benidipine / Generic mfg. - LARVOL DELTA

Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study. (PubMed, J Clin Med) - "Symptomatic improvement showed only a weak association with BP reduction. These findings should be interpreted within the limitations of an observational study and warrant confirmation in controlled comparative studies."

Journal • Real-world evidence • Cardiovascular • Coronary Artery Disease • Hypertension

Reversible cerebral vasoconstriction syndrome with concomitant recurrent subarachnoid hemorrhage and coronary vasospastic angina: A manifestation of systemic vasoconstriction syndrome. (PubMed, Surg Neurol Int) - "Treatment with benidipine and nicorandil was initiated thereafter, and no recurrence of either cardiac or neurological symptoms was observed, with complete resolution of cerebral vasoconstriction on follow-up imaging. Although each condition is potentially reversible, their coexistence supports the concept of systemic vasoconstriction syndrome and underscores the need for vigilance regarding extracranial vascular involvement in patients with RCVS. Early recognition and targeted vasodilator therapy may be essential to prevent serious neurological and cardiovascular complications."

Journal • Cardiovascular • Hematological Disorders • Pain • Subarachnoid Hemorrhage

Mechanism of fatty acid uptake and inhibition in human FATP2. (PubMed, bioRxiv) - "These findings provide a structural framework for understanding vectorial fatty acid channeling and a scaffold for developing modulators of metabolic flux. Cryo-EM structures of human FATP2 reveal a membrane-anchored lollipop topologyEndogenous fatty acids within a hydrophobic tunnel delineate the fatty acid uptake pathwayIsradipine and benidipine displace fatty acids to trap a non-productive conformationAcyl-CoA product inhibition may provide negative feedback via steric occlusion."

Journal • Hepatology • Metabolic Dysfunction-Associated Steatotic Liver Disease • Oncology • SLC27A2

Benidipine-induced lichenoid drug eruption. (PubMed, Natl Med J India) - No abstract available

Journal • Lichen Planus

Analysis of a serious adverse reaction of rhabdomyolysis precipitated by a possible interaction of methylprednisolone with atorvastatin: a case report. (PubMed, Eur J Hosp Pharm) - "Due to the recurrence of nephrotic syndrome, methylprednisolone, torasemide, benidipine and atorvastatin were prescribed after admission to hospital. The temporal correlation between the drug combination and symptom onset, coupled with rapid clinical and biochemical improvement after atorvastatin discontinuation, supported a diagnosis of rhabdomyolysis due to a potential drug-drug interaction between atorvastatin and methylprednisolone, likely exacerbated by hypoproteinaemia. This case highlights the need for clinicians and pharmacists to be vigilant for such drug-drug interactions, particularly in patients with predisposing conditions like hypoproteinaemia."

Journal • Dyslipidemia • Glomerulonephritis • Musculoskeletal Pain • Nephrology • Pulmonary Disease • Renal Disease • MB

Bioanalytical HPLC Method for Quantification of Benidipine in Rat Plasma: Stability and Application to Pharmacokinetic Study. (PubMed, J Chromatogr Sci) - "Benidipine's pharmacokinetic parameters were suitably assessed in Sprague-Dawley rats after a single oral dosage (0.822 mg/kg). The findings demonstrated the suitability and applicability of the developed bioanalytical HPLC approach as a tool for the pharmacokinetic analysis of benidipine."

Journal • PK/PD data • Preclinical • Cardiovascular • Hypertension

Greenness Assessment of HPLC-UV Method for Simultaneous Estimation of Four Antihypertensive Drugs. (PubMed, J Chromatogr Sci) - "An environmentally friendly HPLC method was developed to estimate angiotensin receptor blocker (telmisartan) and calcium channel blockers (cilnidipine, benidipine and azelnidipine) in a single run. To assess the environmental impact of the method, five greenness evaluation criteria, namely, the Green Analytical Procedure Index, Analytical GREEness, Chlortox Scale, Blue Applicability Grade Index, and Red-Blue-Green 12, were adopted. Concerning all the tools, the proposed method was found to be green."

Journal

'The monthly curse': menstrual-associated coronary artery vasospasm in a premenopausal woman-a case report. (PubMed, Eur Heart J Case Rep) - "Sublingual administration of nitroglycerin resulted in the prompt relief of symptoms and resolution of ST-segment changes...She was closely monitored in an outpatient setting and was prescribed a combination of benidipine and nicorandil...In recent years, oestrogen replacement therapy has been reported to confer therapeutic benefits in this patient population. Early multidisciplinary collaboration involving gynaecologists and timely initiation of hormonal therapy may alter the clinical course and prevent fatal outcomes in such patients."

Journal • Cardiovascular • Critical care • Myocardial Infarction • Pain

Recurrent acute coronary syndrome caused by refractory vasospastic angina in a patient with essential thrombocythemia: a case report. (PubMed, Eur Heart J Case Rep) - "Her ET medication was switched from anagrelide to hydroxyurea and vasodilatory therapy was intensified with benidipine, diltiazem, and nicorandil. A multidisciplinary diagnostic approach, including OCT and histopathological evaluation and spasm provocation, can help to identify the underlying pathophysiology of ACS. Tailored therapy, verified through invasive provocation tests under vasodilation, successfully controlled the symptoms and prevented recurrence."

Journal • Acute Coronary Syndrome • Cardiovascular • Essential Thrombocythemia • Hematological Disorders • Myeloproliferative Neoplasm • Thrombocytosis

Rapid dissolving microneedle patch integrated with benidipine-loaded nanotransfersomes for transdermal drug delivery: optimization, characterizations, and preclinical bioavailability assessment. (PubMed, Drug Deliv Transl Res) - "Ex-vivo results indicated superior permeation compared to BEN-TF or BEN-DMNs alone, while the in-vivo study confirmed improved bioavailability versus both oral tablets and BEN-DMNs. This hybrid delivery platform offers a promising strategy for improving the systemic delivery of BEN."

Journal • Preclinical • Cardiovascular • Hypertension

A Case of Benidipine-Induced Lichenoid Drug Eruption (EADV 2025) - "Considering the temporal relationship, benidipine was discontinued based on the suspicion of benidipine-induced LDE and doxazosin was initiated. This case expands the spectrum of adverse cutaneous reactions associated with calcium channel blockers, underscoring the importance of prompt recognition and management of LDE. Clinicians should remain vigilant for LDE in patients presenting with compatible eruptions following antihypertensive therapy, particularly when involving less commonly implicated agents like benidipine."

Clinical • Cardiovascular • Dermatopathology • Hypertension • Inflammation • Lichen Planus

Benidipine-TR: Benidipine in Hypertensive and/or Chronic Coronary Syndrome Patients (clinicaltrials.gov) - P=N/A | N=800 | Enrolling by invitation | Sponsor: The Society of Prevention and Awareness of Cardiovascular Diseases | Not yet recruiting ➔ Enrolling by invitation | Initiation date: Jun 2025 ➔ Mar 2025

Enrollment open • Trial initiation date • Cardiovascular • Hypertension

Slowly Burning Down the House: The Role of Calcium in Spotted Fever Rickettsiosis Pathogenesis (ASM Microbe 2025) - "Additionally, in a dose-dependent manner, both benidipine and nifedipine (L-type VGCCb) delayed R. parkeri-induced VP and bacterial growth...Replicating but not heat-killed R. parkeri caused EC VP; bacterial protein synthesis was necessary for EC barrier dysfunction since subinhibitory doxycycline doses delayed R. parkeri-induced EC dysfunction without inhibiting bacteria growth...parkeri EC infection leads to calcium entry and ATP consumption that promote fitness; limiting compensatory calcium influx by VGCCbs impairs bacterial division, hinders bacterial spread cell-to-cell, disrupts growth, and mitigates R. parkeri-induced EC VP. These findings suggest that rickettsial manipulation of host cell homeostasis and calcium flux is key to rickettsial fitness, pathogenicity, and disease severity."

Infectious Disease • CDH5

Effects of antihypertensive drugs on the metabolism of mobocertinib in rats both in vitro and in vivo. (PubMed, Drug Metab Dispos) - "The inhibitory mechanism of mobocertinib was further investigated for nicardipine, irbesartan, telmisartan, carvedilol, prazosin hydrochloride, and spironolactone. In this study, the most common antihypertensive drugs were found to inhibit the metabolism of mobocertinib in vitro. We found that benidipine, nicardipine, telmisartan, and irbesartan inhibited the metabolism of mobocertinib in vitro and in vivo."

Journal • Preclinical

Design, Characterization, and Evaluation of Solid-Self-Nano-Emulsifying Drug Delivery of Benidipine with Telmisartan: Quality by Design Approach. (PubMed, ACS Omega) - "Furthermore, BT11 demonstrated stability throughout the product's stability testing. These findings suggest that the oral S-SNEDDS formulation of BD and TEL can enhance the drugs' water solubility, potentially improving therapeutic outcomes and increasing patient compliance."

Journal

Efficacy and Safety of Dihydropyridine Calcium Channel Blockers for Primary Hypertension: A Bayesian Network Meta-analysis. (PubMed, Curr Hypertens Rev) - "In the office setting, levamlodipine may be the best treatment for primary hypertension, and lacidipine shows good safety."

Clinical • Journal • Retrospective data • Cardiovascular • Hypertension

Benidipine-TR: Benidipine in Hypertensive And/or Chronic Coronary Syndrome Patients (clinicaltrials.gov) - P=N/A | N=800 | Not yet recruiting | Sponsor: The Society of Prevention and Awareness of Cardiovascular Diseases

New trial • Cardiovascular • Hypertension

Is cloudy peritoneal dialysate associated with adverse drug reactions to benidipine? (PubMed, Perit Dial Int) - "This study confirms that benidipine can cause non-infectious chyloperitoneum, underscoring the need for attention to adverse drug reactions to avoid unnecessary resource use. Further investigation is required to guide antihypertensive medication choices in PD patients."

Adverse drug reaction • Journal • Cardiovascular • Hypertension

Refractory vasospastic angina in a patient with autoimmune hepatitis managed by using combined non-invasive provocation tests: A case report. (PubMed, J Cardiol Cases) - "Invasive coronary angiography and pharmacological spasm provocation tests under oral prednisolone (20 mg) revealed multi-vessel spasms with ST elevation but no obstructed coronary arteries. To assess the effectiveness of the pharmacotherapy following a Ca2+ antagonist (benidipine) administration, we adopted non-invasive and non-pharmacological coronary vasospasm provocation tests (cold-pressor stress, isometric handgrip exercise, and hyperventilation)...Discontinuation of corticosteroids is often difficult, and long-term administration may be inevitable. Evaluation of the fluctuated spasmogenicity during long-term observation of autoimmune hepatitis may be crucial."

Journal • Allergy • Autoimmune Hepatitis • Cardiovascular • Eosinophilia • Hepatitis C • Hepatology • Immunology • Inflammation

Identification and validation of diagnostic genes associated with neutrophil extracellular traps of type 2 diabetes mellitus. (PubMed, Front Genet) - "The gene-drug network included CACNA1C-Isradipine, CACNA1C-Benidipine and other relationship pairs. FGF1 and AGER were markedly regulated downwards in the T2DM group. Through bioinformatic analysis, we identified NETs-related diagnostic genes (ITIH3, FGF1, NRCAM, AGER, CACNA1C) in T2DM, and explored their mechanism of action from different aspects, providing new ideas for the studies related to diagnosis and treatment of T2DM."

Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus • AGER • CACNA1A • MIR455 • STAT1

Benidipine Hydrochloride Inhibits NLRP3 Inflammasome Activation by Inhibiting LPS-Induced NF-κB Signaling in THP-1 Macrophages. (PubMed, J Inflamm Res) - "Furthermore, benidipine hydrochloride significantly decreased the generation of ROS. Based on these results, we deduced that benidipine hydrochloride prevents ROS formation in THP-1 macrophages and LPS-induced NF-κB signaling, which in turn prevents the activation of NLRP3 inflammasomes and the release of IL-1β."

Journal • GSDMD • IL1B • NLRP3 • TLR4

Pathological and functional significance of aging mouse kidneys: clinical implications to reduce the risk of hyper- or hypokalemia in the elderly. (PubMed, Kidney Res Clin Pract) - "In our basic studies, antihypertensive drugs (benidipine, nifedipine, verapamil, diltiazem) and anticholesterol drugs (lovastatin, simvastatin, pravastatin) strongly suppressed the leukocyte Kv1.3 channels and thus exerted anti-inflammatory effects. Given such pharmacological properties of these drugs, they may also be useful in slowing the progression of tubulointerstitial fibrosis in aging kidneys and reducing the risk of hyper- or hypokalemia in elderly patients."

Journal • Preclinical • Atherosclerosis • Cardiovascular • Dyslipidemia • Fibrosis • Glomerulonephritis • Immunology • Inflammation

Effects of adenosine triphosphate, Lacidipine, and Benidipine on 5-fluorouracil-induced kidney damage in rats. (PubMed, Eur Rev Med Pharmacol Sci) - "It may be possible to prevent nephrotoxicity by adding ATP + Benidipine or ATP to 5-FU treatment."

Journal • Preclinical • CAT

Structural bases of inhibitory mechanism of CaV1.2 channel inhibitors. (PubMed, Nat Commun) - "Here, we report cryo-EM structures of CaV1.2 in the absence or presence of the antirheumatic drug tetrandrine or antihypertensive drug benidipine. Its hydrophobic sidechain, phenylpiperidine, is positioned at the exterior of the pore domain and cradled within a hydrophobic pocket formed by S5DIII, S6DIII, and S6DIV helices, providing additional interactions to exert inhibitory effects on both L-type and T-type voltage gated calcium channels. These findings provide the structural foundation for the rational design and optimization of therapeutic inhibitors of voltage-gated calcium channels."

Journal • Cardiovascular • Heart Failure

Benidipine impairs innate immunity converting sublethal to lethal infections in a murine model of spotted fever rickettsiosis. (PubMed, PLoS Negl Trop Dis) - "The unexpected findings stand in stark contrast to recent discussions of the benefits of calcium channel blockers for viral infections and chronic infectious or inflammatory diseases. A role for calcium channel blockers in exacerbation of human rickettsiosis and acute inflammatory infections should be evaluated by a retrospective review of patient's outcomes and medications."

Journal • Preclinical • Infectious Disease • Inflammation