methamphetamine / Generic mfg. - LARVOL DELTA

Comprehensive examination of demographic, psychological, cognitive, biochemical, and genetic profiles of methamphetamine addicts. (PubMed, J Genet Eng Biotechnol) - "The findings underscore the impact of prolonged MA use on neurochemical balance and gene expression, contributing to the development of aggressive behaviors and addictive patterns. Tailored treatment strategies that integrate genetic and psychological profiling, along with longitudinal monitoring, are essential to address the multifactorial nature of methamphetamine addiction and improve clinical outcomes."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Psychiatry • COMT • SLC6A4

Methamphetamine-Induced Coronary Vasospasm and Recurrent Cardiac Arrest: A Quick Glance May Not Be Good Enough. (PubMed, JACC Case Rep) - "Methamphetamine can induce severe coronary vasospasm, endothelial dysfunction, and atherosclerotic plaque disruption. Vasodilators should be considered during coronary angiography before determining next steps in management."

Journal • Acute Coronary Syndrome • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Myocardial Infarction • Myocardial Ischemia • Ventricular Tachycardia

Comparison between a chimeric anti-methamphetamine monoclonal antibody and humanized antibodies on pharmacological effects of methamphetamine. (PubMed, Psychopharmacology (Berl)) - "The 7F9 variable region is the most promising to treat MUD."

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Integrative metabolomics and machine learning reveal diagnostic biomarkers for gelsenicine intoxication. (PubMed, J Ethnopharmacol) - "By combining untargeted metabolomics with ML, a classification model based on creatinine, Val-Ser, and Tyr-Phe was established. The model effectively distinguishes GFI from multiple hypoxia-related deaths and demonstrates high accuracy, sensitivity, and specificity, indicating its potential for forensic precision identification and clinical diagnosis of gelsenicine poisoning."

Biomarker • Journal • CNS Disorders • Depression • Inflammation • Pain • Psychiatry

Fentanyl test strip use and homelessness among people who use drugs in Rhode Island. (PubMed, Int J Drug Policy) - "We found that housing status was not independently and longitudinally associated with FTS use; however, people who used crystal methamphetamine were more than twice as likely to have used FTS in the past month. Future research exploring how differential housing situations may affect uptake of harm reduction services is needed to prevent fentanyl overdose."

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Methamphetamine Use, Post-Traumatic Stress, and Substance Use Consequences Among American Indians with a Substance Use Problem. (PubMed, Subst Use Misuse) - "Tribal members who report methamphetamine as their primary drug and those who have higher PTSD scores experience significant substance use consequences. Interventions that address stimulant use and traumatic stress are needed to improve health outcomes in this population."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry

Deep Proteome Profiling of Rat Dorsal Striatal Synaptoneurosomes Following Methamphetamine Exposure. (PubMed, ACS Chem Neurosci) - "These findings highlight coordinated molecular remodeling of striatal synapses in response to Meth and demonstrate the utility of deep SN proteomics in addiction research. Deep, low-input SN proteomics nominates vesicle acidification, mitochondrial ATP supply, and proteasome function as testable pathway-level targets in addiction."

Journal • Preclinical • CNS Disorders • Psychiatry

A Novel Care Navigation Intervention for Patients with Methamphetamine Use Disorder. (PubMed, Community Ment Health J) - "Among 94 patients who received this intervention as part of a randomized controlled trial, 64% were considered engaged with at least 2 or more visits with the care navigator Patients had substantial barriers to care-85% of patients were not stably housed, 83% were unemployed, and 46% lacked access to a phone-and the most common domains of need were accessing addiction treatment, housing resources, or communication needs such as a phone or interpreter services. This intervention poses a model for connecting patients with MaUD to treatment after acute care encounters."

Journal • CNS Disorders • Infectious Disease • Mood Disorders • Psychiatry

From Synaptic Plasticity to Neurotoxicity: Endocannabinoid Influence on Addiction and Neurodegeneration. (PubMed, Int J Mol Sci) - "Chronic exposure to drugs of abuse, including alcohol, opioids, cocaine, and methamphetamine, perturbs eCBS homeostasis, promoting oxidative stress, neuroinflammation, excitotoxicity, mitochondrial dysfunction, and protein aggregation-pathological features common to Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis...Despite these advances, critical gaps remain in delineating how substance-induced eCBS alterations precipitate neurodegenerative cascades. Addressing these gaps will be essential for harnessing the eCBS as a therapeutic target to mitigate addiction-driven neurotoxicity and age-related cognitive decline."

Journal • Review • Addiction (Opioid and Alcohol) • Alzheimer's Disease • Amyotrophic Lateral Sclerosis • CNS Disorders • Huntington's Disease • Inflammation • Metabolic Disorders • Movement Disorders • Parkinson's Disease • Psychiatry

Epigenetic Landscapes of Methamphetamine Addiction: Unravelling the Diagnostic Potential of Gene Methylation. (PubMed, Addict Biol) - "These findings provide valuable insights for the development of diagnostic biomarkers and targeted therapeutic interventions. Future research will focus on elucidating the functional roles of these genes in the pathophysiology of methamphetamine addiction and their potential applications in treatment strategies."

Journal • CNS Disorders • Psychiatry • LIAS • USP7

Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms. (PubMed, Front Pharmacol) - "Collectively, these findings demonstrate that Meth and neuroHIV inhibit astrocyte function, which could exacerbate mPFC neuronal dysfunction in MUD and/or neuroHIV. They also suggest that Meth- and neuroHIV-induced astrocytic K+ channel function was mediated by TAAR1-and/or chemokine receptor-coupled signaling pathways."

Journal • CNS Disorders • Cognitive Disorders • Developmental Disorders • Human Immunodeficiency Virus • Infectious Disease

Effects of methamphetamines in patients with tibial shaft fractures: a retrospective cohort study at a Level 1 trauma center. (PubMed, OTA Int) - "Methamphetamine use is associated with risk of postoperative infection, nonunion, and multiple reoperations in orthopaedic trauma patients with tibial shaft fractures. Level III."

Journal • Retrospective data • Infectious Disease • Musculoskeletal Diseases • Orthopedics

The Impact of Childhood Maltreatment Experiences on Emotion Regulation in Chinese Methamphetamine-Dependent Inpatients: A Mediation Model. (PubMed, Clin Psychol Psychother) - "Additionally, rumination mediated the relationship between childhood maltreatment and impaired emotion regulation. Our findings suggest a significant association between childhood maltreatment and impaired emotion regulation in MDIs, with rumination serving as a key mediator of this relationship."

Journal • Cardiovascular • Hypertension • Mood Disorders • Psychiatry • Suicidal Ideation

Estimated Prevalence of Substance Use Disorders Among US Adolescents and Emerging Adults by Substance Class, Severity, and Age, 2022. (PubMed, JAACAP Open) - "Conversely, the prevalence and severity of SUDs generally varied across age groups among those who reported past-year use of less commonly used substances (heroin, methamphetamine)...Allocation of developmentally appropriate prevention and treatment resources should account for the distribution of mild to severe SUDs across adolescence. The field would likely benefit from further study of these issues in diverse samples."

Journal • Addiction (Opioid and Alcohol)

Protective Effects of SA-31 In a Psychostimulant-Induced Neurotoxicity Model Using SH-SY5Y Cells. (PubMed, Eur J Pharm Sci) - "These findings suggest that SA-31 confers neuroprotection by enhancing MS activity, upregulating antioxidant defenses, and improving mitochondrial function. Further studies in rodent models of addiction are planned to evaluate its therapeutic potential for psychostimulant use disorders and related neurodegenerative conditions."

Journal • CNS Disorders • Metabolic Disorders • Psychiatry • CAT • IL1B

Insomnia is associated with psychological distress in individuals with methamphetamine dependence. (PubMed, Australas Psychiatry) - "This study examined the relationship between insomnia severity and psychological distress in treatment-seeking individuals with methamphetamine dependence.MethodsThis is a secondary cross-sectional analysis of baseline data from 152 participants enrolled in a randomised controlled trial of lisdexamfetamine versus placebo for methamphetamine dependence. In adjusted models, insomnia remained associated with distress: each 1-point ISI increase related to a 2.1-2.5% rise in DASS-21 depression and stress scores (β = 0.021-0.025, p = .003-.007), and a 6.5% increase in total scores (β = 0.063, p < .001); the association with anxiety was attenuated.ConclusionsOur study identified insomnia as an independent correlate of psychological distress in treatment-seeking individuals with methamphetamine dependence. Findings underscore sleep problems' relevance and support further research into sleep-focused interventions."

Journal • CNS Disorders • Depression • Insomnia • Mood Disorders • Psychiatry • Sleep Disorder

Bioaccumulation of Psychoactive Contaminants and Their Effects on Brain-Gonad-Sperm Neurotransmitter Networks in Fish. (PubMed, Environ Sci Technol) - "Here, we investigated the effects of environmentally relevant concentrations of a mixture of seven PSYCs (citalopram, donepezil, gabapentin, methamphetamine, sertraline, tramadol, and venlafaxine) on European perch (Perca fluviatilis) during a 23 day exposure. No significant changes were observed in gonadal histopathology or sperm-quality parameters; however, the observed molecular alterations suggest potential consequences under longer or chronic exposures. These findings identify sperm as a previously overlooked target for psychoactive pollutants and reveal neurochemical disruption along the brain-gonad-sperm axis as a previously unrecognized mechanism through which PSYCs may affect fish physiology."

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The effect of dextromethorphan on reward-related behaviors: A systematic review of preclinical and clinical evidence. (PubMed, J Affect Disord) - "Extant literature suggests that DXM administration attenuates reward-related behaviors in rats. There is a paucity of human studies investigating the effect of DXM on reward outcomes. Future research should prioritize the investigation of the effect of DXM on validated reward paradigms in persons with anhedonia."

Journal • Preclinical • Review • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

tRF-M2-Regulated Dopamine Receptor D2 Expression Attenuates Methamphetamine Reinstatement Behavior in Rats. (PubMed, Ann N Y Acad Sci) - "These findings show that tRF-M2 regulates Drd2 expression via Akt-Gsk3β-CREB signaling, thereby inhibiting drug-seeking behavior in addiction models. These results provide valuable mechanistic insights into neuroepigenetic regulation of psychostimulant addiction and identify promising candidates for therapeutic intervention against methamphetamine relapse."

Journal • Preclinical • CNS Disorders • Psychiatry • DRD2

Impact of morphine dependence and withdrawal on economic demand for fentanyl, cocaine, and methamphetamine in rats. (PubMed, Drug Alcohol Depend) - "These results demonstrate that opioid withdrawal increases motivation for opioid use while reducing motivation for stimulants, particularly at higher costs. Understanding these dynamics is crucial for developing effective polysubstance treatments addressing both opioid dependence and stimulant co-use."

Journal • Preclinical • Addiction (Opioid and Alcohol)

Systemic inflammatory indices as biomarkers in adolescents with methamphetamine use disorder: a case-control study. (PubMed, J Addict Dis) - "Adolescents with MUD demonstrate marked systemic inflammatory alterations detectable through routine hematological indices. These markers may serve as low-cost, clinically accessible biomarkers for identifying high-risk individuals and monitoring disease severity, with implications for early intervention and personalized treatment."

Biomarker • Journal • CNS Disorders • Hematological Disorders • Immunology • Inflammation • Psychiatry • Systemic Inflammatory Response Syndrome

Retraction Note: Expression of heat shock protein (HSP 72 kDa) during acute methamphetamine intoxication depends on brain hyperthermia: neurotoxicity or neuroprotection? (PubMed, J Neural Transm (Vienna)) - No abstract available

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Methamphetamine Overdose and Hyperthermia in a 41-Year-Old Man Found Unresponsive. (PubMed, Cureus) - "Postmortem toxicology from femoral blood revealed a methamphetamine concentration of 680 ng/mL and an amphetamine concentration of 55 ng/mL. This case provides an opportunity to discuss the multiple mechanisms through which stimulants contribute to hyperthermia as well as potential treatment strategies."

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Evaluation of mitochondrial DNA copy number alterations and their clinical correlates in methamphetamine use disorder. (PubMed, J Psychiatr Res) - "No significant associations were found between mtDNA copy number and psychometric scale scores or clinical characteristics, including history of suicide attempts, self-mutilation, violent behavior, hospitalization, withdrawal symptoms, or drug-induced psychosis (p > .05). In summary, our results indicate a marked decrease in peripheral blood mtDNA copy number among individuals with MUD, along with a significant inverse relationship between mtDNA copy number and the duration of substance use, suggesting cumulative mitochondrial stress associated with chronic methamphetamine exposure."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Substances and substance combinations among accidental substance-related acute toxicity deaths (AATDs) in Canada from 2016 to 2017. (PubMed, BMC Public Health) - "Fentanyl, cocaine, alcohol, and methamphetamine were the top substances contributing to the 7,902 AATDs identified between 2016 and 2017 in Canada. Opioids and stimulants are both detected in and contribute to a majority of AATDs, but the substance-related acute toxicity death crisis is complex and attributable to many substance classes. Understanding these differences will allow for targeted substance-related policies, prevention, and harm reduction efforts."

Journal • Addiction (Opioid and Alcohol)