Befinfer (interferon β-1a biosimilar) / Clausen Laboratories - LARVOL DELTA

Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: An insight into the efflux-metabolism alliance. (PubMed) - "This effect disappeared in the presence of a CYP3A4 inducer dexamethasone. These results indicated that CYP3A4 could influence P-gp efflux, transport and uptake of CLA enantiomers as CYP3A4 substrates and that a duel inhibition to CYP3A4/ P-glycoprotein could enhance their absorption and bioavailability, which provides new insight into the efflux-metabolism alliance and will benefit the clinical pharmacology of (-)CLA as a candidate drug for treatment of Alzheimer's disease."

Journal • Alzheimer's Disease • Biosimilar

Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway. (PubMed) - J Ethnopharmacol - "Clausenidin extracted from Clausena excavata Burm.f. is an anti-hepG2 cell compound as shown by its ability to induce apoptosis through the mitochondrial pathway of apoptosis. Clausenidin can potentially be developed into an anticancer compound."

Journal • Biosimilar • Gastrointestinal Cancer • Hepatocellular Cancer • Oncology

Circumstances surrounding non-fatal opioid overdoses attended by ambulance services. (PubMed) - Drug Alcohol Rev - "The temporal patterns suggest that non-fatal overdoses occur during non-recreational time periods. The longer ambulance response time and disposition for private addresses indicate potential opportunities for peer interventions. Our analysis describes circumstances surrounding non-fatal overdoses and can be useful in guiding relevant, targeted prevention interventions. [Madah-Amiri D, Clausen T, Myrmel L, Brattebø G, Lobmaier P. Circumstances surrounding non-fatal opioid overdoses attended by ambulance services. Drug Alcohol Rev 2016;00:000-000]."

Journal • Biosimilar

Four new species of Phylloporia (Hymenochaetales, Basidiomycota) from tropical China with a key to Phylloporia species worldwide. (PubMed) - "In addition, the phylogenetic position of P. tiliae, which was recently described from China, was confirmed in the Phylloporia clade. A key is provided for all 30 accepted species of Phylloporia."

Journal • Biosimilar