TL-925 / Telios Pharma - LARVOL DELTA

Evaluation of TL-925 for the Treatment of Allergic Conjunctivitis (clinicaltrials.gov) - P2 | N=66 | Recruiting | Sponsor: Telios Pharma, Inc.

New P2 trial • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology

A Study of TL-925 Ophthalmic Emulsion as a Treatment for Dry Eye Disease (clinicaltrials.gov) - P2 | N=880 | Active, not recruiting | Sponsor: Telios Pharma, Inc. | Recruiting ➔ Active, not recruiting

Enrollment closed • Dry Eye Disease • Ophthalmology

A Study Of TL-925 For The Treatment of AC (clinicaltrials.gov) - P2 | N=80 | Completed | Sponsor: Telios Pharma, Inc. | Recruiting ➔ Completed

Trial completion • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology

A Study of TL-925 Ophthalmic Emulsion as a Treatment for Dry Eye Disease (clinicaltrials.gov) - P2 | N=880 | Recruiting | Sponsor: Telios Pharma, Inc. | N=670 ➔ 880

Enrollment change • Dry Eye Disease • Ophthalmology

TL-925, a First-in-Class, Topical, Bruton's Tyrosine Kinase Inhibitor (BTKi) in Subjects (Subjs) with Moderate to Severe Dry Eye Disease (DED) (ARVO 2024) - "The consistency of results across ocular regions, rapid onset of improvements in signs and symptoms, confirmation in different settings (pre/post CAE), and novel therapeutic approach underscore the promise of 925 as a safe, well-tolerated, effective treatment for DED, with disease-modifying potential."

Clinical • Dry Eye Disease • Ocular Inflammation • Ophthalmology

TL-925, a First-in-class, Topical, Bruton's Tyrosine Kinase (BTK) Inhibitor Regulates the Ocular Inflammatory Response (ARVO 2024) - "895 inhibits MC-driven immune and cytokine responses in DED and AC. In vitro, 895 prevented MC activation, degranulation, and cytokine production, indicating potent modulation of the innate and adaptive immune response. In vivo, ocular administration of 925 ensured near-complete inhibition of BTK to target tissue at optimal drug concentrations."

Conjunctivitis • Dry Eye Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • CD34 • CD63 • CXCL8

A Study Of TL-925 For The Treatment of AC (clinicaltrials.gov) - P2 | N=70 | Recruiting | Sponsor: Telios Pharma, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology

A Study of TL-925 Ophthalmic Emulsion as a Treatment for Dry Eye Disease (clinicaltrials.gov) - P2 | N=670 | Recruiting | Sponsor: Telios Pharma, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open • Dry Eye Disease • Ophthalmology

A Study Of TL-925 For The Treatment of AC (clinicaltrials.gov) - P2 | N=70 | Not yet recruiting | Sponsor: Telios Pharma, Inc.

New P2 trial • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology

A Study of TL-925 Ophthalmic Emulsion as a Treatment for Dry Eye Disease (clinicaltrials.gov) - P2 | N=670 | Not yet recruiting | Sponsor: Telios Pharma, Inc.

New P2 trial • Dry Eye Disease • Ophthalmology

A Study of TL-925 for the Treatment of Allergic Conjunctivitis (clinicaltrials.gov) - P2 | N=70 | Recruiting | Sponsor: Telios Pharma, Inc.

New P2 trial • Conjunctivitis • Ocular Infections • Ocular Inflammation • Ophthalmology

A Study of TL-925 as a Treatment for Dry Eye Disease (clinicaltrials.gov) - P2 | N=107 | Completed | Sponsor: Telios Pharma, Inc. | Active, not recruiting ➔ Completed

Trial completion • Dry Eye Disease • Ophthalmology

A Study of TL-925 as a Treatment for Dry Eye Disease (clinicaltrials.gov) - P2 | N=100 | Active, not recruiting | Sponsor: Telios Pharma, Inc. | Recruiting ➔ Active, not recruiting

Enrollment closed • Dry Eye Disease • Ophthalmology

A Study of TL-925 as a Treatment for Dry Eye Disease (clinicaltrials.gov) - P2 | N=100 | Recruiting | Sponsor: Telios Pharma, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open • Dry Eye Disease • Ophthalmology

A Study of TL-925 as a Treatment for Dry Eye Disease (clinicaltrials.gov) - P2 | N=100 | Not yet recruiting | Sponsor: Telios Pharma, Inc.

New P2 trial • Dry Eye Disease • Ophthalmology