Capsulin (oral insulin) / Diabetology - LARVOL DELTA

Safety and Efficacy of an Oral Insulin (Capsulin) in Patients with Early-Stage Type 2 Diabetes: A Dose-Ranging Phase IIb Study. (PubMed, Diabetes Obes Metab) - "Capsulin oral insulin administered twice per day at a dose of 150iu per capsule is safe, with no confirmed treatment-linked hypoglycaemic events, and results in significant decreases from baseline in HbA1c, Fasting Plasma Glucose and triglycerides."

Journal • P2b data • Diabetes • Hypoglycemia • Metabolic Disorders • Type 2 Diabetes Mellitus

[VIRTUAL] A Phase 2b Study of Oral Insulin (Capsulin) Administered to Patients with Type 2 Diabetes (ADA 2021) - "There were no concomitant medications employed other than metformin, whose dose was fixed throughout the study. The group demonstrating the highest level of efficacy was the 150iu twice daily group, which was the original anticipated target dose, based on previous studies. The data support progression of Diabetology’s oral insulin programme towards conduct of large-scale phase 3 studies."

Clinical • Late-breaking abstract • P2b data • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Role of the bHLH transcription factor TCF21 in development and tumorigenesis. (PubMed, Braz J Med Biol Res) - "For this review, PubMed databases and keywords such as TCF21, POD-1, capsulin, tumors, carcinomas, tumorigenesis, development, and mechanism of action were utilized. Articles were selected within a historical context as were a number of citations from journals with relevant impact."

Journal • Immunology • Oncology • TCF21

Unique gene program of rat small resistance mesenteric arteries as revealed by deep RNA sequencing. (PubMed) - mRNAs that were not expressed at a level consistent with impugned function include skeletal myogenic factors, IKK2, nonmuscle myosin, and Gnb3. This screening analysis of gene expression in the small mesenteric resistance arteries suggests testable hypotheses regarding unique aspects of small artery function in the regional control of blood flow.

Journal • Biosimilar

To roll the eyes and snap a bite - function, development and evolution of craniofacial muscles. (PubMed, Semin Cell Dev Biol) - "We also trace the origin of head muscle in the chordate ancestors of vertebrates and discuss links with smooth-type muscle in the primitive chordate pharynx. We look out as to how the special properties of head muscle precursor and stem cells, in particular their competence to contribute to the heart, could be exploited in regenerative medicine."

Journal • Review