methamphetamine / Generic mfg. - LARVOL DELTA

Antecedents of Fentanyl Coinvolvement in Deaths Attributed to Stimulant Poisoning in San Francisco, CA. (PubMed, J Addict Med) - "Our findings add to existing evidence that fentanyl-stimulant deaths are markedly different than stimulant-no-opioid deaths. The association of opioid-related emergency department history with fentanyl involvement in death reinforces a potential touch point for overdose prevention efforts (eg, naloxone, medications for opioid use disorder). Our finding of cardiac conditions being associated with lower odds of fentanyl involvement in death supports the hypothesis that stimulant-no-opioid deaths may be driven by cardiovascular conditions."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • Substance Abuse

Changing Drug Consumption Patterns Among Clients Attending the Medically Supervised Injecting Centre, Sydney: Implications for Service Provision and Harm Reduction Response. (PubMed, Drug Alcohol Rev) - "There has been an increase in amphetamine injection at MSIC, with the most frequent service attenders most likely to report injecting both opioids and amphetamines. There has been no parallel increase in disruptive behaviour. Those exclusively injecting amphetamines do not attend the service frequently. Strategies to support opportunistic intervention are clearly warranted."

Journal • Addiction (Opioid and Alcohol)

Formulation and Delivery Systems of Cocaine and Methamphetamine Scent Mimics. (PubMed, Int J Anal Chem) - "Cotton material provides a safe, durable and inexpensive medium for pseudoscent storage and release. The pseudoscent delivery systems are easy to formulate, store and distribute, thus enabling widespread use for both specialised training and public educational purposes."

Journal • CNS Disorders • Psychiatry

The effects of high-intensity interval training on cardiac fibrosis biomarkers in rats with methamphetamine-induced cardiac fibrosis. (PubMed, J Sports Med Phys Fitness) - "These findings suggest that HIIT does not reverse METH-induced upregulation of cardiac fibrosis markers. Further studies are warranted to explore alternative or complementary interventions in the context of METH-associated cardiac fibrosis."

Journal • Preclinical • Cardiovascular • Fibrosis • Immunology • COL1A1 • COL3A1 • POSTN

Co-involvement of stimulants with opioids in North America: A 'silent epidemic'. (PubMed, PLOS Ment Health) - "We discuss evidence for a 'silent epidemic' alongside the opioid epidemic comprising co-ingestion of stimulants including methamphetamine and cocaine...Given the contribution of stimulants to the ongoing drug poisoning crisis there is an urgent need to develop and implement strategies that reduce the health risks associated with stimulant use. To achieve this, we must raise awareness among clinicians, policymakers and the general public regarding the potential impacts of stimulant use, including deliberate and unaware co-use of stimulants and opioids, on drug poisoning deaths, population health and the healthcare system."

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Non-pharmacotherapy for craving in methamphetamine use disorder: a systematic review and network meta-analysis of randomised controlled trials. (PubMed, Behav Brain Res) - "This study confirms that several non-pharmacotherapies are effective for managing craving in MUD. Exercise and TMS are particularly promising for reducing craving. The findings, synthesized within a novel "Intervention-Circuit-Symptom" integrative framework, provide a robust evidence base to inform clinical decision-making and guide the future development of MUD treatment guidelines."

Journal • Retrospective data • Review • CNS Disorders • Psychiatry

Application of Wastewater-Based Epidemiology in Japan to Estimate the Prevalence of Substance Use Including Methamphetamine and Ephedrine. (PubMed, Chem Asian J) - "This study provides the first objective evidence of population-level methamphetamine use in a large urban catchment of Japan, which is relatively low compared to other countries. The findings demonstrate the feasibility of wastewater analysis as a complementary surveillance approach to the existing system, enabling more responsive and evidence-based drug policy."

Journal • CNS Disorders • Epilepsy • Infectious Disease • Novel Coronavirus Disease

Overdose risk in the context of chemsex among gay, bisexual, and other men who have sex with men. (PubMed, Harm Reduct J) - "Chemsex is defined as the use of psychoactive substances - most commonly methamphetamine, synthetic cathinones, and Gamma-hydroxybutyrate/Gamma butyrolactone (GHB/GBL) - to enhance sexual activity primarily among gay, bisexual, and other men who have sex with men (GBM)...There is an urgent need for targeted research, improved data collection, and tailored harm reduction strategies to better understand and reduce overdose risk within chemsex contexts. Addressing these gaps is essential for reducing preventable deaths and improving health outcomes in this population."

Journal • Review • Human Immunodeficiency Virus • Infectious Disease

'A fine line between euphoria and death': a qualitative study exploring gamma-hydroxybutyrate (GHB) use among people who identify as heterosexual living in Australia. (PubMed, Harm Reduct J) - "In our heterosexual sample of people who use GHB in Australia, we identified novel aspects of GHB use characterised by escapism, intentional risk-taking, and gendered harm reduction strategies, while stigma featured alongside GHB use. Findings highlight gaps in public health education, particularly regarding intentional dosing towards unconsciousness, misconceptions about overdose management, and barriers to help seeking. Targeted, context-specific harm reduction and mental health interventions responsive to these experiences are required."

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PrEP Readiness Interventions for Sustained Motivation (PRISM) (clinicaltrials.gov) - P=N/A | N=400 | Recruiting | Sponsor: Florida International University | Enrolling by invitation ➔ Recruiting | Phase classification: P2 ➔ PN/A | N=840 ➔ 400 | Trial completion date: Apr 2027 ➔ Apr 2028 | Trial primary completion date: Apr 2027 ➔ Dec 2027

Enrollment change • Enrollment status • Phase classification • Trial completion date • Trial primary completion date • Human Immunodeficiency Virus • Infectious Disease

Substance use and treatment utilization patterns of working-age American men who were not in employment, education, or training (NEET) during the COVID-19 pandemic. (PubMed, Res Sq) - "After adjusting for sociodemographic factors, NEET status was significantly associated with higher odds of prescription tranquilizer/sedative use disorder (aOR = 3.54, 1.97-6.37), methamphetamine use disorder (aOR = 3.10, 95% CI: 1.82-5.28), and prescription pain‑reliever use disorder (aOR = 2.88, 1.82-4.53), while being inversely associated with alcohol use disorder (aOR = 0.68, 0.54-0.85)...Adjusted models showed higher odds of past-year SUDs but lower rates of alcohol use disorder. Targeted interventions should include age-appropriate, culturally tailored, and substance-specific treatment programs to improve public health."

Journal • Addiction (Opioid and Alcohol) • Infectious Disease • Novel Coronavirus Disease • Pain

Client Experiences of a Telephone-Delivered Intervention for Methamphetamine Use Disorder. (PubMed, Drug Alcohol Rev) - "Evidence of therapeutic relationships was found in participant accounts of experiencing non-judgemental support from counsellors. However, some participants reported in-person treatment would create a stronger therapeutic relationship. Many participants described a sense of comfort the telephone format afforded them, permitting anonymity and facilitating openness. Participants reported the telephone modality to be highly accessible and convenient, particularly for those with multiple commitments. Participants reported various benefits, including greater insight regarding their methamphetamine use and reduced methamphetamine use. Contrastingly, some participants felt their use was too severe and complex to be treated via telephone. Telephone-delivered interventions represent a potentially valuable initial step in the treatment trajectory for people with methamphetamine use disorder."

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Risk based tiered residential methamphetamine remediation limits. (PubMed, medRxiv) - "If all recommended alternate concentration limits are implemented, an estimated 50% additional cost reduction is possible with tiered limits based on contact time. These alternate limits still allow the occupant dose to fall below the recommended dose levels, which implies that these LOAs, MOAs, and HVAC systems are being over remediated when they are required to be remediated to the same limit as NOAs."

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Substance abuse in first-episode psychosis at Chris Hani Baragwanath Hospital. (PubMed, S Afr J Psychiatr) - "It emphasised the need for integrated strategies for the treatment of mental health and substance use. It provides a crucial insight into the socio-demographic and clinical predictors of substance use in patients with FEP, which can inform clinical practice and intervention strategies."

Journal • CNS Disorders • Psychiatry • Substance Abuse

Shifting views on decriminalization in British Columbia: insights from public opinion polling, 2024-2025. (PubMed, Am J Drug Alcohol Abuse) - "Background: In January 2023, British Columbia (BC) implemented a three-year pilot decriminalizing possession of up to 2.5 grams of certain illegal drugs, including opioids, cocaine, methamphetamine, and MDMA, the first policy of its kind in Canada...Without visible improvements in overdose prevention, service access, and public communication, the policy's long-term viability remains uncertain. Sustained investments in harm reduction and strategic public messaging are essential."

Journal • Addiction (Opioid and Alcohol)

Digital health interventions for people who use methamphetamine: a scoping review. (PubMed, Front Psychiatry) - "Future research should explore long-term outcomes, hybrid models, and co-designed approaches with a focus on gender and equity. With further development, DHIs may play a valuable role in the broader intervention landscape."

Journal • Review

Occurrence and Ecotoxicological Risks of Pharmaceuticals and Illicit Drugs in Effluent and Unsheltered Homelessness-Impacted River Systems. (PubMed, Arch Environ Contam Toxicol) - "Several PIDs were found to be ubiquitous in the effluent-impacted sites (e.g. lidocaine, metoprolol tartrate, diclofenac acid and methamphetamine). Pharmaceuticals except sulfamethoxazole were detected at concentrations far below Predicted-no effect concentration (PNEC) values across all effluent and unsheltered homelessness-impacted river systems, indicating negligible (low) or moderate ecological risks to algae and crustaceans. However, relying solely on single-compound risk assessment might underestimate cumulative ecological risk."

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Gender Differences in Sociodemographic and Clinical Characteristics of Methamphetamine Use in Saudi Arabia. (PubMed, Saudi Med J) - "Female methamphetamine users demonstrate greater vulnerability with earlier onset, more psychiatric comorbidities, and worse psychosocial outcomes. Targeted interventions are needed for female methamphetamine users in Saudi Arabia."

Journal • Retrospective data • CNS Disorders • Depression • Mood Disorders • Psychiatry

Methamphetamine regulates microglial polarization and glycolytic activity to promote Parkinson's disease through the LIPH/LPA/PI3K/AKT signaling axis. (PubMed, Int Immunopharmacol) - "METH may promote M1 polarization and glycolytic activity in microglia by activating LIPH/LPA/PI3K/AKT signaling, thus promoting the progression of PD."

Journal • Behavior Disorders • CNS Disorders • Mental Retardation • Metabolic Disorders • Movement Disorders • Parkinson's Disease • Psychiatry • CD86 • IL6 • LIPH • MRC1 • TNFA

Aripiprazole advances delayed sleep-wake rhythm in methamphetamine-treated mice. (PubMed, Chronobiol Int) - "This entrainment was also accompanied by changes in sleep architecture. These findings brought insights into the mechanism how APZ acts on patients with CRSWD, especially with internal desynchronization."

Journal • Preclinical • Sleep Disorder • Sleep Wake Cycle Disorder

Evaluating screening test protocols to assess methamphetamine contamination in buildings. (PubMed, J Occup Environ Hyg) - "These data and analyses demonstrate that simplified and less costly sampling protocols can be a valid screening approach. A sampling protocol for meth screening tests is provided and includes aliquots from the hotspots with the highest concentrations."

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The 'K-Podemic': a narrative review on drug-laced vaping for frontline clinicians. (PubMed, Singapore Med J) - "Although e-cigarettes were initially promoted in some countries as a tool for nicotine replacement and restricted in others due to concerns about potential misuse, there is now growing concern over drug-laced e-cigarettes containing illicit substances such as etomidate, ketamine, heroin and methamphetamine, which pose serious public health risks. In this review, we sought to provide practical guidance for frontline clinicians in the identification and management of suspected cases of drug-laced e-cigarette use and its associated medical complications. We also highlight the current preventative and mitigating strategies adopted by the government to address this public health epidemic."

Journal • CNS Disorders • Psychiatry

High Rates of Intimate Partner Violence Among Diverse Young Sexual Minority Men Who Use Substances. (PubMed, Sex Health) - "These findings highlight the syndemic interplay between substance use and IPV among YSMM. Public health responses must prioritize culturally responsive, trauma-informed interventions that account for the unique developmental and intersectional contexts of this population."

Journal • Human Immunodeficiency Virus • Infectious Disease • Mood Disorders

Piloting wastewater-based monitoring on a university campus to inform public health surveillance and response for opioids and other high-risk substances. (PubMed, J Water Health) - "Fentanyl, norfentanyl, and xylazine were consistently below their method reporting limits across all 54 samples, consistent with recent declines in national overdose and wastewater datasets. The highest detection frequencies were associated with methamphetamine (22-50%), amphetamine (39-83%), and a THC metabolite (50-100%). This study also highlights the implications of sample type (grab vs. composite) and day of week for wastewater-based epidemiology (WBE). Considering that the use of opioid-related WBE as an actionable public health surveillance tool is still relatively new, additional case studies are needed to explore the potential of this emerging tool and increase confidence in deploying public health interventions in response to wastewater data."

Journal • Addiction (Opioid and Alcohol)

Dynamic Crystalline Nanofibers for Analyte-Specific Fluorescence Sensing. (PubMed, Anal Chem) - "The dynamic nanofibers function robustly in complex environments such as hair spray and car exhaust, and exhibit high sensitivity toward amine-type drugs, with detection limits as low as 1 ng for methamphetamine and fentanyl. This work underscores the potential of dynamic molecular crystals to deliver substantially expanded signal diversity for advanced sensing applications."

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