Daflon (micronized purified flavonoid fraction) / Servier - LARVOL DELTA

Daflon attenuates cisplatin-induced cerebellar neurotoxicity, anxiety-like behavior, and motor dysfunction by downregulating TLR4/NF-kB signaling. (PubMed, BMC Pharmacol Toxicol) - "In conclusion, daflon confers neuroprotection against cisplatin-induced cerebellar neurotoxicity through the suppression of TLR4/NF-kB-mediated oxidative-inflammatory and apoptotic injury."

Journal • Inflammation • Oncology • Psychiatry • CASP3 • CAT • IL1B • IL6 • MPO • TLR4

Daflon Enhances Morphine Analgesia and Mitigates Tolerance in a Rat Neuropathic Pain Model. (PubMed, Pharmaceuticals (Basel)) - "Importantly, the combination approach may allow for lower opioid dosages, minimizing the risks of opioid-related side effects. Overall, morphine and Daflon co-administration offers a promising and safer strategy for managing neuropathic pain and preserving spinal cord integrity."

Journal • Preclinical • Addiction (Opioid and Alcohol) • Inflammation • Neuralgia • Pain • FAP • GFAP • HMOX1 • IL10 • IL1B • IL6 • NFE2L2 • TNFA

Daflon and Centrum mitigate vancomycin-induced nephrotoxicity in rats by ameliorating oxidative stress, DNA damage, apoptosis, and inflammation. (PubMed, Front Toxicol) - "DF and CE attenuated VM-induced nephrotoxicity through antioxidant, anti-inflammatory, and DNA-protective mechanisms. Their combination provided superior renal protection by reducing oxidative stress, inflammation, and apoptosis, while enhancing antioxidant defenses and DNA repair capacity."

Journal • Preclinical • Hematological Disorders • Infectious Disease • Inflammation • Renal Disease • CAT • IL1B • KIM1 • PARP1 • RIPK1 • TNFA

Case Report: Micronized purified flavonoid fraction [Daflon]-induced bradycardia. (PubMed, Front Pharmacol) - "We reported a new effect of MPFF as an attenuator of the heart rate. Because venous insufficiency decreased during the observed drug administration period, further studies are needed to examine whether the ability of diosmin and hesperidin to reduce vein disorders is directly linked to their action on heart rate."

Journal • Cardiovascular • Inflammation

Daflon attenuates sleep deprivation-induced neurocognitive deficit in male Wistar rat by activating AMPK/Nrf2/HO-1 and downregulating Bax/Bcl-2/caspase 3 apoptotic signaling (WSS 2025) - "In conclusion, this study revealed that daflon improves neurocognition in sleep-deprived rats by activating AMPK/Nrf2/HO-1 and downregulating Bax/Bcl-2/caspase 3 apoptotic signaling."

Preclinical • Mood Disorders • Psychiatry • BAX • BCL2 • CASP3 • CAT • IL1B • IL6 • TNFA

Glue Embolization vs Conservative Treatment for Pelvic Congestion Syndrome (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Tanta University | Trial completion date: Dec 2024 ➔ Oct 2025 | Trial primary completion date: Dec 2024 ➔ Oct 2025

Trial completion date • Trial primary completion date

Effect of Micronized Purified Flavonoid Fraction Containing Hesperidin and Diosmin on Vincristine-Induced Neuropathy in Rats; the Role of Nitric Oxide Pathway. (PubMed, Iran J Pharm Res) - "Micronized purified flavonoid fraction may be an effective treatment for VIPN by reducing mechanical allodynia, thermal hyperalgesia, and TNF-α and IL-6 levels in DRG tissue. The NO pathway may play a role in the effectiveness of MPFF in treating VIPN."

Journal • Preclinical • Neuralgia • Oncology • Pain • Peripheral Neuropathic Pain • IL6 • TNFA

Micronized purified flavonoid fraction (daflon) improves sexual function by modulating NF-kB /NO/cGMP and steroidogenic signaling in cisplatin-treated male Wistar rats. (PubMed, Biochem Biophys Rep) - "In conclusion, the daflon improved sexual function in rats treated with cisplatin. This involved the downregulation of NF-kB and enhancement of the cavernosal NO/cGMP pathway and testicular steroidogenic signaling."

Journal • Preclinical • Infertility • Sexual Disorders

Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery (clinicaltrials.gov) - P4 | N=106 | Completed | Sponsor: Taipei Medical University Shuang Ho Hospital | Recruiting ➔ Completed | Trial completion date: Mar 2026 ➔ Mar 2025 | Trial primary completion date: Dec 2025 ➔ Jan 2025

Trial completion • Trial completion date • Trial primary completion date • Gastrointestinal Disorder

Somatic Changes of Maternal High-Fat Diet on Offspring-Possible Deleterious Effects of Flavonoids? (PubMed, Nutrients) - "Interestingly, the offspring of the groups that received flavonoids in addition to the HFD had significantly smaller dimensions compared to both the HFD group and the control group. The results of this experimental study reinforce what is already known about the effects of obesity on the gestation period and offspring and at the same time, the current study highlights the existence of possible adverse effects of flavonoid compounds on the development of pregnancy and offspring, opening the way for future studies on the benefits and risks of using these compounds during gestational period."

Journal • Genetic Disorders • Metabolic Disorders • Obesity • LEP • NAMPT

Prescription versus over-the-counter venotonics: HPLC-DAD and static digestive model simulation comparison. (PubMed, Int Angiol) - "Our experimental results show that the contents of both listed active substances, diosmin and hesperidin, met the declared amounts in all tested medicaments. Digestion simulation showed identical behaviour in prescription and OTC venotonics. The active substances could not be determined in the non-alkalized sample. Digestion did not affect the solubility of the tested drugs."

Clinical • Journal • Cardiovascular

Potential anti-schistosomal effect of Daflon, a repurposed drug targeting different stages of Schistosome maturity. (PubMed, Parasitol Res) - "DAF was administrated at a dose of 100 mg/kg/mouse on days zero, 21, and 42 post-infection towards the invasive, immature, and mature stages of Schistosoma mansoni respectively in comparison to the standard anti-schistosomal drug (Praziquantel). The female worm from DAF-treated groups showed tegumental edema with loss of the spines at the posterior end. Compared to the documented reduction of testosterone levels and distortion of testicular architecture in the S. mansoni-infected untreated group, DAF significantly restored testosterone levels and testicular architecture."

Journal • Fibrosis • Immunology • Infectious Disease

Glue Embolization vs Conservative Treatment for Pelvic Congestion Syndrome (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Tanta University | Not yet recruiting ➔ Recruiting

Enrollment open

Glue Embolization vs Conservative Treatment for Pelvic Congestion Syndrome (clinicaltrials.gov) - P=N/A | N=40 | Not yet recruiting | Sponsor: Tanta University

New trial

Clinical Study to Evaluate the Possible Efficacy and Safety of Diosmin and Hesperidin Combined Therapy in Patients With Helicobacter Pylori Infection (clinicaltrials.gov) - P1/2 | N=46 | Recruiting | Sponsor: Sadat City University

New P1/2 trial • Infectious Disease

Testicular toxicity in cisplatin-treated Wistar rats is mitigated by Daflon and associated with modulation of Nrf2/HO-1 and TLR4/NF-kB signaling. (PubMed, J Trace Elem Med Biol) - "Collectively, the ameliorative effect of daflon on cisplatin-induced testicular toxicity is associated with inhibition of oxidative stress and TLR4/NF-kB-mediated inflammatory pathways and activation of Nrf2/HO-1 signaling."

Journal • Preclinical • Infertility • Inflammation • Sexual Disorders • CASP3 • CAT • IL1B • IL6 • NFE2L2 • TLR4 • TNFA

Ameliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen in male Wistar rats. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "These reproductive hormones, testicular glycogen, and sperm parameters improved in the Daflon-treated groups. Hence, pre-treatment with flavonoid fractions of diosmin and hesperidin mitigated CPF-induced reproductive toxicity."

Journal • Preclinical • Anesthesia

Challenging conventions: Reconsidering the indication for endovenous ablation in CEAP 2 patients. (PubMed, Phlebology) - "As a result, we do not find it appropriate and do not recommend that every patient with complaints of chronic venous insufficiency and an indication for endovenous ablation undergo ablation without evaluating lower extremity venous hemodynamics."

Journal • Cardiovascular

Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery (clinicaltrials.gov) - P4 | N=150 | Recruiting | Sponsor: Taipei Medical University Shuang Ho Hospital | Not yet recruiting ➔ Recruiting | Initiation date: Dec 2024 ➔ Dec 2023

Enrollment open • Surgery • Trial initiation date • Gastrointestinal Disorder

VOS: Outcomes of Different Treatment Options in Chronic Venous Disease (clinicaltrials.gov) - P=N/A | N=2000 | Not yet recruiting | Sponsor: Universitaire Ziekenhuizen KU Leuven

New trial

Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery (clinicaltrials.gov) - P4 | N=150 | Not yet recruiting | Sponsor: Taipei Medical University Shuang Ho Hospital

New P4 trial • Surgery • Gastrointestinal Disorder

Evaluation of the Effects of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome (clinicaltrials.gov) - P4 | N=120 | Not yet recruiting | Sponsor: Ain Shams University

New P4 trial • Polycystic Ovary Syndrome • IL6

"Et au final 0.0054% de risque, une fois rapporté au nombre total de doses (ce qui est normal). Mois que le daflon ou l'homéopathie, donc." (@loulou2745)

Effect of daflon-500, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats. (PubMed, Toxicol Res) - "The levels of these oxidative and biochemical parameters were alleviated in the group pretreated with Daflon-500 . Results of this study demonstrated that pre-treatment with Daflon-500 mitigated CP-induced alterations in oxidative and biochemical parameters apparently due to the antioxidant effect of the flavonoid compound."

Journal • Preclinical • Anesthesia • Pain • CAT

Aspiration of Excessive Endometrial Fluid at the Day of Ovum Retrieval Plus Diosmin in (ICSI) Cycles (clinicaltrials.gov) - P=N/A | N=200 | Completed | Sponsor: Benha University | Unknown status ➔ Completed | N=100 ➔ 200 | Trial completion date: Dec 2020 ➔ Nov 2021 | Trial primary completion date: Nov 2020 ➔ Nov 2021

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Infertility • Sexual Disorders