cimetidine / Generic mfg. - LARVOL DELTA

Cloning of a novel cyanobacterial serotonin N-acetyltransferase gene CySNAT3 and its integration with transcriptomic drug repurposing in pediatric obstructive sleep-disordered breathing. (PubMed, Front Pharmacol) - "Cimetidine and diethylstilbestrol have been experimentally linked to the melatonin pathway, suggesting that these four drugs may act through modulation of melatonin signaling. This study provides a new molecular foundation for pediatric oSDB treatment by integrating a novel cyanobacterial SNAT enzyme tool with transcriptome-derived drug candidates."

Journal • CNS Disorders • Pediatrics • Sleep Disorder • CYP2C19 • WNT7A

Pharmacokinetic and safety interactions between aildenafil and clarithromycin, cimetidine, or rifampin in healthy subjects. (PubMed, Br J Clin Pharmacol) - "Coadministration of aildenafil with the strong CYP3A4 inhibitor clarithromycin increased aildenafil AUC0-∞ by 2.58-fold and Cmax by 1.67-fold; therefore, dose adjustment should be guided by clinical response and tolerability. In contrast, coadministration with the strong CYP3A4 inducer rifampin is not recommended."

Journal • PK/PD data

Conformational flexibility governs phosphate-induced solubility enhancement: a comparative study of cimetidine and famotidine by pH-dependent dissolution, NMR titration, DOSY, and DFT analysis. (PubMed, Eur J Pharm Biopharm) - "DFT-based Boltzmann analysis reveals that CIM possesses a broad low-energy conformer ensemble (partition function Z = 2.62), whereas FAM is dominated by a single rigid geometry (Z = 1.10). The correlation between conformational entropy and phosphate-induced solubility enhancement suggests that molecular flexibility is a key determinant of ion-specific buffer effects, with implications for BCS solubility classification using phosphate-buffered media."

Journal

Efficient determination of ranitidine, famotidine, and cimetidine in environmental and biological matrices using a NH₂-bimetallic MIL-88(Fe/Ni)@SiO₂/Fe₃O₄ composite and dispersive micro solid-phase extraction. (PubMed, Anal Bioanal Chem) - "The method was successfully applied to tap, river, and well water, as well as human urine samples, achieving excellent relative recovery rates (89.8-95.3%), even in samples from individuals who had ingested the drugs. The adsorbent could be reused for three cycles without significant loss in performance."

Journal

Biotransformation of cimetidine by Chlamydomonas sp. SI-16: CYP450-driven detoxification and immobilized photobioreactor validation. (PubMed, J Hazard Mater) - "A bio-rope immobilized photobioreactor also delivered 78.6% stable CIM removal, demonstrating engineering feasibility. As the first systematic report on CYP450-mediated CIM degradation and detoxification by environmental microalgae, these findings provide an engineering-feasible biocatalytic strategy for anti-ulcer pharmaceutical remediation in wastewater."

Journal • HRH2

Seasonal variations in erythropoietic protoporphyria patients' responses about sun behaviour, symptoms, and treatment effect. (PubMed, Photodiagnosis Photodyn Ther) - "As patients with EPP in Northern European countries may be free of symptoms during winter, their individual evaluation of sun behavior in summer, the severity of summer symptoms, and effect of oral treatment with Cimetidine and/or zinc sulphate may vary greatly depending on season when answering our EPP DLQI questionnaire...Erythrocyte PpIX decreased by 14 µmol/L during treatment. These observations may help the clinician decide when to schedule follow-up consultations for patients with EPP."

Journal • Genetic Disorders • Metabolic Disorders

Ameliorative effects of onion anthocyanin extract on spermatogenic function in cimetidine-induced testicular toxicity in male mice. (PubMed, J Adv Pharm Technol Res) - "Daily sperm production increased significantly, showing a leftward shift in dose-response (ED50: 45.7 mg/kg vs. 57.9 mg/kg for anthocyanin alone). Onion anthocyanins exert potent, dose-dependent protective effects against cimetidine-induced testicular toxicity by preserving spermatogenesis and endocrine homeostasis, supporting their translational potential as fertility-protective adjuncts during gonadotoxic drug exposure."

Journal • Preclinical

Immobilized horseradish peroxidase hybrid biocatalysts for degradation of pharmaceuticals and other emerging micropollutants. (PubMed, PLoS One) - "For example, full degradation was achieved for MBT (100%), meloxicam (99.5%) and caffeic acid (98.6%). In contrast, prometryn and MCPA showed only partial degradation, reaching 19.2% and 20%, respectively, and no degradation was observed for fluometuron and atenolol...For instance, roxithromycin degradation increased from 0.5% to 58.2% with ZnO-HRP, and for cimetidine, TiO₂-HRP improved degradation from 0.3% to 60.1% without HOBT and from 9.0% to 66.7% with HOBT...Finally, an integrated HRP enzyme and chemical oxidation remediation strategy was applied to degrade two pollutants, trimethoprim and DEET. For trimethoprim, TiO2-HRP combined with H2O2 and UV achieved approximately 30% degradation, while for DEET, both TiO2-HRP + H2O2 + UV and ZnO-HRP + H2O2 + UV resulted in around 40% degradation, thereby highlighting a novel application for these hybrid peroxidase-photocatalysts."

Journal

Proton Pump Inhibitors and H2-Receptor Blockers as Culprit Agents in Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis: A Systematic Review of Case Reports (ACG 2026) - "While antibiotics, anticonvulsants, and allopurinol are well-established culprits, proton pump inhibitors (PPIs) and H2-receptor blockers (H2RBs), among the most widely prescribed drug classes globally, are underrecognized triggers...PPIs were implicated in 62% of cases; lansoprazole, omeprazole, and pantoprazole were most frequent. H2RBs accounted for 38%, with ranitidine and cimetidine most common... Twenty studies met inclusion criteria, including one two-patient case series, yielding 21 cases (10 TEN, 11 SJS). Median age was 50 years; 62% were female. Median latency to onset was 10 days."

Case report • Clinical • Review • Acute Respiratory Distress Syndrome • Cardiovascular • Infectious Disease • Renal Disease • Respiratory Diseases • Septic Shock • Steven-Johnson Syndrome

Dapsone: strategies for increasing patient tolerance. (PubMed, Environ Toxicol Pharmacol) - "Pre-clinical and in vitro studies also suggest that prior administration of the antioxidant α-lipoic acid may potentially augment cimetidine's attenuation of dapsone-mediated methaemoglobin's formation through its conversion to dihydrolipoic acid which can restrict methaemoglobin formation within the erythrocyte. Hence, it is hypothesised that concomitant α-lipoic acid will improve the amelioration of dapsone-mediated methaemoglobin formation compared with cimetidine alone, potentially promoting the drug's clinical tolerance and utility in dermatology."

Journal • Review • Dermatology • Hematological Disorders

Hepatoerythropoietic porphyria in a 2-year-old child: Clinical features and effects of treatment. (PubMed, Mol Genet Metab) - "Neither cholestyramine nor therapeutic phlebotomy was associated with clear biochemical improvement, whereas cimetidine was temporally associated with a decline in urinary porphyrins, although other biomarkers were more variable. This case highlights the importance of considering HEP in children with blistering lesions on sun-exposed skin."

Journal • Dermatology • Genetic Disorders • Hematological Disorders • Hepatology • Metabolic Disorders • Rare Diseases • UROD

Surgical versus medical management of PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis): a systematic review and network meta-analysis. (PubMed, Pediatr Rheumatol Online J) - "Current evidence is insufficient to draw reliable comparative conclusions regarding the relative effectiveness of surgical and medical management for PFAPA. Substantial clinical and methodological heterogeneity, sparse comparative data, and very low-certainty evidence limit interpretation of pooled estimates. Well-designed prospective comparative studies with standardized outcomes are needed to inform treatment decisions."

Journal • Retrospective data • Dental Disorders • Stomatitis

Clarification of the scaling-factor role of the first singular vector in singular value decomposition analysis of fourier-transform infrared spectra: detection of solid-state intermolecular interactions in indomethacin-cimetidine mixtures via the λ2/λ1 ratio. (PubMed, Int J Pharm) - "Cross-system validation across a non-interacting pair (BAM-ASP) and a co-amorphous-forming pair (INM-CIM) demonstrates that the partitioning of spectral information between λ1 (intensity scaling) and λ2/λ1 (qualitative compositional and interaction information) is an intrinsic property of non-centered SVD applied to positive-dominant spectral matrices. This framework provides a rigorous and broadly applicable basis for detecting and characterizing solid-state intermolecular interactions in pharmaceutical binary systems by FTIR spectroscopy."

Journal

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE-Mediated Renal Drug-Drug Interactions in Healthy Volunteers. (PubMed, Clin Pharmacol Ther) - "Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin extrusion proteins (MATE) 1 and 2-K are of major importance. When comparing the IC50 values with unbound inhibitor plasma concentrations, trimethoprim, cimetidine, and pyrimethamine preferentially inhibit the MATE1-mediated transport, whereas dolutegravir inhibits the OCT2-mediated transport of the biomarker candidates. In conclusion, this study further supports the suitability of 5-aminovaleric acid betaine (5AVAB), serotonin (5HT), and 1-methylhistamine (1MH) as promising biomarkers for OCT2/MATE-mediated DDI."

Biomarker • Journal

Role of the arachnoid mater organic anion and cation transporters in the clearance of prostaglandin D2 and metformin from the cerebrospinal fluid in rats. (PubMed, Drug Metab Pharmacokinet) - "The CSF elimination of PGD2 was significantly inhibited by p-aminohippuric acid, diclofenac (substrates/inhibitors of Slc22a6/Oat1 and Slc22a8/Oat3), and taurocholate (a broad substrate/inhibitor of Slco family transporters), whereas that of metformin was blocked by cimetidine, tetraethylammonium, and thiamine (substrates/inhibitors of Slc22a2/Oct2). These results suggested that the PGD2 clearance from the CSF most likely occurred via Slc22a6/Oat1, Slc22a8/Oat3, Slco2a1/Oatp2a1, and Slco2b1/Oatp2b1, while the metformin clearance was primarily mediated by Slc22a2/Oct2, in the arachnoid mater. These transporters would regulate the CSF concentrations of pharmacologically active substances and drugs."

Journal • Preclinical • SLC22A2 • SLCO2B1

Successful treatment of recalcitrant warts in a patient with chronic lymphocytic leukaemia with intralesional Human Papillomavirus 9-valent vaccine (BAD 2026) - "Treatments prescribed included topical imiquimod 5% applied four times weekly for 6 weeks, multiple sessions of cryotherapy, oral cimetidine 400 mg and zinc supplementation 15 mg twice daily, all of which resulted in minimal to no improvement. At his 3-month follow-up, the nasal mucosa and surrounding skin remained clear. This case highlights the potential role of intralesional HPV vaccination as an effective therapeutic option for recalcitrant mucocutaneous warts in immunocompromised patients."

Clinical • Chronic Lymphocytic Leukemia • CNS Disorders • Dermatology • Hematological Malignancies • Leukemia

Early Tonsillectomy for Dual Remission of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome and Immunoglobulin A Nephropathy: A Case Report. (PubMed, Kidney Med) - "Owing to the poor response to cimetidine and significant disruption to schooling, palatine tonsillectomy was performed at 7 years...This case provides the first pediatric case demonstrating that early tonsillectomy alone can effectively treat coexisting PFAPA and IgAN without the need for additional immunosuppressive therapy. The simultaneous clinical and histological remission supports a shared pathogenic mechanism involving tonsillar immune dysfunction and highlights tonsillectomy as a potentially curative intervention for select patients with concurrent tonsil-driven diseases."

Journal • Dental Disorders • Glomerulonephritis • IgA Nephropathy • Infectious Disease • Inflammation • Pediatrics • Renal Disease • Stomatitis

Management of Bladder Pain Syndrome with Hunner's lesions: a series of 32 cases. (PubMed, Fr J Urol) - "in case of BPS with a bladder phenotype and one or more Hunner's lesions, treatment by transurethral resection of the inflammatory lesion is more effective for pain and, to a lesser extent, for pollakiuria than our usual medical treatment (CRP) but does not prevent recurrence after varying periods of time."

Journal • Interstitial Cystitis • Musculoskeletal Pain • Pain • Urology

Alleviating Effect of Intestinal Alkaline Phosphatase on Enterotoxigenic Escherichia coli K99-Induced Diarrhea. (PubMed, Microb Pathog) - "On day 4, the model and intervention groups were pretreated with cimetidine followed by ETEC challenge...The 400 U/mL group further reduced diamine oxidase and D-lactate (P<0.05). In conclusion, IAP effectively alleviated ETEC-induced diarrhea in mice, providing a theoretical basis for the development of novel therapeutic agents against diarrhea."

Journal • Inflammation • MUC2 • MYD88 • OCLN • TJP1 • TLR4

Investigating Immune Microenvironment of Inflammatory Bowel Disease and the Mitochondrial Metabolism-Related Molecular Mechanisms: Combining a Multiomics Approach and Experimental Validation. (PubMed, OMICS) - "Additionally, therapeutic drugs targeting key genes were predicted, including cimetidine, eugenol, chlortetracycline, vincristine, irinotecan, bisacodyl, and sulpiride, with molecular docking validating high affinity between these drugs and key targets. This study constructed a multiomics integrated analysis strategy and identified MRPL35 and MRPL39 as potential markers and therapeutic targets, providing new insights for the diagnosis and treatment of IBD."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • CD4 • CD74 • CXCR4 • ITGB2 • SDC1 • XIST

Effect of Chitosan Nanocarriers on the Interaction between Cimetidine and Bovine Serum Albumin and Its Regulation of Protein Conformation. (PubMed, Chem Biol Interact) - "The CS NPs-CMT complex induces more pronounced structural alterations in BSA (α-helix content decreases from 55.60% to 49.50%). Site-competition experiments reveal that free CMT primarily binds to Site II of BSA, whereas upon loading onto CS NPs, its binding site shifts to Site I. In addition, loading onto CS NPs partially alleviates the competitive inhibition of BSA esterase activity by CMT, while retaining the protective effect of CMT on BSA thiol groups."

Journal

Decontamination from water pollutants and pathogens by electrospun nanofibers doped with heavy-atom-free borafluorene-BODIPY photosensitizers. (PubMed, Beilstein J Nanotechnol) - "Optimization of the material composition revealed that polycaprolactone (PCL), an FDA- and EMA-approved, biodegradable, easily accessible, and cost-efficient polymer, doped with BODIPY at a concentration of only 0.15 wt %, is an efficient photocatalyst for the degradation of the pharmaceutical agents ranitidine, propranolol, and cimetidine, selected as model water pollutants. Furthermore, the materials showed significant photoinactivation of Staphylococcus aureus under white light irradiation compared to the control experiment performed without irradiation. These findings highlight the potential of the electrospun PCL nanofibers as optimal matrix for the immobilization with singlet oxygen photosensitizers and subsequent application in the decontamination of water from pollutants and pathogens."

Journal

Unraveling the molecular landscape and therapeutic strategies for acute kidney injury: insights from transcriptomics, network pharmacology, virtual screening, and in vitro experiments. (PubMed, Mol Divers) - "Molecular docking analysis identified three approved drugs-Ajmaline, Cimetidine, and Tretinoin-with strong binding affinities to the hub proteins, suggesting their potential for repurposing in AKI treatment. Finally, by reviewing knockout mouse models from the Mouse Genome Informatics (MGI) database and conducting in vitro cell experiments, we explored the in vivo and in vitro roles of these core targets, providing experimental evidence of their physiological relevance. Overall, this study integrates cross-cohort transcriptomic profiling, network-based hub prioritization, single-nucleus cell-type localization, translational drug repurposing analyses, and in vitro experimental validation thereby providing a multi-layered framework to prioritize candidate biomarkers for AKI."

Journal • Preclinical • Acute Kidney Injury • Inflammation • Nephrology • Renal Disease • PFKL

Epidermodysplasia verruciformis successfully treated with cimetidine. (PubMed, JAAD Case Rep) - No abstract available

Journal • Human Immunodeficiency Virus • Infectious Disease

Repurposing Cimetidine as a Therapeutic Candidate for Irritable Bowel Syndrome in a Rat Model. (PubMed, Fundam Clin Pharmacol) - "These findings suggest that cimetidine prevents visceral hypersensitivity and colonic hyperpermeability in IBS models through mechanisms involving central orexin signaling possibly triggered by NHE inhibition, NO, and central muscarinic and dopamine D2 receptor pathways. These findings may provide a basis for future therapeutic approaches targeting IBS."

Journal • Preclinical • Gastrointestinal Disorder • Immunology • Pain • DRD2 • TLR4