obesity • Pediatrics • Renal Disease • Transplantation

Putative new biomarkers for renal transporter-mediated drug-drug interactions: Characterization as substrates of organic cation transporter 2, multidrug and toxin extrusion protein 1, and other important drug transporters. (PubMed, Drug Metab Dispos) - "Recently, we demonstrated that treatment with cimetidine, a classical OCT/MATE-inhibitor, decreased the renal excretion of serotonin, tyramine, 1-methylhistamine, 5-amino valeric acid betaine, and 4-guanidinobutanoic acid in humans...These transport proteins are known as important contributors to clinically observed drug-drug interactions. Of the respective 5 compounds, serotonin and 1-methylhistamine are the most promising candidates to be further investigated as biomarkers for interactions via OCT2/MATE1, which could improve drug-drug interaction assessment during clinical drug development."

Biomarker • Journal • Nephrology • SLC22A2

Perioperative Management of GLP-1 Receptor Agonists: A Review of U.S. vs International Guidelines (ASA 2025) - "Additionally, guidelines from France, Australia, and New Zealand advise perioperative administration of pharmacological agents, such as erythromycin, cimetidine with citrate, or other prokinetics to mitigate aspiration risk. The 2024 ASA guidelines recommend that GLP-1 RAs may be continued uninterrupted during the perioperative period for low-risk patients. Low-risk patients are defined as asymptomatic individuals who are in the maintenance phase of dosing, receiving lower or daily doses, and who lack additional risk factors for delayed gastric emptying. International guidelines vary considerably regarding the timing, necessity, risk stratification, and risk mitigation strategies associated with perioperative management of GLP-1 RAs."

Review • Anesthesia • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Use of cimetidine to enhance systemic acyclovir concentrations in patients with ineffective suppressive therapy for recurring herpes simplex virus infections: A novel purpose for an old drug. (PubMed, Br J Clin Pharmacol) - "We report a series of patients nonresponsive to suppressive valacyclovir therapy, explained by subtherapeutic acyclovir plasma levels. After a dose increase, or in some patients only after concomitant prescription of cimetidine, adequate levels were reached associated with significant clinical improvement."

Journal • Herpes Simplex • Infectious Disease

Function of histamine-driven cancer-associated fibroblast and hepatocyte growth factor in the progression of cholangiocarcinoma. (PubMed, Gastroenterol Rep (Oxf)) - "HIF-1α and FOSL1 played crucial roles in driving the proliferation, invasion, and migration of cholangiocarcinoma cells within the tumor microenvironment, orchestrated by CAFs. Furthermore, this study has provided theoretical support for the application of the HA receptor HRH2 inhibitor, Cimetidine, and the HGF receptor cellular mesenchymal-epithelial transition factor (c-MET) inhibitor, Capmatinib, in biliary tract tumors."

Journal • Biliary Cancer • Biliary Tract Cancer • Cholangiocarcinoma • Oncology • Solid Tumor • CAFs • FOSL1 • HGF • HIF1A • HRH2 • MET • MMP10