benidipine / Generic mfg. - LARVOL DELTA

A Case of Benidipine-Induced Lichenoid Drug Eruption (EADV 2025) - No abstract available

Clinical • Lichen Planus

Slowly Burning Down the House: The Role of Calcium in Spotted Fever Rickettsiosis Pathogenesis (ASM Microbe 2025) - "Additionally, in a dose-dependent manner, both benidipine and nifedipine (L-type VGCCb) delayed R. parkeri-induced VP and bacterial growth...Replicating but not heat-killed R. parkeri caused EC VP; bacterial protein synthesis was necessary for EC barrier dysfunction since subinhibitory doxycycline doses delayed R. parkeri-induced EC dysfunction without inhibiting bacteria growth...parkeri EC infection leads to calcium entry and ATP consumption that promote fitness; limiting compensatory calcium influx by VGCCbs impairs bacterial division, hinders bacterial spread cell-to-cell, disrupts growth, and mitigates R. parkeri-induced EC VP. These findings suggest that rickettsial manipulation of host cell homeostasis and calcium flux is key to rickettsial fitness, pathogenicity, and disease severity."

Infectious Disease • CDH5

Effects of antihypertensive drugs on the metabolism of mobocertinib in rats both in vitro and in vivo. (PubMed, Drug Metab Dispos) - "The inhibitory mechanism of mobocertinib was further investigated for nicardipine, irbesartan, telmisartan, carvedilol, prazosin hydrochloride, and spironolactone. In this study, the most common antihypertensive drugs were found to inhibit the metabolism of mobocertinib in vitro. We found that benidipine, nicardipine, telmisartan, and irbesartan inhibited the metabolism of mobocertinib in vitro and in vivo."

Journal • Preclinical

Design, Characterization, and Evaluation of Solid-Self-Nano-Emulsifying Drug Delivery of Benidipine with Telmisartan: Quality by Design Approach. (PubMed, ACS Omega) - "Furthermore, BT11 demonstrated stability throughout the product's stability testing. These findings suggest that the oral S-SNEDDS formulation of BD and TEL can enhance the drugs' water solubility, potentially improving therapeutic outcomes and increasing patient compliance."

Journal

Efficacy and Safety of Dihydropyridine Calcium Channel Blockers for Primary Hypertension: A Bayesian Network Meta-analysis. (PubMed, Curr Hypertens Rev) - "In the office setting, levamlodipine may be the best treatment for primary hypertension, and lacidipine shows good safety."

Clinical • Journal • Retrospective data • Cardiovascular • Hypertension

Benidipine-TR: Benidipine in Hypertensive And/or Chronic Coronary Syndrome Patients (clinicaltrials.gov) - P=N/A | N=800 | Not yet recruiting | Sponsor: The Society of Prevention and Awareness of Cardiovascular Diseases

New trial • Cardiovascular • Hypertension

Is cloudy peritoneal dialysate associated with adverse drug reactions to benidipine? (PubMed, Perit Dial Int) - "This study confirms that benidipine can cause non-infectious chyloperitoneum, underscoring the need for attention to adverse drug reactions to avoid unnecessary resource use. Further investigation is required to guide antihypertensive medication choices in PD patients."

Adverse drug reaction • Journal • Cardiovascular • Hypertension

Refractory vasospastic angina in a patient with autoimmune hepatitis managed by using combined non-invasive provocation tests: A case report. (PubMed, J Cardiol Cases) - "Invasive coronary angiography and pharmacological spasm provocation tests under oral prednisolone (20 mg) revealed multi-vessel spasms with ST elevation but no obstructed coronary arteries. To assess the effectiveness of the pharmacotherapy following a Ca2+ antagonist (benidipine) administration, we adopted non-invasive and non-pharmacological coronary vasospasm provocation tests (cold-pressor stress, isometric handgrip exercise, and hyperventilation)...Discontinuation of corticosteroids is often difficult, and long-term administration may be inevitable. Evaluation of the fluctuated spasmogenicity during long-term observation of autoimmune hepatitis may be crucial."

Journal • Allergy • Autoimmune Hepatitis • Cardiovascular • Eosinophilia • Hepatitis C • Hepatology • Immunology • Inflammation

Identification and validation of diagnostic genes associated with neutrophil extracellular traps of type 2 diabetes mellitus. (PubMed, Front Genet) - "The gene-drug network included CACNA1C-Isradipine, CACNA1C-Benidipine and other relationship pairs. FGF1 and AGER were markedly regulated downwards in the T2DM group. Through bioinformatic analysis, we identified NETs-related diagnostic genes (ITIH3, FGF1, NRCAM, AGER, CACNA1C) in T2DM, and explored their mechanism of action from different aspects, providing new ideas for the studies related to diagnosis and treatment of T2DM."

Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus • AGER • CACNA1A • MIR455 • STAT1

Benidipine Hydrochloride Inhibits NLRP3 Inflammasome Activation by Inhibiting LPS-Induced NF-κB Signaling in THP-1 Macrophages. (PubMed, J Inflamm Res) - "Furthermore, benidipine hydrochloride significantly decreased the generation of ROS. Based on these results, we deduced that benidipine hydrochloride prevents ROS formation in THP-1 macrophages and LPS-induced NF-κB signaling, which in turn prevents the activation of NLRP3 inflammasomes and the release of IL-1β."

Journal • GSDMD • IL1B • NLRP3 • TLR4

Pathological and functional significance of aging mouse kidneys: clinical implications to reduce the risk of hyper- or hypokalemia in the elderly. (PubMed, Kidney Res Clin Pract) - "In our basic studies, antihypertensive drugs (benidipine, nifedipine, verapamil, diltiazem) and anticholesterol drugs (lovastatin, simvastatin, pravastatin) strongly suppressed the leukocyte Kv1.3 channels and thus exerted anti-inflammatory effects. Given such pharmacological properties of these drugs, they may also be useful in slowing the progression of tubulointerstitial fibrosis in aging kidneys and reducing the risk of hyper- or hypokalemia in elderly patients."

Journal • Preclinical • Atherosclerosis • Cardiovascular • Dyslipidemia • Fibrosis • Glomerulonephritis • Immunology • Inflammation

Effects of adenosine triphosphate, Lacidipine, and Benidipine on 5-fluorouracil-induced kidney damage in rats. (PubMed, Eur Rev Med Pharmacol Sci) - "It may be possible to prevent nephrotoxicity by adding ATP + Benidipine or ATP to 5-FU treatment."

Journal • Preclinical • CAT

Structural bases of inhibitory mechanism of CaV1.2 channel inhibitors. (PubMed, Nat Commun) - "Here, we report cryo-EM structures of CaV1.2 in the absence or presence of the antirheumatic drug tetrandrine or antihypertensive drug benidipine. Its hydrophobic sidechain, phenylpiperidine, is positioned at the exterior of the pore domain and cradled within a hydrophobic pocket formed by S5DIII, S6DIII, and S6DIV helices, providing additional interactions to exert inhibitory effects on both L-type and T-type voltage gated calcium channels. These findings provide the structural foundation for the rational design and optimization of therapeutic inhibitors of voltage-gated calcium channels."

Journal • Cardiovascular • Heart Failure

Benidipine impairs innate immunity converting sublethal to lethal infections in a murine model of spotted fever rickettsiosis. (PubMed, PLoS Negl Trop Dis) - "The unexpected findings stand in stark contrast to recent discussions of the benefits of calcium channel blockers for viral infections and chronic infectious or inflammatory diseases. A role for calcium channel blockers in exacerbation of human rickettsiosis and acute inflammatory infections should be evaluated by a retrospective review of patient's outcomes and medications."

Journal • Preclinical • Infectious Disease • Inflammation

Anti-inflammatory activity of benidipine hydrochloride in LPS-activated mammalian macrophages. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Therefore, it had anti-inflammatory activity. At the clinical setting this study suggests that BH can be utilized as hypertension drug that can suppress the inflammation associated with it."

Journal • Cardiovascular • Hypertension • Inflammation • CSF2 • IL6 • TNFA

Effects of benidipine, paracetamol, and their combination on postoperative and normal tissue pain thresholds. (PubMed, Front Pharmacol) - " The combination of the L-type Ca channel blocker benidipine and paracetamol (BPC) may provide potent analgesia. Our experimental results support that BPC may be useful in the treatment of severe pain that cannot be adequately inhibited by paracetamol."

Journal • Pain • IL6

Effect of benidipine alone and in combination with bosentan and sildenafil in amelioration of pulmonary arterial hypertension in experimental model in rats. (PubMed, J Cardiovasc Pharmacol) - "In HUVEC's cells, the expression of α-SMA was increased, whereas eNOS decreased after TGF-β exposure and was substantially reversed after pre-treatment with benidipine. We concluded that benidipine and its combination with bosentan and sildenafil exhibit beneficial effects in MCT-induced PAH through the α-SMA/TGF-β/eNOS signaling pathway."

Combination therapy • Journal • Preclinical • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • NOS3 • TGFB1

Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema. (PubMed, Aging (Albany NY)) - "Aside from the well-known senolytic, ABT-263, we identified other potentially new senescence-eliminating compounds, including a new class of molecules, the dihydropyridine family of calcium voltage-gated channel (CaV) blockers. The dihydropyridine family of CaV blockers thus constitutes a new class of senolytics that could improve lung diseases. Hence, our work paves the way for further studies on the senolytic activity of CaV blockers in different senescence contexts and age-related diseases."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Pulmonary Emphysema • Respiratory Diseases

Quality by design aided self-nano emulsifying drug delivery systems development for the oral delivery of Benidipine: Improvement of biopharmaceutical performance. (PubMed, Drug Deliv) - "Accelerated stability tests validated the product's stability. Therefore, the development of oral S-SNEDDS of BD may be advantageous for raising BD's water solubility and expanding their releasing capabilities, thereby boosting oral absorption."

Journal

Comparison of the Effect of Benidipine and Amlodipine on Clinical and Biochemical Parameters in CKD with Hypertension and Proteinuria (KIDNEY WEEK 2023) - "Benidipine is more effective than amlodipine in reducing proteinuria and blood pressure in chronic kidney patients with hypertension"

Clinical • Cardiovascular • Hypertension • Nephrology • Renal Disease

Molecular docking analysis of calcium channel blockers with ALR2 and RAGE. (PubMed, Bioinformation) - "We report that 1, 4-dihydropyridine compounds, particularly Benidipine, bind to the active sites with good efficiency. Thus, 1,4 dihydropyridine derivatives can be considered for further confirmation in drug discovery."

Journal • Diabetes • Metabolic Disorders • AKR1B1

Spotted fever rickettsia-induced microvascular endothelial barrier dysfunction is delayed by the calcium channel blocker benidipine. (PubMed, Biochem Biophys Res Commun) - "These data suggest that growth of R. parkeri inside endothelial cells is associated with impairment of endothelial cell monolayer integrity due to Ca flooding through specific, benidipine-sensitive T- or N/Q-type Ca channels but not through nifedipine-sensitive L-type Ca channels. Further study will be required to discern the exact nature of the Ca channels and Ca+ transporting system(s) involved, any contributions of the pathogen toward this process, as well as the suitability of benidipine and new dihydropyridine derivatives as complimentary therapeutic drugs against Rickettsia-induced vascular failure."

Journal • Cardiovascular • Infectious Disease

Protective effect of adenosine triphosphate and benidipine separately or together against cardiotoxicity caused by bevacizumab. (PubMed, Biotech Histochem) - "We found that ATP and benidipine alone or in combination reduced cardiac damage associated with the use of bevacizumab. ATP + benidipine combined therapy produced the most favorable results."

Journal • Cardiovascular

A Case of Life-threatening Vasospastic Angina Induced by Carteolol Eye Drops. (PubMed, Intern Med) - "Even though benidipine, a calcium channel blocker. Once the carteolol eyedrops were discontinued, the VSA resolved. This case demonstrates that carteolol eye drops can induce life-threatening VSA."

Journal • Cardiovascular • Glaucoma • Ophthalmology • Ventricular Tachycardia

Suppressing Delayed Rectifier Potassium Channels (Kv1.3) in T Lymphocytes and Its Therapeutic Efficacy in Rats With CKD (KIDNEY WEEK 2022) - "This drug also reduced the number of proliferating leukocytes with a significant decrease in the pro-inflammatory cytokine expression. Conclusion Taken together, these in vitro and in vivo findings suggested the therapeutic potency of Kv1.3-channel inhibitors, such as benidipine, in the treatment or prevention of CKD."

Preclinical • Chronic Kidney Disease • Fibrosis • Hodgkin Lymphoma • Immunology • Nephrology • Renal Disease