methamphetamine / Generic mfg. - LARVOL DELTA

A History of Methamphetamine Use Disorder in People with HIV Is Associated with Altered Functional Response to Risky Choice. (PubMed, Viruses) - "A longer estimated duration of HIV infection was associated with greater ACC activation to risky choices for PWH regardless of METH use history. These findings suggest that PWH and a history of METH use disorder may exhibit compensatory activation of regions associated with decision-making in the context of rewards and that the effects of HIV and past METH use might not be additive."

Journal • Human Immunodeficiency Virus • Infectious Disease

Circuit and molecular mechanisms underlying incubation of methamphetamine craving in the prelimbic cortex. (PubMed, Neuron) - "Selective KCNC2 knockdown in SST or PV INs significantly suppressed drug seeking during early or prolonged withdrawal, respectively. These findings uncover the distinct contributions of PL IN subtypes to the incubation of craving and identify KCNC2 as a potential phase-specific therapeutic target in MUD."

Journal

Pathology of Vaccine-Preventable Diseases (USCAP 2026) - "Case 2 58-year-old man with history of methamphetamine use...Comfort with histologic diagnosis and assistance from microbiology colleagues is key. Postmortem diagnostic techniques include Gram stain Tissue culture PCR: tissue and CSF Evening Specialty Presentation (PDF): Click to View"

Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • CNS Disorders • Epilepsy • Hematological Disorders • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Obstructive Sleep Apnea • Otorhinolaryngology • Pneumococcal Infections • Pneumonia • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Septic Shock • Sleep Apnea • Sleep Disorder • Systemic Lupus Erythematosus • Thrombosis

CCK2R regulates METH-induced CPP acquisition within VTA-BLA-BNST circuit in male mice. (PubMed, Transl Psychiatry) - "Methamphetamine (METH) addiction is a severe public health issue driven by maladaptive neuroplasticity in reward circuits...Electrophysiological and Golgi staining analyses confirmed CCK2R's critical role in regulating neuronal excitability and structural plasticity. Our findings demonstrate that CCK2R in the VTADA→BLAGlu → BNST circuit is essential for METH CPP acquisition, highlighting its potential as a therapeutic target for addiction."

Journal • Preclinical • CNS Disorders • Psychiatry • CCKBR

The Association Between Drug Craving and Suicidal Thoughts and Behavior in Chinese Male Methamphetamine Inpatients: The Mediating Effect of Depressive Symptoms. (PubMed, Subst Use Misuse) - "Depressive symptoms serve as a mediator in the relationship between drug craving and STBs in MAUD inpatients. These findings highlight the necessity of incorporating depressive symptoms screening and intervention into addiction treatment which may be related to a lower prevalence of suicide risk."

Journal • CNS Disorders • Depression • Psychiatry • Suicidal Ideation

Clarifying Selected Citations and Interpretations in 'Underage deaths associated with substance-related harm in Taiwan: A national 10-year study'. (PubMed, Addiction) - No abstract available

Journal

Cardiovascular Conditions and Symptoms in Deaths Attributed to Acute Stimulant Toxicity. (PubMed, Circ Popul Health Outcomes) - "The underlying cause of deaths attributed to acute stimulant (methamphetamine or cocaine) toxicity is poorly understood, although cardiovascular events are believed to contribute. Premortem cardiovascular conditions and symptoms were common among stimulant decedents and were more prevalent among deaths attributed to stimulants without opioids compared with those involving fentanyl. In addition to opioid overdose prevention efforts, people who use stimulants might benefit from aggressive prevention and treatment of cardiovascular disease."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Coronary Artery Disease • Hypertension

Effects of nonpharmacological manipulations and repeated xanomeline treatment on methamphetamine-vs-food choice in Sprague Dawley and Long Evans rats. (PubMed, Drug Alcohol Depend) - "These results demonstrate that methamphetamine-vs-food choice was sensitive to parametric manipulations in rats and that xanomeline may warrant further consideration as a MUD pharmacotherapy."

Journal • Preclinical

A decade of change: trends in drug and alcohol use in Iran (2010-2019). (PubMed, BMC Public Health) - "The increasing prevalence of drugs and alcohol is alarming. Understanding these trends is essential for shaping public health policies and interventions."

Journal

From substance-induced psychosis to schizophrenia: Predictors of treatment response and transition to chronic psychotic illness-A systematic review. (PubMed, Schizophr Res) - "Treatment response in SIPDs is determined by multiple interacting factors. Moderate-certainty predictors (temporal onset, negative symptoms, premorbid functioning) provide the strongest basis for clinical decision-making, while lower-certainty findings require validation before widespread implementation."

Journal • Review • CNS Disorders • Psychiatry • Schizophrenia

Direct Methamphetamine Sensing in Flowing Wastewater via a 3D-Printed Flow-Through Cell. (PubMed, J Xenobiot) - "To our knowledge, this is the first demonstration of direct electrochemical sensing of MET in flowing wastewater using a 3D-printed flow-through platform. The simple, disposable design provides an actionable foundation for portable, near-real-time sewer surveillance and motivates antifouling/auto-cleaning strategies for long-term deployment."

Journal

Paradoxical role of the mesocorticolimbic Netrin1-DCC pathway in social competition and vulnerability to methamphetamine abuse during adolescence. (PubMed, Mol Psychiatry) - "Following dopamine fiber immunostaining, these outcomes were attributed to ectopic mesolimbic dopamine fibers, which enhanced risk-taking behavior in winners that had DCC knockout. Collectively, our work elucidates a molecular mechanism through which social competition influences adolescent brain development and behavior, particularly in relation to drug susceptibility."

Journal • Colorectal Cancer • Oncology • Solid Tumor • DCC • NTN1

Differences in anxiety, depression, and heart rate variability between patients with methamphetamine use disorder and heroin use disorder patients on methadone maintenance treatment. (PubMed, BMC Psychiatry) - No abstract available

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Stimulant-induced Psychosis: A Comparative Systematic Review and Meta-analysis of Psychotic Outcomes from Therapeutic and Nontherapeutic Use of Stimulants. (PubMed, J Addict Med) - "Stimulant-induced psychosis occurs in both therapeutic and nontherapeutic contexts but at vastly different prevalence rates. While prescribed stimulants pose a low but clinically relevant risk, particularly in individuals with psychiatric vulnerability, nontherapeutic use carries a substantial burden of psychosis with significant public health implications. These findings underscore the need for careful monitoring in clinical practice, risk profiling, and targeted harm-reduction strategies in nonmedical use settings."

Journal • Retrospective data • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

The effect of rTMS combined with physical exercise on people with methamphetamine use disorders: An acute experimental study. (PubMed, J Psychiatr Res) - "A single session of moderate-intensity physical exercise demonstrates acute benefits for both psychological and physiological withdrawal recovery in people with MUD. More importantly, it is essential to combine rTMS (particularly 10 Hz) with physical exercise, as this integrated approach can strengthen the sustainability of benefits and serve as an effective supplementary method to promote both physical and psychological recovery in this population."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

The reach, effectiveness, implementation, and maintenance of a New York City harm reduction program enrolling priority populations who use meth, 2017-2022. (PubMed, Drug Alcohol Depend) - "At reassessment, less than half reported recent methamphetamine use. Seroconversions occurred mostly among MSM of color, suggesting that greater engagement and support are needed for priority populations. Findings align with prior research showing frequent HIV seroconversion and a high need for non-medical services among MSM using methamphetamine."

Journal • Human Immunodeficiency Virus • Infectious Disease

Dynamic shifts in crystal methamphetamine and heroin price and purity in metropolitan Melbourne and rural Victoria, Australia, 2009-2020. (PubMed, Int J Drug Policy) - "Overall declines in both crystal methamphetamine and heroin purity-adjusted prices in Victoria suggests that, by 2019, people who purchased these drugs received more drug for a given purchase than in previous years. These changes closely match trends seen in some key harms such as opioid overdose."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Epilepsy

Drug positivity, co-detection patterns, and demographic predictors in patients seeking substance use disorder treatment, United States, 2023. (PubMed, Addict Behav) - "This study highlights variations in substance presence and co-detection across 14 drug categories in SUD treatment patients, underscoring the need for tailored prevention and treatment strategies."

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Implementing a Contingency Management Program Addressing Methamphetamine Use For and With the People of Hawaii (clinicaltrials.gov) - P=N/A | N=20 | Completed | Sponsor: Queen's Medical Center | Recruiting ➔ Completed | Trial completion date: Sep 2025 ➔ Dec 2025 | Trial primary completion date: Sep 2025 ➔ Dec 2025

Trial completion • Trial completion date • Trial primary completion date

Neurostructural alterations, trait impulsivity, and genetic architecture in individuals with methamphetamine dependence: a multimodal imaging-genetics study. (PubMed, Transl Psychiatry) - "These findings suggest the thalamus as a critical structural substrate that links impulse control with METH-related neurotoxicity, emphasizing the role of cytoskeletal dynamics and ciliary function. Genetic variants that influence thalamic vulnerability may serve as promising biomarkers for risk stratification and the development of personalized interventions in MUD."

Journal

What Is Known about Substance Use in Hawai'i: A Scoping Review. (PubMed, Hawaii J Health Soc Welf) - "The granularity of geographical data was found to be at island-level and the 3 most common substances reported were alcohol, marijuana, and methamphetamine. Most documents used national datasets for reporting substance use in Hawai'i. The findings identified gaps in the literature that can be filled by future research such as focusing on the rise of substance use among older adults, disaggregating data on Pacific Islander populations in Hawai'i, reporting substance use data in geographical areas smaller than island-level, increasing the collection of data on groups that have a high risk for health problems or are underserved by health services, and intensifying collection of data about fentanyl use in Hawai'i."

Journal • Substance Abuse

The Complex Relationship between ADHD, Substance Use Disorders, and Prescription Stimulants (PAS 2026) - "When used appropriately, prescription stimulants in adolescents and adults with ADHD do not increase the risk for SUD. Virtual care of ADHD appears safe in terms of subsequent stimulant and other SUDs. Learning Objectives: Participants will be able to describe the association between adolescent prescription stimulant misuse and later risk for cocaine and methamphetamine use in young adulthood."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Susac Syndrome in an ICU Patient With History of Methamphetamine Use (SCCM 2026) - "Rituximab was chosen over cyclophosphamide to minimize further immunosuppression in the setting of persistent respiratory infection. Furthermore, the case underscores the challenges of initiating immunomodulators for Susac syndrome patients in the ICU setting. Early collaboration with a multidisciplinary team, especially with specialties such as neurology and ophthalmology, is essential for maximizing patient outcomes."

Clinical • CNS Disorders • Infectious Disease • Ophthalmology • Otorhinolaryngology • Rare Diseases • Respiratory Diseases • Septic Shock

Fatal Toxic Exposure: Fentanyl, "Dust-Off," or Both? (SCCM 2026) - "Given overlapping features with opioid toxicity, especially in polysubstance users, this case underscores the importance of considering inhalants in the differential diagnosis of drug-related cardiac arrest.Description: A 32-year-old female with IVDU and polysubstance abuse (methamphetamine, opioids, inhalants) was found unresponsive after unknown downtime. EMS identified PEA arrest; CPR, two rounds of epinephrine, and 6 mg naloxone were given, achieving ROSC...Early recognition is critical due to rapid onset and risk of irreversible hypoxic injury. Greater awareness is needed, as these agents are widely available, frequently abused, and often overlooked."

Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Diabetes • Metabolic Disorders • Vascular Neurology

Synergistic disruption of the blood-brain barrier in tree shrews by Methamphetamine and HIV-1 Tat via TRPM2-Mediated astrocyte inflammation. (PubMed, Brain Behav Immun) - "This study revealed that METH and Tat could synergistically activate astrocytic TRPM2 channels to induce astrocyte-derived inflammatory response, and ultimately resulted in BBB injury. These findings highlight astrocyte-mediated inflammation as an important mechanism by which METH and Tat synergistically damage the BBB, and the TRPM2 channel represents a promising therapeutic target, providing novel insights into the mechanism of neurotoxicity caused by METH and HIV-1 Tat."

Journal • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Psychiatry