Daflon (micronized purified flavonoid fraction) / Servier - LARVOL DELTA

Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery (clinicaltrials.gov) - P4 | N=106 | Completed | Sponsor: Taipei Medical University Shuang Ho Hospital | Recruiting ➔ Completed | Trial completion date: Mar 2026 ➔ Mar 2025 | Trial primary completion date: Dec 2025 ➔ Jan 2025

Trial completion • Trial completion date • Trial primary completion date • Gastrointestinal Disorder

Somatic Changes of Maternal High-Fat Diet on Offspring-Possible Deleterious Effects of Flavonoids? (PubMed, Nutrients) - "Interestingly, the offspring of the groups that received flavonoids in addition to the HFD had significantly smaller dimensions compared to both the HFD group and the control group. The results of this experimental study reinforce what is already known about the effects of obesity on the gestation period and offspring and at the same time, the current study highlights the existence of possible adverse effects of flavonoid compounds on the development of pregnancy and offspring, opening the way for future studies on the benefits and risks of using these compounds during gestational period."

Journal • Genetic Disorders • Metabolic Disorders • Obesity • LEP • NAMPT

Prescription versus over-the-counter venotonics: HPLC-DAD and static digestive model simulation comparison. (PubMed, Int Angiol) - "Our experimental results show that the contents of both listed active substances, diosmin and hesperidin, met the declared amounts in all tested medicaments. Digestion simulation showed identical behaviour in prescription and OTC venotonics. The active substances could not be determined in the non-alkalized sample. Digestion did not affect the solubility of the tested drugs."

Clinical • Journal • Cardiovascular

Potential anti-schistosomal effect of Daflon, a repurposed drug targeting different stages of Schistosome maturity. (PubMed, Parasitol Res) - "DAF was administrated at a dose of 100 mg/kg/mouse on days zero, 21, and 42 post-infection towards the invasive, immature, and mature stages of Schistosoma mansoni respectively in comparison to the standard anti-schistosomal drug (Praziquantel). The female worm from DAF-treated groups showed tegumental edema with loss of the spines at the posterior end. Compared to the documented reduction of testosterone levels and distortion of testicular architecture in the S. mansoni-infected untreated group, DAF significantly restored testosterone levels and testicular architecture."

Journal • Fibrosis • Immunology • Infectious Disease

Glue Embolization vs Conservative Treatment for Pelvic Congestion Syndrome (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Tanta University | Not yet recruiting ➔ Recruiting

Enrollment open

Glue Embolization vs Conservative Treatment for Pelvic Congestion Syndrome (clinicaltrials.gov) - P=N/A | N=40 | Not yet recruiting | Sponsor: Tanta University

New trial

Clinical Study to Evaluate the Possible Efficacy and Safety of Diosmin and Hesperidin Combined Therapy in Patients With Helicobacter Pylori Infection (clinicaltrials.gov) - P1/2 | N=46 | Recruiting | Sponsor: Sadat City University

New P1/2 trial • Infectious Disease

Testicular toxicity in cisplatin-treated Wistar rats is mitigated by Daflon and associated with modulation of Nrf2/HO-1 and TLR4/NF-kB signaling. (PubMed, J Trace Elem Med Biol) - "Collectively, the ameliorative effect of daflon on cisplatin-induced testicular toxicity is associated with inhibition of oxidative stress and TLR4/NF-kB-mediated inflammatory pathways and activation of Nrf2/HO-1 signaling."

Journal • Preclinical • Infertility • Inflammation • Sexual Disorders • CASP3 • CAT • IL1B • IL6 • NFE2L2 • TLR4 • TNFA

Ameliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen in male Wistar rats. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "These reproductive hormones, testicular glycogen, and sperm parameters improved in the Daflon-treated groups. Hence, pre-treatment with flavonoid fractions of diosmin and hesperidin mitigated CPF-induced reproductive toxicity."

Journal • Preclinical • Anesthesia

Challenging conventions: Reconsidering the indication for endovenous ablation in CEAP 2 patients. (PubMed, Phlebology) - "As a result, we do not find it appropriate and do not recommend that every patient with complaints of chronic venous insufficiency and an indication for endovenous ablation undergo ablation without evaluating lower extremity venous hemodynamics."

Journal • Cardiovascular

Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery (clinicaltrials.gov) - P4 | N=150 | Recruiting | Sponsor: Taipei Medical University Shuang Ho Hospital | Not yet recruiting ➔ Recruiting | Initiation date: Dec 2024 ➔ Dec 2023

Enrollment open • Surgery • Trial initiation date • Gastrointestinal Disorder

VOS: Outcomes of Different Treatment Options in Chronic Venous Disease (clinicaltrials.gov) - P=N/A | N=2000 | Not yet recruiting | Sponsor: Universitaire Ziekenhuizen KU Leuven

New trial

Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery (clinicaltrials.gov) - P4 | N=150 | Not yet recruiting | Sponsor: Taipei Medical University Shuang Ho Hospital

New P4 trial • Surgery • Gastrointestinal Disorder

Evaluation of the Effects of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome (clinicaltrials.gov) - P4 | N=120 | Not yet recruiting | Sponsor: Ain Shams University

New P4 trial • Polycystic Ovary Syndrome • IL6

"Et au final 0.0054% de risque, une fois rapporté au nombre total de doses (ce qui est normal). Mois que le daflon ou l'homéopathie, donc." (@loulou2745)

Effect of daflon-500, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats. (PubMed, Toxicol Res) - "The levels of these oxidative and biochemical parameters were alleviated in the group pretreated with Daflon-500 . Results of this study demonstrated that pre-treatment with Daflon-500 mitigated CP-induced alterations in oxidative and biochemical parameters apparently due to the antioxidant effect of the flavonoid compound."

Journal • Preclinical • Anesthesia • Pain • CAT

Aspiration of Excessive Endometrial Fluid at the Day of Ovum Retrieval Plus Diosmin in (ICSI) Cycles (clinicaltrials.gov) - P=N/A | N=200 | Completed | Sponsor: Benha University | Unknown status ➔ Completed | N=100 ➔ 200 | Trial completion date: Dec 2020 ➔ Nov 2021 | Trial primary completion date: Nov 2020 ➔ Nov 2021

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Infertility • Sexual Disorders

Clinical non-inferiority study between Micronized purified flavonoid fraction 1000 mg, one chewable tablet per day and Micronized Purified Flavonoid Fraction 500 mg, 2 tablets daily after eight weeks of treatment in patients suffering from symptomatic Chronic Venous Disease (CVD). A naponta egy rágótablettában alkalmazott 1000 mg mikronizált tisztított flavonoid frakció (MPFF) és a naponta 2... (clinicaltrialsregister.eu) - P3 | N=570 | Completed | Sponsor: Institut de Recherches Internationales SERVIER (I.R.I.S.)

Head-to-Head • New P3 trial • Cardiovascular

Clozapine-Induced Carpopedal Lymphedema: A Case Report (APA 2022) - "The patient has been using levothyroxine (125 mcg/day), ASA (100 mg/day), prednisolone (5 mg/day), ezetimibe (10 mg/day), atorvastatin (10 mg/day), benidipine (4 mg/day), nebivolol (5 mg/day) when clozapine treatment was initiated and carpopedal edema developed around 4 weeks after the onset of the treatment when clozapine dose was increased to 100 mg. Following the development of edema, clozapine was stopped and switched to amisulpride. In addition, although the patient was using benidipe for more than 2 years without any complaints, benidipine was switched to telmisartan/hydochlorothiazide, due to known common side effects of calcium channel blockers in causing peripheral edema...Our observation can be explained as an idiosyncratic drug reaction or a complex drug-drug interaction that precipitated lymphedema through unknown mechanisms. Additional preclinical studies and controlled trials are to be performed to verify this observation."

Clinical • Agranulocytosis • Cardiovascular • CNS Disorders • Granulocytopenia • Hematological Disorders • Inflammation • Neutropenia • Psychiatry • Schizophrenia

The Efficacy and Safety of Different Phlebotonic Drugs in Children With Venous Malformations (clinicaltrials.gov) - P=N/A; N=1000; Recruiting; Sponsor: Center for Vascular Pathology, Moscow

Clinical • New trial

Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review. (PubMed, Eur J Drug Metab Pharmacokinet) - "However, diosmin exhibits inhibitory effects on different metabolic enzymes. This encourages the investigation of its potential therapeutic effect and safety in different diseases in clinical trials, while taking potential interactions into consideration."

Journal • Review • Fibrosis

Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats. (PubMed, Toxicol Res) - "Data obtained from the current study indicate that rats exposed to sub-chronic doses of lead acetate show increased blood lead levels, electrolyte imbalance, alongside impairment in ZPP levels, activities of antioxidant enzymes, and histopathology, while pretreatment using daflon mitigated the ensued perturbations. This, therefore, suggests that consumption of foods enriched with flavonoid fractions of diosmin and hesperidin may be beneficial for individuals inhabiting lead-polluted environments."

Journal • Preclinical

Comparative efficacy of various methods of treatment of chronic venous oedema in real clinical practice (PubMed, Angiol Sosud Khir) - P=N/A | "MPFF and Detragel appear to be effective and safe components of comprehensive conservative therapy of chronic oedema induced by primary varicose veins of lower extremities."

Clinical • Journal • Cardiovascular • Varicose Veins

'de Novo' Repurposing of Daflon As Anti-Intestinal Parasitic Drug in Experimental Giardiasis. (PubMed, Exp Parasitol) - "This study indicated promising actions of Daflon 500 as an anti-giardial drug, and the results demonstrated its potential effect in improving the intestinal epithelial tissue and disturbing the Giardia stages when it was taken collectively with Metronidazole."

Journal • Infectious Disease

Pharmacological correction of total venous reflux in patients with varicose veins (PubMed, Angiol Sosud Khir) - "Thus, the administration of the micronized purified flavonoid fraction for 1 month in primary venous disease led to a decrease in the total venous reflux. The effect of the micronized purified flavonoid fraction on the total venous reflux was higher in younger patients and in patients with a lower clinical class of the disease."

Clinical • Journal • Varicose Veins