BNT162b5 Bivalent / BioNTech - LARVOL DELTA

A Study to Learn About New COVID-19 RNA Vaccine Candidates in COVID-19 Vaccine-Experienced Healthy Individuals (clinicaltrials.gov) - P2/3 | N=1454 | Completed | Sponsor: BioNTech SE | Active, not recruiting ➔ Completed

Trial completion • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Study to Learn About New COVID-19 RNA Vaccine Candidates in COVID-19 Vaccine-Experienced Healthy Individuals (clinicaltrials.gov) - P2/3 | N=1424 | Active, not recruiting | Sponsor: BioNTech SE | Recruiting ➔ Active, not recruiting | N=700 ➔ 1424

Enrollment change • Enrollment closed • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Study to Learn About New COVID-19 RNA Vaccine Candidates as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Individuals (clinicaltrials.gov) - P2/3 | N=700 | Recruiting | Sponsor: BioNTech SE | Phase classification: P2 ➔ P2/3

Phase classification • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Study to Learn About New COVID-19 RNA Vaccine Candidates as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Individuals (clinicaltrials.gov) - P2 | N=700 | Recruiting | Sponsor: BioNTech SE | Active, not recruiting ➔ Recruiting | N=1143 ➔ 700 | Trial completion date: Apr 2023 ➔ Jan 2024 | Trial primary completion date: Apr 2023 ➔ Jan 2024

Enrollment change • Enrollment open • Trial completion date • Trial primary completion date • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Study to Learn About New COVID-19 RNA Vaccine Candidates as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Individuals (clinicaltrials.gov) - P2 | N=1143 | Active, not recruiting | Sponsor: BioNTech SE | Phase classification: P2/3 ➔ P2

Phase classification • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Safety and Effects of an Investigational COVID-19 Vaccine as a Booster in Healthy People (clinicaltrials.gov) - P1 | N=180 | Recruiting | Sponsor: BioNTech SE | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Study to Learn About New COVID-19 RNA Vaccine Candidates as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Individuals (clinicaltrials.gov) - P2/3 | N=1143 | Active, not recruiting | Sponsor: BioNTech SE | Recruiting ➔ Active, not recruiting | Phase classification: P2 ➔ P2/3

Enrollment closed • Phase classification • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Study to Learn About New COVID-19 RNA Vaccine Candidates as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Individuals (clinicaltrials.gov) - P2 | N=1100 | Recruiting | Sponsor: BioNTech SE | N=700 ➔ 1100

Enrollment change • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Safety and Effects of an Investigational COVID-19 Vaccine as a Booster in Healthy People (clinicaltrials.gov) - P1 | N=180 | Not yet recruiting | Sponsor: BioNTech SE

New P1 trial • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Study to Learn About New COVID-19 RNA Vaccine Candidates as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Individuals (clinicaltrials.gov) - P2 | N=700 | Recruiting | Sponsor: BioNTech SE | N=200 ➔ 700

Enrollment change • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Study to Learn About a New COVID-19 RNA Vaccine Candidate as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Adults (clinicaltrials.gov) - P2 | N=200 | Recruiting | Sponsor: BioNTech SE | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Study to Learn About a New COVID-19 RNA Vaccine Candidate as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Adults (clinicaltrials.gov) - P2 | N=200 | Not yet recruiting | Sponsor: BioNTech SE

New P2 trial • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases