BAX 499
/ Takeda
- LARVOL DELTA
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September 07, 2012
Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia
(Thromb Res)
- By TFPI BAX499 effectively neutralized TFPI inhibition of FXa & FXa dependent inhibition of TF/FVIIa; When used up to 500nM BAX499 did not inhibit FXa or TF/FVIIa; BAX499 repaired the clotting time but failed to appreciably impact the propagation phase of thrombin generation in induced hemophilia B whole blood
Review • Hemophilia
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