KP214 / Zevra Therap - LARVOL DELTA

Influence of the polysaccharide capsule on virulence and fitness of Klebsiella pneumoniae. (PubMed, Front Microbiol) - "Infections of Galleria mellonella larvae showed a significantly decreased virulence potential of the CPS-deficient mutant. In conclusion, our data indicate a crucial role of CPS in vivo."

Journal • CNS Disorders • Hepatology • Infectious Disease • Pneumonia • Respiratory Diseases

Convergence of plant sterols and host eukaryotic cell-derived defensive lipids at the infectious pathogen-host interface. (PubMed, Biochimie) - "Convergence of ingested plant sterols and host eukaryotic cell-derived defensive lipids mitigates the disruptive effects of bacterial toxic effector molecules. Structural or immunological similarities (molecular mimicry) between ingested plant sterols and host defensive lipids play an important role in modulating bacterial signalling that occurs at the pathogen-host interface and in the mitigation of infection- and inflammation-driven pathological processes."

Journal • Infectious Disease • Inflammation • Pneumonia • CAT • IL1B • IL6 • PTX3

Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae. (PubMed, Acta Pharm Sin B) - "Polymyxin B and polymyxin E (colistin) are presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales, Acinetobacter baumannii, and Klebsiella pneumoniae. This is the first report of polymyxin resistance caused by IS26 intramolecular transposition mediated mgrB truncation in chromosome in K. pneumoniae. The findings broaden our scope of knowledge for polymyxin resistance and enriched our understanding of how bacteria can manage to survive in the presence of antibiotics."

Journal • Infectious Disease • Pneumonia

Endogenous ethanol-producing bacteria interference in pathogen-host crosstalk. (PubMed, Endocr Metab Immune Disord Drug Targets) - "However, compared to Kp52145-stimulation alone, W. confusa NRRL-B-14171 treatment significantly potentiated Kp52145-induced suppression of IL-25. using the same condition as mentioned above and compared to Kp52145-stimulation alone, L. reuteri 20016 treatment altered the secretion pattern in response to Kp52145: L. reuteri 20016-treated cells displayed less aversive responses towards Kp52145, suggesting that L. reuteri 20016 modulation may act differently on Kp52145 - induced signaling."

Journal • Infectious Disease • Inflammation • Pneumonia • MMP1

The Acquisition of Colistin Resistance Is Associated to the Amplification of a Large Chromosomal Region in Klebsiella pneumoniae kp52145. (PubMed, Int J Mol Sci) - "The only common genetic change observed in the strains that evolved in the presence of colistin was the amplification of a 34 Kb sequence, homologous to a prophage (Enterobacteria phage Fels-2). Our data support that gene amplification can be a driving force in the acquisition of colistin resistance by K. pneumoniae."

Journal • Infectious Disease • Pneumonia